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Items: 43

1.

Translatability of the S7A core battery respiratory safety pharmacology studies: Preclinical respiratory and related clinical adverse events.

Paglialunga S, Morimoto BH, Clark M, Friedrichs GS.

J Pharmacol Toxicol Methods. 2018 Sep - Oct;99:106596. doi: 10.1016/j.vascn.2019.106596. Epub 2019 Jun 5.

PMID:
31173885
2.

A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium.

Boulay E, Abernathy MM, Chui R, Friedrichs GS, Gendron-Parra N, Greiter-Wilke A, Guillon JM, Koerner JE, Menard A, Steidl-Nichols J, Pierson J, Pugsley MK, Rossman EI, Strauss D, Troncy E, Valentin JP, Wisialowski T, Authier S.

Int J Toxicol. 2019 Jan/Feb;38(1):23-32. doi: 10.1177/1091581818813601. Epub 2018 Dec 19.

PMID:
30567462
3.

Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.

Spence S, Deurinck M, Ju H, Traebert M, McLean L, Marlowe J, Emotte C, Tritto E, Tseng M, Shultz M, Friedrichs GS.

Toxicol Sci. 2016 Sep;153(1):39-54. doi: 10.1093/toxsci/kfw104. Epub 2016 Jun 2.

PMID:
27255383
4.

Translational assessment of cardiac contractility by echocardiography in the telemetered rat.

Tang HM, Ju H, Zhao S, LaDuke C, Hahn S, Glick J, Carey C, Friedrichs GS.

J Pharmacol Toxicol Methods. 2016 Jan-Feb;77:24-32. doi: 10.1016/j.vascn.2015.09.005. Epub 2015 Sep 30.

PMID:
26427954
5.

Benchmarking safety pharmacology regulatory packages and best practice.

Lindgren S, Bass AS, Briscoe R, Bruse K, Friedrichs GS, Kallman MJ, Markgraf C, Patmore L, Pugsley MK.

J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):99-109. doi: 10.1016/j.vascn.2008.07.001. Epub 2008 Jul 19.

PMID:
18692579
6.

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys.

Haushalter TM, Friedrichs GS, Reynolds DL, Barecki-Roach M, Pastino G, Hayes R, Bass AS.

Br J Pharmacol. 2008 Aug;154(7):1457-64. doi: 10.1038/bjp.2008.275. Epub 2008 Jul 7.

7.

The pathway-selective estrogen receptor ligand WAY-169916 displays differential activity in ischemia-reperfusion injury models.

Harnish DC, Liu X, Kenney T, Winneker RC, Chadwick C, Friedrichs GS, Kilbourne EJ.

J Cardiovasc Pharmacol. 2006 Jun;47(6):788-95.

PMID:
16810080
8.

Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies.

Friedrichs GS, Patmore L, Bass A.

J Pharmacol Toxicol Methods. 2005 Jul-Aug;52(1):6-11. Review.

PMID:
15975833
9.

Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1 inhibitor, in a canine model of coronary artery thrombosis.

Hennan JK, Elokdah H, Leal M, Ji A, Friedrichs GS, Morgan GA, Swillo RE, Antrilli TM, Hreha A, Crandall DL.

J Pharmacol Exp Ther. 2005 Aug;314(2):710-6. Epub 2005 Apr 28.

PMID:
15860572
10.

Design and synthesis of oxadiazolidinediones as inhibitors of plasminogen activator inhibitor-1.

Gopalsamy A, Kincaid SL, Ellingboe JW, Groeling TM, Antrilli TM, Krishnamurthy G, Aulabaugh A, Friedrichs GS, Crandall DL.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3477-80.

PMID:
15177456
11.

Novel human metabolites of the angiotensin-II antagonist tasosartan and their pharmacological effects.

Elokdah HM, Friedrichs GS, Chai SY, Harrison BL, Primeau J, Chlenov M, Crandall DL.

Bioorg Med Chem Lett. 2002 Aug 5;12(15):1967-71.

PMID:
12113820
12.

Sphingosine modulates myocyte electrophysiology, induces negative inotropy, and decreases survival after myocardial ischemia.

Friedrichs GS, Swillo RE, Jow B, Bridal T, Numann R, Warner LM, Killar LM, Sidek K.

J Cardiovasc Pharmacol. 2002 Jan;39(1):18-28.

PMID:
11743224
13.

Experimental models of atrial fibrillation/flutter.

Friedrichs GS.

J Pharmacol Toxicol Methods. 2000 Mar-Apr;43(2):117-23. Review.

PMID:
11150739
14.

Adrenergic-dependent Effect of Adenosine-induced Ventricular Fibrillation in the Isolated Rabbit Heart.

Friedrichs GS, Chi L, Park JL, Lucchesi BR.

J Cardiovasc Pharmacol Ther. 1997 Oct;2(4):299-308.

PMID:
10684471
15.

Tedisamil in a chronic canine model of atrial flutter.

Fischbach PS, Johnston PV, Friedrichs GS, Lucchesi BR.

J Cardiovasc Pharmacol. 1999 Aug;34(2):212-8.

PMID:
10445672
16.

Antifibrillatory efficacy of long-term tedisamil administration in a postinfarcted canine model of ischemic ventricular fibrillation.

Friedrichs GS, Abreu JN, Driscoll EM Jr, Borlak J, Lucchesi BR.

J Cardiovasc Pharmacol. 1998 Jan;31(1):56-66.

PMID:
9456278
17.

Tedisamil Attenuates Ventricular Fibrillation in a Conscious Canine Model of Sudden Cardiac Death.

Friedrichs GS, Abreu JN, Cousins GR, Chi L, Borlak J, Lucchesi BR.

J Cardiovasc Pharmacol Ther. 1996 Oct;1(4):313-324.

PMID:
10684432
18.

Orally effective CVS-1123 prevents coronary artery thrombosis in the conscious dog.

Cousins GR, Friedrichs GS, Sudo Y, Rebello SS, Rote WE, Vlasuk GP, Nolan TG, Mendoza C, Lucchesi BR.

Circulation. 1996 Oct 1;94(7):1705-12.

PMID:
8840864
19.
20.

5-hydroxydecanoate fails to attenuate ventricular fibrillation in a conscious canine model of sudden cardiac death.

Friedrichs GS, Abreu JN, Black SC, Chi L, Lucchesi BR.

Eur J Pharmacol. 1996 Jun 13;306(1-3):99-106.

PMID:
8813621
21.

Protective Effects of Ranolazine on Ventricular Fibrillation Induced by Activation of the ATP-Dependent Potassium Channel in the Rabbit Heart.

Gralinski MR, Chi L, Park JL, Friedrichs GS, Tanhehco EJ, McCormack JG, Lucchesi BR.

J Cardiovasc Pharmacol Ther. 1996 Apr;1(2):141-148.

PMID:
10684411
22.

Effects of tedisamil (KC-8857) on cardiac electrophysiology and ventricular fibrillation in the rabbit isolated heart.

Chi L, Park JL, Friedrichs GS, Banglawala YA, Perez MA, Tanhehco EJ, Lucchesi BR.

Br J Pharmacol. 1996 Mar;117(6):1261-9.

23.

Cardioprotective effects of heparin or N-acetylheparin in an in vivo model of myocardial ischaemic and reperfusion injury.

Black SC, Gralinski MR, Friedrichs GS, Kilgore KS, Driscoll EM, Lucchesi BR.

Cardiovasc Res. 1995 May;29(5):629-36.

PMID:
7606750
24.

MS-551 protects against ventricular fibrillation in a chronic canine model of sudden cardiac death.

Friedrichs GS, Chi L, Gralinski MR, Black SC, Basler GC, Mu DX, Pewitt SR, Johnson CR, Lucchesi BR.

J Cardiovasc Pharmacol. 1995 Feb;25(2):314-23.

PMID:
7752658
25.

Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis.

Markland FS, Friedrichs GS, Pewitt SR, Lucchesi BR.

Circulation. 1994 Nov;90(5):2448-56.

PMID:
7955202
26.

Effect of Ado A1- and A2-receptor activation on ventricular fibrillation during hypoxia-reoxygenation.

Chi L, Friedrichs GS, Oh JY, Green AL, Lucchesi BR.

Am J Physiol. 1994 Oct;267(4 Pt 2):H1447-54.

PMID:
7943390
27.

Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart.

Friedrichs GS, Kilgore KS, Manley PJ, Gralinski MR, Lucchesi BR.

Circ Res. 1994 Oct;75(4):701-10.

PMID:
7923616
28.

Antifibrillatory effects of clofilium in the rabbit isolated heart.

Friedrichs GS, Chi L, Green AL, Lucchesi BR.

Br J Pharmacol. 1994 Sep;113(1):209-15.

29.

Protective effects of the SOD-mimetic SC-52608 against ischemia/reperfusion damage in the rabbit isolated heart.

Kilgore KS, Friedrichs GS, Johnson CR, Schasteen CS, Riley DP, Weiss RH, Ryan U, Lucchesi BR.

J Mol Cell Cardiol. 1994 Aug;26(8):995-1006.

30.

The complement system in myocardial ischaemia/reperfusion injury.

Kilgore KS, Friedrichs GS, Homeister JW, Lucchesi BR.

Cardiovasc Res. 1994 Apr;28(4):437-44. Review. No abstract available.

PMID:
8181029
31.

ATP sensitive potassium channels and ischemic heart disease.

Chi L, Black SC, Friedrichs GS, Lucchesi BR.

Cardiovasc Res. 1994 Jan;28(1):136-7. No abstract available.

PMID:
8111782
32.

Antiarrhythmic agent, MS-551, protects against pinacidil + hypoxia-induced ventricular fibrillation in Langendorff-perfused rabbit isolated heart.

Friedrichs GS, Chi L, Black SC, Manley PJ, Lucchesi BR.

J Cardiovasc Pharmacol. 1994 Jan;23(1):120-6.

PMID:
7511723
33.

Phorbol ester-induced ventricular fibrillation in the Langendorff-perfused rabbit heart: antagonism by staurosporine and glibenclamide.

Black SC, Fagbemi SO, Chi L, Friedrichs GS, Lucchesi BR.

J Mol Cell Cardiol. 1993 Dec;25(12):1427-38.

34.

Antiarrhythmic versus antifibrillatory actions: inference from experimental studies.

Lucchesi BR, Chi L, Friedrichs GS, Black SC, Uprichard AC.

Am J Cardiol. 1993 Nov 26;72(16):25F-44F. Review.

PMID:
8237827
35.

The autonomic nervous system, myocardial infarct size and ventricular fibrillation.

Black SC, Friedrichs GS, Lucchesi BR.

J Mol Cell Cardiol. 1993 Nov;25(11):1291-2. No abstract available.

PMID:
8301664
36.

Antifibrillatory effects of ibutilide in the rabbit isolated heart: mediation via ATP-dependent potassium channels.

Friedrichs GS, Chi L, Black SC, Manley PJ, Oh JY, Lucchesi BR.

J Pharmacol Exp Ther. 1993 Sep;266(3):1348-54.

PMID:
8371141
37.

Adenosine deaminase and BW A1433U attenuate hypoxia-induced ventricular ectopy.

Leone RJ Jr, Friedrichs GS, Merrill GF.

J Appl Physiol (1985). 1993 Apr;74(4):1543-8.

PMID:
8514667
38.

Cardiovascular applications of the ALOPEX optimization technique.

Friedrichs GS, Berger DS, Micheli-Tzanakou E.

J Biomed Eng. 1993 Jan;15(1):74-8.

PMID:
8419686
39.

Flow-dependent antiarrhythmic properties of ammonia during catecholamine-driven ventricular tachycardia.

Malootian A, Friedrichs GS, Merrill GF.

Can J Physiol Pharmacol. 1992 Jan;70(1):94-9.

PMID:
1581859
40.

Route dependent effects of 2-chloroadenosine and theophylline in isolated perfused guinea pig hearts.

Wei HW, Friedrichs GS, Merrill GF.

Cardiovasc Res. 1991 Jul;25(7):529-36.

PMID:
1913744
41.

Adenosine deaminase and adenosine attenuate ventricular arrhythmias caused by norepinephrine.

Friedrichs GS, Merrill GF.

Am J Physiol. 1991 Mar;260(3 Pt 2):H979-84.

PMID:
2000991
42.

Coronary vasodilation caused by intravenous cocaine in the anesthetized beagle.

Friedrichs GS, Wei HM, Merrill GF.

Can J Physiol Pharmacol. 1990 Jul;68(7):893-7.

PMID:
2383802
43.

Plasma lipid concentrations in college students performing self-selected exercise.

Merrill GF, Friedrichs GS.

J Am Coll Nutr. 1990 Jun;9(3):226-30.

PMID:
2358618

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