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Items: 1 to 50 of 68

1.

New Techniques to Study Intracellular Receptors in Living Cells: Insights Into RIG-I-Like Receptor Signaling.

Corby MJ, Raicu V, Frick DN.

Adv Exp Med Biol. 2018 Nov 24. doi: 10.1007/5584_2018_297. [Epub ahead of print]

PMID:
30471070
2.

Role of the Conserved DECH-Box Cysteine in Coupling Hepatitis C Virus Helicase-Catalyzed ATP Hydrolysis to RNA Unwinding.

Yerukhimovich MM, Marohnic CC, Frick DN.

Biochemistry. 2018 Oct 30;57(43):6247-6255. doi: 10.1021/acs.biochem.8b00796. Epub 2018 Oct 16.

PMID:
30281972
3.

Quantitative microspectroscopic imaging reveals viral and cellular RNA helicase interactions in live cells.

Corby MJ, Stoneman MR, Biener G, Paprocki JD, Kolli R, Raicu V, Frick DN.

J Biol Chem. 2017 Jul 7;292(27):11165-11177. doi: 10.1074/jbc.M117.777045. Epub 2017 May 8.

4.

Shape-based virtual screening, synthesis and evaluation of novel pyrrolone derivatives as antiviral agents against HCV.

Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A.

Bioorg Med Chem Lett. 2017 Feb 15;27(4):936-940. doi: 10.1016/j.bmcl.2016.12.087. Epub 2017 Jan 3.

PMID:
28089348
5.

Novel symmetrical phenylenediamines as potential anti-hepatitis C virus agents.

Bassetto M, Ferla S, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, O'Donnell R, Brancale A.

Antivir Chem Chemother. 2015 Dec;24(5-6):155-160. doi: 10.1177/2040206616676353. Epub 2016 Nov 4.

6.

In silico identification, design and synthesis of novel piperazine-based antiviral agents targeting the hepatitis C virus helicase.

Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Courtney-Smith M, Brancale A.

Eur J Med Chem. 2017 Jan 5;125:1115-1131. doi: 10.1016/j.ejmech.2016.10.043. Epub 2016 Oct 23.

PMID:
27810598
7.

Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication.

Bassetto M, Leyssen P, Neyts J, Yerukhimovich MM, Frick DN, Brancale A.

Eur J Med Chem. 2016 Nov 10;123:31-47. doi: 10.1016/j.ejmech.2016.07.035. Epub 2016 Jul 19.

PMID:
27474921
8.

Bicyclic octahydrocyclohepta[b]pyrrol-4(1H)one derivatives as novel selective anti-hepatitis C virus agents.

Kaushik-Basu N, Ratmanova NK, Manvar D, Belov DS, Cevik O, Basu A, Yerukhimovich MM, Lukyanenko ER, Andreev IA, Belov GM, Manfroni G, Cecchetti V, Frick DN, Kurkin AV, Altieri A, Barreca ML.

Eur J Med Chem. 2016 Oct 21;122:319-325. doi: 10.1016/j.ejmech.2016.06.041. Epub 2016 Jun 23.

PMID:
27376494
9.

Analysis of the Enzymatic Activity of an NS3 Helicase Genotype 3a Variant Sequence Obtained from a Relapse Patient.

Provazzi PJ, Mukherjee S, Hanson AM, Nogueira ML, Carneiro BM, Frick DN, Rahal P.

PLoS One. 2015 Dec 10;10(12):e0144638. doi: 10.1371/journal.pone.0144638. eCollection 2015.

10.

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN.

ACS Infect Dis. 2015 Mar 13;1(3):140-148.

11.

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Ndjomou J, Corby MJ, Sweeney NL, Hanson AM, Aydin C, Ali A, Schiffer CA, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

ACS Chem Biol. 2015 Aug 21;10(8):1887-96. doi: 10.1021/acschembio.5b00101. Epub 2015 May 22.

12.

Discovery of the 2-phenyl-4,5,6,7-Tetrahydro-1H-indole as a novel anti-hepatitis C virus targeting scaffold.

Andreev IA, Manvar D, Barreca ML, Belov DS, Basu A, Sweeney NL, Ratmanova NK, Lukyanenko ER, Manfroni G, Cecchetti V, Frick DN, Altieri A, Kaushik-Basu N, Kurkin AV.

Eur J Med Chem. 2015;96:250-8. doi: 10.1016/j.ejmech.2015.04.022. Epub 2015 Apr 10.

13.

Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.

Mukherjee S, Weiner WS, Schroeder CE, Simpson DS, Hanson AM, Sweeney NL, Marvin RK, Ndjomou J, Kolli R, Isailovic D, Schoenen FJ, Frick DN.

ACS Chem Biol. 2014 Oct 17;9(10):2393-403. doi: 10.1021/cb500512z. Epub 2014 Aug 15.

14.

The interdomain interface in bifunctional enzyme protein 3/4A (NS3/4A) regulates protease and helicase activities.

Aydin C, Mukherjee S, Hanson AM, Frick DN, Schiffer CA.

Protein Sci. 2013 Dec;22(12):1786-98. doi: 10.1002/pro.2378. Epub 2013 Oct 19.

15.

Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.

Shadrick WR, Mukherjee S, Hanson AM, Sweeney NL, Frick DN.

Biochemistry. 2013 Sep 10;52(36):6151-9. doi: 10.1021/bi4006495. Epub 2013 Aug 26.

16.

Hepatitis C Virus NS3 Helicase Inhibitor Discovery.

Li K, Frankowski KJ, Hanson AM, Ndjomou J, Shanahan MA, Mukherjee S, Kolli R, Shadrick WR, Sweeney NL, Belon CA, Neuenswander B, Ferguson J, Aubé J, Schoenen FJ, Blagg BSJ, Frick DN.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 16 [updated 2013 Mar 14].

17.

Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.

Sweeney NL, Shadrick WR, Mukherjee S, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

J Biol Chem. 2013 Jul 5;288(27):19949-57. doi: 10.1074/jbc.M113.463166. Epub 2013 May 23.

18.

An ire1-phk1 chimera reveals a dispensable role of autokinase activity in endoplasmic reticulum stress response.

Mannan MA, Shadrick WR, Biener G, Shin BS, Anshu A, Raicu V, Frick DN, Dey M.

J Mol Biol. 2013 Jun 26;425(12):2083-99. doi: 10.1016/j.jmb.2013.02.036. Epub 2013 Mar 27.

19.

Discovering new medicines targeting helicases: challenges and recent progress.

Shadrick WR, Ndjomou J, Kolli R, Mukherjee S, Hanson AM, Frick DN.

J Biomol Screen. 2013 Aug;18(7):761-81. doi: 10.1177/1087057113482586. Epub 2013 Mar 27. Review.

20.

Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.

Ndjomou J, Kolli R, Mukherjee S, Shadrick WR, Hanson AM, Sweeney NL, Bartczak D, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

Antiviral Res. 2012 Nov;96(2):245-55. doi: 10.1016/j.antiviral.2012.08.006. Epub 2012 Aug 25.

21.

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.

Mukherjee S, Hanson AM, Shadrick WR, Ndjomou J, Sweeney NL, Hernandez JJ, Bartczak D, Li K, Frankowski KJ, Heck JA, Arnold LA, Schoenen FJ, Frick DN.

Nucleic Acids Res. 2012 Sep 1;40(17):8607-21. Epub 2012 Jun 27.

22.

Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase.

Hanson AM, Hernandez JJ, Shadrick WR, Frick DN.

Methods Enzymol. 2012;511:463-83. doi: 10.1016/B978-0-12-396546-2.00021-8.

23.

Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.

Mastrangelo E, Pezzullo M, De Burghgraeve T, Kaptein S, Pastorino B, Dallmeier K, de Lamballerie X, Neyts J, Hanson AM, Frick DN, Bolognesi M, Milani M.

J Antimicrob Chemother. 2012 Aug;67(8):1884-94. doi: 10.1093/jac/dks147. Epub 2012 Apr 25.

24.

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN.

J Med Chem. 2012 Apr 12;55(7):3319-30. doi: 10.1021/jm300021v. Epub 2012 Mar 22.

25.

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT.

J Infect Dis. 2011 Aug 15;204(4):609-16. doi: 10.1093/infdis/jir303.

26.

HCV Helicase: Structure, Function, and Inhibition.

Frick DN.

In: Tan SL, editor. Hepatitis C Viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 7.

27.

Dimerization-driven interaction of hepatitis C virus core protein with NS3 helicase.

Mousseau G, Kota S, Takahashi V, Frick DN, Strosberg AD.

J Gen Virol. 2011 Jan;92(Pt 1):101-11. doi: 10.1099/vir.0.023325-0. Epub 2010 Sep 29.

28.

PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.

Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.

Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. doi: 10.1128/AAC.00399-10. Epub 2010 Jun 1.

29.

Development of novel therapies for hepatitis C.

Lemon SM, McKeating JA, Pietschmann T, Frick DN, Glenn JS, Tellinghuisen TL, Symons J, Furman PA.

Antiviral Res. 2010 Apr;86(1):79-92. doi: 10.1016/j.antiviral.2010.02.003. Review.

PMID:
20417376
30.

The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.

Meng X, Zhou Y, Lee EY, Lee MY, Frick DN.

Biochemistry. 2010 May 4;49(17):3545-54. doi: 10.1021/bi100042b.

31.

A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities.

Frick DN, Ginzburg O, Lam AM.

Methods Mol Biol. 2010;587:223-33. doi: 10.1007/978-1-60327-355-8_16.

32.
33.

Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.

Belon CA, High YD, Lin TI, Pauwels F, Frick DN.

Biochemistry. 2010 Mar 9;49(9):1822-32. doi: 10.1021/bi901974a.

34.

Fuel specificity of the hepatitis C virus NS3 helicase.

Belon CA, Frick DN.

J Mol Biol. 2009 May 15;388(4):851-64. doi: 10.1016/j.jmb.2009.03.059. Epub 2009 Mar 28.

35.

Cyclophilin B stimulates RNA synthesis by the HCV RNA dependent RNA polymerase.

Heck JA, Meng X, Frick DN.

Biochem Pharmacol. 2009 Apr 1;77(7):1173-80. doi: 10.1016/j.bcp.2008.12.019. Epub 2009 Jan 6.

36.

DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.

Meng X, Zhou Y, Zhang S, Lee EY, Frick DN, Lee MY.

Nucleic Acids Res. 2009 Feb;37(2):647-57. doi: 10.1093/nar/gkn1000. Epub 2008 Dec 11.

37.

Monitoring helicase activity with molecular beacons.

Belon CA, Frick DN.

Biotechniques. 2008 Oct;45(4):433-40, 442. doi: 10.2144/000112834.

38.

Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes.

Heck JA, Lam AM, Narayanan N, Frick DN.

Antimicrob Agents Chemother. 2008 Jun;52(6):1901-11. doi: 10.1128/AAC.01496-07. Epub 2008 Apr 7.

39.

Analysis of the evolutionary forces in an immunodominant CD8 epitope in hepatitis C virus at a population level.

Neumann-Haefelin C, Frick DN, Wang JJ, Pybus OG, Salloum S, Narula GS, Eckart A, Biezynski A, Eiermann T, Klenerman P, Viazov S, Roggendorf M, Thimme R, Reiser M, Timm J.

J Virol. 2008 Apr;82(7):3438-51. doi: 10.1128/JVI.01700-07. Epub 2008 Jan 23. Erratum in: J Virol. 2011 May;85(9):4634.

40.
41.
42.
43.

Understanding helicases as a means of virus control.

Frick DN, Lam AM.

Curr Pharm Des. 2006;12(11):1315-38. Review.

44.
45.

Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations.

Frick DN, Rypma RS, Lam AM, Frenz CM.

Nucleic Acids Res. 2004 Oct 12;32(18):5519-28. Print 2004.

46.

Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding.

Lam AM, Rypma RS, Frick DN.

Nucleic Acids Res. 2004 Aug 2;32(13):4060-70. Print 2004.

47.

The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently.

Frick DN, Rypma RS, Lam AM, Gu B.

J Biol Chem. 2004 Jan 9;279(2):1269-80. Epub 2003 Oct 29.

48.

Helicases as antiviral drug targets.

Frick DN.

Drug News Perspect. 2003 Jul-Aug;16(6):355-62. Review.

49.

Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action.

Lam AM, Keeney D, Frick DN.

J Biol Chem. 2003 Nov 7;278(45):44514-24. Epub 2003 Aug 27.

50.

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