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Items: 1 to 50 of 253

1.

Genetic therapies, human genetic enhancement, and … eugenics?

Friedmann T.

Gene Ther. 2019 Jul 4. doi: 10.1038/s41434-019-0088-1. [Epub ahead of print] No abstract available.

PMID:
31273325
2.

In support of mitochondrial replacement therapy.

Adashi EY, Caplan AL, Capron A, Chapman AR, Cho M, Clayton EW, Cohen IG, Cook-Deegan R, Faden RR, Friedmann T, Gostin LO, Greely HT, Johnston J, Juengst E, King PA, Knowles LP, Lyerly AD, McGuire AL, Moreno JD, Rothenberg K, Truog RD, Walters L.

Nat Med. 2019 Jun;25(6):870-871. doi: 10.1038/s41591-019-0477-4. No abstract available.

PMID:
31160819
3.

Rethinking Human Enhancement as Collective Welfarism.

Bavelier D, Savulescu J, Fried LP, Friedmann T, Lathan CE, Schürle S, Beard JR.

Nat Hum Behav. 2019 Mar;3(3):204-206. doi: 10.1038/s41562-019-0545-2. Epub 2019 Feb 11.

4.

Gene therapy for spinomuscular atrophy: a biomedical advance, a missed opportunity for more equitable drug pricing.

Friedmann T.

Gene Ther. 2017 Sep;24(9):503-505. doi: 10.1038/gt.2017.48. Epub 2017 Jun 22.

PMID:
28639617
5.

Next Generation "Omics" Approaches in the "Fight" against Blood Doping.

Wang G, Karanikolou A, Verdouka I, Friedmann T, Pitsiladis Y.

Med Sport Sci. 2017;62:119-128. doi: 10.1159/000470919. Epub 2017 Jun 1.

PMID:
28571016
6.

Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial.

Eekers DBP, Roelofs E, Jelen U, Kirk M, Granzier M, Ammazzalorso F, Ahn PH, Janssens GORJ, Hoebers FJP, Friedmann T, Solberg T, Walsh S, Troost EGC, Kaanders JHAM, Lambin P.

Radiother Oncol. 2016 Dec;121(3):387-394. doi: 10.1016/j.radonc.2016.08.020. Epub 2016 Sep 14.

7.

An ASGCT Perspective on the National Academies Genome Editing Summit.

Friedmann T.

Mol Ther. 2016 Feb;24(1):1-2. doi: 10.1038/mt.2015.228. No abstract available.

8.

ASGCT and JSGT Joint Position Statement on Human Genomic Editing.

Friedmann T, Jonlin EC, King NMP, Torbett BE, Wivel NA, Kaneda Y, Sadelain M.

Mol Ther. 2015 Aug;23(8):1282. doi: 10.1038/mt.2015.118. No abstract available.

9.

Alzheimer's disease shares gene expression aberrations with purinergic dysregulation of HPRT deficiency (Lesch-Nyhan disease).

Kang TH, Friedmann T.

Neurosci Lett. 2015 Mar 17;590:35-9. doi: 10.1016/j.neulet.2015.01.042. Epub 2015 Jan 27.

PMID:
25636690
10.

Synthesis of azobenzenealkylmaleimide probes to photocontrol the enzyme activity of a bacterial histone deacetylase-like amidohydrolase.

Horstmann B, Korbus M, Friedmann T, Wolff C, Thiele CM, Meyer-Almes FJ.

Bioorg Chem. 2014 Dec;57:155-61. doi: 10.1016/j.bioorg.2014.10.004. Epub 2014 Oct 24.

PMID:
25462992
11.
12.

Spinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice.

Szentirmay AK, Király KP, Lenkey N, Lackó E, Al-Khrasani M, Friedmann T, Timár J, Gyarmati S, Tóth G, Fürst S, Riba P.

Brain Res Bull. 2013 Jan;90:66-71. doi: 10.1016/j.brainresbull.2012.09.006. Epub 2012 Sep 17.

PMID:
22995282
13.

Evolving concepts and techniques for anti-doping.

Friedmann T, Flenker U, Georgakopoulos C, Alsayrafi M, Sottas PE, Williams SA, Gill RD.

Bioanalysis. 2012 Jul;4(13):1667-80. doi: 10.4155/bio.12.146.

PMID:
22831482
14.

Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy.

Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, Montini E, Bushman F, Sorrentino BP, Carrondo M, Malech H, Gahrton G, Shapiro R, Wolff L, Rosenthal E, Jambou R, Zaia J, Kohn DB.

Mol Ther. 2012 Jun;20(6):1084-94. doi: 10.1038/mt.2012.93. No abstract available.

15.

The successful clinical use of viral vectors for human gene therapy. Preface.

Friedmann T.

Methods Enzymol. 2012;507:xvii-xx. doi: 10.1016/B978-0-12-386509-0.00027-2. No abstract available.

PMID:
22365783
16.

Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase.

Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3377-82. doi: 10.1073/pnas.1118067109. Epub 2012 Feb 13.

17.

MicroRNA-mediated dysregulation of neural developmental genes in HPRT deficiency: clues for Lesch-Nyhan disease?

Guibinga GH, Hrustanovic G, Bouic K, Jinnah HA, Friedmann T.

Hum Mol Genet. 2012 Feb 1;21(3):609-22. doi: 10.1093/hmg/ddr495. Epub 2011 Oct 31.

18.

Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progression.

Tsimikas S, Miyanohara A, Hartvigsen K, Merki E, Shaw PX, Chou MY, Pattison J, Torzewski M, Sollors J, Friedmann T, Lai NC, Hammond HK, Getz GS, Reardon CA, Li AC, Banka CL, Witztum JL.

J Am Coll Cardiol. 2011 Oct 11;58(16):1715-27. doi: 10.1016/j.jacc.2011.07.017.

19.

HPRT deficiency coordinately dysregulates canonical Wnt and presenilin-1 signaling: a neuro-developmental regulatory role for a housekeeping gene?

Kang TH, Guibinga GH, Jinnah HA, Friedmann T.

PLoS One. 2011 Jan 28;6(1):e16572. doi: 10.1371/journal.pone.0016572. Erratum in: PLoS One. 2011;6(3). doi: 10.1371/annotation/893f09fd-ab24-4119-93f4-44a03a3342f9. Jinnah, H A [added].

20.

Effects of opioid agonist and antagonist in dams exposed to morphine during the perinatal period.

Sobor M, Timár J, Riba P, Friedmann T, Király KP, Gyarmati S, Al-Khrasani M, Fürst S.

Brain Res Bull. 2011 Jan 15;84(1):53-60. doi: 10.1016/j.brainresbull.2010.10.001. Epub 2010 Oct 8.

PMID:
20934489
21.

Preparation of pseudotyped lentiviral vectors resistant to inactivation by serum complement.

Guibinga GH, Friedmann T.

Cold Spring Harb Protoc. 2010 Jul 1;2010(7):pdb.prot5420. doi: 10.1101/pdb.prot5420.

PMID:
20647353
22.

How close are we to gene doping?

Friedmann T.

Hastings Cent Rep. 2010 Mar-Apr;40(2):20-2. No abstract available.

PMID:
20391845
23.

Ethics. Gene doping and sport.

Friedmann T, Rabin O, Frankel MS.

Science. 2010 Feb 5;327(5966):647-8. doi: 10.1126/science.1177801. No abstract available.

PMID:
20133558
24.

Novel approach to demonstrate high efficacy of mu opioids in the rat vas deferens: a simple model of predictive value.

Riba P, Friedmann T, Király KP, Al-Khrasani M, Sobor M, Asim MF, Spetea M, Schmidhammer H, Furst S.

Brain Res Bull. 2010 Jan 15;81(1):178-84. doi: 10.1016/j.brainresbull.2009.09.011.

PMID:
19800397
25.

Deficiency of the housekeeping gene hypoxanthine-guanine phosphoribosyltransferase (HPRT) dysregulates neurogenesis.

Guibinga GH, Hsu S, Friedmann T.

Mol Ther. 2010 Jan;18(1):54-62. doi: 10.1038/mt.2009.178. Epub 2009 Aug 11.

26.
27.

An integrated funding mechanism for clinical trials in human gene therapy.

Nienhuis A, Friedmann T.

Mol Ther. 2009 Jul;17(7):1117-8. doi: 10.1038/mt.2009.129. No abstract available.

28.
29.

The ASGT and ethical codes for clinical research.

Friedmann T.

Mol Ther. 2008 Oct;16(10):1643-4. doi: 10.1038/mt.2008.193. No abstract available.

30.

In memoriam: J. Edwin Seegmiller, M.D. (1920-2006).

Becker MA, Friedmann T, Raivio KO, Hershfield MS, Nuki G.

Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):554-6. doi: 10.1080/15257770802135638. No abstract available.

PMID:
18600502
31.

Characterization of the gene delivery properties of baculoviral-based virosomal vectors.

Guibinga GH, Song S, Loring J, Friedmann T.

J Virol Methods. 2008 Mar;148(1-2):277-82. doi: 10.1016/j.jviromet.2007.11.007. Epub 2008 Jan 18.

PMID:
18207578
32.

A new serious adverse event in a gene therapy study.

Friedmann T.

Mol Ther. 2007 Nov;15(11):1899-900. No abstract available.

33.

Partial characterization of the proteome of the mouse striatum.

Guo LT, Friedmann T, King CC.

Proteomics. 2007 Nov;7(21):3867-9.

PMID:
17922512
34.
35.

A decade of accomplishments: gene therapy and the ASGT.

Friedmann T.

Mol Ther. 2007 Sep;15(9):1576-8. No abstract available.

36.

Happy Anniversary.

Friedmann T.

Mol Ther. 2007 Jun;15(6):1035-1036. doi: 10.1038/sj.mt.6300191. Epub 2016 Dec 7. No abstract available.

37.
38.

Gene doping in sports: the science and ethics of genetically modified athletes.

Schneider AJ, Friedmann T.

Adv Genet. 2006;51:1-110. Review. No abstract available.

PMID:
16504745
39.

Lessons for the stem cell discourse from the gene therapy experience.

Friedmann T.

Perspect Biol Med. 2005 Autumn;48(4):585-91.

PMID:
16227669
41.

Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.

Fürst S, Riba P, Friedmann T, Tímar J, Al-Khrasani M, Obara I, Makuch W, Spetea M, Schütz J, Przewlocki R, Przewlocka B, Schmidhammer H.

J Pharmacol Exp Ther. 2005 Feb;312(2):609-18. Epub 2004 Sep 21.

PMID:
15383636
42.

Clinical gene therapy: lessons from the ether dome.

Friedmann T.

Mol Ther. 2004 Aug;10(2):205-6. No abstract available.

43.

In vivo evaluation of tetrahedral amorphous carbon.

LaVan DA, Padera RF, Friedmann TA, Sullivan JP, Langer R, Kohane DS.

Biomaterials. 2005 Feb;26(5):465-73.

PMID:
15276354
44.

Experimental demonstration of a laterally deformable optical nanoelectromechanical system grating transducer.

Keeler BE, Carr DW, Sullivan JP, Friedmann TA, Wendt JR.

Opt Lett. 2004 Jun 1;29(11):1182-4.

PMID:
15209240
45.

Discrepant effects of culture conditions on survival and function of dopaminergic neurons.

Smith DW, Friedmann T.

Neuroreport. 2004 Apr 29;15(6):1025-8.

PMID:
15076727
46.
47.

In vitro opioid activity profiles of 6-amino acid substituted derivatives of 14-O-methyloxymorphone.

Spetea M, Friedmann T, Riba P, Schütz J, Wunder G, Langer T, Schmidhammer H, Fürst S.

Eur J Pharmacol. 2004 Jan 12;483(2-3):301-8.

PMID:
14729121
48.

Plus ça change...

Friedmann T.

Mol Ther. 2003 Nov;8(5):701. No abstract available.

49.

Effects of structural modifications of N-CPM-normorphine derivatives on agonist and antagonist activities in isolated organs.

Riba P, Tóth Z, Hosztafi S, Friedmann T, Fürst S.

Acta Biol Hung. 2003;54(2):177-81.

PMID:
14535623
50.

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