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Items: 1 to 50 of 126

1.

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo.

Gammage PA, Viscomi C, Simard ML, Costa ASH, Gaude E, Powell CA, Van Haute L, McCann BJ, Rebelo-Guiomar P, Cerutti R, Zhang L, Rebar EJ, Zeviani M, Frezza C, Stewart JB, Minczuk M.

Nat Med. 2018 Sep 24. doi: 10.1038/s41591-018-0165-9. [Epub ahead of print]

PMID:
30250142
2.

Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer.

Lord SR, Cheng WC, Liu D, Gaude E, Haider S, Metcalf T, Patel N, Teoh EJ, Gleeson F, Bradley K, Wigfield S, Zois C, McGowan DR, Ah-See ML, Thompson AM, Sharma A, Bidaut L, Pollak M, Roy PG, Karpe F, James T, English R, Adams RF, Campo L, Ayers L, Snell C, Roxanis I, Frezza C, Fenwick JD, Buffa FM, Harris AL.

Cell Metab. 2018 Sep 12. pii: S1550-4131(18)30522-9. doi: 10.1016/j.cmet.2018.08.021. [Epub ahead of print]

3.

New Dihydrostilbene Derivatives from Chloraea chrysantha.

Tomassini L, Piovano M, Ventrone A, Pani V, Frezza C, Nicoletti M.

Chem Biodivers. 2018 Sep 21. doi: 10.1002/cbdv.201800360. [Epub ahead of print]

PMID:
30239121
4.

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation.

Johnson TI, Costa ASH, Ferguson AN, Frezza C.

Cell Death Dis. 2018 Sep 6;9(9):913. doi: 10.1038/s41419-018-0912-3.

5.

New Developments in the Synthesis of EMICORON.

Pitorri M, Franceschin M, Serafini I, Ciccòla A, Frezza C, Bianco A.

High Throughput. 2018 Aug 29;7(3). pii: E22. doi: 10.3390/ht7030022.

6.

Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.

Pell VR, Spiroski AM, Mulvey J, Burger N, Costa ASH, Logan A, Gruszczyk AV, Rosa T, James AM, Frezza C, Murphy MP, Krieg T.

J Mol Cell Cardiol. 2018 Oct;123:88-91. doi: 10.1016/j.yjmcc.2018.08.010. Epub 2018 Aug 15.

PMID:
30118790
7.

Phytochemical profile of Euphorbia peplus L. collected in Central Italy and NMR semi-quantitative analysis of the diterpenoid fraction.

Frezza C, Venditti A, Sciubba F, Tomai P, Antonetti M, Franceschin M, Di Cocco ME, Gentili A, Delfini M, Serafini M, Bianco A.

J Pharm Biomed Anal. 2018 Oct 25;160:152-159. doi: 10.1016/j.jpba.2018.07.059. Epub 2018 Jul 31.

PMID:
30086508
8.

mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma.

Drusian L, Nigro EA, Mannella V, Pagliarini R, Pema M, Costa ASH, Benigni F, Larcher A, Chiaravalli M, Gaude E, Montorsi F, Capitanio U, Musco G, Frezza C, Boletta A.

Cell Rep. 2018 Jul 31;24(5):1093-1104.e6. doi: 10.1016/j.celrep.2018.06.106.

9.

Histidine metabolism boosts cancer therapy.

Frezza C.

Nature. 2018 Jul;559(7715):484-485. doi: 10.1038/d41586-018-05573-4. No abstract available.

PMID:
30030511
10.

Detection of picramic acid and picramate in henné products by NMR Spectroscopy.

Nicoletti M, Frezza C, Tomassini L, Serafini M, Bianco A.

Nat Prod Res. 2018 Jun 22:1-6. doi: 10.1080/14786419.2018.1485676. [Epub ahead of print]

PMID:
29932742
11.

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues.

Franceschin M, Cianni L, Pitorri M, Micheli E, Cacchione S, Frezza C, Serafini M, Hu MH, Su H, Huang Z, Gu L, Bianco A.

Molecules. 2018 Jun 12;23(6). pii: E1423. doi: 10.3390/molecules23061423.

12.

HPLC and NMR analysis of the phenyl-ethanoid glycosides pattern of Verbascum thapsus L. cultivated in the Etnean area.

Frezza C, Bianco A, Serafini M, Foddai S, Salustri M, Reverberi M, Gelardi L, Bonina A, Bonina FP.

Nat Prod Res. 2018 May 14:1-7. doi: 10.1080/14786419.2018.1473398. [Epub ahead of print]

PMID:
29757004
13.

Metabolomic Profiling in Acute ST-Segment-Elevation Myocardial Infarction Identifies Succinate as an Early Marker of Human Ischemia-Reperfusion Injury.

Kohlhauer M, Dawkins S, Costa ASH, Lee R, Young T, Pell VR, Choudhury RP, Banning AP, Kharbanda RK; Oxford Acute Myocardial Infarction (OxAMI) Study, Saeb-Parsy K, Murphy MP, Frezza C, Krieg T, Channon KM.

J Am Heart Assoc. 2018 Apr 6;7(8). pii: e007546. doi: 10.1161/JAHA.117.007546.

14.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

15.

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.

Bantug GR, Fischer M, Grählert J, Balmer ML, Unterstab G, Develioglu L, Steiner R, Zhang L, Costa ASH, Gubser PM, Burgener AV, Sauder U, Löliger J, Belle R, Dimeloe S, Lötscher J, Jauch A, Recher M, Hönger G, Hall MN, Romero P, Frezza C, Hess C.

Immunity. 2018 Mar 20;48(3):542-555.e6. doi: 10.1016/j.immuni.2018.02.012. Epub 2018 Mar 6.

16.

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation.

Peruzzotti-Jametti L, Bernstock JD, Vicario N, Costa ASH, Kwok CK, Leonardi T, Booty LM, Bicci I, Balzarotti B, Volpe G, Mallucci G, Manferrari G, Donegà M, Iraci N, Braga A, Hallenbeck JM, Murphy MP, Edenhofer F, Frezza C, Pluchino S.

Cell Stem Cell. 2018 Mar 1;22(3):355-368.e13. doi: 10.1016/j.stem.2018.01.020. Epub 2018 Feb 22.

17.

Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition.

Gallipoli P, Giotopoulos G, Tzelepis K, Costa ASH, Vohra S, Medina-Perez P, Basheer F, Marando L, Di Lisio L, Dias JML, Yun H, Sasca D, Horton SJ, Vassiliou G, Frezza C, Huntly BJP.

Blood. 2018 Apr 12;131(15):1639-1653. doi: 10.1182/blood-2017-12-820035. Epub 2018 Feb 20.

18.

NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.

Gaude E, Schmidt C, Gammage PA, Dugourd A, Blacker T, Chew SP, Saez-Rodriguez J, O'Neill JS, Szabadkai G, Minczuk M, Frezza C.

Mol Cell. 2018 Feb 15;69(4):581-593.e7. doi: 10.1016/j.molcel.2018.01.034.

19.

Phytochemical profiles, antioxidant and anti-acetylcholinesterasic activities of the leaf extracts of Rhamnus lycioides subsp. oleoides (L.) Jahand. & Maire in different solvents.

Benamar H, Rarivoson E, Tomassini L, Frezza C, Marouf A, Bennaceur M, Nicoletti M.

Nat Prod Res. 2018 Jan 5:1-7. doi: 10.1080/14786419.2017.1422182. [Epub ahead of print]

PMID:
29304683
20.

Quantification of HTLV-1 reverse transcriptase activity in ATL patients treated with zidovudine and interferon-α.

Macchi B, Balestrieri E, Frezza C, Grelli S, Valletta E, Marçais A, Marino-Merlo F, Turpin J, Bangham CR, Hermine O, Mastino A, Bazarbachi A.

Blood Adv. 2017 May 5;1(12):748-752. doi: 10.1182/bloodadvances.2016001370. eCollection 2017 May 9.

21.

High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism.

Braicu EI, Darb-Esfahani S, Schmitt WD, Koistinen KM, Heiskanen L, Pöhö P, Budczies J, Kuhberg M, Dietel M, Frezza C, Denkert C, Sehouli J, Hilvo M.

Oncotarget. 2017 Oct 26;8(61):102912-102922. doi: 10.18632/oncotarget.22076. eCollection 2017 Nov 28.

22.

Iridoids of Chemotaxonomy Relevance, a New Antirrhinoside Ester and Other Constituents from Kickxia spuria subsp. integrifolia (Brot.) R.Fern.

Venditti A, Frezza C, Serafini I, Ciccòla A, Sciubba F, Serafini M, Bianco A.

Chem Biodivers. 2018 Feb;15(2). doi: 10.1002/cbdv.201700473. Epub 2018 Jan 22.

PMID:
29239523
23.

Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells.

Gonçalves E, Sciacovelli M, Costa ASH, Tran MGB, Johnson TI, Machado D, Frezza C, Saez-Rodriguez J.

Metab Eng. 2018 Jan;45:149-157. doi: 10.1016/j.ymben.2017.11.011. Epub 2017 Nov 27.

24.

Lignans and secoiridoid glycosides from the stem barks of Jasminum tortuosum.

Tomassini L, Ventrone A, Frezza C, Serafini I, Bianco A, Cometa MF.

Nat Prod Res. 2018 Aug;32(15):1853-1857. doi: 10.1080/14786419.2017.1404597. Epub 2017 Nov 15.

PMID:
29140106
25.

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.

Tyrakis PA, Yurkovich ME, Sciacovelli M, Papachristou EK, Bridges HR, Gaude E, Schreiner A, D'Santos C, Hirst J, Hernandez-Fernaud J, Springett R, Griffiths JR, Frezza C.

Cell Rep. 2017 Oct 24;21(4):1036-1047. doi: 10.1016/j.celrep.2017.09.092.

26.

Iridoid glycosides and polyphenolic compounds from Teucrium chamaedrys L.

Frezza C, Venditti A, Matrone G, Serafini I, Foddai S, Bianco A, Serafini M.

Nat Prod Res. 2018 Jul;32(13):1583-1589. doi: 10.1080/14786419.2017.1392948. Epub 2017 Oct 23.

PMID:
29058476
27.

Development and evaluation of a simple and effective RT-qPCR inhibitory assay for detection of the efficacy of compounds towards HIV reverse transcriptase.

Marino-Merlo F, Frezza C, Papaianni E, Valletta E, Mastino A, Macchi B.

Appl Microbiol Biotechnol. 2017 Nov;101(22):8249-8258. doi: 10.1007/s00253-017-8544-6. Epub 2017 Sep 30.

PMID:
28963576
28.

Mitochondrial Metabolism: Yin and Yang for Tumor Progression.

Valcarcel-Jimenez L, Gaude E, Torrano V, Frezza C, Carracedo A.

Trends Endocrinol Metab. 2017 Oct;28(10):748-757. doi: 10.1016/j.tem.2017.06.004. Review.

29.

Synthesis of potential HIV integrase inhibitors inspired by natural polyphenol structures.

Righi G, Pelagalli R, Isoni V, Tirotta I, Marini M, Palagri M, Dallocchio R, Dessì A, Macchi B, Frezza C, Forte G, Dalla Cort A, Portalone G, Bovicelli P.

Nat Prod Res. 2018 Aug;32(16):1893-1901. doi: 10.1080/14786419.2017.1354191. Epub 2017 Jul 27.

PMID:
28748719
30.

Extracellular vesicles are independent metabolic units with asparaginase activity.

Iraci N, Gaude E, Leonardi T, Costa ASH, Cossetti C, Peruzzotti-Jametti L, Bernstock JD, Saini HK, Gelati M, Vescovi AL, Bastos C, Faria N, Occhipinti LG, Enright AJ, Frezza C, Pluchino S.

Nat Chem Biol. 2017 Sep;13(9):951-955. doi: 10.1038/nchembio.2422. Epub 2017 Jul 3.

31.

Exploiting tumour addiction with a serine and glycine-free diet.

Amelio I, Melino G, Frezza C.

Cell Death Differ. 2017 Aug;24(8):1311-1313. doi: 10.1038/cdd.2017.83. Epub 2017 Jun 2. No abstract available.

32.

Metabolic Reprogramming and Oncogenesis: One Hallmark, Many Organelles.

Costa ASH, Frezza C.

Int Rev Cell Mol Biol. 2017;332:213-231. doi: 10.1016/bs.ircmb.2017.01.001. Epub 2017 Mar 15. Review.

PMID:
28526133
33.

Reassessment of the polar fraction of Stachys alopecuros (L.) Benth. subsp. divulsa (Ten.) Grande (Lamiaceae) from the Monti Sibillini National Park: A potential source of bioactive compounds.

Venditti A, Frezza C, Lorenzetti LM, Maggi F, Serafini M, Bianco A.

J Intercult Ethnopharmacol. 2017 Apr 12;6(2):144-153. doi: 10.5455/jice.20170327073801. eCollection 2017 Apr-Jun.

34.

Mammalian Circadian Period, But Not Phase and Amplitude, Is Robust Against Redox and Metabolic Perturbations.

Putker M, Crosby P, Feeney KA, Hoyle NP, Costa ASH, Gaude E, Frezza C, O'Neill JS.

Antioxid Redox Signal. 2018 Mar 1;28(7):507-520. doi: 10.1089/ars.2016.6911. Epub 2017 Jun 26.

35.

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer.

Sciacovelli M, Frezza C.

FEBS J. 2017 Oct;284(19):3132-3144. doi: 10.1111/febs.14090. Epub 2017 May 21. Review.

36.

Mitochondrial metabolites: undercover signalling molecules.

Frezza C.

Interface Focus. 2017 Apr 6;7(2):20160100. doi: 10.1098/rsfs.2016.0100. Review.

37.

Terpenoids and More Polar Compounds from the Male Cones of Wollemia nobilis.

Venditti A, Frezza C, Sciubba F, Foddai S, Serafini M, Bianco A.

Chem Biodivers. 2017 Mar;14(3). doi: 10.1002/cbdv.201600332. Epub 2017 Mar 11.

PMID:
28296157
38.

Phytochemical analysis of the ethanolic extract of Agathis robusta (C. Moore ex F. Muell.) F.M. Bailey.

Venditti A, Frezza C, Campanelli C, Foddai S, Bianco A, Serafini M.

Nat Prod Res. 2017 Jul;31(14):1604-1611. doi: 10.1080/14786419.2017.1288625. Epub 2017 Feb 8.

PMID:
28278682
39.

Mutations in mitochondrial DNA causing tubulointerstitial kidney disease.

Connor TM, Hoer S, Mallett A, Gale DP, Gomez-Duran A, Posse V, Antrobus R, Moreno P, Sciacovelli M, Frezza C, Duff J, Sheerin NS, Sayer JA, Ashcroft M, Wiesener MS, Hudson G, Gustafsson CM, Chinnery PF, Maxwell PH.

PLoS Genet. 2017 Mar 7;13(3):e1006620. doi: 10.1371/journal.pgen.1006620. eCollection 2017 Mar.

40.

Identification of Methylated Deoxyadenosines in Genomic DNA by dA6m DNA Immunoprecipitation.

Koziol MJ, Bradshaw CR, Allen GE, Costa AS, Frezza C.

Bio Protoc. 2016 Nov 5;6(21). pii: e1990. doi: 10.21769/BioProtoc.1990.

41.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG.

Cell Metab. 2017 Feb 7;25(2):482. doi: 10.1016/j.cmet.2017.01.014. No abstract available.

42.

Serine Is an Essential Metabolite for Effector T Cell Expansion.

Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, Verway MJ, Raissi TC, Tsui H, Boukhaled G, Henriques da Costa S, Frezza C, Krawczyk CM, Friedman A, Manfredi M, Richer MJ, Hess C, Jones RG.

Cell Metab. 2017 Feb 7;25(2):345-357. doi: 10.1016/j.cmet.2016.12.011. Epub 2017 Jan 19. Erratum in: Cell Metab. 2017 Feb 7;25(2):482.

43.

Primary and secondary metabolites of an European edible mushroom and its nutraceutical value: Suillus bellinii (Inzenga) Kuntze.

Venditti A, Frezza C, Sciubba F, Serafini M, Bianco A.

Nat Prod Res. 2017 Aug;31(16):1910-1919. doi: 10.1080/14786419.2016.1267731. Epub 2016 Dec 26.

PMID:
28013555
44.

Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs.

Righi G, Pelagalli R, Isoni V, Tirotta I, Dallocchio R, Dessì A, Macchi B, Frezza C, Rossetti I, Bovicelli P.

Nat Prod Res. 2017 Feb;31(4):397-403. doi: 10.1080/14786419.2016.1169413. Epub 2016 Apr 10.

PMID:
28010138
45.

Chemical Traits of Hemiparasitism in Odontites luteus.

Venditti A, Frezza C, Foddai S, Serafini M, Nicoletti M, Bianco A.

Chem Biodivers. 2017 Apr;14(4). doi: 10.1002/cbdv.201600416. Epub 2017 Mar 23.

PMID:
27997755
46.

Polar constituents, protection against reactive oxygen species, and nutritional value of Chinese artichoke (Stachys affinis Bunge).

Venditti A, Frezza C, Celona D, Bianco A, Serafini M, Cianfaglione K, Fiorini D, Ferraro S, Maggi F, Lizzi AR, Celenza G.

Food Chem. 2017 Apr 15;221:473-481. doi: 10.1016/j.foodchem.2016.10.096. Epub 2016 Oct 24.

PMID:
27979230
47.

Metabolic synthetic lethality in cancer therapy.

Zecchini V, Frezza C.

Biochim Biophys Acta Bioenerg. 2017 Aug;1858(8):723-731. doi: 10.1016/j.bbabio.2016.12.003. Epub 2016 Dec 9. Review.

48.

Polar Constituents, Essential Oil and Antioxidant Activity of Marsh Woundwort (Stachys palustris L.).

Venditti A, Frezza C, Bianco A, Serafini M, Cianfaglione K, Nagy DU, Iannarelli R, Caprioli G, Maggi F.

Chem Biodivers. 2017 Mar;14(3). doi: 10.1002/cbdv.201600401. Epub 2017 Feb 22.

PMID:
27943586
49.

Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.

Burr SP, Costa AS, Grice GL, Timms RT, Lobb IT, Freisinger P, Dodd RB, Dougan G, Lehner PJ, Frezza C, Nathan JA.

Cell Metab. 2016 Nov 8;24(5):740-752. doi: 10.1016/j.cmet.2016.09.015. Epub 2016 Oct 27.

50.

Fumarate drives EMT in renal cancer.

Sciacovelli M, Frezza C.

Cell Death Differ. 2017 Jan;24(1):1-2. doi: 10.1038/cdd.2016.137. Epub 2016 Nov 25. No abstract available.

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