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Proteasome Inhibitor Drugs.

Fricker LD.

Annu Rev Pharmacol Toxicol. 2020 Jan 6;60:457-476. doi: 10.1146/annurev-pharmtox-010919-023603. Epub 2019 Sep 3.


Identification and characterization of RSIY-11, a novel seminal peptide derived from semenogelin-1, which acts as a neutral endopeptidase inhibitor modulating sperm motility.

Fritz R, Mukherjee A, Zaghi S, Agalliu I, Jindal S, Tashima AK, Fricker LD, Davies KP.

J Assist Reprod Genet. 2019 Sep;36(9):1891-1900. doi: 10.1007/s10815-019-01524-8. Epub 2019 Jul 26.


Effect of Protein Denaturation and Enzyme Inhibitors on Proteasomal-Mediated Production of Peptides in Human Embryonic Kidney Cells.

Dasgupta S, Fishman MA, Castro LM, Tashima AK, Ferro ES, Fricker LD.

Biomolecules. 2019 May 28;9(6). pii: E207. doi: 10.3390/biom9060207.


Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets.

Fricker LD.

Adv Pharmacol. 2018;82:85-102. doi: 10.1016/bs.apha.2017.09.001. Epub 2017 Nov 8. Review.


Quantitative Peptidomics with Five-plex Reductive Methylation labels.

Tashima AK, Fricker LD.

J Am Soc Mass Spectrom. 2018 May;29(5):866-878. doi: 10.1007/s13361-017-1852-3. Epub 2017 Dec 12.


Orphan neuropeptides and receptors: Novel therapeutic targets.

Fricker LD, Devi LA.

Pharmacol Ther. 2018 May;185:26-33. doi: 10.1016/j.pharmthera.2017.11.006. Epub 2017 Nov 22. Review.


Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains.

Garcia-Pardo J, Tanco S, Díaz L, Dasgupta S, Fernandez-Recio J, Lorenzo J, Aviles FX, Fricker LD.

PLoS One. 2017 Nov 13;12(11):e0187778. doi: 10.1371/journal.pone.0187778. eCollection 2017.


ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

Berezniuk I, Rodriguiz RM, Zee ML, Marcus DJ, Pintar J, Morgan DJ, Wetsel WC, Fricker LD.

J Neurochem. 2017 Nov;143(3):268-281. doi: 10.1111/jnc.14209.


Analysis of the Yeast Peptidome and Comparison with the Human Peptidome.

Dasgupta S, Yang C, Castro LM, Tashima AK, Ferro ES, Moir RD, Willis IM, Fricker LD.

PLoS One. 2016 Sep 29;11(9):e0163312. doi: 10.1371/journal.pone.0163312. eCollection 2016.


Identification of GPR83 as the receptor for the neuroendocrine peptide PEN.

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA.

Sci Signal. 2016 Apr 26;9(425):ra43. doi: 10.1126/scisignal.aad0694.


Knockdown of Carboxypeptidase A6 in Zebrafish Larvae Reduces Response to Seizure-Inducing Drugs and Causes Changes in the Level of mRNAs Encoding Signaling Molecules.

Lopes MW, Sapio MR, Leal RB, Fricker LD.

PLoS One. 2016 Apr 6;11(4):e0152905. doi: 10.1371/journal.pone.0152905. eCollection 2016.


Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.

Dasgupta S, Fishman MA, Mahallati H, Castro LM, Tashima AK, Ferro ES, Fricker LD.

PLoS One. 2015 Dec 21;10(12):e0145333. doi: 10.1371/journal.pone.0145333. eCollection 2015.


Limitations of Mass Spectrometry-Based Peptidomic Approaches.

Fricker LD.

J Am Soc Mass Spectrom. 2015 Dec;26(12):1981-91. doi: 10.1007/s13361-015-1231-x. Epub 2015 Aug 25.


Novel carboxypeptidase A6 (CPA6) mutations identified in patients with juvenile myoclonic and generalized epilepsy.

Sapio MR, Vessaz M, Thomas P, Genton P, Fricker LD, Salzmann A.

PLoS One. 2015 Apr 13;10(4):e0123180. doi: 10.1371/journal.pone.0123180. eCollection 2015.


ProSAAS-derived peptides are differentially processed and sorted in mouse brain and AtT-20 cells.

Wardman JH, Fricker LD.

PLoS One. 2014 Aug 22;9(8):e104232. doi: 10.1371/journal.pone.0104232. eCollection 2014.


Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.

Dasgupta S, Castro LM, Dulman R, Yang C, Schmidt M, Ferro ES, Fricker LD.

PLoS One. 2014 Jul 31;9(7):e103604. doi: 10.1371/journal.pone.0103604. eCollection 2014.


Carboxypeptidases in disease: insights from peptidomic studies.

Sapio MR, Fricker LD.

Proteomics Clin Appl. 2014 Jun;8(5-6):327-37. doi: 10.1002/prca.201300090. Epub 2014 Mar 24. Review.


GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding.

Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD, Devi LA.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-6. doi: 10.1073/pnas.1312938110. Epub 2013 Sep 16.


Zebrafish cytosolic carboxypeptidases 1 and 5 are essential for embryonic development.

Lyons PJ, Sapio MR, Fricker LD.

J Biol Chem. 2013 Oct 18;288(42):30454-62. doi: 10.1074/jbc.M113.497933. Epub 2013 Sep 10.


Cytosolic carboxypeptidase 5 removes α- and γ-linked glutamates from tubulin.

Berezniuk I, Lyons PJ, Sironi JJ, Xiao H, Setou M, Angeletti RH, Ikegami K, Fricker LD.

J Biol Chem. 2013 Oct 18;288(42):30445-53. doi: 10.1074/jbc.M113.497917. Epub 2013 Sep 10.


Quantitative peptidomics of Purkinje cell degeneration mice.

Berezniuk I, Sironi JJ, Wardman J, Pasek RC, Berbari NF, Yoder BK, Fricker LD.

PLoS One. 2013 Apr 8;8(4):e60981. doi: 10.1371/journal.pone.0060981. Print 2013.


Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice.

Rodriguiz RM, Wilkins JJ, Creson TK, Biswas R, Berezniuk I, Fricker AD, Fricker LD, Wetsel WC.

Int J Neuropsychopharmacol. 2013 Aug;16(7):1623-34. doi: 10.1017/S1461145713000059. Epub 2013 Feb 27.


Analysis of peptides secreted from cultured mouse brain tissue.

Gelman JS, Dasgupta S, Berezniuk I, Fricker LD.

Biochim Biophys Acta. 2013 Nov;1834(11):2408-17. doi: 10.1016/j.bbapap.2013.01.043. Epub 2013 Feb 10.


Alterations of the intracellular peptidome in response to the proteasome inhibitor bortezomib.

Gelman JS, Sironi J, Berezniuk I, Dasgupta S, Castro LM, Gozzo FC, Ferro ES, Fricker LD.

PLoS One. 2013;8(1):e53263. doi: 10.1371/journal.pone.0053263. Epub 2013 Jan 7.


Naturally occurring carboxypeptidase A6 mutations: effect on enzyme function and association with epilepsy.

Sapio MR, Salzmann A, Vessaz M, Crespel A, Lyons PJ, Malafosse A, Fricker LD.

J Biol Chem. 2012 Dec 14;287(51):42900-9. doi: 10.1074/jbc.M112.414094. Epub 2012 Oct 26.


Mass spectrometry of immunolabeled neurons--the best of both techniques.

Fricker LD.

Chem Biol. 2012 Aug 24;19(8):931-2. doi: 10.1016/j.chembiol.2012.08.003.


Peptidomic analysis of HEK293T cells: effect of the proteasome inhibitor epoxomicin on intracellular peptides.

Fricker LD, Gelman JS, Castro LM, Gozzo FC, Ferro ES.

J Proteome Res. 2012 Mar 2;11(3):1981-90. doi: 10.1021/pr2012076. Epub 2012 Feb 16.


Quantitative peptidomics to measure neuropeptide levels in animal models relevant to psychiatric disorders.

Gelman JS, Wardman J, Bhat VB, Gozzo FC, Fricker LD.

Methods Mol Biol. 2012;829:487-503. doi: 10.1007/978-1-61779-458-2_31.


Cytosolic carboxypeptidase 1 is involved in processing α- and β-tubulin.

Berezniuk I, Vu HT, Lyons PJ, Sironi JJ, Xiao H, Burd B, Setou M, Angeletti RH, Ikegami K, Fricker LD.

J Biol Chem. 2012 Feb 24;287(9):6503-17. doi: 10.1074/jbc.M111.309138. Epub 2011 Dec 14.


ProSAAS-derived peptides are colocalized with neuropeptide Y and function as neuropeptides in the regulation of food intake.

Wardman JH, Berezniuk I, Di S, Tasker JG, Fricker LD.

PLoS One. 2011;6(12):e28152. doi: 10.1371/journal.pone.0028152. Epub 2011 Dec 2.


Carboxypeptidase A6 gene (CPA6) mutations in a recessive familial form of febrile seizures and temporal lobe epilepsy and in sporadic temporal lobe epilepsy.

Salzmann A, Guipponi M, Lyons PJ, Fricker LD, Sapio M, Lambercy C, Buresi C, Ouled Amar Bencheikh B, Lahjouji F, Ouazzani R, Crespel A, Chaigne D, Malafosse A.

Hum Mutat. 2012 Jan;33(1):124-35. doi: 10.1002/humu.21613. Epub 2011 Oct 31.


Carboxypeptidase O is a glycosylphosphatidylinositol-anchored intestinal peptidase with acidic amino acid specificity.

Lyons PJ, Fricker LD.

J Biol Chem. 2011 Nov 11;286(45):39023-32. doi: 10.1074/jbc.M111.265819. Epub 2011 Sep 15.


Peptidomic approaches to study proteolytic activity.

Lyons PJ, Fricker LD.

Curr Protoc Protein Sci. 2011 Aug;Chapter 18:Unit18.13. doi: 10.1002/0471140864.ps1813s65.


Quantitative peptidomics of mice lacking peptide-processing enzymes.

Wardman J, Fricker LD.

Methods Mol Biol. 2011;768:307-23. doi: 10.1007/978-1-61779-204-5_17.


Regulation of neuropeptide processing enzymes by catecholamines in endocrine cells.

Helwig M, Vivoli M, Fricker LD, Lindberg I.

Mol Pharmacol. 2011 Aug;80(2):304-13. doi: 10.1124/mol.111.072090. Epub 2011 May 3.


Peptidomic analysis of human cell lines.

Gelman JS, Sironi J, Castro LM, Ferro ES, Fricker LD.

J Proteome Res. 2011 Apr 1;10(4):1583-92. doi: 10.1021/pr100952f. Epub 2011 Feb 17.


Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding.

Lyons PJ, Ma LH, Baker R, Fricker LD.

PLoS One. 2010 Sep 24;5(9):e12967. doi: 10.1371/journal.pone.0012967.


Substrate specificity of human carboxypeptidase A6.

Lyons PJ, Fricker LD.

J Biol Chem. 2010 Dec 3;285(49):38234-42. doi: 10.1074/jbc.M110.158626. Epub 2010 Sep 20.


Fishing for the hidden peptidome in health and disease (drug abuse).

Fricker LD, Sweedler JV.

AAPS J. 2010 Dec;12(4):679-82. doi: 10.1208/s12248-010-9228-7. Epub 2010 Sep 18. Review.


A defect in cytosolic carboxypeptidase 1 (Nna1) causes autophagy in Purkinje cell degeneration mouse brain.

Berezniuk I, Fricker LD.

Autophagy. 2010 May;6(4):558-9. doi: 10.4161/auto.6.4.11813. Epub 2010 May 16.


Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.

Wardman JH, Zhang X, Gagnon S, Castro LM, Zhu X, Steiner DF, Day R, Fricker LD.

J Neurochem. 2010 Jul;114(1):215-25. doi: 10.1111/j.1471-4159.2010.06760.x. Epub 2010 Apr 19.


Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.

Sidyelyeva G, Wegener C, Schoenfeld BP, Bell AJ, Baker NE, McBride SM, Fricker LD.

Cell Mol Life Sci. 2010 Sep;67(17):2991-3004. doi: 10.1007/s00018-010-0369-8. Epub 2010 Apr 13.


Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing.

Tanco S, Zhang X, Morano C, Avilés FX, Lorenzo J, Fricker LD.

J Biol Chem. 2010 Jun 11;285(24):18385-96. doi: 10.1074/jbc.M109.060350. Epub 2010 Apr 12.


Hemopressin and other bioactive peptides from cytosolic proteins: are these non-classical neuropeptides?

Gelman JS, Fricker LD.

AAPS J. 2010 Sep;12(3):279-89. doi: 10.1208/s12248-010-9186-0. Epub 2010 Apr 10. Review.


The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation.

Morgan DJ, Wei S, Gomes I, Czyzyk T, Mzhavia N, Pan H, Devi LA, Fricker LD, Pintar JE.

J Neurochem. 2010 Jun;113(5):1275-84. doi: 10.1111/j.1471-4159.2010.06706.x. Epub 2010 Mar 26.


Hemopressins and other hemoglobin-derived peptides in mouse brain: comparison between brain, blood, and heart peptidome and regulation in Cpefat/fat mice.

Gelman JS, Sironi J, Castro LM, Ferro ES, Fricker LD.

J Neurochem. 2010 May;113(4):871-80. doi: 10.1111/j.1471-4159.2010.06653.x. Epub 2010 Feb 24.


CCP1/Nna1 functions in protein turnover in mouse brain: Implications for cell death in Purkinje cell degeneration mice.

Berezniuk I, Sironi J, Callaway MB, Castro LM, Hirata IY, Ferro ES, Fricker LD.

FASEB J. 2010 Jun;24(6):1813-23. doi: 10.1096/fj.09-147942. Epub 2010 Jan 8.


Neuropeptidomic analysis establishes a major role for prohormone convertase-2 in neuropeptide biosynthesis.

Zhang X, Pan H, Peng B, Steiner DF, Pintar JE, Fricker LD.

J Neurochem. 2010 Mar;112(5):1168-79. doi: 10.1111/j.1471-4159.2009.06530.x. Epub 2009 Dec 7.


Multiple isotopic labels for quantitative mass spectrometry.

Morano C, Zhang X, Fricker LD.

Anal Chem. 2008 Dec 1;80(23):9298-309.

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