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Items: 13

1.

EPHB6 augments both development and drug sensitivity of triple-negative breast cancer tumours.

Toosi BM, El Zawily A, Truitt L, Shannon M, Allonby O, Babu M, DeCoteau J, Mousseau D, Ali M, Freywald T, Gall A, Vizeacoumar FS, Kirzinger MW, Geyer CR, Anderson DH, Kim T, Welm AL, Siegel P, Vizeacoumar FJ, Kusalik A, Freywald A.

Oncogene. 2018 Apr 27. doi: 10.1038/s41388-018-0228-x. [Epub ahead of print]

PMID:
29700392
2.

An integrated computational and experimental study uncovers FUT9 as a metabolic driver of colorectal cancer.

Auslander N, Cunningham CE, Toosi BM, McEwen EJ, Yizhak K, Vizeacoumar FS, Parameswaran S, Gonen N, Freywald T, Bhanumathy KK, Freywald A, Vizeacoumar FJ, Ruppin E.

Mol Syst Biol. 2017 Dec 1;13(12):956. doi: 10.15252/msb.20177739.

3.

The EphB6 receptor is overexpressed in pediatric T cell acute lymphoblastic leukemia and increases its sensitivity to doxorubicin treatment.

El Zawily A, McEwen E, Toosi B, Vizeacoumar FS, Freywald T, Vizeacoumar FJ, Freywald A.

Sci Rep. 2017 Nov 7;7(1):14767. doi: 10.1038/s41598-017-15200-3.

4.

The intrinsically kinase-inactive EPHB6 receptor predisposes cancer cells to DR5-induced apoptosis by promoting mitochondrial fragmentation.

El Zawily AM, Toosi BM, Freywald T, Indukuri VV, Vizeacoumar FJ, Leary SC, Freywald A.

Oncotarget. 2016 Nov 22;7(47):77865-77877. doi: 10.18632/oncotarget.12838.

5.

Targeting synthetic lethality between the SRC kinase and the EPHB6 receptor may benefit cancer treatment.

Paul JM, Toosi B, Vizeacoumar FS, Bhanumathy KK, Li Y, Gerger C, El Zawily A, Freywald T, Anderson DH, Mousseau D, Kanthan R, Zhang Z, Vizeacoumar FJ, Freywald A.

Oncotarget. 2016 Aug 2;7(31):50027-50042. doi: 10.18632/oncotarget.10569.

6.

Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining.

Jessulat M, Malty RH, Nguyen-Tran DH, Deineko V, Aoki H, Vlasblom J, Omidi K, Jin K, Minic Z, Hooshyar M, Burnside D, Samanfar B, Phanse S, Freywald T, Prasad B, Zhang Z, Vizeacoumar F, Krogan NJ, Freywald A, Golshani A, Babu M.

Mol Cell Biol. 2015 Jul;35(14):2448-63. doi: 10.1128/MCB.00007-15. Epub 2015 May 11.

7.

Yeast mitochondrial protein-protein interactions reveal diverse complexes and disease-relevant functional relationships.

Jin K, Musso G, Vlasblom J, Jessulat M, Deineko V, Negroni J, Mosca R, Malty R, Nguyen-Tran DH, Aoki H, Minic Z, Freywald T, Phanse S, Xiang Q, Freywald A, Aloy P, Zhang Z, Babu M.

J Proteome Res. 2015 Feb 6;14(2):1220-37. doi: 10.1021/pr501148q. Epub 2015 Jan 20.

PMID:
25546499
8.

Ligand stimulation induces clathrin- and Rab5-dependent downregulation of the kinase-dead EphB6 receptor preceded by the disruption of EphB6-Hsp90 interaction.

Allonby O, El Zawily AM, Freywald T, Mousseau DD, Chlan J, Anderson D, Benmerah A, Sidhu V, Babu M, DeCoteau J, Freywald A.

Cell Signal. 2014 Dec;26(12):2645-57. doi: 10.1016/j.cellsig.2014.08.007. Epub 2014 Aug 23.

PMID:
25152371
9.

EphB receptors trigger Akt activation and suppress Fas receptor-induced apoptosis in malignant T lymphocytes.

Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, Narendran A, Xiang J, Weng A, Napper S, Freywald A.

J Immunol. 2011 Dec 1;187(11):5983-94. doi: 10.4049/jimmunol.1003482. Epub 2011 Oct 28.

10.

The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells.

Truitt L, Freywald T, DeCoteau J, Sharfe N, Freywald A.

Cancer Res. 2010 Feb 1;70(3):1141-53. doi: 10.1158/0008-5472.CAN-09-1710. Epub 2010 Jan 19.

11.

In human leukemia cells ephrin-B-induced invasive activity is supported by Lck and is associated with reassembling of lipid raft signaling complexes.

Jiang G, Freywald T, Webster J, Kozan D, Geyer R, DeCoteau J, Narendran A, Freywald A.

Mol Cancer Res. 2008 Feb;6(2):291-305. doi: 10.1158/1541-7786.MCR-07-0047.

12.

Promoter analysis of the gene encoding the beta-subunit of the rat amiloride-sensitive epithelial sodium channel.

Bremner HR, Freywald T, O'Brodovich HM, Otulakowski G.

Am J Physiol Lung Cell Mol Physiol. 2002 Jan;282(1):L124-34.

13.

Translational activation and repression by distinct elements within the 5'-UTR of ENaC alpha-subunit mRNA.

Otulakowski G, Freywald T, Wen Y, O'Brodovich H.

Am J Physiol Lung Cell Mol Physiol. 2001 Nov;281(5):L1219-31.

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