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Items: 1 to 50 of 69

1.

T Cell Repertoire Dynamics during Pregnancy in Multiple Sclerosis.

Ramien C, Yusko EC, Engler JB, Gamradt S, Patas K, Schweingruber N, Willing A, Rosenkranz SC, Diemert A, Harrison A, Vignali M, Sanders C, Robins HS, Tolosa E, Heesen C, Arck PC, Scheffold A, Chan K, Emerson RO, Friese MA, Gold SM.

Cell Rep. 2019 Oct 22;29(4):810-815.e4. doi: 10.1016/j.celrep.2019.09.025.

2.

Pregnancy Enables Expansion of Disease-Specific Regulatory T Cells in an Animal Model of Multiple Sclerosis.

Engler JB, Heckmann NF, Jäger J, Gold SM, Friese MA.

J Immunol. 2019 Oct 1;203(7):1743-1752. doi: 10.4049/jimmunol.1900611. Epub 2019 Aug 23.

PMID:
31444265
3.

Neuronal vulnerability and multilineage diversity in multiple sclerosis.

Schirmer L, Velmeshev D, Holmqvist S, Kaufmann M, Werneburg S, Jung D, Vistnes S, Stockley JH, Young A, Steindel M, Tung B, Goyal N, Bhaduri A, Mayer S, Engler JB, Bayraktar OA, Franklin RJM, Haeussler M, Reynolds R, Schafer DP, Friese MA, Shiow LR, Kriegstein AR, Rowitch DH.

Nature. 2019 Sep;573(7772):75-82. doi: 10.1038/s41586-019-1404-z. Epub 2019 Jul 17.

PMID:
31316211
4.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H.

Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27.

5.

Bassoon proteinopathy drives neurodegeneration in multiple sclerosis.

Schattling B, Engler JB, Volkmann C, Rothammer N, Woo MS, Petersen M, Winkler I, Kaufmann M, Rosenkranz SC, Fejtova A, Thomas U, Bose A, Bauer S, Träger S, Miller KK, Brück W, Duncan KE, Salinas G, Soba P, Gundelfinger ED, Merkler D, Friese MA.

Nat Neurosci. 2019 Jun;22(6):887-896. doi: 10.1038/s41593-019-0385-4. Epub 2019 Apr 22.

PMID:
31011226
6.

Arc/Arg3.1 defines dendritic cells and Langerhans cells with superior migratory ability independent of phenotype and ontogeny in mice.

Tintelnot J, Ufer F, Engler JB, Winkler H, Lücke K, Mittrücker HW, Friese MA.

Eur J Immunol. 2019 May;49(5):724-736. doi: 10.1002/eji.201847797. Epub 2019 Mar 6.

PMID:
30786014
7.

Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.

Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ.

Immunity. 2019 Feb 19;50(2):462-476.e8. doi: 10.1016/j.immuni.2018.12.010. Epub 2019 Feb 12.

PMID:
30770246
8.

Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways.

Hierweger AM, Engler JB, Friese MA, Reichardt HM, Lydon J, DeMayo F, Mittrücker HW, Arck PC.

Am J Reprod Immunol. 2019 Feb;81(2):e13084. doi: 10.1111/aji.13084. Epub 2019 Jan 28.

PMID:
30604567
9.

Sex differences in autoimmune disorders of the central nervous system.

Gold SM, Willing A, Leypoldt F, Paul F, Friese MA.

Semin Immunopathol. 2019 Mar;41(2):177-188. doi: 10.1007/s00281-018-0723-8. Epub 2018 Oct 25.

PMID:
30361800
10.

Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood.

Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C, Kouassi NM, Preuß A, Pilnitz-Stolze G, Müller U, Thanisch S, Richter M, Scharrenberg R, Kraus V, Dörk R, Schau L, Herder V, Gerhauser I, Pfankuche VM, Käufer C, Waltl I, Moraes T, Sellau J, Hoenow S, Schmidt-Chanasit J, Jansen S, Schattling B, Ittrich H, Bartsch U, Renné T, Bartenschlager R, Arck P, Cadar D, Friese MA, Vapalahti O, Lotter H, Benites S, Rolling L, Gabriel M, Baumgärtner W, Morellini F, Hölter SM, Amarie O, Fuchs H, Hrabe de Angelis M, Löscher W, Calderon de Anda F, Gabriel G.

Nat Microbiol. 2018 Oct;3(10):1161-1174. doi: 10.1038/s41564-018-0236-1. Epub 2018 Sep 10.

PMID:
30202017
11.

Metabolomic Profiles for Primary Progressive Multiple Sclerosis Stratification and Disease Course Monitoring.

Stoessel D, Stellmann JP, Willing A, Behrens B, Rosenkranz SC, Hodecker SC, Stürner KH, Reinhardt S, Fleischer S, Deuschle C, Maetzler W, Berg D, Heesen C, Walther D, Schauer N, Friese MA, Pless O.

Front Hum Neurosci. 2018 Jun 4;12:226. doi: 10.3389/fnhum.2018.00226. eCollection 2018.

12.

T Cell Phenotype and T Cell Receptor Repertoire in Patients with Major Depressive Disorder.

Patas K, Willing A, Demiralay C, Engler JB, Lupu A, Ramien C, Schäfer T, Gach C, Stumm L, Chan K, Vignali M, Arck PC, Friese MA, Pless O, Wiedemann K, Agorastos A, Gold SM.

Front Immunol. 2018 Feb 20;9:291. doi: 10.3389/fimmu.2018.00291. eCollection 2018.

13.

Production of IL-17 by MAIT Cells Is Increased in Multiple Sclerosis and Is Associated with IL-7 Receptor Expression.

Willing A, Jäger J, Reinhardt S, Kursawe N, Friese MA.

J Immunol. 2018 Feb 1;200(3):974-982. doi: 10.4049/jimmunol.1701213. Epub 2018 Jan 3.

14.

Prenatal Administration of Betamethasone Causes Changes in the T Cell Receptor Repertoire Influencing Development of Autoimmunity.

Gieras A, Gehbauer C, Perna-Barrull D, Engler JB, Diepenbruck I, Glau L, Joosse SA, Kersten N, Klinge S, Mittrücker HW, Friese MA, Vives-Pi M, Tolosa E.

Front Immunol. 2017 Nov 13;8:1505. doi: 10.3389/fimmu.2017.01505. eCollection 2017.

15.

Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation.

Ufer F, Vargas P, Engler JB, Tintelnot J, Schattling B, Winkler H, Bauer S, Kursawe N, Willing A, Keminer O, Ohana O, Salinas-Riester G, Pless O, Kuhl D, Friese MA.

Sci Immunol. 2016 Sep 23;1(3):eaaf8665. doi: 10.1126/sciimmunol.aaf8665.

PMID:
28783680
16.

Maraviroc as possible treatment for PML-IRIS in natalizumab-treated patients with MS.

Hodecker SC, Stürner KH, Becker V, Elias-Hamp B, Holst B, Friese MA, Heesen C.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 8;4(2):e325. doi: 10.1212/NXI.0000000000000325. eCollection 2017 Mar. No abstract available.

17.

Ruxolitinib treatment in a patient with neuromyelitis optica: A case report.

Hodecker SC, Stellmann JP, Rosenkranz SC, Young K, Holst B, Friese MA, Heesen C.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 3;4(2):e328. doi: 10.1212/NXI.0000000000000328. eCollection 2017 Mar. No abstract available.

18.

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy.

Engler JB, Kursawe N, Solano ME, Patas K, Wehrmann S, Heckmann N, Lühder F, Reichardt HM, Arck PC, Gold SM, Friese MA.

Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):E181-E190. doi: 10.1073/pnas.1617115114. Epub 2017 Jan 3.

19.

Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis.

Schattling B, Fazeli W, Engeland B, Liu Y, Lerche H, Isbrandt D, Friese MA.

JCI Insight. 2016 Nov 17;1(19):e89810. doi: 10.1172/jci.insight.89810.

20.

Plasticity of Th17 Cells in Autoimmune Kidney Diseases.

Krebs CF, Turner JE, Paust HJ, Kapffer S, Koyro T, Krohn S, Ufer F, Friese MA, Flavell RA, Stockinger B, Steinmetz OM, Stahl RA, Huber S, Panzer U.

J Immunol. 2016 Jul 15;197(2):449-57. doi: 10.4049/jimmunol.1501831. Epub 2016 Jun 6.

21.

Multiple sclerosis: Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor.

Rühl G, Niedl AG, Patronov A, Siewert K, Pinkert S, Kalemanov M, Friese MA, Attfield KE, Antes I, Hohlfeld R, Dornmair K.

Neurol Neuroimmunol Neuroinflamm. 2016 May 17;3(4):e241. doi: 10.1212/NXI.0000000000000241. eCollection 2016 Aug.

22.

Sex effects on inflammatory and neurodegenerative processes in multiple sclerosis.

Ramien C, Taenzer A, Lupu A, Heckmann N, Engler JB, Patas K, Friese MA, Gold SM.

Neurosci Biobehav Rev. 2016 Aug;67:137-46. doi: 10.1016/j.neubiorev.2015.12.015. Epub 2016 Jan 8. Review.

PMID:
26773723
23.

Widespread synaptic loss in multiple sclerosis.

Friese MA.

Brain. 2016 Jan;139(Pt 1):2-4. doi: 10.1093/brain/awv349. No abstract available.

PMID:
26747852
24.

Multiple sclerosis associated genetic variants of CD226 impair regulatory T cell function.

Piédavent-Salomon M, Willing A, Engler JB, Steinbach K, Bauer S, Eggert B, Ufer F, Kursawe N, Wehrmann S, Jäger J, Reinhardt S, Friese MA.

Brain. 2015 Nov;138(Pt 11):3263-74. doi: 10.1093/brain/awv256. Epub 2015 Sep 10.

PMID:
26359290
25.

Immunopathology of multiple sclerosis.

Dendrou CA, Fugger L, Friese MA.

Nat Rev Immunol. 2015 Sep 15;15(9):545-58. doi: 10.1038/nri3871. Epub 2015 Aug 7. Review.

PMID:
26250739
26.

[Stem cell transplantation for multiple sclerosis. Hamburg experiences and state of international research].

Stellmann JP, Stürner KH, Ufer F, Havemeister S, Pöttgen J, Ayuk Ayuketang F, Kröger N, Friese MA, Heesen C.

Nervenarzt. 2015 Aug;86(8):989-96. doi: 10.1007/s00115-015-4305-x. German.

PMID:
25956824
27.

Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke.

Gelderblom M, Melzer N, Schattling B, Göb E, Hicking G, Arunachalam P, Bittner S, Ufer F, Herrmann AM, Bernreuther C, Glatzel M, Gerloff C, Kleinschnitz C, Meuth SG, Friese MA, Magnus T.

Stroke. 2014 Nov;45(11):3395-402. doi: 10.1161/STROKEAHA.114.005836. Epub 2014 Sep 18.

PMID:
25236871
28.

CD8⁺ MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL-18 serum levels in multiple sclerosis.

Willing A, Leach OA, Ufer F, Attfield KE, Steinbach K, Kursawe N, Piedavent M, Friese MA.

Eur J Immunol. 2014 Oct;44(10):3119-28. doi: 10.1002/eji.201344160. Epub 2014 Aug 19.

29.

A vaccine targeting mutant IDH1 induces antitumour immunity.

Schumacher T, Bunse L, Pusch S, Sahm F, Wiestler B, Quandt J, Menn O, Osswald M, Oezen I, Ott M, Keil M, Balß J, Rauschenbach K, Grabowska AK, Vogler I, Diekmann J, Trautwein N, Eichmüller SB, Okun J, Stevanović S, Riemer AB, Sahin U, Friese MA, Beckhove P, von Deimling A, Wick W, Platten M.

Nature. 2014 Aug 21;512(7514):324-7. doi: 10.1038/nature13387. Epub 2014 Jun 25.

PMID:
25043048
30.

Acquired channelopathies as contributors to development and progression of multiple sclerosis.

Schattling B, Eggert B, Friese MA.

Exp Neurol. 2014 Dec;262 Pt A:28-36. doi: 10.1016/j.expneurol.2013.12.006. Epub 2014 Mar 20. Review.

PMID:
24656770
31.

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis.

Friese MA, Schattling B, Fugger L.

Nat Rev Neurol. 2014 Apr;10(4):225-38. doi: 10.1038/nrneurol.2014.37. Epub 2014 Mar 18. Review.

PMID:
24638138
32.

Neutrophils amplify autoimmune central nervous system infiltrates by maturing local APCs.

Steinbach K, Piedavent M, Bauer S, Neumann JT, Friese MA.

J Immunol. 2013 Nov 1;191(9):4531-9. doi: 10.4049/jimmunol.1202613. Epub 2013 Sep 23.

33.

Plasma levels of neuron specific enolase quantify the extent of neuronal injury in murine models of ischemic stroke and multiple sclerosis.

Gelderblom M, Daehn T, Schattling B, Ludewig P, Bernreuther C, Arunachalam P, Matschke J, Glatzel M, Gerloff C, Friese MA, Magnus T.

Neurobiol Dis. 2013 Nov;59:177-82. doi: 10.1016/j.nbd.2013.07.017. Epub 2013 Aug 9.

PMID:
23932916
34.

Pregnancy and multiple sclerosis: feto-maternal immune cross talk and its implications for disease activity.

Patas K, Engler JB, Friese MA, Gold SM.

J Reprod Immunol. 2013 Mar;97(1):140-6. doi: 10.1016/j.jri.2012.10.005. Review.

PMID:
23432880
35.

A clinical and neurobiological case of IgM NMDA receptor antibody associated encephalitis mimicking bipolar disorder.

Choe CU, Karamatskos E, Schattling B, Leypoldt F, Liuzzi G, Gerloff C, Friese MA, Mulert C.

Psychiatry Res. 2013 Jul 30;208(2):194-6. doi: 10.1016/j.psychres.2012.09.035. Epub 2012 Dec 13.

PMID:
23246244
36.

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.

Nat Med. 2012 Dec;18(12):1805-11. doi: 10.1038/nm.3015. Epub 2012 Nov 18.

PMID:
23160238
37.

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke.

Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam TV, Leypoldt F, Simova O, Thom V, Friese MA, Prinz I, Hölscher C, Glatzel M, Korn T, Gerloff C, Tolosa E, Magnus T.

Blood. 2012 Nov 1;120(18):3793-802. doi: 10.1182/blood-2012-02-412726. Epub 2012 Sep 13.

PMID:
22976954
38.

CD8-mediated inflammatory central nervous system disorders.

Willing A, Friese MA.

Curr Opin Neurol. 2012 Jun;25(3):316-21. doi: 10.1097/WCO.0b013e328352ea8b. Review.

PMID:
22547102
39.

Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

McMahon RM, Friis L, Siebold C, Friese MA, Fugger L, Jones EY.

Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):447-54. doi: 10.1107/S0907444911007888. Epub 2011 Apr 13.

40.

Multiple enlarged nerves on neurosonography: an unusual paraneoplastic case.

Leypoldt F, Friese MA, Böhm J, Bäumer T.

Muscle Nerve. 2011 May;43(5):756-8. doi: 10.1002/mus.22010.

PMID:
21484827
41.

[Autoimmune synaptic encephalopathies].

Friese MA, Magnus T.

Nervenarzt. 2011 Oct;82(10):1239-49. doi: 10.1007/s00115-010-3219-x. Review. German.

PMID:
21424416
42.

IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.

Tzartos JS, Craner MJ, Friese MA, Jakobsen KB, Newcombe J, Esiri MM, Fugger L.

Am J Pathol. 2011 Feb;178(2):794-802. doi: 10.1016/j.ajpath.2010.10.043.

43.

Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model.

Vergo S, Craner MJ, Etzensperger R, Attfield K, Friese MA, Newcombe J, Esiri M, Fugger L.

Brain. 2011 Feb;134(Pt 2):571-84. doi: 10.1093/brain/awq337. Epub 2011 Jan 13.

PMID:
21233144
44.

N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes.

Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS, Friese MA, Galea I, Kullmann DM, Beeson D, Lang B, Bien CG, Vincent A.

Brain. 2010 Jun;133(Pt 6):1655-67. doi: 10.1093/brain/awq113.

45.

[Multiple sclerosis].

Friese MA.

Dtsch Med Wochenschr. 2010 Mar;135(11):527-31. doi: 10.1055/s-0030-1249199. Epub 2010 Mar 10. German. No abstract available.

PMID:
20221970
46.

Pathogenic CD8(+) T cells in multiple sclerosis.

Friese MA, Fugger L.

Ann Neurol. 2009 Aug;66(2):132-41. doi: 10.1002/ana.21744. Review.

PMID:
19743458
47.

From genes to function: the next challenge to understanding multiple sclerosis.

Fugger L, Friese MA, Bell JI.

Nat Rev Immunol. 2009 Jun;9(6):408-17. doi: 10.1038/nri2554. Review.

PMID:
19444306
48.

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides.

Harkiolaki M, Holmes SL, Svendsen P, Gregersen JW, Jensen LT, McMahon R, Friese MA, van Boxel G, Etzensperger R, Tzartos JS, Kranc K, Sainsbury S, Harlos K, Mellins ED, Palace J, Esiri MM, van der Merwe PA, Jones EY, Fugger L.

Immunity. 2009 Mar 20;30(3):348-57. doi: 10.1016/j.immuni.2009.01.009. Erratum in: Immunity. 2009 Apr;30(4):610.

49.

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis.

Friese MA, Jakobsen KB, Friis L, Etzensperger R, Craner MJ, McMahon RM, Jensen LT, Huygelen V, Jones EY, Bell JI, Fugger L.

Nat Med. 2008 Nov;14(11):1227-35. doi: 10.1038/nm.1881. Epub 2008 Oct 26.

PMID:
18953350
50.

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis.

Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM, Fugger L.

Am J Pathol. 2008 Jan;172(1):146-55. Epub 2007 Dec 21.

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