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Items: 26


Control of Acinetobacter baumannii outbreak in the neonatal intensive care unit in Latvia: whole-genome sequencing powered investigation and closure of the ward.

Gramatniece A, Silamikelis I, Zahare I, Urtans V, Zahare I, Dimina E, Saule M, Balode A, Radovica-Spalvina I, Klovins J, Fridmanis D, Dumpis U.

Antimicrob Resist Infect Control. 2019 May 22;8:84. doi: 10.1186/s13756-019-0537-z. eCollection 2019.


Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.

Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J.

Clin Epigenetics. 2018 Dec 13;10(1):156. doi: 10.1186/s13148-018-0593-x.


Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.

Elbere I, Kalnina I, Silamikelis I, Konrade I, Zaharenko L, Sekace K, Radovica-Spalvina I, Fridmanis D, Gudra D, Pirags V, Klovins J.

PLoS One. 2018 Sep 27;13(9):e0204317. doi: 10.1371/journal.pone.0204317. eCollection 2018.


A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies.

Gudra D, Shoaie S, Fridmanis D, Klovins J, Wefer H, Silamikelis I, Peculis R, Kalnina I, Elbere I, Radovica-Spalvina I, Hultcrantz R, Šķenders Ģ, Leja M, Engstrand L.

Gut. 2019 Sep;68(9):1723-1725. doi: 10.1136/gutjnl-2018-316225. Epub 2018 Sep 21. No abstract available.


Microbiome symbionts and diet diversity incur costs on the immune system of insect larvae.

Krams IA, Kecko S, Jõers P, Trakimas G, Elferts D, Krams R, Luoto S, Rantala MJ, Inashkina I, Gudrā D, Fridmanis D, Contreras-Garduño J, Grantiņa-Ieviņa L, Krama T.

J Exp Biol. 2017 Nov 15;220(Pt 22):4204-4212. doi: 10.1242/jeb.169227. Epub 2017 Sep 22.


The effects of ibuprofen on activated sludge: Shift in bacterial community structure and resistance to ciprofloxacin.

Davids M, Gudra D, Radovica-Spalvina I, Fridmanis D, Bartkevics V, Muter O.

J Hazard Mater. 2017 Oct 15;340:291-299. doi: 10.1016/j.jhazmat.2017.06.065. Epub 2017 Jun 28.


ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?

Fridmanis D, Roga A, Klovins J.

Front Endocrinol (Lausanne). 2017 Feb 6;8:13. doi: 10.3389/fendo.2017.00013. eCollection 2017. Review.


Removal of pharmaceuticals from municipal wastewaters at laboratory scale by treatment with activated sludge and biostimulation.

Muter O, P Erkons I, Selga T, Berzins A, Gudra D, Radovica-Spalvina I, Fridmanis D, Bartkevics V.

Sci Total Environ. 2017 Apr 15;584-585:402-413. doi: 10.1016/j.scitotenv.2017.01.023. Epub 2017 Jan 24.


Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

Zaharenko L, Kalnina I, Geldnere K, Konrade I, Grinberga S, Židzik J, Javorský M, Lejnieks A, Nikitina-Zake L, Fridmanis D, Peculis R, Radovica-Spalvina I, Hartmane D, Pugovics O, Tkáč I, Klimčáková L, Pīrāgs V, Klovins J.

Eur J Endocrinol. 2016 Dec;175(6):531-540. Epub 2016 Sep 8.


Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population.

Radovica-Spalvina I, Latkovskis G, Silamikelis I, Fridmanis D, Elbere I, Ventins K, Ozola G, Erglis A, Klovins J.

BMC Med Genet. 2015 Sep 28;16:86. doi: 10.1186/s12881-015-0230-x.


Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

Radovica I, Fridmanis D, Silamikelis I, Nikitina-Zake L, Klovins J.

Meta Gene. 2014 Aug 20;2:565-78. doi: 10.1016/j.mgene.2014.07.006. eCollection 2014 Dec.


Replacement of short segments within transmembrane domains of MC2R disrupts retention signal.

Fridmanis D, Petrovska R, Pjanova D, Schiöth HB, Klovins J.

J Mol Endocrinol. 2014 Oct;53(2):201-15. doi: 10.1530/JME-14-0169. Epub 2014 Jul 29.


The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Rovite V, Petrovska R, Vaivade I, Kalnina I, Fridmanis D, Zaharenko L, Peculis R, Pirags V, Schioth HB, Klovins J.

Mol Biol Rep. 2014 Mar;41(3):1491-500. doi: 10.1007/s11033-013-2994-4. Epub 2014 Jan 3.


Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.

Kalnina I, Zaharenko L, Vaivade I, Rovite V, Nikitina-Zake L, Peculis R, Fridmanis D, Geldnere K, Jacobsson JA, Almen MS, Pirags V, Schiöth HB, Klovins J.

Gene. 2013 Sep 25;527(2):462-8. doi: 10.1016/j.gene.2013.06.079. Epub 2013 Jul 13.


The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

Radovica I, Fridmanis D, Vaivade I, Nikitina-Zake L, Klovins J.

PLoS One. 2013 May 13;8(5):e64191. doi: 10.1371/journal.pone.0064191. Print 2013.


Identification of glyoxalase 1 polymorphisms associated with enzyme activity.

Peculis R, Konrade I, Skapare E, Fridmanis D, Nikitina-Zake L, Lejnieks A, Pirags V, Dambrova M, Klovins J.

Gene. 2013 Feb 15;515(1):140-3. doi: 10.1016/j.gene.2012.11.009. Epub 2012 Nov 29.


Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.

Tarasova L, Kalnina I, Geldnere K, Bumbure A, Ritenberga R, Nikitina-Zake L, Fridmanis D, Vaivade I, Pirags V, Klovins J.

Pharmacogenet Genomics. 2012 Sep;22(9):659-66. doi: 10.1097/FPC.0b013e3283561666.


Stronger association of common variants in TCF7L2 gene with nonobese type 2 diabetes in the Latvian population.

Kalnina I, Geldnere K, Tarasova L, Nikitina-Zake L, Peculis R, Fridmanis D, Pirags V, Klovins J.

Exp Clin Endocrinol Diabetes. 2012 Sep;120(8):466-8. doi: 10.1055/s-0032-1306298. Epub 2012 Mar 22.


Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.

Ignatovica V, Latkovskis G, Peculis R, Megnis K, Schioth HB, Vaivade I, Fridmanis D, Pirags V, Erglis A, Klovins J.

Mol Biol Rep. 2012 Feb;39(2):1917-25. doi: 10.1007/s11033-011-0938-4. Epub 2011 Jun 4.


Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R).

Fridmanis D, Petrovska R, Kalnina I, Slaidina M, Peculis R, Schiöth HB, Klovins J.

Mol Cell Endocrinol. 2010 Jun 10;321(2):175-83. doi: 10.1016/j.mce.2010.02.032. Epub 2010 Mar 3.


Formation of new genes explains lower intron density in mammalian Rhodopsin G protein-coupled receptors.

Fridmanis D, Fredriksson R, Kapa I, Schiöth HB, Klovins J.

Mol Phylogenet Evol. 2007 Jun;43(3):864-80. Epub 2006 Nov 17.


Unusual genomic structure: melanocortin receptors in Fugu.

Schiöth HB, Haitina T, Fridmanis D, Klovins J.

Ann N Y Acad Sci. 2005 Apr;1040:460-3. Review.


Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution.

Lagerström MC, Fredriksson R, Bjarnadóttir TK, Fridmanis D, Holmquist T, Andersson J, Yan YL, Raudsepp T, Zoorob R, Kukkonen JP, Lundin LG, Klovins J, Chowdhary BP, Postlethwait JH, Schiöth HB.

Genomics. 2005 Jun;85(6):688-703.


Cloning of two melanocortin (MC) receptors in spiny dogfish: MC3 receptor in cartilaginous fish shows high affinity to ACTH-derived peptides while it has lower preference to gamma-MSH.

Klovins J, Haitina T, Ringholm A, Löwgren M, Fridmanis D, Slaidina M, Stier S, Schiöth HB.

Eur J Biochem. 2004 Nov;271(21):4320-31.


The melanocortin system in Fugu: determination of POMC/AGRP/MCR gene repertoire and synteny, as well as pharmacology and anatomical distribution of the MCRs.

Klovins J, Haitina T, Fridmanis D, Kilianova Z, Kapa I, Fredriksson R, Gallo-Payet N, Schiöth HB.

Mol Biol Evol. 2004 Mar;21(3):563-79. Epub 2003 Dec 23.


High affinity agonistic metal ion binding sites within the melanocortin 4 receptor illustrate conformational change of transmembrane region 3.

Lagerström MC, Klovins J, Fredriksson R, Fridmanis D, Haitina T, Ling MK, Berglund MM, Schiöth HB.

J Biol Chem. 2003 Dec 19;278(51):51521-6. Epub 2003 Sep 30.

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