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Items: 1 to 50 of 233

1.

Pharmacokinetics, immunogenicity, safety and preliminary efficacy of subcutaneous turoctocog alfa pegol in previously treated patients with severe hemophilia A (alleviate 1).

Klamroth R, Feistritzer C, Friedrich U, Lentz SR, Reichwald K, Zak M, Chowdary P.

J Thromb Haemost. 2019 Oct 16. doi: 10.1111/jth.14660. [Epub ahead of print]

PMID:
31618804
2.

Selective ribosome profiling to study interactions of translating ribosomes in yeast.

Galmozzi CV, Merker D, Friedrich UA, Döring K, Kramer G.

Nat Protoc. 2019 Aug;14(8):2279-2317. doi: 10.1038/s41596-019-0185-z. Epub 2019 Jul 22.

PMID:
31332354
3.

Validation and educational impact study of the NANEP high-fidelity simulation model for open preperitoneal mesh repair of umbilical hernia.

Friedrich U, Backhaus J, Zipper CT, König S, Mavroveli S, Wiegering A, Olbrecht S, Puppe F, Dietz UA.

Hernia. 2019 Jul 19. doi: 10.1007/s10029-019-02004-9. [Epub ahead of print]

PMID:
31325054
4.

Monitoring Cell-Type-Specific Gene Expression Using Ribosome Profiling In Vivo During Cardiac Hemodynamic Stress.

Doroudgar S, Hofmann C, Boileau E, Malone B, Riechert E, Gorska AA, Jakobi T, Sandmann C, Jürgensen L, Kmietczyk V, Malovrh E, Burghaus J, Rettel M, Stein F, Younesi F, Friedrich UA, Mauz V, Backs J, Kramer G, Katus HA, Dieterich C, Völkers M.

Circ Res. 2019 Aug 2;125(4):431-448. doi: 10.1161/CIRCRESAHA.119.314817. Epub 2019 Jul 9.

5.

A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data.

Sharma AK, Sormanni P, Ahmed N, Ciryam P, Friedrich UA, Kramer G, O'Brien EP.

PLoS Comput Biol. 2019 May 23;15(5):e1007070. doi: 10.1371/journal.pcbi.1007070. eCollection 2019 May.

6.

Identification of the retinoschisin-binding site on the retinal Na/K-ATPase.

Plössl K, Straub K, Schmid V, Strunz F, Wild J, Merkl R, Weber BHF, Friedrich U.

PLoS One. 2019 May 2;14(5):e0216320. doi: 10.1371/journal.pone.0216320. eCollection 2019.

7.

Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling.

Shiber A, Döring K, Friedrich U, Klann K, Merker D, Zedan M, Tippmann F, Kramer G, Bukau B.

Nature. 2018 Sep;561(7722):268-272. doi: 10.1038/s41586-018-0462-y. Epub 2018 Aug 29.

8.

A randomized trial of safety, pharmacokinetics and pharmacodynamics of concizumab in people with hemophilia A.

Eichler H, Angchaisuksiri P, Kavakli K, Knoebl P, Windyga J, Jiménez-Yuste V, Hyseni A, Friedrich U, Chowdary P.

J Thromb Haemost. 2018 Nov;16(11):2184-2195. doi: 10.1111/jth.14272. Epub 2018 Sep 30.

PMID:
30137664
9.

Pathomechanism of mutated and secreted retinoschisin in X-linked juvenile retinoschisis.

Plössl K, Schmid V, Straub K, Schmid C, Ammon M, Merkl R, Weber BHF, Friedrich U.

Exp Eye Res. 2018 Dec;177:23-34. doi: 10.1016/j.exer.2018.07.021. Epub 2018 Jul 21.

PMID:
30040949
10.

Bryophytes and Organic layers Control Uptake of Airborne Nitrogen in Low-N Environments.

Bähring A, Fichtner A, Friedrich U, von Oheimb G, Härdtle W.

Front Plant Sci. 2017 Dec 4;8:2080. doi: 10.3389/fpls.2017.02080. eCollection 2017.

11.

Retinoschisin is linked to retinal Na/K-ATPase signaling and localization.

Plössl K, Royer M, Bernklau S, Tavraz NN, Friedrich T, Wild J, Weber BHF, Friedrich U.

Mol Biol Cell. 2017 Aug 1;28(16):2178-2189. doi: 10.1091/mbc.E17-01-0064. Epub 2017 Jun 14.

12.

Concizumab, an anti-tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay.

Waters EK, Sigh J, Friedrich U, Hilden I, Sørensen BB.

Haemophilia. 2017 Sep;23(5):769-776. doi: 10.1111/hae.13260. Epub 2017 Jun 8.

PMID:
28594458
13.

The X-linked juvenile retinoschisis protein retinoschisin is a novel regulator of mitogen-activated protein kinase signalling and apoptosis in the retina.

Plössl K, Weber BH, Friedrich U.

J Cell Mol Med. 2017 Apr;21(4):768-780. doi: 10.1111/jcmm.13019. Epub 2016 Dec 20.

14.

A Step in Between: [Sn3Bi3](5-) and Its Structural Relationship to [Sn3Bi5](3-) and [Sn4Bi4](4.).

Friedrich U, Korber N.

ChemistryOpen. 2016 May 25;5(4):306-10. doi: 10.1002/open.201600037. eCollection 2016 Aug.

15.

Hes3 expression in the adult mouse brain is regulated during demyelination and remyelination.

Toutouna L, Nikolakopoulou P, Poser SW, Masjkur J, Arps-Forker C, Troullinaki M, Grossklaus S, Bosak V, Friedrich U, Ziemssen T, Bornstein SR, Chavakis T, Androutsellis-Theotokis A.

Brain Res. 2016 Jul 1;1642:124-130. doi: 10.1016/j.brainres.2016.03.014. Epub 2016 Mar 25.

PMID:
27018293
16.

Structural recovery of the retina in a retinoschisin-deficient mouse after gene replacement therapy by solid lipid nanoparticles.

Apaolaza PS, Del Pozo-Rodríguez A, Solinís MA, Rodríguez JM, Friedrich U, Torrecilla J, Weber BH, Rodríguez-Gascón A.

Biomaterials. 2016 Jun;90:40-9. doi: 10.1016/j.biomaterials.2016.03.004. Epub 2016 Mar 3.

PMID:
26986855
17.

Accurate prediction of cellular co-translational folding indicates proteins can switch from post- to co-translational folding.

Nissley DA, Sharma AK, Ahmed N, Friedrich UA, Kramer G, Bukau B, O'Brien EP.

Nat Commun. 2016 Feb 18;7:10341. doi: 10.1038/ncomms10341.

18.

Solid lipid nanoparticle-based vectors intended for the treatment of X-linked juvenile retinoschisis by gene therapy: In vivo approaches in Rs1h-deficient mouse model.

Apaolaza PS, Del Pozo-Rodríguez A, Torrecilla J, Rodríguez-Gascón A, Rodríguez JM, Friedrich U, Weber BH, Solinís MA.

J Control Release. 2015 Nov 10;217:273-83. doi: 10.1016/j.jconrel.2015.09.033. Epub 2015 Sep 21.

PMID:
26400864
19.

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling.

Friedrich U, Datta S, Schubert T, Plössl K, Schneider M, Grassmann F, Fuchshofer R, Tiefenbach KJ, Längst G, Weber BH.

Hum Mol Genet. 2015 Nov 15;24(22):6361-73. doi: 10.1093/hmg/ddv346. Epub 2015 Aug 26.

PMID:
26310622
20.

A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).

Grassmann F, Friedrich U, Fauser S, Schick T, Milenkovic A, Schulz HL, von Strachwitz CN, Bettecken T, Lichtner P, Meitinger T, Arend N, Wolf A, Haritoglou C, Rudolph G, Chakravarthy U, Silvestri G, McKay GJ, Freitag-Wolf S, Krawczak M, Smith RT, Merriam JC, Merriam JE, Allikmets R, Heid IM, Weber BH.

Neuromolecular Med. 2015 Jun;17(2):111-20. doi: 10.1007/s12017-015-8342-1. Epub 2015 Feb 14.

21.

Safety and pharmacokinetics of anti-TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial.

Chowdary P, Lethagen S, Friedrich U, Brand B, Hay C, Abdul Karim F, Klamroth R, Knoebl P, Laffan M, Mahlangu J, Miesbach W, Dalsgaard Nielsen J, Martín-Salces M, Angchaisuksiri P.

J Thromb Haemost. 2015 May;13(5):743-54. doi: 10.1111/jth.12864. Epub 2015 Apr 6.

22.

(18-Crown-6)potassium(I) di-phenyl-stibate(-1).

Kaas M, Friedrich U, Korber N.

Acta Crystallogr Sect E Struct Rep Online. 2014 Jun 14;70(Pt 7):m260. doi: 10.1107/S1600536814013282. eCollection 2014 Jul 1.

23.

Cs5Sn9(OH)·4NH3.

Friedrich U, Korber N.

Acta Crystallogr Sect E Struct Rep Online. 2014 May 31;70(Pt 6):i29. doi: 10.1107/S1600536814011817. eCollection 2014 Jun 1.

24.

Evidence of solubility of the acetylide ion C2(2-): syntheses and crystal structures of K2C2⋅2 NH3, Rb2C2⋅2 NH3, and Cs2C2⋅7 NH3.

Hamberger M, Liebig S, Friedrich U, Korber N, Ruschewitz U.

Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13006-10. doi: 10.1002/anie.201206349. Epub 2012 Nov 19.

PMID:
23161511
25.

Synthesis of heteroatomic Zintl anions in liquid ammonia--the new highly charged [Sn4Bi4]4- and fully ordered [Sn2Bi2]2-.

Friedrich U, Neumeier M, Koch C, Korber N.

Chem Commun (Camb). 2012 Nov 4;48(85):10544-6.

PMID:
22992539
26.

Mechanisms of purple moor-grass (Molinia caerulea) encroachment in dry heathland ecosystems with chronic nitrogen inputs.

Friedrich U, von Oheimb G, Dziedek C, Kriebitzsch WU, Selbmann K, Härdtle W.

Environ Pollut. 2011 Dec;159(12):3553-9. doi: 10.1016/j.envpol.2011.08.010. Epub 2011 Aug 27.

PMID:
21872975
27.

Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon.

Ehmann R, Boedeker E, Friedrich U, Sagert J, Dippon J, Friedel G, Walles T.

Eur Respir J. 2012 Mar;39(3):669-76. doi: 10.1183/09031936.00051711. Epub 2011 Aug 18.

28.

Safety and pharmacokinetics of subcutaneously administered recombinant activated factor VII (rFVIIa).

Tiede A, Friedrich U, Stenmo C, Allen G, Giangrande P, Goudemand J, Hay C, Holmström M, Klamroth R, Lethagen S, McKenzie S, Miesbach W, Negrier C, Yuste VJ, Berntorp E.

J Thromb Haemost. 2011 Jun;9(6):1191-9. doi: 10.1111/j.1538-7836.2011.04293.x.

29.

Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.

Friedrich U, Myers CA, Fritsche LG, Milenkovich A, Wolf A, Corbo JC, Weber BH.

Hum Mol Genet. 2011 Apr 1;20(7):1387-99. doi: 10.1093/hmg/ddr020. Epub 2011 Jan 20.

30.

The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis.

Friedrich U, Stöhr H, Hilfinger D, Loenhardt T, Schachner M, Langmann T, Weber BH.

Hum Mol Genet. 2011 Mar 15;20(6):1132-42. doi: 10.1093/hmg/ddq557. Epub 2010 Dec 31.

PMID:
21196491
31.

Diagnostic 131I whole-body scintigraphy 1 year after thyroablative therapy in patients with differentiated thyroid cancer: correlation of results to the individual risk profile and long-term follow-up.

Berger F, Friedrich U, Knesewitsch P, Hahn K.

Eur J Nucl Med Mol Imaging. 2011 Mar;38(3):451-8. doi: 10.1007/s00259-010-1657-0. Epub 2010 Nov 18.

PMID:
21085953
32.

The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention.

Roessler A, Friedrich U, Vogelsang H, Bauer A, Kaatz M, Hipler UC, Schmidt I, Jahreis G.

Clin Exp Allergy. 2008 Jan;38(1):93-102. Epub 2007 Nov 19.

PMID:
18028460
33.

Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults.

Klein A, Friedrich U, Vogelsang H, Jahreis G.

Eur J Clin Nutr. 2008 May;62(5):584-93. Epub 2007 Apr 18.

PMID:
17440520
34.

Gravitational biology within the German Space Program: goals, achievements, and perspectives.

Ruyters G, Friedrich U.

Protoplasma. 2006 Dec;229(2-4):95-100. Epub 2006 Dec 16. Review.

PMID:
17180489
35.

Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.

Heck E, Friedrich U, Gack MU, Lengenfelder D, Schmidt M, Müller-Fleckenstein I, Fleckenstein B, Ensser A, Biesinger B.

J Virol. 2006 Oct;80(20):9934-42.

37.

New prenylated benzoic acid derivatives of Piper hispidum.

Friedrich U, Siems K, Solis PN, Gupta MP, Jenett-Siems K.

Pharmazie. 2005 Jun;60(6):455-7.

PMID:
15997836
38.

Breakpoints around the HOXD cluster result in various limb malformations.

Dlugaszewska B, Silahtaroglu A, Menzel C, Kübart S, Cohen M, Mundlos S, Tümer Z, Kjaer K, Friedrich U, Ropers HH, Tommerup N, Neitzel H, Kalscheuer VM.

J Med Genet. 2006 Feb;43(2):111-8. Epub 2005 Jun 24.

39.

Trisomy 3q25.1-qter and monosomy 8p23.1-pter in a patient: cytogenetic and molecular analysis with delineation of the phenotype.

Zafra de la Rosa G, Venegas-Vega CA, Monroy N, Contreras-Bucio G, Friedrich U, Houman M, Saad A, Fernández P, Kofman-Alfaro S, Cervantes A.

Am J Med Genet A. 2005 Jul 30;136(3):259-64. Review.

PMID:
15957183
40.

Cytotoxicity of plants used in traditional medicine in Yemen.

Al-Fatimi M, Friedrich U, Jenett-Siems K.

Fitoterapia. 2005 Jun;76(3-4):355-8.

PMID:
15890471
41.

Situs ambiguus in a female fetus with balanced (X;21) translocation--evidence for functional nullisomy of the ZIC3 gene?

Fritz B, Kunz J, Knudsen GP, Louwen F, Kennerknecht I, Eiben B, Orstavik KH, Friedrich U, Rehder H.

Eur J Hum Genet. 2005 Jan;13(1):34-40.

42.

Altered inactivation pathway of factor Va by activated protein C in the presence of heparin.

Nicolaes GA, Sørensen KW, Friedrich U, Tans G, Rosing J, Autin L, Dahlbäck B, Villoutreix BO.

Eur J Biochem. 2004 Jul;271(13):2724-36.

43.

Telomerase activity in chronic inflammatory bowel disease.

Kleideiter E, Friedrich U, Möhring A, Walker S, Höring E, Maier K, Fritz P, Thon KP, Klotz U.

Dig Dis Sci. 2003 Dec;48(12):2328-32.

PMID:
14714621
44.

Tumorigenic conversion of endothelial cells.

Krump-Konvalinkova V, Kleideiter E, Friedrich U, Klotz U, Kirkpatrick CJ.

Exp Mol Pathol. 2003 Oct;75(2):154-9.

PMID:
14516778
45.

Telomerase activity in cell lines of pediatric soft tissue sarcomas.

Kleideiter E, Schwab M, Friedrich U, Koscielniak E, Schafer BW, Klotz U.

Pediatr Res. 2003 Nov;54(5):718-23. Epub 2003 Aug 6.

PMID:
12904596
46.

Microbial community and physicochemical analysis of an industrial waste gas biofilter and design of 16S rRNA-targeting oligonucleotide probes.

Friedrich U, Van Langenhove H, Altendorf K, Lipski A.

Environ Microbiol. 2003 Mar;5(3):183-201. Erratum in: Environ Microbiol. 2003 May;5(5):439.

PMID:
12588298
47.

High bacterial diversity of a waste gas-degrading community in an industrial biofilter as shown by a 16S rDNA clone library.

Friedrich U, Prior K, Altendorf K, Lipski A.

Environ Microbiol. 2002 Nov;4(11):721-34.

PMID:
12460280
48.

Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787.

Pahl A, Zhang M, Török K, Kuss H, Friedrich U, Magyar Z, Szekely J, Horvath K, Brune K, Szelenyi I.

J Pharmacol Exp Ther. 2002 May;301(2):738-46.

PMID:
11961080
49.

Structural investigation of the binding of a herpesviral protein to the SH3 domain of tyrosine kinase Lck.

Schweimer K, Hoffmann S, Bauer F, Friedrich U, Kardinal C, Feller SM, Biesinger B, Sticht H.

Biochemistry. 2002 Apr 23;41(16):5120-30.

PMID:
11955060
50.

Peripheral T-cell lymphoma in herpesvirus saimiri-infected tamarins: tumor cell lines reveal subgroup-specific differences.

Reiss C, Niedobitek G, Hör S, Lisner R, Friedrich U, Bodemer W, Biesinger B.

Virology. 2002 Mar 1;294(1):31-46.

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