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Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.

Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE.

Nat Commun. 2019 Jul 1;10(1):2965. doi: 10.1038/s41467-019-10943-1.


The development and ecology of the Japanese macaque gut microbiome from weaning to early adolescence in association with diet.

Prince AL, Pace RM, Dean T, Takahashi D, Kievit P, Friedman JE, Aagaard KM.

Am J Primatol. 2019 May 7:e22980. doi: 10.1002/ajp.22980. [Epub ahead of print]


Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.

Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA, Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P, Gannon M.

Mol Metab. 2019 Jul;25:73-82. doi: 10.1016/j.molmet.2019.03.010. Epub 2019 Apr 12.


Differential effects of intrauterine growth restriction and a hypersinsulinemic-isoglycemic clamp on metabolic pathways and insulin action in the fetal liver.

Jones AK, Brown LD, Rozance PJ, Serkova NJ, Hay WW Jr, Friedman JE, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2019 May 1;316(5):R427-R440. doi: 10.1152/ajpregu.00359.2018. Epub 2019 Feb 13.


Corrigendum: C/EBPβ Deletion Promotes Expansion of Functionally Poor Intestinal Regulatory T Cells.

Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF.

J Crohns Colitis. 2019 Apr 26;13(5):672. doi: 10.1093/ecco-jcc/jjy194. No abstract available.


The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD.

Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE.

Nat Commun. 2018 Oct 26;9(1):4462. doi: 10.1038/s41467-018-06929-0. Erratum in: Nat Commun. 2019 Jul 1;10(1):2965.


Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?

Friedman JE.

Diabetes. 2018 Nov;67(11):2137-2151. doi: 10.2337/dbi17-0011. Review.


Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.

Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE.

Mol Metab. 2018 Dec;18:25-41. doi: 10.1016/j.molmet.2018.09.008. Epub 2018 Sep 28.


Cecal volvulus caused by internal herniation after roux-en-y gastric bypass surgery.

Rehfuss JP, Friedman JE, Tan SA, Lottenberg LL, Goldstein LE.

J Surg Case Rep. 2018 Sep 11;2018(9):rjy241. doi: 10.1093/jscr/rjy241. eCollection 2018 Sep.


Preconception Micronutrient Supplementation Reduced Circulating Branched Chain Amino Acids at 12 Weeks Gestation in an Open Trial of Guatemalan Women Who Are Overweight or Obese.

Borengasser SJ, Baker PR 2nd, Kerns ME, Miller LV, Palacios AP, Kemp JF, Westcott JE, Morrison SD, Hernandez TL, Garces A, Figueroa L, Friedman JE, Hambidge KM, Krebs NF.

Nutrients. 2018 Sep 11;10(9). pii: E1282. doi: 10.3390/nu10091282.


Mitochondrial role in the neonatal predisposition to developing nonalcoholic fatty liver disease.

Baker PR 2nd, Friedman JE.

J Clin Invest. 2018 Aug 31;128(9):3692-3703. doi: 10.1172/JCI120846. Epub 2018 Aug 31. Review.


Bioactive components in human milk are differentially associated with rates of lean and fat mass deposition in infants of mothers with normal vs. elevated BMI.

Young BE, Levek C, Reynolds RM, Rudolph MC, MacLean P, Hernandez TL, Friedman JE, Krebs NF.

Pediatr Obes. 2018 Oct;13(10):598-606. doi: 10.1111/ijpo.12394. Epub 2018 Aug 9.


C/EBPβ Deletion Promotes Expansion of Poorly Functional Intestinal Regulatory T Cells.

Collins CB, Puthoor PR, Nguyen TT, Strassheim D, Jedlicka P, Friedman JE, de Zoeten EF.

J Crohns Colitis. 2018 Nov 28;12(12):1475-1485. doi: 10.1093/ecco-jcc/jjy105. Erratum in: J Crohns Colitis. 2019 Apr 26;13(5):672.


A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes.

Barbour LA, Scifres C, Valent AM, Friedman JE, Buchanan TA, Coustan D, Aagaard K, Thornburg KL, Catalano PM, Galan HL, Hay WW Jr, Frias AE, Shankar K, Simmons RA, Moses RG, Sacks DA, Loeken MR.

Am J Obstet Gynecol. 2018 Oct;219(4):367.e1-367.e7. doi: 10.1016/j.ajog.2018.06.013. Epub 2018 Jun 28.


Postprandial Triglycerides Predict Newborn Fat More Strongly than Glucose in Women with Obesity in Early Pregnancy.

Barbour LA, Farabi SS, Friedman JE, Hirsch NM, Reece MS, Van Pelt RE, Hernandez TL.

Obesity (Silver Spring). 2018 Aug;26(8):1347-1356. doi: 10.1002/oby.22246. Epub 2018 Jun 22.


Placental lipoprotein lipase activity is positively associated with newborn adiposity.

Heerwagen MJR, Gumina DL, Hernandez TL, Van Pelt RE, Kramer AW, Janssen RC, Jensen DR, Powell TL, Friedman JE, Winn VD, Barbour LA.

Placenta. 2018 Apr;64:53-60. doi: 10.1016/j.placenta.2018.03.001. Epub 2018 Mar 5.


Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates.

Pace RM, Prince AL, Ma J, Belfort BDW, Harvey AS, Hu M, Baquero K, Blundell P, Takahashi D, Dean T, Kievit P, Sullivan EL, Friedman JE, Grove K, Aagaard KM.

BMC Microbiol. 2018 Apr 5;18(1):28. doi: 10.1186/s12866-018-1169-9.


Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice.

Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR.

Hepatol Commun. 2018 Jan 22;2(3):313-328. doi: 10.1002/hep4.1139. eCollection 2018 Mar.


Early Microbes Modify Immune System Development and Metabolic Homeostasis-The "Restaurant" Hypothesis Revisited.

Nash MJ, Frank DN, Friedman JE.

Front Endocrinol (Lausanne). 2017 Dec 13;8:349. doi: 10.3389/fendo.2017.00349. eCollection 2017. Review.


Altered gene expression and metabolism in fetal umbilical cord mesenchymal stem cells correspond with differences in 5-month-old infant adiposity gain.

Baker PR 2nd, Patinkin ZW, Shapiro ALB, de la Houssaye BA, Janssen RC, Vanderlinden LA, Dabelea D, Friedman JE.

Sci Rep. 2017 Dec 22;7(1):18095. doi: 10.1038/s41598-017-17588-4.


Low Neonatal Plasma n-6/n-3 PUFA Ratios Regulate Offspring Adipogenic Potential and Condition Adult Obesity Resistance.

Rudolph MC, Jackman MR, Presby DM, Houck JA, Webb PG, Johnson GC, Soderborg TK, de la Houssaye BA, Yang IV, Friedman JE, MacLean PS.

Diabetes. 2018 Apr;67(4):651-661. doi: 10.2337/db17-0890. Epub 2017 Nov 14.


Maternal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants.

Boyle KE, Patinkin ZW, Shapiro ALB, Bader C, Vanderlinden L, Kechris K, Janssen RC, Ford RJ, Smith BK, Steinberg GR, Davidson EJ, Yang IV, Dabelea D, Friedman JE.

Mol Metab. 2017 Nov;6(11):1503-1516. doi: 10.1016/j.molmet.2017.08.012. Epub 2017 Sep 1.


Maternal obesity and increased neonatal adiposity correspond with altered infant mesenchymal stem cell metabolism.

Baker PR 2nd, Patinkin Z, Shapiro AL, De La Houssaye BA, Woontner M, Boyle KE, Vanderlinden L, Dabelea D, Friedman JE.

JCI Insight. 2017 Nov 2;2(21). pii: 94200. doi: 10.1172/jci.insight.94200.


Maternal modifiers of the infant gut microbiota: metabolic consequences.

Mulligan CM, Friedman JE.

J Endocrinol. 2017 Oct;235(1):R1-R12. doi: 10.1530/JOE-17-0303. Epub 2017 Jul 27. Review.


Human milk insulin is related to maternal plasma insulin and BMI: but other components of human milk do not differ by BMI.

Young BE, Patinkin Z, Palmer C, de la Houssaye B, Barbour LA, Hernandez T, Friedman JE, Krebs NF.

Eur J Clin Nutr. 2017 Sep;71(9):1094-1100. doi: 10.1038/ejcn.2017.75. Epub 2017 May 17.


The maternal microbiome: Cause or consequence of obesity risk in the next generation?

Friedman JE.

Obesity (Silver Spring). 2017 Mar;25(3):497-498. doi: 10.1002/oby.21795. Epub 2017 Feb 8. No abstract available.


Infant Adiposity is Independently Associated with a Maternal High Fat Diet but not Related to Niacin Intake: The Healthy Start Study.

Shapiro ALB, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D.

Matern Child Health J. 2017 Aug;21(8):1662-1668. doi: 10.1007/s10995-016-2258-8.


Metabolic Inflexibility with Obesity and the Effects of Fenofibrate on Skeletal Muscle Fatty Acid Oxidation.

Boyle KE, Friedman JE, Janssen RC, Underkofler C, Houmard JA, Rasouli N.

Horm Metab Res. 2017 Jan;49(1):50-57. doi: 10.1055/s-0042-111517. Epub 2016 Aug 2.


Myoblast replication is reduced in the IUGR fetus despite maintained proliferative capacity in vitro.

Soto SM, Blake AC, Wesolowski SR, Rozance PJ, Barthel KB, Gao B, Hetrick B, McCurdy CE, Garza NG, Hay WW Jr, Leinwand LA, Friedman JE, Brown LD.

J Endocrinol. 2017 Mar;232(3):475-491. doi: 10.1530/JOE-16-0123. Epub 2017 Jan 4.


Reply to M Gotteland and F Magne.

Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA.

Am J Clin Nutr. 2017 Jan;105(1):234-236. doi: 10.3945/ajcn.116.140749. No abstract available.


Early PQQ supplementation has persistent long-term protective effects on developmental programming of hepatic lipotoxicity and inflammation in obese mice.

Jonscher KR, Stewart MS, Alfonso-Garcia A, DeFelice BC, Wang XX, Luo Y, Levi M, Heerwagen MJ, Janssen RC, de la Houssaye BA, Wiitala E, Florey G, Jonscher RL, Potma EO, Fiehn O, Friedman JE.

FASEB J. 2017 Apr;31(4):1434-1448. doi: 10.1096/fj.201600906R. Epub 2016 Dec 22.


Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI.

Rudolph MC, Young BE, Lemas DJ, Palmer CE, Hernandez TL, Barbour LA, Friedman JE, Krebs NF, MacLean PS.

Int J Obes (Lond). 2017 Apr;41(4):510-517. doi: 10.1038/ijo.2016.211. Epub 2016 Nov 23.


Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model.

Harris RA, Alcott CE, Sullivan EL, Takahashi D, McCurdy CE, Comstock S, Baquero K, Blundell P, Frias AE, Kahr M, Suter M, Wesolowski S, Friedman JE, Grove KL, Aagaard KM.

Sci Rep. 2016 Nov 4;6:36123. doi: 10.1038/srep36123.


Developmental origins of NAFLD: a womb with a clue.

Wesolowski SR, Kasmi KC, Jonscher KR, Friedman JE.

Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):81-96. doi: 10.1038/nrgastro.2016.160. Epub 2016 Oct 26. Review.


Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques.

McCurdy CE, Schenk S, Hetrick B, Houck J, Drew BG, Kaye S, Lashbrook M, Bergman BC, Takahashi DL, Dean TA, Nemkov T, Gertsman I, Hansen KC, Philp A, Hevener AL, Chicco AJ, Aagaard KM, Grove KL, Friedman JE.

JCI Insight. 2016 Oct 6;1(16):e86612. doi: 10.1172/jci.insight.86612.


Nicotinamide Promotes Adipogenesis in Umbilical Cord-Derived Mesenchymal Stem Cells and Is Associated with Neonatal Adiposity: The Healthy Start BabyBUMP Project.

Shapiro AL, Boyle KE, Dabelea D, Patinkin ZW, De la Houssaye B, Ringham BM, Glueck DH, Barbour LA, Norris JM, Friedman JE.

PLoS One. 2016 Jul 14;11(7):e0159575. doi: 10.1371/journal.pone.0159575. eCollection 2016.


Correction: Spaceflight Activates Lipotoxic Pathways in Mouse Liver.

Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ.

PLoS One. 2016 May 4;11(5):e0155282. doi: 10.1371/journal.pone.0155282. eCollection 2016.


Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome.

Lemas DJ, Young BE, Baker PR 2nd, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE.

Am J Clin Nutr. 2016 May;103(5):1291-300. doi: 10.3945/ajcn.115.126375.


Maternal diet quality in pregnancy and neonatal adiposity: the Healthy Start Study.

Shapiro AL, Kaar JL, Crume TL, Starling AP, Siega-Riz AM, Ringham BM, Glueck DH, Norris JM, Barbour LA, Friedman JE, Dabelea D.

Int J Obes (Lond). 2016 Jul;40(7):1056-62. doi: 10.1038/ijo.2016.79. Epub 2016 May 2.


Spaceflight Activates Lipotoxic Pathways in Mouse Liver.

Jonscher KR, Alfonso-Garcia A, Suhalim JL, Orlicky DJ, Potma EO, Ferguson VL, Bouxsein ML, Bateman TA, Stodieck LS, Levi M, Friedman JE, Gridley DS, Pecaut MJ.

PLoS One. 2016 Apr 20;11(4):e0152877. doi: 10.1371/journal.pone.0152877. eCollection 2016. Erratum in: PLoS One. 2016;11(5):e0155282.


C/EBPβ in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis.

Rahman SM, Baquero KC, Choudhury M, Janssen RC, de la Houssaye BA, Sun M, Miyazaki-Anzai S, Wang S, Moustaid-Moussa N, Miyazaki M, Friedman JE.

Atherosclerosis. 2016 Jul;250:172-9. doi: 10.1016/j.atherosclerosis.2016.03.040. Epub 2016 Apr 1.


Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle.

Soderborg TK, Borengasser SJ, Barbour LA, Friedman JE.

Diabetologia. 2016 May;59(5):895-906. doi: 10.1007/s00125-016-3880-0. Epub 2016 Feb 2. Review.


Mesenchymal Stem Cells From Infants Born to Obese Mothers Exhibit Greater Potential for Adipogenesis: The Healthy Start BabyBUMP Project.

Boyle KE, Patinkin ZW, Shapiro AL, Baker PR 2nd, Dabelea D, Friedman JE.

Diabetes. 2016 Mar;65(3):647-59. doi: 10.2337/db15-0849. Epub 2015 Dec 2.


Higher Intake of PUFAs Is Associated with Lower Total and Visceral Adiposity and Higher Lean Mass in a Racially Diverse Sample of Children.

Cardel M, Lemas DJ, Jackson KH, Friedman JE, Fernández JR.

J Nutr. 2015 Sep;145(9):2146-52. doi: 10.3945/jn.115.212365. Epub 2015 Aug 12.


Limited capacity for glucose oxidation in fetal sheep with intrauterine growth restriction.

Brown LD, Rozance PJ, Bruce JL, Friedman JE, Hay WW Jr, Wesolowski SR.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R920-8. doi: 10.1152/ajpregu.00197.2015. Epub 2015 Jul 29.


Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study.

Hernandez TL, Van Pelt RE, Anderson MA, Reece MS, Reynolds RM, de la Houssaye BA, Heerwagen M, Donahoo WT, Daniels LJ, Chartier-Logan C, Janssen RC, Friedman JE, Barbour LA.

Diabetes Care. 2016 Jan;39(1):39-42. doi: 10.2337/dc15-0515. Epub 2015 Jul 29.


Striking differences in estimates of infant adiposity by new and old DXA software, PEAPOD and skin-folds at 2 weeks and 1 year of life.

Barbour LA, Hernandez TL, Reynolds RM, Reece MS, Chartier-Logan C, Anderson MK, Kelly T, Friedman JE, Van Pelt RE.

Pediatr Obes. 2016 Aug;11(4):264-71. doi: 10.1111/ijpo.12055. Epub 2015 Jul 22.


Associations of maternal weight status prior and during pregnancy with neonatal cardiometabolic markers at birth: the Healthy Start study.

Lemas DJ, Brinton JT, Shapiro AL, Glueck DH, Friedman JE, Dabelea D.

Int J Obes (Lond). 2015 Oct;39(10):1437-42. doi: 10.1038/ijo.2015.109. Epub 2015 Jun 9.

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