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Items: 32

1.

Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.

Egli-Spichtig D, Imenez Silva PH, Glaudemans B, Gehring N, Bettoni C, Zhang MYH, Pastor-Arroyo EM, Schönenberger D, Rajski M, Hoogewijs D, Knauf F, Misselwitz B, Frey-Wagner I, Rogler G, Ackermann D, Ponte B, Pruijm M, Leichtle A, Fiedler GM, Bochud M, Ballotta V, Hofmann S, Perwad F, Föller M, Lang F, Wenger RH, Frew I, Wagner CA.

Kidney Int. 2019 May 14. pii: S0085-2538(19)30465-X. doi: 10.1016/j.kint.2019.04.009. [Epub ahead of print]

PMID:
31301888
2.

Elevated oxysterol levels in human and mouse livers reflect nonalcoholic steatohepatitis.

Raselli T, Hearn T, Wyss A, Atrott K, Peter A, Frey-Wagner I, Spalinger MR, Maggio EM, Sailer AW, Schmitt J, Schreiner P, Moncsek A, Mertens J, Scharl M, Griffiths WJ, Bueter M, Geier A, Rogler G, Wang Y, Misselwitz B.

J Lipid Res. 2019 Jul;60(7):1270-1283. doi: 10.1194/jlr.M093229. Epub 2019 May 21.

3.

The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.

Wyss A, Raselli T, Perkins N, Ruiz F, Schmelczer G, Klinke G, Moncsek A, Roth R, Spalinger MR, Hering L, Atrott K, Lang S, Frey-Wagner I, Mertens JC, Scharl M, Sailer AW, Pabst O, Hersberger M, Pot C, Rogler G, Misselwitz B.

Mucosal Immunol. 2019 May;12(3):733-745. doi: 10.1038/s41385-019-0140-x. Epub 2019 Feb 11.

4.

Administration of the Hyper-immune Bovine Colostrum Extract IMM-124E Ameliorates Experimental Murine Colitis.

Spalinger MR, Atrott K, Baebler K, Schwarzfischer M, Melhem H, Peres DR, Lalazar G, Rogler G, Scharl M, Frey-Wagner I.

J Crohns Colitis. 2019 May 27;13(6):785-797. doi: 10.1093/ecco-jcc/jjy213.

PMID:
30590526
5.

Lack of the pH-sensing Receptor TDAG8 [GPR65] in Macrophages Plays a Detrimental Role in Murine Models of Inflammatory Bowel Disease.

Tcymbarevich I, Richards SM, Russo G, Kühn-Georgijevic J, Cosin-Roger J, Baebler K, Lang S, Bengs S, Atrott K, Bettoni C, Gruber S, Frey-Wagner I, Scharl M, Misselwitz B, Wagner CA, Seuwen K, Rogler G, Ruiz PA, Spalinger M, de Vallière C.

J Crohns Colitis. 2019 Feb 1;13(2):245-258. doi: 10.1093/ecco-jcc/jjy152.

PMID:
30535144
6.

Intestinal Activation of pH-Sensing Receptor OGR1 [GPR68] Contributes to Fibrogenesis.

Hutter S, van Haaften WT, Hünerwadel A, Baebler K, Herfarth N, Raselli T, Mamie C, Misselwitz B, Rogler G, Weder B, Dijkstra G, Meier CF, de Vallière C, Weber A, Imenez Silva PH, Wagner CA, Frey-Wagner I, Ruiz PA, Hausmann M.

J Crohns Colitis. 2018 Nov 15;12(11):1348-1358. doi: 10.1093/ecco-jcc/jjy118.

7.

Gp96 deficiency affects TLR4 functionality and impairs ERK and p38 phosphorylation.

Cosin-Roger J, Spalinger MR, Ruiz PA, Stanzel C, Terhalle A, Wolfram L, Melhem H, Atrott K, Lang S, Frey-Wagner I, Fried M, Scharl M, Hausmann M, Rogler G.

PLoS One. 2018 Feb 15;13(2):e0193003. doi: 10.1371/journal.pone.0193003. eCollection 2018.

8.

Preventive Trichuris suis ova (TSO) treatment protects immunocompetent rabbits from DSS colitis but may be detrimental under conditions of immunosuppression.

Leonardi I, Gerstgrasser A, Schmidt TSB, Nicholls F, Tewes B, Greinwald R, von Mering C, Rogler G, Frey-Wagner I.

Sci Rep. 2017 Nov 28;7(1):16500. doi: 10.1038/s41598-017-16287-4.

9.

The Proton-activated Receptor GPR4 Modulates Intestinal Inflammation.

Wang Y, de Vallière C, Imenez Silva PH, Leonardi I, Gruber S, Gerstgrasser A, Melhem H, Weber A, Leucht K, Wolfram L, Hausmann M, Krieg C, Thomasson K, Boyman O, Frey-Wagner I, Rogler G, Wagner CA.

J Crohns Colitis. 2018 Feb 28;12(3):355-368. doi: 10.1093/ecco-jcc/jjx147.

10.

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation.

Cosin-Roger J, Simmen S, Melhem H, Atrott K, Frey-Wagner I, Hausmann M, de Vallière C, Spalinger MR, Spielmann P, Wenger RH, Zeitz J, Vavricka SR, Rogler G, Ruiz PA.

Nat Commun. 2017 Jul 24;8(1):98. doi: 10.1038/s41467-017-00213-3.

11.

Gastroresistant oral peptide for fluorescence imaging of colonic inflammation.

Luciani P, Estella-Hermoso de Mendoza A, Casalini T, Lang S, Atrott K, Spalinger MR, Pratsinis A, Sobek J, Frey-Wagner I, Schumacher J, Leroux JC, Rogler G.

J Control Release. 2017 Sep 28;262:118-126. doi: 10.1016/j.jconrel.2017.07.024. Epub 2017 Jul 19.

PMID:
28734901
12.

Effects of oral antibiotics and isotretinoin on the murine gut microbiota.

Becker E, Schmidt TSB, Bengs S, Poveda L, Opitz L, Atrott K, Stanzel C, Biedermann L, Rehman A, Jonas D, von Mering C, Rogler G, Frey-Wagner I.

Int J Antimicrob Agents. 2017 Sep;50(3):342-351. doi: 10.1016/j.ijantimicag.2017.03.017. Epub 2017 Jul 6.

PMID:
28689869
13.

Prdx6 Deficiency Ameliorates DSS Colitis: Relevance of Compensatory Antioxidant Mechanisms.

Melhem H, Spalinger MR, Cosin-Roger J, Atrott K, Lang S, Wojtal KA, Vavricka SR, Rogler G, Frey-Wagner I.

J Crohns Colitis. 2017 Jul 1;11(7):871-884. doi: 10.1093/ecco-jcc/jjx016.

PMID:
28199527
14.

Doxycycline, metronidazole and isotretinoin: Do they modify microRNA/mRNA expression profiles and function in murine T-cells?

Becker E, Bengs S, Aluri S, Opitz L, Atrott K, Stanzel C, Castro PAR, Rogler G, Frey-Wagner I.

Sci Rep. 2016 Nov 17;6:37082. doi: 10.1038/srep37082.

15.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 Nov 1;126(11):4388. doi: 10.1172/JCI90897. Epub 2016 Nov 1. No abstract available.

16.

Cell-specific Activation of the Nrf2 Antioxidant Pathway Increases Mucosal Inflammation in Acute but Not in Chronic Colitis.

Gerstgrasser A, Melhem H, Leonardi I, Atrott K, Schäfer M, Werner S, Rogler G, Frey-Wagner I.

J Crohns Colitis. 2017 Apr 1;11(4):485-499. doi: 10.1093/ecco-jcc/jjw172.

PMID:
27683801
17.

Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal Inflammation.

Rau M, Stieger B, Monte MJ, Schmitt J, Jahn D, Frey-Wagner I, Raselli T, Marin JJ, Müllhaupt B, Rogler G, Geier A.

Inflamm Bowel Dis. 2016 Oct;22(10):2382-9. doi: 10.1097/MIB.0000000000000879.

18.

Deficiency of Protein Tyrosine Phosphatase Non-Receptor Type 2 in Intestinal Epithelial Cells Has No Appreciable Impact on Dextran Sulphate Sodium Colitis Severity But Promotes Wound Healing.

Kasper SH, Spalinger MR, Leonardi I, Gerstgrasser A, Raselli T, Gottier C, Atrott K, Frey-Wagner I, Fischbeck-Terhalle A, Rogler G, Scharl M.

Digestion. 2016;93(4):249-59. doi: 10.1159/000445289. Epub 2016 Apr 27.

19.

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.

Spalinger MR, Kasper S, Gottier C, Lang S, Atrott K, Vavricka SR, Scharl S, Raselli T, Frey-Wagner I, Gutte PM, Grütter MG, Beer HD, Contassot E, Chan AC, Dai X, Rawlings DJ, Mair F, Becher B, Falk W, Fried M, Rogler G, Scharl M.

J Clin Invest. 2016 May 2;126(5):1783-800. doi: 10.1172/JCI83669. Epub 2016 Apr 4. Erratum in: J Clin Invest. 2016 Nov 1;126(11):4388.

20.

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome.

Ruiz PA, Morón B, Becker HM, Lang S, Atrott K, Spalinger MR, Scharl M, Wojtal KA, Fischbeck-Terhalle A, Frey-Wagner I, Hausmann M, Kraemer T, Rogler G.

Gut. 2017 Jul;66(7):1216-1224. doi: 10.1136/gutjnl-2015-310297. Epub 2016 Feb 4.

21.

G Protein-coupled pH-sensing Receptor OGR1 Is a Regulator of Intestinal Inflammation.

de Vallière C, Wang Y, Eloranta JJ, Vidal S, Clay I, Spalinger MR, Tcymbarevich I, Terhalle A, Ludwig MG, Suply T, Fried M, Kullak-Ublick GA, Frey-Wagner I, Scharl M, Seuwen K, Wagner CA, Rogler G.

Inflamm Bowel Dis. 2015 Jun;21(6):1269-81. doi: 10.1097/MIB.0000000000000375.

22.

Oral administration of dextran sodium sulphate induces a caecum-localized colitis in rabbits.

Leonardi I, Nicholls F, Atrott K, Cee A, Tewes B, Greinwald R, Rogler G, Frey-Wagner I.

Int J Exp Pathol. 2015 Jun;96(3):151-62. doi: 10.1111/iep.12117. Epub 2015 Feb 26.

23.

PTPN2 controls differentiation of CD4⁺ T cells and limits intestinal inflammation and intestinal dysbiosis.

Spalinger MR, Kasper S, Chassard C, Raselli T, Frey-Wagner I, Gottier C, Lang S, Atrott K, Vavricka SR, Mair F, Becher B, Lacroix C, Fried M, Rogler G, Scharl M.

Mucosal Immunol. 2015 Jul;8(4):918-29. doi: 10.1038/mi.2014.122. Epub 2014 Dec 10.

PMID:
25492475
24.

Exogenous heat shock protein gp96 ameliorates CD4+CD62L+ T-cell-mediated transfer colitis.

Fischbeck A, Schreiter K, Leucht K, Frey-Wagner I, Lang S, Hausmann M, Fried M, Falk W, Rogler G.

Inflamm Bowel Dis. 2014 Nov;20(11):1933-41. doi: 10.1097/MIB.0000000000000175.

PMID:
25185687
25.

Regulation of the expression of chaperone gp96 in macrophages and dendritic cells.

Wolfram L, Fischbeck A, Frey-Wagner I, Wojtal KA, Lang S, Fried M, Vavricka SR, Hausmann M, Rogler G.

PLoS One. 2013 Oct 16;8(10):e76350. doi: 10.1371/journal.pone.0076350. eCollection 2013.

26.

Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice.

Pineton de Chambrun G, Body-Malapel M, Frey-Wagner I, Djouina M, Deknuydt F, Atrott K, Esquerre N, Altare F, Neut C, Arrieta MC, Kanneganti TD, Rogler G, Colombel JF, Cortot A, Desreumaux P, Vignal C.

Mucosal Immunol. 2014 May;7(3):589-601. doi: 10.1038/mi.2013.78. Epub 2013 Oct 16.

27.

Differential cystine and dibasic amino acid handling after loss of function of the amino acid transporter b0,+AT (Slc7a9) in mice.

Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G, Wagner CA.

Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1645-55. doi: 10.1152/ajprenal.00221.2013. Epub 2013 Oct 9.

28.

Activation of protein tyrosine phosphatase non-receptor type 2 by spermidine exerts anti-inflammatory effects in human THP-1 monocytes and in a mouse model of acute colitis.

Morón B, Spalinger M, Kasper S, Atrott K, Frey-Wagner I, Fried M, McCole DF, Rogler G, Scharl M.

PLoS One. 2013 Sep 9;8(9):e73703. doi: 10.1371/journal.pone.0073703. eCollection 2013.

29.

Effects of retinoids in mouse models of colitis: benefit or danger to the gastrointestinal tract?

Frey-Wagner I, Fischbeck A, Cee A, Leonardi I, Gruber S, Becker E, Atrott K, Lang S, Rogler G.

Inflamm Bowel Dis. 2013 Oct;19(11):2356-65. doi: 10.1097/MIB.0b013e31829cf1fc.

PMID:
23899542
30.

The effects of vitamin A on cells of innate immunity in vitro.

Wojtal KA, Wolfram L, Frey-Wagner I, Lang S, Scharl M, Vavricka SR, Rogler G.

Toxicol In Vitro. 2013 Aug;27(5):1525-32. doi: 10.1016/j.tiv.2013.03.013. Epub 2013 Apr 2.

31.

Knock-out of β-glucosidase 2 has no influence on dextran sulfate sodium-induced colitis.

Scharl M, Leucht K, Frey-Wagner I, Zeitz J, Hausmann M, Fischbeck A, Liebisch G, Kellermeier S, Pesch T, Arikkat J, Schmitz G, Fried M, Yildiz Y, Rogler G.

Digestion. 2011;84(2):156-67. doi: 10.1159/000327380. Epub 2011 May 12.

32.

Sphingomyelin induces cathepsin D-mediated apoptosis in intestinal epithelial cells and increases inflammation in DSS colitis.

Fischbeck A, Leucht K, Frey-Wagner I, Bentz S, Pesch T, Kellermeier S, Krebs M, Fried M, Rogler G, Hausmann M, Humpf HU.

Gut. 2011 Jan;60(1):55-65. doi: 10.1136/gut.2009.201988. Epub 2010 Nov 12.

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