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Items: 39


Targeting the unfolded protein response in head and neck and oral cavity cancers.

Cole DW, Svider PF, Shenouda KG, Lee PB, Yoo NG, McLeod TM, Mutchnick SA, Yoo GH, Kaufman RJ, Callaghan MU, Fribley AM.

Exp Cell Res. 2019 May 7. pii: S0014-4827(19)30157-0. doi: 10.1016/j.yexcr.2019.04.007. [Epub ahead of print] Review.


Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma.

Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM.

J Clin Med. 2019 May 6;8(5). pii: E611. doi: 10.3390/jcm8050611.


Disparities in impact of nasopharyngeal cancer: An analysis of global health burden.

Ramsey T, Hojjat H, Yuhan B, Svider PF, Eloy JA, Folbe AJ, Raza SN, Fribley AM.

Laryngoscope. 2019 Mar 19. doi: 10.1002/lary.27532. [Epub ahead of print]


Identification of Portimine B, a New Cell Permeable Spiroimine That Induces Apoptosis in Oral Squamous Cell Carcinoma.

Fribley AM, Xi Y, Makris C, Alves-de-Souza C, York R, Tomas C, Wright JLC, Strangman WK.

ACS Med Chem Lett. 2018 Dec 26;10(2):175-179. doi: 10.1021/acsmedchemlett.8b00473. eCollection 2019 Feb 14.


Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer.

Rosati R, Polin L, Ducker C, Li J, Bao X, Selvakumar D, Kim S, Xhabija B, Larsen M, McFall T, Huang Y, Kidder BL, Fribley A, Saxton J, Kakuta H, Shaw P, Ratnam M.

Clin Cancer Res. 2018 Dec 15;24(24):6509-6522. doi: 10.1158/1078-0432.CCR-18-0982. Epub 2018 Sep 5.


Laryngeal cancer: Global socioeconomic trends in disease burden and smoking habits.

Ramsey T, Guo E, Svider PF, Lin H, Syeda S, Raza SN, Fribley AM.

Laryngoscope. 2018 Sep;128(9):2039-2053. doi: 10.1002/lary.27068. Epub 2018 Mar 6.


Benzethonium chloride activates ER stress and reduces proliferation in HNSCC.

Rayess HM, Xi Y, Garshott DM, Brownell AL, Yoo GH, Callaghan MU, Fribley AM.

Oral Oncol. 2018 Jan;76:27-33. doi: 10.1016/j.oraloncology.2017.11.018. Epub 2017 Nov 30. No abstract available.


Celastrol induces apoptosis in hepatocellular carcinoma cells via targeting ER-stress/UPR.

Ren B, Liu H, Gao H, Liu S, Zhang Z, Fribley AM, Callaghan MU, Xu Z, Zeng Q, Li Y.

Oncotarget. 2017 Oct 10;8(54):93039-93050. doi: 10.18632/oncotarget.21750. eCollection 2017 Nov 3.


Oropharyngeal lymphoma: A US population based analysis.

Rayess HM, Nissan M, Gupta A, Carron MA, Raza SN, Fribley AM.

Oral Oncol. 2017 Oct;73:147-151. doi: 10.1016/j.oraloncology.2017.08.018. Epub 2017 Sep 5.


Systemic therapy for head and neck squamous cell carcinoma: Historical perspectives and recent breakthroughs.

Blasco MA, Svider PF, Raza SN, Jacobs JR, Folbe AJ, Saraf P, Eloy JA, Baredes S, Fribley AM.

Laryngoscope. 2017 Nov;127(11):2565-2569. doi: 10.1002/lary.26629. Epub 2017 Jun 5. Review.


The Utility of Real-Time Quantitative Polymerase Chain Reaction Genotype Detection in the Diagnosis of Urinary Tract Infections in Children.

Felt JR, Yurkovich C, Garshott DM, Kamat D, Farooqi A, Fribley AM, Callaghan MU, Hebert K.

Clin Pediatr (Phila). 2017 Sep;56(10):912-919. doi: 10.1177/0009922817706144. Epub 2017 Apr 24.


Recent trends in oropharyngeal cancer funding and public interest.

Blasco MA, Svider PF, Tenbrunsel T, Vellaichamy G, Yoo GH, Fribley AM, Raza SN.

Laryngoscope. 2017 Jun;127(6):1345-1350. doi: 10.1002/lary.26471. Epub 2017 Apr 11.


Dimethyl fumarate ameliorates myoclonus stemming from protein misfolding in oligodendrocytes.

Southwood CM, Garshott DM, Richardson CR, Seraji-Bozorgzad N, Fribley AM, Gow A.

J Neurochem. 2017 Jul;142(1):103-117. doi: 10.1111/jnc.14035. Epub 2017 May 3.


Topical agents for oral cancer chemoprevention: A systematic review of the literature.

Chau L, Jabara JT, Lai W, Svider PF, Warner BM, Lin HS, Raza SN, Fribley AM.

Oral Oncol. 2017 Apr;67:153-159. doi: 10.1016/j.oraloncology.2017.02.014. Epub 2017 Mar 2. Review.


Evidence for Increased Response to Induced Endoplasmic Reticulum Stress in Myeloid Cells in Acquired Aplastic Anemia.

Sidhu A, Callaghan MU, Gadgeel MS, Buck SA, Fribley AM, Savaşan S.

J Pediatr Hematol Oncol. 2017 Apr;39(3):e163-e166. doi: 10.1097/MPH.0000000000000810.


Head and Neck Cancer.

Svider PF, Blasco MA, Raza SN, Shkoukani M, Sukari A, Yoo GH, Folbe AJ, Lin HS, Fribley AM.

Otolaryngol Head Neck Surg. 2017 Jan;156(1):10-13. doi: 10.1177/0194599816674672. Epub 2016 Nov 14.


Recent Trends in Oral Cavity Cancer Research Support in the United States.

Fribley AM, Svider PF, Warner BM, Garshott DM, Raza SN, Kirkwood KL.

J Dent Res. 2017 Jan;96(1):17-22. doi: 10.1177/0022034516680556.


Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions.

Southwood CM, Fykkolodziej B, Maheras KJ, Garshott DM, Estill M, Fribley AM, Gow A.

J Neurosci. 2016 Jun 22;36(25):6803-19. doi: 10.1523/JNEUROSCI.1118-15.2016.


Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis.

Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, Tamayo-Castillo G, Sherman DH, Kaufman RJ, Fribley AM.

ACS Med Chem Lett. 2015 Sep 8;6(11):1122-7. doi: 10.1021/acsmedchemlett.5b00133. eCollection 2015 Nov 12.


Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts.

Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH.

ACS Med Chem Lett. 2015 Jul 6;6(8):877-81. doi: 10.1021/acsmedchemlett.5b00127. eCollection 2015 Aug 13.


Induction of BCL2-Interacting Killer, BIK, is Mediated for Anti-Cancer Activity of Curcumin in Human Head and Neck Squamous Cell Carcinoma Cells.

Xi Y, Gao H, Callaghan MU, Fribley AM, Garshott DM, Xu ZX, Zeng Q, Li YL.

J Cancer. 2015 Feb 12;6(4):327-32. doi: 10.7150/jca.11185. eCollection 2015.


Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.

Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, Callaghan MU, Golden JE, Fribley AM, Kaufman RJ.

ACS Med Chem Lett. 2014 Oct 29;5(12):1278-1283. eCollection 2014 Dec 11.


Cantharidins induce ER stress and a terminal unfolded protein response in OSCC.

Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM.

J Dent Res. 2015 Feb;94(2):320-9. doi: 10.1177/0022034514559376. Epub 2014 Nov 25.


Celastrol induces unfolded protein response-dependent cell death in head and neck cancer.

Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ.

Exp Cell Res. 2015 Jan 15;330(2):412-22. doi: 10.1016/j.yexcr.2014.08.014. Epub 2014 Aug 17.


Novel mutations causing biotinidase deficiency in individuals identified by newborn screening in Michigan including an unique intronic mutation that alters mRNA expression of the biotinidase gene.

Li H, Spencer L, Nahhas F, Miller J, Fribley A, Feldman G, Conway R, Wolf B.

Mol Genet Metab. 2014 Jul;112(3):242-6. doi: 10.1016/j.ymgme.2014.04.002. Epub 2014 Apr 16.


The role of HTS in drug discovery at the University of Michigan.

Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z, Stuckey JA, Sun D, Sherman DH.

Comb Chem High Throughput Screen. 2014 Mar;17(3):210-30. Review.


Serum prognostic biomarkers in head and neck cancer patients.

Lin HS, Siddiq F, Talwar HS, Chen W, Voichita C, Draghici S, Jeyapalan G, Chatterjee M, Fribley A, Yoo GH, Sethi S, Kim H, Sukari A, Folbe AJ, Tainsky MA.

Laryngoscope. 2014 Aug;124(8):1819-26. doi: 10.1002/lary.24567. Epub 2014 Jan 29.


SMAD4 is a potential prognostic marker in human breast carcinomas.

Liu NN, Xi Y, Callaghan MU, Fribley A, Moore-Smith L, Zimmerman JW, Pasche B, Zeng Q, Li YL.

Tumour Biol. 2014 Jan;35(1):641-50. doi: 10.1007/s13277-013-1088-1. Epub 2013 Aug 24.


Impact of targeting insulin-like growth factor signaling in head and neck cancers.

Limesand KH, Chibly AM, Fribley A.

Growth Horm IGF Res. 2013 Oct;23(5):135-40. doi: 10.1016/j.ghir.2013.06.001. Epub 2013 Jun 29. Review.


Selective small molecule activator of the apoptotic arm of the UPR.

Flaherty DP, Golden JE, Liu C, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Suyama E, Nguyen K, Vasile S, Salaniwal S, Stonich D, Su Y, Mangravita-Novo A, Vicchiarelli M, Smith LH, Diwan J, Chung TDY, Pinkerton AB, Aubé J, Miller JR, Garshott DM, Callaghan MU, Fribley AM, Kaufman RJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 1 [updated 2013 Feb 28].


Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ.

J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893. Epub 2011 Aug 15.


Large-scale analysis of UPR-mediated apoptosis in human cells.

Fribley AM, Miller JR, Reist TE, Callaghan MU, Kaufman RJ.

Methods Enzymol. 2011;491:57-71. doi: 10.1016/B978-0-12-385928-0.00004-3.


Head and neck tumor cell radiation response occurs in the presence of IGF1.

Victory K, Burd R, Fribley A, Sittadjody S, Arnett D, Klein RR, Limesand KH.

J Dent Res. 2011 Mar;90(3):347-52. doi: 10.1177/0022034510388037. Epub 2010 Nov 12.


Regulation of apoptosis by the unfolded protein response.

Fribley A, Zhang K, Kaufman RJ.

Methods Mol Biol. 2009;559:191-204. doi: 10.1007/978-1-60327-017-5_14.


Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa.

Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY.

J Biol Chem. 2006 Oct 20;281(42):31440-7. Epub 2006 Aug 23.


Proteasome inhibitor induces apoptosis through induction of endoplasmic reticulum stress.

Fribley A, Wang CY.

Cancer Biol Ther. 2006 Jul;5(7):745-8. Epub 2006 Jul 1.


Wnt-1 signaling inhibits apoptosis by activating beta-catenin/T cell factor-mediated transcription.

Chen S, Guttridge DC, You Z, Zhang Z, Fribley A, Mayo MW, Kitajewski J, Wang CY.

J Cell Biol. 2001 Jan 8;152(1):87-96.

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