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Items: 1 to 50 of 84

1.

Refinement of the Region for Split Hand/Foot Malformation 5 on 2q31.1.

Theisen A, Rosenfeld JA, Shane K, McBride KL, Atkin JF, Gaba C, Hoo J, Kurczynski TW, Schnur RE, Coffey LB, Zackai EH, Schimmenti L, Friedman N, Zabukovec M, Ball S, Pagon R, Lucas A, Brasington CK, Spence JE, Sparks S, Banks V, Smith W, Friedberg T, Wyatt PR, Aust M, Tervo R, Crowley A, Skidmore D, Lamb AN, Ravnan B, Sahoo T, Schultz R, Torchia BS, Sgro M, Chitayat D, Shaffer LG.

Mol Syndromol. 2010;1(5):262-271. Epub 2011 May 18.

2.

In silico platform for xenobiotics ADME-T pharmacological properties modeling and prediction. Part I: Beyond the reduction of animal model use.

Huynh L, Masereeuw R, Friedberg T, Ingelman-Sundberg M, Manivet P.

Drug Discov Today. 2009 Apr;14(7-8):401-5. Review.

PMID:
19340929
3.

Cornelia de Lange syndrome (CdLS): prenatal and autopsy findings.

Chong K, Keating S, Hurst S, Summers A, Berger H, Seaward G, Martin N, Friedberg T, Chitayat D.

Prenat Diagn. 2009 May;29(5):489-94. doi: 10.1002/pd.2228.

PMID:
19242925
4.

Raine syndrome: a rare lethal osteosclerotic bone dysplasia. Prenatal diagnosis, autopsy, and neuropathological findings.

Chitayat D, Shannon P, Keating S, Toi A, Blaser S, Friedberg T, Superti-Furga A, Chong K, Unger S.

Am J Med Genet A. 2007 Dec 15;143A(24):3280-5.

PMID:
18000911
5.

Establishment of functional human cytochrome P450 monooxygenase systems in Escherichia coli.

Pritchard MP, McLaughlin L, Friedberg T.

Methods Mol Biol. 2006;320:19-29.

PMID:
16719371
6.

Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2.

Spears KJ, Ross J, Stenhouse A, Ward CJ, Goh LB, Wolf CR, Morgan P, Ayrton A, Friedberg TH.

Biochem Pharmacol. 2005 Feb 1;69(3):415-23. Epub 2004 Dec 22.

PMID:
15652233
7.

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Rencurel F, Stenhouse A, Hawley SA, Friedberg T, Hardie DG, Sutherland C, Wolf CR.

J Biol Chem. 2005 Feb 11;280(6):4367-73. Epub 2004 Nov 29.

8.

Proteasomal degradation of human CYP1B1: effect of the Asn453Ser polymorphism on the post-translational regulation of CYP1B1 expression.

Bandiera S, Weidlich S, Harth V, Broede P, Ko Y, Friedberg T.

Mol Pharmacol. 2005 Feb;67(2):435-43. Epub 2004 Oct 14.

PMID:
15486049
9.

Glucuronidation as a mechanism of intrinsic drug resistance in colon cancer cells: contribution of drug transport proteins.

Cummings J, Zelcer N, Allen JD, Yao D, Boyd G, Maliepaard M, Friedberg TH, Smyth JF, Jodrell DI.

Biochem Pharmacol. 2004 Jan 1;67(1):31-9.

PMID:
14667926
10.

In vitro metabolism of genistein and tangeretin by human and murine cytochrome P450s.

Breinholt VM, Rasmussen SE, Brøsen K, Friedberg TH.

Pharmacol Toxicol. 2003 Jul;93(1):14-22.

PMID:
12828569
11.

An amperometric biosensor with human CYP3A4 as a novel drug screening tool.

Joseph S, Rusling JF, Lvov YM, Friedberg T, Fuhr U.

Biochem Pharmacol. 2003 Jun 1;65(11):1817-26.

PMID:
12781333
12.

Comparative study of the metabolism of drug substrates by human cytochrome P450 3A4 expressed in bacterial, yeast and human lymphoblastoid cells.

Andrews J, Abd-Ellah MF, Randolph NL, Kenworthy KE, Carlile DJ, Friedberg T, Houston JB.

Xenobiotica. 2002 Nov;32(11):937-47.

PMID:
12487724
13.

Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.

Goh LB, Spears KJ, Yao D, Ayrton A, Morgan P, Roland Wolf C, Friedberg T.

Biochem Pharmacol. 2002 Dec 1;64(11):1569-78.

PMID:
12429346
14.

The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19.

Härtter S, Tybring G, Friedberg T, Weigmann H, Hiemke C.

Pharm Res. 2002 Jul;19(7):1034-7.

PMID:
12180536
15.

Cytochrome P450 polymorphisms as risk factors for steroid hormone-related cancers.

Friedberg T.

Am J Pharmacogenomics. 2001;1(2):83-91. Review.

PMID:
12174676
16.

In vitro investigation of cytochrome P450-mediated metabolism of dietary flavonoids.

Breinholt VM, Offord EA, Brouwer C, Nielsen SE, Brøsen K, Friedberg T.

Food Chem Toxicol. 2002 May;40(5):609-16.

PMID:
11955666
17.

CYP3A4 active site volume modification by mutagenesis of leucine 211.

Fowler SM, Taylor JM, Friedberg T, Wolf CR, Riley RJ.

Drug Metab Dispos. 2002 Apr;30(4):452-6.

PMID:
11901100
18.
19.

Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin.

Härtter S, Wang X, Weigmann H, Friedberg T, Arand M, Oesch F, Hiemke C.

J Clin Psychopharmacol. 2001 Apr;21(2):167-74.

20.

Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping.

Baron JM, Goh LB, Yao D, Wolf CR, Friedberg T.

J Pharmacol Exp Ther. 2001 Feb;296(2):351-8.

PMID:
11160617
21.

Engineering of a functional human NADH-dependent cytochrome P450 system.

Döhr O, Paine MJ, Friedberg T, Roberts GC, Wolf CR.

Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):81-6.

22.

Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.

Yao D, Ding S, Burchell B, Wolf CR, Friedberg T.

J Pharmacol Exp Ther. 2000 Jul;294(1):387-95.

PMID:
10871337
23.

Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol.

Li DN, Seidel A, Pritchard MP, Wolf CR, Friedberg T.

Pharmacogenetics. 2000 Jun;10(4):343-53.

PMID:
10862525
24.

Amino acid 305 determines catalytic center accessibility in CYP3A4.

Fowler SM, Riley RJ, Pritchard MP, Sutcliffe MJ, Friedberg T, Wolf CR.

Biochemistry. 2000 Apr 18;39(15):4406-14.

PMID:
10757990
25.

Mechanism-based inactivation of cytochrome P450 3A4 by L-754,394.

Lightning LK, Jones JP, Friedberg T, Pritchard MP, Shou M, Rushmore TH, Trager WF.

Biochemistry. 2000 Apr 18;39(15):4276-87.

PMID:
10757976
26.

Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli.

McGinnity DF, Griffin SJ, Moody GC, Voice M, Hanlon S, Friedberg T, Riley RJ.

Drug Metab Dispos. 1999 Sep;27(9):1017-23.

PMID:
10460801
27.

Merits and limitations of recombinant models for the study of human P450-mediated drug metabolism and toxicity: an intralaboratory comparison.

Friedberg T, Pritchard MP, Bandera M, Hanlon SP, Yao D, McLaughlin LA, Ding S, Burchell B, Wolf CR.

Drug Metab Rev. 1999 May;31(2):523-44. Review.

PMID:
10335451
28.

Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo.

Voice MW, Zhang Y, Wolf CR, Burchell B, Friedberg T.

Arch Biochem Biophys. 1999 Jun 1;366(1):116-24.

PMID:
10334871
29.

Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism.

Li DN, Pritchard MP, Hanlon SP, Burchell B, Wolf CR, Friedberg T.

J Pharmacol Exp Ther. 1999 May;289(2):661-7.

PMID:
10215637
30.

Electrospray ionization mass spectrometric analysis of intact cytochrome P450: identification of tienilic acid adducts to P450 2C9.

Koenigs LL, Peter RM, Hunter AP, Haining RL, Rettie AE, Friedberg T, Pritchard MP, Shou M, Rushmore TH, Trager WF.

Biochemistry. 1999 Feb 23;38(8):2312-9.

PMID:
10029524
32.

Detoxification of optically active bay- and fjord-region polycyclic aromatic hydrocarbon dihydrodiol epoxides by human glutathione transferase P1-1 expressed in Chinese hamster V79 cells.

Seidel A, Friedberg T, Löllmann B, Schwierzok A, Funk M, Frank H, Holler R, Oesch F, Glatt H.

Carcinogenesis. 1998 Nov;19(11):1975-81.

PMID:
9855012
33.

Effect of phenytoin on cytochrome P450 2B mRNA expression in primary rat astrocyte cultures.

Ibach B, Appel K, Gebicke-Haerter P, Meyer RP, Friedberg T, Knoth R, Volk B.

J Neurosci Res. 1998 Nov 1;54(3):402-11.

PMID:
9819145
34.

The role of the hydrophobic domain in orienting natural signal sequences within the ER membrane.

Eusebio A, Friedberg T, Spiess M.

Exp Cell Res. 1998 May 25;241(1):181-5.

PMID:
9633526
35.

Molecular biological methods for characterizing drug-metabolizing enzymes in hepatic and extrahepatic tissues.

Friedberg T.

Skin Pharmacol Appl Skin Physiol. 1998 Mar-Apr;11(2):61-9. Review.

PMID:
9603656
36.
37.

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.

Smith G, Modi S, Pillai I, Lian LY, Sutcliffe MJ, Pritchard MP, Friedberg T, Roberts GC, Wolf CR.

Biochem J. 1998 May 1;331 ( Pt 3):783-92.

38.

Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli.

Pritchard MP, Glancey MJ, Blake JA, Gilham DE, Burchell B, Wolf CR, Friedberg T.

Pharmacogenetics. 1998 Feb;8(1):33-42.

PMID:
9511179
39.
40.

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

Pritchard MP, Ossetian R, Li DN, Henderson CJ, Burchell B, Wolf CR, Friedberg T.

Arch Biochem Biophys. 1997 Sep 15;345(2):342-54.

PMID:
9308909
41.

The membrane anchor of microsomal epoxide hydrolase from human, rat, and rabbit displays an unexpected membrane topology.

Holler R, Arand M, Mecky A, Oesch F, Friedberg T.

Biochem Biophys Res Commun. 1997 Jul 30;236(3):754-9. Erratum in: Biochem Biophys Res Commun. 2003 Jul 4;306(3):797. Meckey, A [corrected to Mecky, A].

PMID:
9245728
42.

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

Blake JA, Pritchard M, Ding S, Smith GC, Burchell B, Wolf CR, Friedberg T.

FEBS Lett. 1996 Nov 18;397(2-3):210-4.

44.

Investigating the role of the microsomal epoxide hydrolase membrane topology and its implication for drug metabolism pathways.

Friedberg T, Löllmann B, Becker R, Holler R, Arand M, Oesch F.

Adv Exp Med Biol. 1996;387:17-24. Review. No abstract available.

PMID:
8794189
45.
46.

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

Ding S, Lake BG, Friedberg T, Wolf CR.

Biochem J. 1995 Feb 15;306 ( Pt 1):161-6.

47.
48.

Mechanism-based predictions of interactions.

Oesch F, Oesch-Bartlomowicz B, Arens J, Fähndrich F, Vogel E, Friedberg T, Glatt H.

Environ Health Perspect. 1994 Nov;102 Suppl 9:5-9.

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