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Items: 14


Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.


Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.

Kritzer JA, Freyzon Y, Lindquist S.

FEMS Yeast Res. 2018 May 1;18(3). doi: 10.1093/femsyr/foy027.


In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons.

Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):242-250.e4. doi: 10.1016/j.cels.2017.01.002. Epub 2017 Jan 25.


Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways.

Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, Costanzo M, San Luis BJ, Schöndorf DC, Barrasa MI, Ehsani S, Sanjana N, Zhong Q, Gasser T, Bartel DP, Vidal M, Deleidi M, Boone C, Fraenkel E, Berger B, Lindquist S.

Cell Syst. 2017 Feb 22;4(2):157-170.e14. doi: 10.1016/j.cels.2016.12.011. Epub 2017 Jan 25.


Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons.

Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S.

Science. 2013 Nov 22;342(6161):983-7. doi: 10.1126/science.1245296. Epub 2013 Oct 24.


Detecting force-induced molecular transitions with fluorescence resonant energy transfer.

Tarsa PB, Brau RR, Barch M, Ferrer JM, Freyzon Y, Matsudaira P, Lang MJ.

Angew Chem Int Ed Engl. 2007;46(12):1999-2001. doi: 10.1002/anie.200604546. No abstract available.


Enhanced detection sensitivity using a novel solid-phase incorporated affinity fluorescent protein biosensor.

Zhong JQ, Freyzon Y, Ehrlich DJ, Matsudaira P.

Biomol Eng. 2004 Apr;21(2):67-72.


The light chain binding domain of expressed smooth muscle heavy meromyosin acts as a mechanical lever.

Warshaw DM, Guilford WH, Freyzon Y, Krementsova E, Palmiter KA, Tyska MJ, Baker JE, Trybus KM.

J Biol Chem. 2000 Nov 24;275(47):37167-72.


Kinetic characterization of a monomeric unconventional myosin V construct.

Trybus KM, Krementsova E, Freyzon Y.

J Biol Chem. 1999 Sep 24;274(39):27448-56.


A 7-amino-acid insert in the heavy chain nucleotide binding loop alters the kinetics of smooth muscle myosin in the laser trap.

Lauzon AM, Tyska MJ, Rovner AS, Freyzon Y, Warshaw DM, Trybus KM.

J Muscle Res Cell Motil. 1998 Nov;19(8):825-37.


An insert in the motor domain determines the functional properties of expressed smooth muscle myosin isoforms.

Rovner AS, Freyzon Y, Trybus KM.

J Muscle Res Cell Motil. 1997 Feb;18(1):103-10.


Spare the rod, spoil the regulation: necessity for a myosin rod.

Trybus KM, Freyzon Y, Faust LZ, Sweeney HL.

Proc Natl Acad Sci U S A. 1997 Jan 7;94(1):48-52.


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