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A yeast suppressor screen used to identify mammalian SIRT1 as a proviral factor for MERS-CoV replication.

Weston S, Matthews KL, Lent R, Vlk A, Haupt R, Kingsbury T, Frieman MB.

J Virol. 2019 May 29. pii: JVI.00197-19. doi: 10.1128/JVI.00197-19. [Epub ahead of print]


Bats and Coronaviruses.

Banerjee A, Kulcsar K, Misra V, Frieman M, Mossman K.

Viruses. 2019 Jan 9;11(1). pii: E41. doi: 10.3390/v11010041. Review.


MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells.

Cong Y, Hart BJ, Gross R, Zhou H, Frieman M, Bollinger L, Wada J, Hensley LE, Jahrling PB, Dyall J, Holbrook MR.

PLoS One. 2018 Mar 22;13(3):e0194868. doi: 10.1371/journal.pone.0194868. eCollection 2018.


Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors.

Sisk JM, Frieman MB, Machamer CE.

J Gen Virol. 2018 May;99(5):619-630. doi: 10.1099/jgv.0.001047. Epub 2018 Mar 20.


Middle East Respiratory Syndrome and Severe Acute Respiratory Syndrome: Current Therapeutic Options and Potential Targets for Novel Therapies.

Dyall J, Gross R, Kindrachuk J, Johnson RF, Olinger GG Jr, Hensley LE, Frieman MB, Jahrling PB.

Drugs. 2017 Dec;77(18):1935-1966. doi: 10.1007/s40265-017-0830-1. Review.


Monocyte DPP4 Expression in Human Atherosclerosis Is Associated With Obesity and Dyslipidemia.

Rao X, Deiuliis JA, Mihai G, Varghese J, Xia C, Frieman MB, Sztalryd C, Sun XJ, Quon MJ, Taylor SI, Rajagopalan S, Zhong J.

Diabetes Care. 2018 Jan;41(1):e1-e3. doi: 10.2337/dc17-0672. Epub 2017 Nov 10. No abstract available.


Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection.

Venkataraman T, Coleman CM, Frieman MB.

J Virol. 2017 May 26;91(12). pii: e00182-17. doi: 10.1128/JVI.00182-17. Print 2017 Jun 15.


The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis.

Venkataraman T, Frieman MB.

Antiviral Res. 2017 Jul;143:142-150. doi: 10.1016/j.antiviral.2017.03.022. Epub 2017 Apr 5. Review.


MERS-CoV spike nanoparticles protect mice from MERS-CoV infection.

Coleman CM, Venkataraman T, Liu YV, Glenn GM, Smith GE, Flyer DC, Frieman MB.

Vaccine. 2017 Mar 14;35(12):1586-1589. doi: 10.1016/j.vaccine.2017.02.012. Epub 2017 Feb 23.


A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses.

Moser LA, Ramirez-Carvajal L, Puri V, Pauszek SJ, Matthews K, Dilley KA, Mullan C, McGraw J, Khayat M, Beeri K, Yee A, Dugan V, Heise MT, Frieman MB, Rodriguez LL, Bernard KA, Wentworth DE, Stockwell TB, Shabman RS.

mSystems. 2016 Jun 7;1(3). pii: e00039-15. eCollection 2016 May-Jun.


One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus.

Wirblich C, Coleman CM, Kurup D, Abraham TS, Bernbaum JG, Jahrling PB, Hensley LE, Johnson RF, Frieman MB, Schnell MJ.

J Virol. 2017 Jan 3;91(2). pii: e02040-16. doi: 10.1128/JVI.02040-16. Print 2017 Jan 15.


CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome.

Coleman CM, Sisk JM, Halasz G, Zhong J, Beck SE, Matthews KL, Venkataraman T, Rajagopalan S, Kyratsous CA, Frieman MB.

J Virol. 2016 Dec 16;91(1). pii: e01825-16. doi: 10.1128/JVI.01825-16. Print 2017 Jan 1.


Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens.

Sisk JM, Frieman MB.

ACS Infect Dis. 2015 Sep 11;1(9):401-2. doi: 10.1021/acsinfecdis.5b00089. Epub 2015 Aug 21.


Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.

Coleman CM, Sisk JM, Mingo RM, Nelson EA, White JM, Frieman MB.

J Virol. 2016 Sep 12;90(19):8924-33. doi: 10.1128/JVI.01429-16. Print 2016 Oct 1.


Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo.

Luke T, Wu H, Zhao J, Channappanavar R, Coleman CM, Jiao JA, Matsushita H, Liu Y, Postnikova EN, Ork BL, Glenn G, Flyer D, Defang G, Raviprakash K, Kochel T, Wang J, Nie W, Smith G, Hensley LE, Olinger GG, Kuhn JH, Holbrook MR, Johnson RF, Perlman S, Sullivan E, Frieman MB.

Sci Transl Med. 2016 Feb 17;8(326):326ra21. doi: 10.1126/scitranslmed.aaf1061.


Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross.

Gralinski LE, Ferris MT, Aylor DL, Whitmore AC, Green R, Frieman MB, Deming D, Menachery VD, Miller DR, Buus RJ, Bell TA, Churchill GA, Threadgill DW, Katze MG, McMillan L, Valdar W, Heise MT, Pardo-Manuel de Villena F, Baric RS.

PLoS Genet. 2015 Oct 9;11(10):e1005504. doi: 10.1371/journal.pgen.1005504. eCollection 2015 Oct.


Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.

J Virol. 2015 Dec;89(23):11820-33. doi: 10.1128/JVI.02274-15. Epub 2015 Sep 16.


Growth and Quantification of MERS-CoV Infection.

Coleman CM, Frieman MB.

Curr Protoc Microbiol. 2015 May 1;37:15E.2.1-9. doi: 10.1002/9780471729259.mc15e02s37.


Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection.

Pascal KE, Coleman CM, Mujica AO, Kamat V, Badithe A, Fairhurst J, Hunt C, Strein J, Berrebi A, Sisk JM, Matthews KL, Babb R, Chen G, Lai KM, Huang TT, Olson W, Yancopoulos GD, Stahl N, Frieman MB, Kyratsous CA.

Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8738-43. doi: 10.1073/pnas.1510830112. Epub 2015 Jun 29.


The Global Virus Network: Challenging chikungunya.

McSweegan E, Weaver SC, Lecuit M, Frieman M, Morrison TE, Hrynkow S.

Antiviral Res. 2015 Aug;120:147-52. doi: 10.1016/j.antiviral.2015.06.003. Epub 2015 Jun 10. Review.


Virus Research. Foreword. Nidoviruses II.

Frieman M, Sola I, Enjuanes L.

Virus Res. 2015 Apr 16;202:1-2. doi: 10.1016/j.virusres.2015.05.013. No abstract available.


SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors.

Mojica SA, Hovis KM, Frieman MB, Tran B, Hsia RC, Ravel J, Jenkins-Houk C, Wilson KL, Bavoil PM.

Mol Biol Cell. 2015 May 15;26(10):1918-34. doi: 10.1091/mbc.E14-11-1530. Epub 2015 Mar 18.


Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ.

Astry B, Venkatesha SH, Laurence A, Christensen-Quick A, Garzino-Demo A, Frieman MB, O'Shea JJ, Moudgil KD.

Clin Immunol. 2015 Apr;157(2):228-38. doi: 10.1016/j.clim.2015.01.011. Epub 2015 Feb 7.


Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding.

Nita-Lazar M, Banerjee A, Feng C, Amin MN, Frieman MB, Chen WH, Cross AS, Wang LX, Vasta GR.

Mol Immunol. 2015 May;65(1):1-16. doi: 10.1016/j.molimm.2014.12.010. Epub 2015 Jan 16.


Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis.

Kindrachuk J, Ork B, Hart BJ, Mazur S, Holbrook MR, Frieman MB, Traynor D, Johnson RF, Dyall J, Kuhn JH, Olinger GG, Hensley LE, Jahrling PB.

Antimicrob Agents Chemother. 2015 Feb;59(2):1088-99. doi: 10.1128/AAC.03659-14. Epub 2014 Dec 8.


Virus Research. Nidoviruses I. Foreword.

Enjuanes L, Sola I, Frieman MB.

Virus Res. 2014 Dec 19;194:1-2. doi: 10.1016/j.virusres.2014.11.017. No abstract available.


The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity.

Matthews K, Schäfer A, Pham A, Frieman M.

Virol J. 2014 Dec 7;11:209. doi: 10.1186/s12985-014-0209-9.


Treating MERS-CoV during an outbreak.

Coleman CM, Frieman MB.

Lancet Infect Dis. 2014 Nov;14(11):1030-1031. doi: 10.1016/S1473-3099(14)70939-9. Epub 2014 Sep 29. No abstract available.


NKT Cell Responses to B Cell Lymphoma.

Li J, Sun W, Subrahmanyam PB, Page C, Younger KM, Tiper IV, Frieman M, Kimball AS, Webb TJ.

Med Sci (Basel). 2014 Jun 1;2(2):82-97.


Standards for sequencing viral genomes in the era of high-throughput sequencing.

Ladner JT, Beitzel B, Chain PS, Davenport MG, Donaldson EF, Frieman M, Kugelman JR, Kuhn JH, O'Rear J, Sabeti PC, Wentworth DE, Wiley MR, Yu GY; Threat Characterization Consortium, Sozhamannan S, Bradburne C, Palacios G.

MBio. 2014 Jun 17;5(3):e01360-14. doi: 10.1128/mBio.01360-14.


The art of war: battles between virus and host.

Frieman M.

Curr Opin Virol. 2014 Jun;6:76-7. doi: 10.1016/j.coviro.2014.05.001. Epub 2014 Jun 2. No abstract available.


Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection.

Dyall J, Coleman CM, Hart BJ, Venkataraman T, Holbrook MR, Kindrachuk J, Johnson RF, Olinger GG Jr, Jahrling PB, Laidlaw M, Johansen LM, Lear-Rooney CM, Glass PJ, Hensley LE, Frieman MB.

Antimicrob Agents Chemother. 2014 Aug;58(8):4885-93. doi: 10.1128/AAC.03036-14. Epub 2014 May 19.


Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.

Adedeji AO, Singh K, Kassim A, Coleman CM, Elliott R, Weiss SR, Frieman MB, Sarafianos SG.

Antimicrob Agents Chemother. 2014 Aug;58(8):4894-8. doi: 10.1128/AAC.02994-14. Epub 2014 May 19.


Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice.

Coleman CM, Liu YV, Mu H, Taylor JK, Massare M, Flyer DC, Smith GE, Frieman MB.

Vaccine. 2014 May 30;32(26):3169-3174. doi: 10.1016/j.vaccine.2014.04.016. Epub 2014 Apr 13.


Coronaviruses: important emerging human pathogens.

Coleman CM, Frieman MB.

J Virol. 2014 May;88(10):5209-12. doi: 10.1128/JVI.03488-13. Epub 2014 Mar 5. Review.


The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling.

Matthews KL, Coleman CM, van der Meer Y, Snijder EJ, Frieman MB.

J Gen Virol. 2014 Apr;95(Pt 4):874-82. doi: 10.1099/vir.0.062059-0. Epub 2014 Jan 17.


Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation.

Kim WK, Jain D, Sánchez MD, Koziol-White CJ, Matthews K, Ge MQ, Haczku A, Panettieri RA Jr, Frieman MB, López CB.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):437-48. doi: 10.1164/rccm.201307-1338OC.


Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays.

Hart BJ, Dyall J, Postnikova E, Zhou H, Kindrachuk J, Johnson RF, Olinger GG Jr, Frieman MB, Holbrook MR, Jahrling PB, Hensley L.

J Gen Virol. 2014 Mar;95(Pt 3):571-7. doi: 10.1099/vir.0.061911-0. Epub 2013 Dec 9.


Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus.

Coleman CM, Matthews KL, Goicochea L, Frieman MB.

J Gen Virol. 2014 Feb;95(Pt 2):408-12. doi: 10.1099/vir.0.060640-0. Epub 2013 Nov 6.


Emergence of the Middle East respiratory syndrome coronavirus.

Coleman CM, Frieman MB.

PLoS Pathog. 2013;9(9):e1003595. doi: 10.1371/journal.ppat.1003595. Epub 2013 Sep 5. Review. No abstract available.


Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection.

Page C, Goicochea L, Matthews K, Zhang Y, Klover P, Holtzman MJ, Hennighausen L, Frieman M.

J Virol. 2012 Dec;86(24):13334-49. doi: 10.1128/JVI.01689-12. Epub 2012 Sep 26.


Evidence supporting a zoonotic origin of human coronavirus strain NL63.

Huynh J, Li S, Yount B, Smith A, Sturges L, Olsen JC, Nagel J, Johnson JB, Agnihothram S, Gates JE, Frieman MB, Baric RS, Donaldson EF.

J Virol. 2012 Dec;86(23):12816-25. doi: 10.1128/JVI.00906-12. Epub 2012 Sep 19.


Yeast based small molecule screen for inhibitors of SARS-CoV.

Frieman M, Basu D, Matthews K, Taylor J, Jones G, Pickles R, Baric R, Engel DA.

PLoS One. 2011;6(12):e28479. doi: 10.1371/journal.pone.0028479. Epub 2011 Dec 2.


Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection.

Peng X, Gralinski L, Ferris MT, Frieman MB, Thomas MJ, Proll S, Korth MJ, Tisoncik JR, Heise M, Luo S, Schroth GP, Tumpey TM, Li C, Kawaoka Y, Baric RS, Katze MG.

MBio. 2011 Nov 15;2(6). pii: e00198-11. doi: 10.1128/mBio.00198-11. Print 2011.


Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.

Frieman M, Yount B, Agnihothram S, Page C, Donaldson E, Roberts A, Vogel L, Woodruff B, Scorpio D, Subbarao K, Baric RS.

J Virol. 2012 Jan;86(2):884-97. doi: 10.1128/JVI.05957-11. Epub 2011 Nov 9.


Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza.

Chen WH, Toapanta FR, Shirey KA, Zhang L, Giannelou A, Page C, Frieman MB, Vogel SN, Cross AS.

Immunol Lett. 2012 Jan 30;141(2):227-34. doi: 10.1016/j.imlet.2011.10.009. Epub 2011 Oct 20.


Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA.

Genome Res. 2011 Aug;21(8):1213-22. doi: 10.1101/gr.111310.110. Epub 2011 Mar 15.


Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling.

Peng X, Gralinski L, Armour CD, Ferris MT, Thomas MJ, Proll S, Bradel-Tretheway BG, Korth MJ, Castle JC, Biery MC, Bouzek HK, Haynor DR, Frieman MB, Heise M, Raymond CK, Baric RS, Katze MG.

MBio. 2010 Oct 26;1(5). pii: e00206-10. doi: 10.1128/mBio.00206-10.


Metagenomic analysis of the viromes of three North American bat species: viral diversity among different bat species that share a common habitat.

Donaldson EF, Haskew AN, Gates JE, Huynh J, Moore CJ, Frieman MB.

J Virol. 2010 Dec;84(24):13004-18. doi: 10.1128/JVI.01255-10. Epub 2010 Oct 6.


Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection.

Zornetzer GA, Frieman MB, Rosenzweig E, Korth MJ, Page C, Baric RS, Katze MG.

J Virol. 2010 Nov;84(21):11297-309. doi: 10.1128/JVI.01130-10. Epub 2010 Aug 11.

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