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Streptococcal inhibitor of complement (SIC) modulates fibrinolysis and enhances bacterial survival within fibrin clots.

Frick IM, Shannon O, Neumann A, Karlsson C, Wikström M, Björck L.

J Biol Chem. 2018 Aug 31;293(35):13578-13591. doi: 10.1074/jbc.RA118.001988. Epub 2018 Jul 12.


Protein SIC Secreted from Streptococcus pyogenes Forms Complexes with Extracellular Histones That Boost Cytokine Production.

Westman J, Chakrakodi B, Snäll J, Mörgelin M, Bruun Madsen M, Hyldegaard O, Neumann A, Frick IM, Norrby-Teglund A, Björck L, Herwald H.

Front Immunol. 2018 Feb 22;9:236. doi: 10.3389/fimmu.2018.00236. eCollection 2018.


Protein-Based Strategies to Identify and Isolate Bacterial Virulence Factors.

Lood R, Frick IM.

Methods Mol Biol. 2017;1535:3-15.


Saliva-Induced Clotting Captures Streptococci: Novel Roles for Coagulation and Fibrinolysis in Host Defense and Immune Evasion.

Wollein Waldetoft K, Mohanty T, Karlsson C, Mörgelin M, Frick IM, Malmström J, Björck L.

Infect Immun. 2016 Sep 19;84(10):2813-23. doi: 10.1128/IAI.00307-16. Print 2016 Oct.


Structure and Interactions of a Dimeric Variant of sHIP, a Novel Virulence Determinant of Streptococcus pyogenes.

Diehl C, Wisniewska M, Frick IM, Streicher W, Björck L, Malmström J, Wikström M.

Front Microbiol. 2016 Feb 5;7:95. doi: 10.3389/fmicb.2016.00095. eCollection 2016.


Group G streptococci mediate fibrinogen-dependent platelet aggregation leading to transient entrapment in platelet aggregates.

Svensson L, Frick IM, Shannon O.

Microbiology. 2016 Jan;162(1):117-26. doi: 10.1099/mic.0.000203. Epub 2015 Oct 27.


Erratum for Holm et al., Activation of the Contact System at the Surface of Fusobacterium necrophorum Represents a Possible Virulence Mechanism in Lemièrre's Syndrome.

Holm K, Frick IM, Björck L, Rasmussen M.

Infect Immun. 2015 Nov;83(11):4451. doi: 10.1128/IAI.01123-15. No abstract available.


Identification of molecular mechanisms used by Finegoldia magna to penetrate and colonize human skin.

Murphy EC, Mörgelin M, Reinhardt DP, Olin AI, Björck L, Frick IM.

Mol Microbiol. 2014 Oct;94(2):403-17. doi: 10.1111/mmi.12773. Epub 2014 Sep 11.


Expression of MIG/CXCL9 in cystic fibrosis and modulation of its activities by elastase of Pseudomonas aeruginosa.

Jovic S, Shikhagaie M, Mörgelin M, Kjellström S, Erjefalt J, Olin AI, Frick IM, Egesten A.

J Innate Immun. 2014;6(6):846-59. doi: 10.1159/000365399. Epub 2014 Aug 9.


Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro.

Burchacka E, Sieńczyk M, Frick IM, Wysocka M, Lesner A, Oleksyszyn J.

Biochimie. 2014 Aug;103:137-43. doi: 10.1016/j.biochi.2014.05.006. Epub 2014 May 22.


Functional and structural properties of a novel protein and virulence factor (Protein sHIP) in Streptococcus pyogenes.

Wisniewska M, Happonen L, Kahn F, Varjosalo M, Malmström L, Rosenberger G, Karlsson C, Cazzamali G, Pozdnyakova I, Frick IM, Björck L, Streicher W, Malmström J, Wikström M.

J Biol Chem. 2014 Jun 27;289(26):18175-88. doi: 10.1074/jbc.M114.565978. Epub 2014 May 13.


Identification of pili on the surface of Finegoldia magna--a gram-positive anaerobic cocci.

Murphy EC, Janulczyk R, Karlsson C, Mörgelin M, Frick IM.

Anaerobe. 2014 Jun;27:40-9. doi: 10.1016/j.anaerobe.2014.03.008. Epub 2014 Mar 29.


FAF and SufA: proteins of Finegoldia magna that modulate the antibacterial activity of histones.

Murphy EC, Mohanty T, Frick IM.

J Innate Immun. 2014;6(3):394-404. doi: 10.1159/000356432. Epub 2013 Dec 11.


Surface proteins of group G Streptococcus in different phases of growth: patterns of production and implications for the host-bacteria relationship.

Wollein Waldetoft K, Karlsson C, Gram M, Malmström J, Mörgelin M, Frick IM, Björck L.

Microbiology. 2014 Feb;160(Pt 2):279-86. doi: 10.1099/mic.0.071332-0. Epub 2013 Nov 12.


Binding of complement inhibitor C4b-binding protein to a highly virulent Streptococcus pyogenes M1 strain is mediated by protein H and enhances adhesion to and invasion of endothelial cells.

Ermert D, Weckel A, Agarwal V, Frick IM, Björck L, Blom AM.

J Biol Chem. 2013 Nov 8;288(45):32172-83. doi: 10.1074/jbc.M113.502955. Epub 2013 Sep 24.


Gram-positive anaerobic cocci--commensals and opportunistic pathogens.

Murphy EC, Frick IM.

FEMS Microbiol Rev. 2013 Jul;37(4):520-53. doi: 10.1111/1574-6976.12005. Epub 2012 Nov 15. Review.


Streptococcal surface proteins activate the contact system and control its antibacterial activity.

Wollein Waldetoft K, Svensson L, Mörgelin M, Olin AI, Nitsche-Schmitz DP, Björck L, Frick IM.

J Biol Chem. 2012 Jul 20;287(30):25010-8. doi: 10.1074/jbc.M112.373217. Epub 2012 May 30.


Constitutive and inflammation-dependent antimicrobial peptides produced by epithelium are differentially processed and inactivated by the commensal Finegoldia magna and the pathogen Streptococcus pyogenes.

Frick IM, Nordin SL, Baumgarten M, Mörgelin M, Sørensen OE, Olin AI, Egesten A.

J Immunol. 2011 Oct 15;187(8):4300-9. doi: 10.4049/jimmunol.1004179. Epub 2011 Sep 14.


Activation of the contact system at the surface of Fusobacterium necrophorum represents a possible virulence mechanism in Lemièrre's syndrome.

Holm K, Frick IM, Björck L, Rasmussen M.

Infect Immun. 2011 Aug;79(8):3284-90. doi: 10.1128/IAI.05264-11. Epub 2011 Jun 6. Erratum in: Infect Immun. 2015 Nov;83(11):4451.


Interaction of Bacteroides fragilis and Bacteroides thetaiotaomicron with the kallikrein-kinin system.

Murphy EC, Mörgelin M, Cooney JC, Frick IM.

Microbiology. 2011 Jul;157(Pt 7):2094-105. doi: 10.1099/mic.0.046862-0. Epub 2011 Apr 28.


Binding of albumin promotes bacterial survival at the epithelial surface.

Egesten A, Frick IM, Mörgelin M, Olin AI, Björck L.

J Biol Chem. 2011 Jan 28;286(4):2469-76. doi: 10.1074/jbc.M110.148171. Epub 2010 Nov 22.


Antibacterial activity of the contact and complement systems is blocked by SIC, a protein secreted by Streptococcus pyogenes.

Frick IM, Shannon O, Åkesson P, Mörgelin M, Collin M, Schmidtchen A, Björck L.

J Biol Chem. 2011 Jan 14;286(2):1331-40. doi: 10.1074/jbc.M110.178350. Epub 2010 Nov 10.


SufA of the opportunistic pathogen finegoldia magna modulates actions of the antibacterial chemokine MIG/CXCL9, promoting bacterial survival during epithelial inflammation.

Karlsson C, Eliasson M, Olin AI, Mörgelin M, Karlsson A, Malmsten M, Egesten A, Frick IM.

J Biol Chem. 2009 Oct 23;284(43):29499-508. doi: 10.1074/jbc.M109.025957. Epub 2009 Jul 23.


SufA - a bacterial enzyme that cleaves fibrinogen and blocks fibrin network formation.

Karlsson C, Mörgelin M, Collin M, Lood R, Andersson ML, Schmidtchen A, Björck L, Frick IM.

Microbiology. 2009 Jan;155(Pt 1):238-48. doi: 10.1099/mic.0.021311-0.


Identification of a novel protein promoting the colonization and survival of Finegoldia magna, a bacterial commensal and opportunistic pathogen.

Frick IM, Karlsson C, Mörgelin M, Olin AI, Janjusevic R, Hammarström C, Holst E, de Château M, Björck L.

Mol Microbiol. 2008 Nov;70(3):695-708. doi: 10.1111/j.1365-2958.2008.06439.x. Epub 2008 Sep 18.


SufA--a novel subtilisin-like serine proteinase of Finegoldia magna.

Karlsson C, Andersson ML, Collin M, Schmidtchen A, Björck L, Frick IM.

Microbiology. 2007 Dec;153(Pt 12):4208-18.


Protein FOG is a moderate inducer of MIG/CXCL9, and group G streptococci are more tolerant than group A streptococci to this chemokine's antibacterial effect.

Linge HM, Sastalla I, Nitsche-Schmitz DP, Egesten A, Frick IM.

Microbiology. 2007 Nov;153(Pt 11):3800-8.


The dual role of the contact system in bacterial infectious disease.

Frick IM, Björck L, Herwald H.

Thromb Haemost. 2007 Sep;98(3):497-502. Review.


M1 protein of Streptococcus pyogenes increases production of the antibacterial CXC chemokine MIG/CXCL9 in pharyngeal epithelial cells.

Eliasson M, Frick IM, Collin M, Sørensen OE, Björck L, Egesten A.

Microb Pathog. 2007 Nov-Dec;43(5-6):224-33. Epub 2007 Aug 2.


Identification of a streptococcal octapeptide motif involved in acute rheumatic fever.

Dinkla K, Nitsche-Schmitz DP, Barroso V, Reissmann S, Johansson HM, Frick IM, Rohde M, Chhatwal GS.

J Biol Chem. 2007 Jun 29;282(26):18686-93. Epub 2007 Apr 23.


Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q.

Nitsche-Schmitz DP, Johansson HM, Sastalla I, Reissmann S, Frick IM, Chhatwal GS.

J Biol Chem. 2007 Jun 15;282(24):17530-6. Epub 2007 Apr 20.


The CXC chemokine MIG/CXCL9 is important in innate immunity against Streptococcus pyogenes.

Egesten A, Eliasson M, Johansson HM, Olin AI, Morgelin M, Mueller A, Pease JE, Frick IM, Bjorck L.

J Infect Dis. 2007 Mar 1;195(5):684-93. Epub 2007 Jan 18.


The contact system--a novel branch of innate immunity generating antibacterial peptides.

Frick IM, Akesson P, Herwald H, Mörgelin M, Malmsten M, Nägler DK, Björck L.

EMBO J. 2006 Nov 29;25(23):5569-78. Epub 2006 Nov 9.


Streptococcal protein FOG, a novel matrix adhesin interacting with collagen I in vivo.

Nitsche DP, Johansson HM, Frick IM, Mörgelin M.

J Biol Chem. 2006 Jan 20;281(3):1670-9. Epub 2005 Nov 8.


Protein FOG--a streptococcal inhibitor of neutrophil function.

Johansson HM, Mörgelin M, Frick IM.

Microbiology. 2004 Dec;150(Pt 12):4211-21.


Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin.

Lejon S, Frick IM, Björck L, Wikström M, Svensson S.

J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21.


SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides.

Frick IM, Akesson P, Rasmussen M, Schmidtchen A, Björck L.

J Biol Chem. 2003 May 9;278(19):16561-6. Epub 2003 Mar 5.


Proteinases of common pathogenic bacteria degrade and inactivate the antibacterial peptide LL-37.

Schmidtchen A, Frick IM, Andersson E, Tapper H, Björck L.

Mol Microbiol. 2002 Oct;46(1):157-68.


Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells.

Frick IM, Axcrona K, Härdig Y, Tapper H, Gustafsson L, Kellner R, Leanderson T, Björck L.

Mol Microbiol. 2002 May;44(4):917-34.


Structure, specificity, and mode of interaction for bacterial albumin-binding modules.

Johansson MU, Frick IM, Nilsson H, Kraulis PJ, Hober S, Jonasson P, Linhult M, Nygren PA, Uhlén M, Björck L, Drakenberg T, Forsén S, Wikström M.

J Biol Chem. 2002 Mar 8;277(10):8114-20. Epub 2001 Dec 18.


Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging.

Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, Berg DE, Covacci A, Engstrand L, Borén T.

Science. 1998 Jan 16;279(5349):373-7.


Structure and stability of protein H and the M1 protein from Streptococcus pyogenes. Implications for other surface proteins of gram-positive bacteria.

Nilson BH, Frick IM, Akesson P, Forsén S, Björck L, Akerström B, Wikström M.

Biochemistry. 1995 Oct 17;34(41):13688-98.


Protein H--a surface protein of Streptococcus pyogenes with separate binding sites for IgG and albumin.

Frick IM, Akesson P, Cooney J, Sjöbring U, Schmidt KH, Gomi H, Hattori S, Tagawa C, Kishimoto F, Björck L.

Mol Microbiol. 1994 Apr;12(1):143-51.


Convergent evolution among immunoglobulin G-binding bacterial proteins.

Frick IM, Wikström M, Forsén S, Drakenberg T, Gomi H, Sjöbring U, Björck L.

Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8532-6.

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