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Items: 1 to 50 of 273


Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility.

Guan J, Zhou W, Hafner M, Blake RA, Chalouni C, Chen IP, De Bruyn T, Giltnane JM, Hartman SJ, Heidersbach A, Houtman R, Ingalla E, Kategaya L, Kleinheinz T, Li J, Martin SE, Modrusan Z, Nannini M, Oeh J, Ubhayakar S, Wang X, Wertz IE, Young A, Yu M, Sampath D, Hager JH, Friedman LS, Daemen A, Metcalfe C.

Cell. 2019 Aug 8;178(4):949-963.e18. doi: 10.1016/j.cell.2019.06.026. Epub 2019 Jul 25.


Injuries associated with long working hours among employees in the US mining industry: risk factors and adverse outcomes.

Friedman LS, Almberg KS, Cohen RA.

Occup Environ Med. 2019 Jun;76(6):389-395. doi: 10.1136/oemed-2018-105558. Epub 2019 Apr 12.


Physicians' Perspectives on Palliative Care for Patients With End-Stage Liver Disease: A National Survey Study.

Ufere NN, Donlan J, Waldman L, Patel A, Dienstag JL, Friedman LS, Corey KE, Hashemi N, Carolan P, Mullen AC, Thiim M, Bhan I, Nipp R, Greer J, Temel J, Chung RT, El-Jawahri A.

Liver Transpl. 2019 Jun;25(6):859-869. doi: 10.1002/lt.25469. Epub 2019 May 3.


Barriers to Use of Palliative Care and Advance Care Planning Discussions for Patients With End-Stage Liver Disease.

Ufere NN, Donlan J, Waldman L, Dienstag JL, Friedman LS, Corey KE, Hashemi N, Carolan P, Mullen AC, Thiim M, Bhan I, Nipp R, Greer JA, Temel JS, Chung RT, El-Jawahri A.

Clin Gastroenterol Hepatol. 2019 Mar 15. pii: S1542-3565(19)30286-1. doi: 10.1016/j.cgh.2019.03.022. [Epub ahead of print]


AGA Clinical Practice Update on Surgical Risk Assessment and Perioperative Management in Cirrhosis: Expert Review.

Northup PG, Friedman LS, Kamath PS.

Clin Gastroenterol Hepatol. 2019 Mar;17(4):595-606. doi: 10.1016/j.cgh.2018.09.043. Epub 2018 Sep 28. Review. No abstract available.


Opioid prescribing practices in patients undergoing surgery for oral cavity cancer.

Pang J, Tringale KR, Tapia VJ, Panuganti BA, Qualliotine JR, Jafari A, Haft SJ, Friedman LS, Furnish T, Brumund KT, Califano JA, Coffey CS.

Laryngoscope. 2018 Oct;128(10):2361-2366. doi: 10.1002/lary.27215. Epub 2018 May 14.


Treatment of Dyslipidemia in Common Liver Diseases.

Speliotes EK, Balakrishnan M, Friedman LS, Corey KE.

Clin Gastroenterol Hepatol. 2018 Aug;16(8):1189-1196. doi: 10.1016/j.cgh.2018.04.023. Epub 2018 Apr 21. No abstract available.


Mine Safety and Health Administration's Part 50 program does not fully capture chronic disease and injury in the Illinois mining industry.

Almberg KS, Friedman LS, Swedler D, Cohen RA.

Am J Ind Med. 2018 May;61(5):436-443. doi: 10.1002/ajim.22826. Epub 2018 Mar 9.


Editorial: avoiding corticosteroids in the treatment of inflammatory bowel disease.

Colizzo FP, Friedman LS.

Aliment Pharmacol Ther. 2018 Jan;47(1):143-144. doi: 10.1111/apt.14399. No abstract available.


Using clinical signs of neglect to identify elder neglect cases.

Friedman LS, Avila S, Liu E, Dixon K, Patch O, Partida R, Zielke H, Giloth B, Friedman D, Moorman L, Meltzer W.

J Elder Abuse Negl. 2017 Aug-Oct;29(4):270-287. doi: 10.1080/08946566.2017.1352551. Epub 2017 Aug 22.


Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle.

Dogan T, Gnad F, Chan J, Phu L, Young A, Chen MJ, Doll S, Stokes MP, Belvin M, Friedman LS, Kirkpatrick DS, Hoeflich KP, Hatzivassiliou G.

J Biol Chem. 2017 Sep 1;292(35):14311-14324. doi: 10.1074/jbc.M117.792754. Epub 2017 Jun 27.


Physical Abuse of Elderly Adults: Victim Characteristics and Determinants of Revictimization.

Friedman LS, Avila S, Rizvi T, Partida R, Friedman D.

J Am Geriatr Soc. 2017 Jul;65(7):1420-1426. doi: 10.1111/jgs.14794. Epub 2017 May 9.


Work-Related Burn Injuries Hospitalized in US Burn Centers: 2002 to 2011.

Huang Z, Friedman LS.

J Occup Environ Med. 2017 Mar;59(3):282-288. doi: 10.1097/JOM.0000000000000948.


Undertriage of Firearm-Related Injuries in a Major Metropolitan Area.

Lale A, Krajewski A, Friedman LS.

JAMA Surg. 2017 May 1;152(5):467-474. doi: 10.1001/jamasurg.2016.5049.


Medical Management of Severe Alcoholic Hepatitis: Expert Review from the Clinical Practice Updates Committee of the AGA Institute.

Mitchell MC, Friedman LS, McClain CJ.

Clin Gastroenterol Hepatol. 2017 Jan;15(1):5-12. doi: 10.1016/j.cgh.2016.08.047. Review.


Introduction of Clinical Practice Update Committee Articles.

Friedman LS, Inadomi JM, Kalloo AM, Katzka DA, Kim LS, Koch J, Lieberman D, Lichtenstein GR, Lim JK, Pandolfino JE, Shin AS, Siedler MR.

Clin Gastroenterol Hepatol. 2017 Jan;15(1):4. doi: 10.1016/j.cgh.2016.11.011. No abstract available.


Case 36-2016. A 50-Year-Old Man with Acute Liver Injury.

Friedman LS, Lee SR, Nelson SB, Masia R.

N Engl J Med. 2016 Nov 24;375(21):2082-2092. No abstract available.


Workers' compensation filings of temporary workers compared to direct hire workers in Illinois, 2007-2012.

Madigan D, Forst L, Friedman LS.

Am J Ind Med. 2017 Jan;60(1):11-19. doi: 10.1002/ajim.22678. Epub 2016 Nov 15.


Evaluation of abnormal liver biochemical test results: Does the hare finally beat the tortoise?

Poterucha JJ, Friedman LS.

J Hepatol. 2017 Feb;66(2):273-274. doi: 10.1016/j.jhep.2016.10.019. Epub 2016 Oct 24. No abstract available.


Response to Comments by Ryan et al.

Friedman LS, Friedman M.

J Occup Environ Med. 2016 Sep;58(9):e339-40. doi: 10.1097/JOM.0000000000000845. No abstract available.


Estimated Costs of Sporadic Gastrointestinal Illness Associated with Surface Water Recreation: A Combined Analysis of Data from NEEAR and CHEERS Studies.

DeFlorio-Barker S, Wade TJ, Jones RM, Friedman LS, Wing C, Dorevitch S.

Environ Health Perspect. 2017 Feb;125(2):215-222. doi: 10.1289/EHP130. Epub 2016 Jul 26.


The PI3K inhibitor taselisib overcomes letrozole resistance in a breast cancer model expressing aromatase.

Hoeflich KP, Guan J, Edgar KA, O'Brien C, Savage H, Wilson TR, Neve RM, Friedman LS, Wallin JJ.

Genes Cancer. 2016 Mar;7(3-4):73-85. doi: 10.18632/genesandcancer.100.


Quantitative phosphoproteomic analysis of the PI3K-regulated signaling network.

Gnad F, Wallin J, Edgar K, Doll S, Arnott D, Robillard L, Kirkpatrick DS, Stokes MP, Vijapurkar U, Hatzivassiliou G, Friedman LS, Belvin M.

Proteomics. 2016 Jul;16(14):1992-7. doi: 10.1002/pmic.201600118. Epub 2016 Jul 8.


Phosphoproteome analysis of the MAPK pathway reveals previously undetected feedback mechanisms.

Gnad F, Doll S, Song K, Stokes MP, Moffat J, Liu B, Arnott D, Wallin J, Friedman LS, Hatzivassiliou G, Belvin M.

Proteomics. 2016 Jul;16(14):1998-2004. doi: 10.1002/pmic.201600119.


Introduction to Clinical Practice Update Committee Articles.

Katzka DA, Friedman LS, Inadomi JM, Kalloo AM, Kim LS, Koch J, Lieberman D, Lichtenstein GR, Lim JK, Pandolfino JE, Shin AS, Siedler MR.

Gastroenterology. 2016 Jul;151(1):45. doi: 10.1053/j.gastro.2016.05.041. Epub 2016 May 27. No abstract available.


Injuries and Safe Communities Accreditation: Is there a link?

Sinelnikov S, Friedman LS, Chavez EA.

Accid Anal Prev. 2016 Jun;91:84-90. doi: 10.1016/j.aap.2016.02.015. Epub 2016 Mar 11.


Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras.

Akutagawa J, Huang TQ, Epstein I, Chang T, Quirindongo-Crespo M, Cottonham CL, Dail M, Slusher BS, Friedman LS, Sampath D, Braun BS.

Leukemia. 2016 Jun;30(6):1335-43. doi: 10.1038/leu.2016.14. Epub 2016 Feb 12.


Injury and Illness Data for Illinois Mining Industry Employees, 1990 to 2012.

Mabila SL, Gracia G, Cohen R, Almberg K, Friedman LS.

J Occup Environ Med. 2015 Dec;57(12):1305-10. doi: 10.1097/JOM.0000000000000554.


Use of sofosbuvir-based direct-acting antiviral therapy for hepatitis C viral infection in patients with severe renal insufficiency.

Hundemer GL, Sise ME, Wisocky J, Ufere N, Friedman LS, Corey KE, Chung RT.

Infect Dis (Lond). 2015;47(12):924-9. doi: 10.3109/23744235.2015.1078908. Epub 2015 Aug 18.


The Education Review Board: A Mechanism for Managing Potential Conflicts of Interest in Medical Education.

Borus JF, Alexander EK, Bierer BE, Bringhurst FR, Clark C, Klanica KE, Stewart EC, Friedman LS.

Acad Med. 2015 Dec;90(12):1611-7. doi: 10.1097/ACM.0000000000000788. Review.


Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.

Ong CC, Gierke S, Pitt C, Sagolla M, Cheng CK, Zhou W, Jubb AM, Strickland L, Schmidt M, Duron SG, Campbell DA, Zheng W, Dehdashti S, Shen M, Yang N, Behnke ML, Huang W, McKew JC, Chernoff J, Forrest WF, Haverty PM, Chin SF, Rakha EA, Green AR, Ellis IO, Caldas C, O'Brien T, Friedman LS, Koeppen H, Rudolph J, Hoeflich KP.

Breast Cancer Res. 2015 Apr 23;17:59. doi: 10.1186/s13058-015-0564-5.


Hospital outcomes and economic costs from poisoning cases in Illinois.

Krajewski AK, Friedman LS.

Clin Toxicol (Phila). 2015 Jun;53(5):433-45. doi: 10.3109/15563650.2015.1030677. Epub 2015 Apr 14.


Teaching in the office.

Friedman LS.

Dig Dis Sci. 2015 Apr;60(4):832-4. doi: 10.1007/s10620-015-3623-y. No abstract available.


GRG Profiles: Lawrence S. Friedman.

Friedman LS.

Dig Dis Sci. 2015 Apr;60(4):827-31. doi: 10.1007/s10620-015-3599-7. No abstract available.


First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors.

Sarker D, Ang JE, Baird R, Kristeleit R, Shah K, Moreno V, Clarke PA, Raynaud FI, Levy G, Ware JA, Mazina K, Lin R, Wu J, Fredrickson J, Spoerke JM, Lackner MR, Yan Y, Friedman LS, Kaye SB, Derynck MK, Workman P, de Bono JS.

Clin Cancer Res. 2015 Jan 1;21(1):77-86. doi: 10.1158/1078-0432.CCR-14-0947. Epub 2014 Nov 4.


Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma.

Chen R, Nishimura MC, Kharbanda S, Peale F, Deng Y, Daemen A, Forrest WF, Kwong M, Hedehus M, Hatzivassiliou G, Friedman LS, Phillips HS.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14217-22. doi: 10.1073/pnas.1409653111. Epub 2014 Sep 15.


PAK1 mediates pancreatic cancer cell migration and resistance to MET inhibition.

Zhou W, Jubb AM, Lyle K, Xiao Q, Ong CC, Desai R, Fu L, Gnad F, Song Q, Haverty PM, Aust D, Grützmann R, Romero M, Totpal K, Neve RM, Yan Y, Forrest WF, Wang Y, Raja R, Pilarsky C, de Jesus-Acosta A, Belvin M, Friedman LS, Merchant M, Jaffee EM, Zheng L, Koeppen H, Hoeflich KP.

J Pathol. 2014 Dec;234(4):502-13. doi: 10.1002/path.4412. Epub 2014 Oct 6.


Amphiregulin and PTEN evoke a multimodal mechanism of acquired resistance to PI3K inhibition.

Edgar KA, Crocker L, Cheng E, Wagle MC, Wongchenko M, Yan Y, Wilson TR, Dompe N, Neve RM, Belvin M, Sampath D, Friedman LS, Wallin JJ.

Genes Cancer. 2014 Mar;5(3-4):113-26.


Complications associated with blood alcohol concentration following injury.

Friedman LS.

Alcohol. 2014 Jun;48(4):391-400. doi: 10.1016/j.alcohol.2014.01.008. Epub 2014 Apr 24.


Case records of the Massachusetts General Hospital. Case 12-2014. A 59-year-old man with fatigue, abdominal pain, anemia, and abnormal liver function.

Friedman LS, Simmons LH, Goldman RH, Sohani AR.

N Engl J Med. 2014 Apr 17;370(16):1542-50. doi: 10.1056/NEJMcpc1314242. No abstract available. Erratum in: N Engl J Med. 2014 Jun 12;370(24):2354.


The role of donor-specific HLA alloantibodies in liver transplantation.

O'Leary JG, Demetris AJ, Friedman LS, Gebel HM, Halloran PF, Kirk AD, Knechtle SJ, McDiarmid SV, Shaked A, Terasaki PI, Tinckam KJ, Tomlanovich SJ, Wood KJ, Woodle ES, Zachary AA, Klintmalm GB.

Am J Transplant. 2014 Apr;14(4):779-87. doi: 10.1111/ajt.12667. Epub 2014 Mar 1.


The association between U.S. Poison Center assistance and length of stay and hospital charges.

Friedman LS, Krajewski A, Vannoy E, Allegretti A, Wahl M.

Clin Toxicol (Phila). 2014 Mar;52(3):198-206. doi: 10.3109/15563650.2014.892125.


Doubling down on the PI3K-AKT-mTOR pathway enhances the antitumor efficacy of PARP inhibitor in triple negative breast cancer model beyond BRCA-ness.

De P, Sun Y, Carlson JH, Friedman LS, Leyland-Jones BR, Dey N.

Neoplasia. 2014 Jan;16(1):43-72. Erratum in: Neoplasia. 2014 Apr;16(4):375. Neoplasia. 2014 Apr;16(4):375.


Becoming a clinician-educator: lessons learned.

Friedman LS.

Gastroenterology. 2014 Mar;146(3):599-601. doi: 10.1053/j.gastro.2014.01.037. Epub 2014 Jan 22. No abstract available.


Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type I 1/2 kinase inhibitors.

Staben ST, Feng JA, Lyle K, Belvin M, Boggs J, Burch JD, Chua CC, Cui H, DiPasquale AG, Friedman LS, Heise C, Koeppen H, Kotey A, Mintzer R, Oh A, Roberts DA, Rouge L, Rudolph J, Tam C, Wang W, Xiao Y, Young A, Zhang Y, Hoeflich KP.

J Med Chem. 2014 Feb 13;57(3):1033-45. doi: 10.1021/jm401768t. Epub 2014 Feb 4.


A description of cases of severe physical abuse in the elderly and 1-year mortality.

Friedman LS, Avila S, Shah M, Tanouye K, Joseph K.

J Elder Abuse Negl. 2014;26(1):1-11. doi: 10.1080/08946566.2013.780944.


Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition.

Kirkpatrick DS, Bustos DJ, Dogan T, Chan J, Phu L, Young A, Friedman LS, Belvin M, Song Q, Bakalarski CE, Hoeflich KP.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19426-31. doi: 10.1073/pnas.1309473110. Epub 2013 Nov 11. Erratum in: Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):562.


Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

Soler A, Serra H, Pearce W, Angulo A, Guillermet-Guibert J, Friedman LS, Viñals F, Gerhardt H, Casanovas O, Graupera M, Vanhaesebroeck B.

J Exp Med. 2013 Sep 23;210(10):1937-45. doi: 10.1084/jem.20121571. Epub 2013 Sep 16.


Mechanism of MEK inhibition determines efficacy in mutant KRAS- versus BRAF-driven cancers.

Hatzivassiliou G, Haling JR, Chen H, Song K, Price S, Heald R, Hewitt JF, Zak M, Peck A, Orr C, Merchant M, Hoeflich KP, Chan J, Luoh SM, Anderson DJ, Ludlam MJ, Wiesmann C, Ultsch M, Friedman LS, Malek S, Belvin M.

Nature. 2013 Sep 12;501(7466):232-6. doi: 10.1038/nature12441. Epub 2013 Aug 11. Erratum in: Nature. 2013 Oct 10;502(7470):258.


Multimodal microvascular imaging reveals that selective inhibition of class I PI3K is sufficient to induce an antivascular response.

Sampath D, Oeh J, Wyatt SK, Cao TC, Koeppen H, Eastham-Anderson J, Robillard L, Ho CC, Ross J, Zhuang G, Reslan HB, Vitorino P, Barck KH, Ungersma SE, Vernes JM, Caunt M, Van Bruggen N, Ye W, Vijapurkar U, Meng YJ, Ferrara N, Friedman LS, Carano RA.

Neoplasia. 2013 Jul;15(7):694-711.

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