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Items: 1 to 50 of 188


BRAF V600E-mutated metastatic pediatric Wilms tumor with complete response to targeted RAF/MEK inhibition.

Obasaju P, Shahab S, Dunn E, Rhee DS, Jiang L, Dome JS, Friedman AD, Argani P, Pratilas CA.

Cold Spring Harb Mol Case Stud. 2020 Apr 1;6(2). pii: a004820. doi: 10.1101/mcs.a004820. Print 2020 Apr.


NF-κB p50-deficient immature myeloid cell (p50-IMC) adoptive transfer slows the growth of murine prostate and pancreatic ductal carcinoma.

Suresh R, Barakat DJ, Barberi T, Zheng L, Jaffee E, Pienta KJ, Friedman AD.

J Immunother Cancer. 2020 Jan;8(1). pii: e000244. doi: 10.1136/jitc-2019-000244.


Atypical Laryngeal Infections: Localized Lesions from Unusual Organisms May Simulate Malignancy.

Yan K, Taxy JB, Paintal A, Friedman AD.

Ann Otol Rhinol Laryngol. 2020 Jan;129(1):82-86. doi: 10.1177/0003489419875755. Epub 2019 Sep 14.


HoxA9 binds and represses the Cebpa +8 kb enhancer.

Peng L, Guo H, Ma P, Sun Y, Dennison L, Aplan PD, Hess JL, Friedman AD.

PLoS One. 2019 May 23;14(5):e0217604. doi: 10.1371/journal.pone.0217604. eCollection 2019.


Progression from the Common Lymphoid Progenitor to B/Myeloid PreproB and ProB Precursors during B Lymphopoiesis Requires C/EBPα.

Guo H, Barberi T, Suresh R, Friedman AD.

J Immunol. 2018 Sep 15;201(6):1692-1704. doi: 10.4049/jimmunol.1800244. Epub 2018 Jul 30.


Absence of host NF-κB p50 induces murine glioblastoma tumor regression, increases survival, and decreases T-cell induction of tumor-associated macrophage M2 polarization.

Barberi T, Martin A, Suresh R, Barakat DJ, Harris-Bookman S, Drake CG, Lim M, Friedman AD.

Cancer Immunol Immunother. 2018 Oct;67(10):1491-1503. doi: 10.1007/s00262-018-2184-2. Epub 2018 Jul 21.


Ideal Characteristics of a Laser-Protected Endotracheal Tube: ABEA and AHNS Member Survey and Biomechanical Testing.

Friedman AD, Gerber ME, Bhayani MK, Kuchta K, Kumar K, Ma A, Ren Y, Zhang LQ.

Ann Otol Rhinol Laryngol. 2018 Apr;127(4):258-265. doi: 10.1177/0003489418757549. Epub 2018 Feb 9.


Absence of myeloid Klf4 reduces prostate cancer growth with pro-atherosclerotic activation of tumor myeloid cells and infiltration of CD8 T cells.

Barakat DJ, Suresh R, Barberi T, Pienta KJ, Simons BW, Friedman AD.

PLoS One. 2018 Jan 11;13(1):e0191188. doi: 10.1371/journal.pone.0191188. eCollection 2018.


ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPα.

Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG.

J Biol Chem. 2017 Nov 17;292(46):18924-18936. doi: 10.1074/jbc.M117.811109. Epub 2017 Sep 12.


The C-terminal multimerization domain is essential for leukemia development by CBFβ-SMMHC in a mouse knockin model.

Zhao L, Alkadi H, Kwon EM, Zhen T, Lichtenberg J, Alemu L, Cheng J, Friedman AD, Liu PP.

Leukemia. 2017 Dec;31(12):2841-2844. doi: 10.1038/leu.2017.262. Epub 2017 Aug 18. No abstract available.


The assembly competence domain is essential for inv(16)-associated acute myeloid leukemia.

Kim HG, LeGrand J, Swindle CS, Nick HJ, Oster RA, Chen D, Purohit-Ghelani S, Cotta CV, Ko R, Gartland L, Reddy V, Hiebert SW, Friedman AD, Klug CA.

Leukemia. 2017 Oct;31(10):2267-2271. doi: 10.1038/leu.2017.236. Epub 2017 Jul 28. No abstract available.


RUNX1 and CBFβ Mutations and Activities of Their Wild-Type Alleles in AML.

Hyde RK, Liu P, Friedman AD.

Adv Exp Med Biol. 2017;962:265-282. doi: 10.1007/978-981-10-3233-2_17. Review.


The Young Innovators Program at the Eshelman Institute for Innovation: a case study examining the role of a professional pharmacy school in enhancing STEM pursuits among secondary school students.

Friedman AD, Melendez CR, Bush AA, Lai SK, McLaughlin JE.

Int J STEM Educ. 2017;4(1):17. doi: 10.1186/s40594-017-0081-4. Epub 2017 Sep 16.


Tankyrase inhibition promotes a stable human naïve pluripotent state with improved functionality.

Zimmerlin L, Park TS, Huo JS, Verma K, Pather SR, Talbot CC Jr, Agarwal J, Steppan D, Zhang YW, Considine M, Guo H, Zhong X, Gutierrez C, Cope L, Canto-Soler MV, Friedman AD, Baylin SB, Zambidis ET.

Development. 2016 Dec 1;143(23):4368-4380. Epub 2016 Sep 22.


Paradoxical Vocal Cord Motion in Pediatric Patients.

Palla J, Friedman AD.

Pediatr Ann. 2016 May 1;45(5):e184-8. doi: 10.3928/00904481-20160331-01. Review.


C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion.

Barakat DJ, Mendonca J, Barberi T, Zhang J, Kachhap SK, Paz-Priel I, Friedman AD.

Cancer Lett. 2016 May 28;375(1):152-161. doi: 10.1016/j.canlet.2016.03.005. Epub 2016 Mar 8.


In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis.

Guo H, Cooper S, Friedman AD.

PLoS One. 2016 Mar 3;11(3):e0150809. doi: 10.1371/journal.pone.0150809. eCollection 2016.


A review of the literature for intra-arterial chemotherapy used to treat retinoblastoma.

Wyse E, Handa JT, Friedman AD, Pearl MS.

Pediatr Radiol. 2016 Aug;46(9):1223-33. doi: 10.1007/s00247-016-3554-6. Epub 2016 Feb 17. Review.


Runx1 Phosphorylation by Src Increases Trans-activation via Augmented Stability, Reduced Histone Deacetylase (HDAC) Binding, and Increased DNA Affinity, and Activated Runx1 Favors Granulopoiesis.

Leong WY, Guo H, Ma O, Huang H, Cantor AB, Friedman AD.

J Biol Chem. 2016 Jan 8;291(2):826-36. doi: 10.1074/jbc.M115.674234. Epub 2015 Nov 23.


Bedside Injection Medialization Laryngoplasty in Immediate Postoperative Patients.

Barbu AM, Gniady JP, Vivero RJ, Friedman AD, Burns JA.

Otolaryngol Head Neck Surg. 2015 Dec;153(6):1007-12. doi: 10.1177/0194599815601393. Epub 2015 Aug 25.


Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells.

Zhang J, Li L, Baldwin AS Jr, Friedman AD, Paz-Priel I.

PLoS One. 2015 Jun 23;10(6):e0130441. doi: 10.1371/journal.pone.0130441. eCollection 2015.


The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors.

Cooper S, Guo H, Friedman AD.

PLoS One. 2015 May 4;10(5):e0126385. doi: 10.1371/journal.pone.0126385. eCollection 2015.


CCAAT/Enhancer binding protein β controls androgen-deprivation-induced senescence in prostate cancer cells.

Barakat DJ, Zhang J, Barberi T, Denmeade SR, Friedman AD, Paz-Priel I.

Oncogene. 2015 Nov 26;34(48):5912-22. doi: 10.1038/onc.2015.41. Epub 2015 Mar 16.


C/EBPα in normal and malignant myelopoiesis.

Friedman AD.

Int J Hematol. 2015 Apr;101(4):330-41. doi: 10.1007/s12185-015-1764-6. Epub 2015 Mar 10. Review.


The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells.

Guo H, Ma O, Friedman AD.

J Leukoc Biol. 2014 Sep;96(3):419-26. doi: 10.1189/jlb.2AB0314-145R. Epub 2014 May 27.


Tetraspecific ligand for tumor-targeted delivery of nanomaterials.

Kim D, Friedman AD, Liu R.

Biomaterials. 2014 Jul;35(23):6026-36. doi: 10.1016/j.biomaterials.2014.04.015. Epub 2014 Apr 28.


Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells.

Ma O, Hong S, Guo H, Ghiaur G, Friedman AD.

PLoS One. 2014 Apr 21;9(4):e95784. doi: 10.1371/journal.pone.0095784. eCollection 2014.


Effect of mandibular tori on glottic exposure during simulated suspension microlaryngoscopy.

Best SR, Kobler JB, Friedman AD, Barbu AM, Zeitels SM, Burns JA.

Ann Otol Rhinol Laryngol. 2014 Mar;123(3):188-94. doi: 10.1177/0003489414522967.


Wilms tumor.

Friedman AD.

Pediatr Rev. 2013 Jul;34(7):328-30; discussion 330. doi: 10.1542/pir.34-7-328. Review. No abstract available.


Salvage endoscopic angiolytic KTP laser treatment of early glottic cancer after failed radiotherapy.

Barbu AM, Burns JA, Lopez-Guerra G, Landau-Zemer T, Friedman AD, Zeitels SM.

Ann Otol Rhinol Laryngol. 2013 Apr;122(4):235-9.


Voice outcomes for photoangiolytic KTP laser treatment of early glottic cancer.

Friedman AD, Hillman RE, Landau-Zemer T, Burns JA, Zeitels SM.

Ann Otol Rhinol Laryngol. 2013 Mar;122(3):151-8.


The smart targeting of nanoparticles.

Friedman AD, Claypool SE, Liu R.

Curr Pharm Des. 2013;19(35):6315-29. Review.


Factor structure of measures of anxiety and depression symptoms in African American youth.

Brown RC, Yaroslavsky I, Quinoy AM, Friedman AD, Brookman RR, Southam-Gerow MA.

Child Psychiatry Hum Dev. 2013 Aug;44(4):525-36. doi: 10.1007/s10578-012-0346-6.


High-force simulated intubation fails to dislocate cricoarytenoid joint in ex vivo human larynges.

Friedman AD, Kobler JB, Landau-Zemer T, Barbu AM, Burns JA.

Ann Otol Rhinol Laryngol. 2012 Nov;121(11):746-53.


Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis.

Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM.

Ann Otol Rhinol Laryngol. 2012 Sep;121(9):587-93.


High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery.

Mehta DD, Zeitels SM, Burns JA, Friedman AD, Deliyski DD, Hillman RE.

Ann Otol Rhinol Laryngol. 2012 May;121(5):341-7.


Submucosal neoplasms of the laryngeal introitus.

Friedman AD, Burns JA, Lutch MJ, Zeitels SM.

J Laryngol Otol. 2012 Jul;126(7):706-13. doi: 10.1017/S0022215112000928. Epub 2012 May 25.


Subepithelial vocal fold infusion: a useful diagnostic and therapeutic technique.

Burns JA, Friedman AD, Lutch MJ, Zeitels SM.

Ann Otol Rhinol Laryngol. 2012 Apr;121(4):224-30.


Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.

Guo H, Ma O, Speck NA, Friedman AD.

Blood. 2012 May 10;119(19):4408-18. doi: 10.1182/blood-2011-12-397091. Epub 2012 Mar 26.


Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study.

Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE.

Ann Otol Rhinol Laryngol. 2011 Oct;120(10):627-34.


C/EBPα, C/EBPα oncoproteins, or C/EBPβ preferentially bind NF-κB p50 compared with p65, focusing therapeutic targeting on the C/EBP:p50 interaction.

Dooher JE, Paz-Priel I, Houng S, Baldwin AS Jr, Friedman AD.

Mol Cancer Res. 2011 Oct;9(10):1395-405. doi: 10.1158/1541-7786.MCR-11-0072. Epub 2011 Aug 3.


Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.

Faraday N, Yanek LR, Yang XP, Mathias R, Herrera-Galeano JE, Suktitipat B, Qayyum R, Johnson AD, Chen MH, Tofler GH, Ruczinski I, Friedman AD, Gylfason A, Thorsteinsdottir U, Bray PF, O'Donnell CJ, Becker DM, Becker LC.

Blood. 2011 Sep 22;118(12):3367-75. doi: 10.1182/blood-2010-11-320788. Epub 2011 Jul 26.


SHP2 tyrosine phosphatase stimulates CEBPA gene expression to mediate cytokine-dependent granulopoiesis.

Zhang L, Friedman AD.

Blood. 2011 Aug 25;118(8):2266-74. doi: 10.1182/blood-2011-01-331157. Epub 2011 Jul 1.


Adiposity, estrogen, and voice: the opera has just begun.

Friedman AD.

Menopause. 2011 Jul;18(7):723-4. doi: 10.1097/gme.0b013e31821f7ee9. No abstract available.


AP-1 protein induction during monopoiesis favors C/EBP: AP-1 heterodimers over C/EBP homodimerization and stimulates FosB transcription.

Hong S, Skaist AM, Wheelan SJ, Friedman AD.

J Leukoc Biol. 2011 Oct;90(4):643-51. doi: 10.1189/jlb.0111043. Epub 2011 May 4.


The developmental regulator protein Gon4l associates with protein YY1, co-repressor Sin3a, and histone deacetylase 1 and mediates transcriptional repression.

Lu P, Hankel IL, Hostager BS, Swartzendruber JA, Friedman AD, Brenton JL, Rothman PB, Colgan JD.

J Biol Chem. 2011 May 20;286(20):18311-9. doi: 10.1074/jbc.M110.133603. Epub 2011 Mar 29.


C/EBPα and C/EBPα oncoproteins regulate nfkb1 and displace histone deacetylases from NF-κB p50 homodimers to induce NF-κB target genes.

Paz-Priel I, Houng S, Dooher J, Friedman AD.

Blood. 2011 Apr 14;117(15):4085-94. doi: 10.1182/blood-2010-07-294470. Epub 2011 Feb 23.


The impact of menopause on voice: past, present, and future.

Friedman AD.

Menopause. 2011 Mar;18(3):248-50. doi: 10.1097/gme.0b013e3182074dd5. No abstract available.


Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.

Guo H, Friedman AD.

J Biol Chem. 2011 Jan 7;286(1):208-15. doi: 10.1074/jbc.M110.149013. Epub 2010 Nov 8.

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