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Items: 1 to 50 of 111

1.

Identification of 2-piperidone as a biomarker of CYP2E1 activity through metabolomic phenotyping.

Cheng J, Chen C, Kristopher KW, Manna SK, Scerba M, Friedman FK, Luecke H, Idle JR, Gonzalez FJ.

Toxicol Sci. 2013 Sep;135(1):37-47. doi: 10.1093/toxsci/kft143. Epub 2013 Jun 28.

2.

Site-specific phosphorylation of raf in cells containing oncogenic ras-p21 is likely mediated by jun-N-terminal kinase.

Adler V, Bowne W, Michl J, Sookraj KA, Ikram K, Pestka S, Izotova L, Zenilman M, Friedman FK, Qu Y, Pincus MR.

Ann Clin Lab Sci. 2008 Winter;38(1):47-56.

PMID:
18316782
3.

Two peptides derived from ras-p21 induce either phenotypic reversion or tumor cell necrosis of ras-transformed human cancer cells.

Adler V, Bowne W, Kamran I, Michl J, Friedman FK, Chin E, Zenilman M, Pincus MR.

Cancer Chemother Pharmacol. 2008 Aug;62(3):491-8. Epub 2007 Dec 8.

PMID:
18066549
4.

The dual-specificity kinases, TOPK and DYRK1A, are critical for oocyte maturation induced by wild-type--but not by oncogenic--ras-p21 protein.

Qu Y, Adler V, Izotova L, Pestka S, Bowne W, Michl J, Boutjdir M, Friedman FK, Pincus MR.

Front Biosci. 2007 Sep 1;12:5089-97.

PMID:
17569632
5.

Rapid conformational dynamics of cytochrome P450 2E1 in a natural biological membrane environment.

Smith SV, Robinson RC, Smith TG, Burks SM, Friedman FK.

Biochemistry. 2006 Dec 26;45(51):15617-23.

PMID:
17176083
6.

PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo.

Michl J, Scharf B, Schmidt A, Huynh C, Hannan R, von Gizycki H, Friedman FK, Brandt-Rauf P, Fine RL, Pincus MR.

Int J Cancer. 2006 Oct 1;119(7):1577-85.

7.

Functional interactions of Raf and MEK with Jun-N-terminal kinase (JNK) result in a positive feedback loop on the oncogenic Ras signaling pathway.

Adler V, Qu Y, Smith SJ, Izotova L, Pestka S, Kung HF, Lin M, Friedman FK, Chie L, Chung D, Boutjdir M, Pincus MR.

Biochemistry. 2005 Aug 16;44(32):10784-95.

PMID:
16086581
8.

Molecular modeling of mammalian cytochrome P450s.

Friedman FK, Robinson RC, Dai R.

Front Biosci. 2004 Sep 1;9:2796-806. Review.

PMID:
15353315
9.

An effector peptide from glutathione-S-transferase-pi strongly and selectively blocks mitotic signaling by oncogenic ras-p21.

Chie L, Adler V, Friedman FK, Chung D, Pincus MR.

Protein J. 2004 Apr;23(3):235-8.

PMID:
15200055
10.
12.

Immunochemical analysis of chromatin.

Bustin M, Robinson RC, Friedman FK.

Methods Enzymol. 2004;376:209-20. Review. No abstract available.

PMID:
14975308
13.

Peptides designed from molecular modeling studies of the ras-p21 protein induce phenotypic reversion of a pancreatic carcinoma cell line but have no effect on normal pancreatic acinar cell growth.

Kanovsky M, Michl J, Botzolaki G, Morin J, Kovac C, Chung DL, Chie L, Friedman FK, Pincus MR.

Cancer Chemother Pharmacol. 2003 Sep;52(3):202-8. Epub 2003 May 29.

PMID:
12783204
14.

Preferential induction of necrosis in human breast cancer cells by a p53 peptide derived from the MDM2 binding site.

Do TN, Rosal RV, Drew L, Raffo AJ, Michl J, Pincus MR, Friedman FK, Petrylak DP, Cassai N, Szmulewicz J, Sidhu G, Fine RL, Brandt-Rauf PW.

Oncogene. 2003 Mar 13;22(10):1431-44.

PMID:
12629507
15.

Identification of the site of inhibition of mitogenic signaling by oncogenic ras-p21 by a ras effector peptide.

Chie L, Friedman FK, Kung HF, Lin MC, Chung D, Pincus MR.

J Protein Chem. 2002 Jul;21(5):367-70.

PMID:
12206511
16.

Inhibition of ras-induced oocyte maturation by peptides from ras-p21 and GTPase activating protein (GAP) identified as being effector domains from molecular dynamics calculations.

Friedman FK, Chie L, Chung D, Robinson R, Brandt-Rauf P, Yamaizumi Z, Pincus MR.

J Protein Chem. 2002 Jul;21(5):361-6.

PMID:
12206510
18.

Arginine to lysine 108 substitution in recombinant CYP1A2 abolishes methoxyresorufin metabolism in lymphoblastoid cells.

Hadjokas NE, Dai R, Friedman FK, Spence MJ, Cusack BJ, Vestal RE, Ma Y.

Br J Pharmacol. 2002 Jun;136(3):347-52.

19.

Peptides from the amino terminal mdm-2-binding domain of p53, designed from conformational analysis, are selectively cytotoxic to transformed cells.

Kanovsky M, Raffo A, Drew L, Rosal R, Do T, Friedman FK, Rubinstein P, Visser J, Robinson R, Brandt-Rauf PW, Michl J, Fine RL, Pincus MR.

Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12438-43. Epub 2001 Oct 16.

20.

Heme pocket disorder in myoglobin: reversal by acid-induced soft refolding.

Piro MC, Militello V, Leone M, Gryczynski Z, Smith SV, Brinigar WS, Cupane A, Friedman FK, Fronticelli C.

Biochemistry. 2001 Oct 2;40(39):11841-50.

PMID:
11570884
21.

Differences in patterns of activation of MAP kinases induced by oncogenic ras-p21 and insulin in oocytes.

Ranginwale M, Smith S, Flom J, Chie L, Kanovsky M, Chung D, Friedman FK, Robinson RC, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR.

Exp Cell Res. 2001 Sep 10;269(1):162-9.

PMID:
11525649
22.

Plasmid expression of a peptide that selectively blocks oncogenic ras-p21-induced oocyte maturation.

Kovac C, Clie L, Morin J, Friedman FK, Robinson R, Chung DL, Kanovsky M, Flom J, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR.

Cancer Chemother Pharmacol. 2001 Jul;48(1):9-14.

PMID:
11488531
23.
24.
25.

The human peroxisome proliferator-activated receptor alpha gene: identification and functional characterization of two natural allelic variants.

Sapone A, Peters JM, Sakai S, Tomita S, Papiha SS, Dai R, Friedman FK, Gonzalez FJ.

Pharmacogenetics. 2000 Jun;10(4):321-33.

PMID:
10862523
26.

Induction of oocyte maturation by jun-N-terminal kinase (JNK) on the oncogenic ras-p21 pathway is dependent on the raf-MEK signal transduction pathway.

Chie L, Amar S, Kung HF, Lin MC, Chen H, Chung DL, Adler V, Ronai Z, Friedman FK, Robinson RC, Kovac C, Brandt-Rauf PW, Yamaizumi Z, Michl J, Pincus MR.

Cancer Chemother Pharmacol. 2000;45(6):441-9.

PMID:
10854130
27.

Identification of the site of inhibition of oncogenic ras-p21-induced signal transduction by a peptide from a ras effector domain.

Chie L, Chen JM, Friedman FK, Chung DL, Amar S, Michl J, Yamaizumi Z, Brandt-Rauf PW, Pincus MR.

J Protein Chem. 1999 Nov;18(8):881-4.

PMID:
10839625
30.

Identification of a glutathione-S-transferase effector domain for inhibition of jun kinase, by molecular dynamics.

Monaco R, Friedman FK, Hyde MJ, Chen JM, Manolatus S, Adler V, Ronai Z, Koslosky W, Pincus MR.

J Protein Chem. 1999 Nov;18(8):859-66.

PMID:
10839622
31.

Molecular modeling of mammalian cytochrome P450s.

Dai R, Pincus MR, Friedman FK.

Cell Mol Life Sci. 2000 Mar;57(3):487-99. Review.

PMID:
10823248
32.

Conformational modulation of human cytochrome P450 2E1 by ethanol and other substrates: a CO flash photolysis study.

Smith SV, Koley AP, Dai R, Robinson RC, Leong H, Markowitz A, Friedman FK.

Biochemistry. 2000 May 16;39(19):5731-7.

PMID:
10801323
33.

ras-p21-induced cell transformation: unique signal transduction pathways and implications for the design of new chemotherapeutic agents.

Pincus MR, Brandt-Rauf PW, Michl J, Carty RP, Friedman FK.

Cancer Invest. 2000;18(1):39-50. Review. No abstract available.

PMID:
10701366
34.

Inhibition of human liver cytochrome P-450 1A2 by the class IB antiarrhythmics mexiletine, lidocaine, and tocainide.

Wei X, Dai R, Zhai S, Thummel KE, Friedman FK, Vestal RE.

J Pharmacol Exp Ther. 1999 May;289(2):853-8.

PMID:
10215663
35.

Inhibition of human cytochrome P450 1A2 by flavones: a molecular modeling study.

Dai R, Zhai S, Wei X, Pincus MR, Vestal RE, Friedman FK.

J Protein Chem. 1998 Oct;17(7):643-50.

PMID:
9853678
36.

Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids.

Zhai S, Dai R, Friedman FK, Vestal RE.

Drug Metab Dispos. 1998 Oct;26(10):989-92.

PMID:
9763404
37.

Inhibition of methoxyresorufin demethylase activity by flavonoids in human liver microsomes.

Zhai S, Dai R, Wei X, Friedman FK, Vestal RE.

Life Sci. 1998;63(8):PL119-23.

PMID:
9718089
38.

Molecular modeling of cytochrome P450 2B1: mode of membrane insertion and substrate specificity.

Dai R, Pincus MR, Friedman FK.

J Protein Chem. 1998 Feb;17(2):121-9.

PMID:
9535274
39.
40.

Inhibition of oncogenic and activated wild-type ras-p21 protein-induced oocyte maturation by peptides from the ras-binding domain of the raf-p74 protein, identified from molecular dynamics calculations.

Chung D, Amar S, Glozman A, Chen JM, Friedman FK, Robinson R, Monaco R, Brandt-Rauf P, Yamaizumi Z, Pincus MR.

J Protein Chem. 1997 Aug;16(6):631-5.

PMID:
9263125
41.
42.

Differential interaction of erythromycin with cytochromes P450 3A1/2 in the endoplasmic reticulum: a CO flash photolysis study.

Koley AP, Dai R, Robinson RC, Markowitz A, Friedman FK.

Biochemistry. 1997 Mar 18;36(11):3237-41.

PMID:
9116001
43.

Conformation-dependent phosphorylation of p53.

Adler V, Pincus MR, Minamoto T, Fuchs SY, Bluth MJ, Brandt-Rauf PW, Friedman FK, Robinson RC, Chen JM, Wang XW, Harris CC, Ronai Z.

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1686-91.

44.

Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4.

Koley AP, Robinson RC, Markowitz A, Friedman FK.

Biochem Pharmacol. 1997 Feb 21;53(4):455-60.

PMID:
9105395
45.

Assembly of human hemoglobin. Studies with Escherichia coli-expressed alpha-globin.

Sanna MT, Razynska A, Karavitis M, Koley AP, Friedman FK, Russu IM, Brinigar WS, Fronticelli C.

J Biol Chem. 1997 Feb 7;272(6):3478-86.

46.

Differential mechanisms of cytochrome P450 inhibition and activation by alpha-naphthoflavone.

Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK.

J Biol Chem. 1997 Feb 7;272(6):3149-52.

47.

Selective inhibition of oncogenic ras-p21 in vivo by agents that block its interaction with jun-N-kinase (JNK) and jun proteins. Implications for the design of selective chemotherapeutic agents.

Amar S, Glozman A, Chung D, Adler V, Ronai Z, Friedman FK, Robinson R, Brandt-Rauf P, Yamaizumi Z, Pincus MR.

Cancer Chemother Pharmacol. 1997;41(1):79-85.

PMID:
9443618
48.

Differential effects of flavonoids on testosterone-metabolizing cytochrome P450s.

Dai R, Jacobson KA, Robinson RC, Friedman FK.

Life Sci. 1997;61(7):PL75-80.

PMID:
9252251
49.

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study.

Koley AP, Buters JT, Robinson RC, Markowitz A, Friedman FK.

Arch Biochem Biophys. 1996 Dec 15;336(2):261-7.

PMID:
8954573
50.

Activation of c-Jun-NH2-kinase by UV irradiation is dependent on p21ras.

Adler V, Pincus MR, Polotskaya A, Montano X, Friedman FK, Ronai Z.

J Biol Chem. 1996 Sep 20;271(38):23304-9.

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