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Items: 45

1.

IL-8 and CXCR1 expression is associated with cancer stem cell-like properties of clear cell renal cancer.

Corrò C, Healy ME, Engler S, Bodenmiller B, Li Z, Schraml P, Weber A, Frew IJ, Rechsteiner M, Moch H.

J Pathol. 2019 Jul;248(3):377-389. doi: 10.1002/path.5267. Epub 2019 Apr 11.

2.

Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma.

Brandt LP, Albers J, Hejhal T, Pfundstein S, Gonçalves AF, Catalano A, Wild PJ, Frew IJ.

Oncotarget. 2018 Apr 13;9(28):19753-19766. doi: 10.18632/oncotarget.24831. eCollection 2018 Apr 13.

3.

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.

Gonçalves AF, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, Shakhova O, Wild PJ, Frew IJ.

Nat Commun. 2017 Nov 13;8(1):1466. doi: 10.1038/s41467-017-01514-3.

4.

Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma.

Brandt LP, Albers J, Hejhal T, Catalano A, Wild PJ, Frew IJ.

PLoS One. 2017 Oct 5;12(10):e0186102. doi: 10.1371/journal.pone.0186102. eCollection 2017.

5.

Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice.

Harlander S, Schönenberger D, Toussaint NC, Prummer M, Catalano A, Brandt L, Moch H, Wild PJ, Frew IJ.

Nat Med. 2017 Jul;23(7):869-877. doi: 10.1038/nm.4343. Epub 2017 May 29.

6.

Induction of long noncoding RNA MALAT1 in hypoxic mice.

Lelli A, Nolan KA, Santambrogio S, Gonçalves AF, Schönenberger MJ, Guinot A, Frew IJ, Marti HH, Hoogewijs D, Wenger RH.

Hypoxia (Auckl). 2015 Oct 8;3:45-52. eCollection 2015.

7.

Vhl deletion in renal epithelia causes HIF-1α-dependent, HIF-2α-independent angiogenesis and constitutive diuresis.

Schönenberger D, Rajski M, Harlander S, Frew IJ.

Oncotarget. 2016 Sep 20;7(38):60971-60985. doi: 10.18632/oncotarget.11275.

8.

Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.

Guinot A, Lehmann H, Wild PJ, Frew IJ.

J Pathol. 2016 Jul;239(3):365-73. doi: 10.1002/path.4736. Epub 2016 May 30.

9.

Cdk4 functions in multiple cell types to control Drosophila intestinal stem cell proliferation and differentiation.

Adlesic M, Frei C, Frew IJ.

Biol Open. 2016 Feb 15;5(3):237-51. doi: 10.1242/bio.016584.

10.

Formation of Renal Cysts and Tumors in Vhl/Trp53-Deficient Mice Requires HIF1α and HIF2α.

Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ.

Cancer Res. 2016 Apr 1;76(7):2025-36. doi: 10.1158/0008-5472.CAN-15-1859. Epub 2016 Jan 12.

11.

Tumour modelling using viral vectors.

Frew IJ.

Oncotarget. 2015 Jun 10;6(16):13854-5. No abstract available.

12.

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours.

Kalathur M, Toso A, Chen J, Revandkar A, Danzer-Baltzer C, Guccini I, Alajati A, Sarti M, Pinton S, Brambilla L, Di Mitri D, Carbone G, Garcia-Escudero R, Padova A, Magnoni L, Tarditi A, Maccari L, Malusa F, Kalathur RK, A Pinna L, Cozza G, Ruzzene M, Delaleu N, Catapano CV, Frew IJ, Alimonti A.

Nat Commun. 2015 Jun 18;6:7227. doi: 10.1038/ncomms8227.

PMID:
26085373
13.

Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation.

Lehmann H, Vicari D, Wild PJ, Frew IJ.

J Am Soc Nephrol. 2015 Nov;26(11):2778-88. doi: 10.1681/ASN.2014090875. Epub 2015 Mar 18.

14.

A versatile modular vector system for rapid combinatorial mammalian genetics.

Albers J, Danzer C, Rechsteiner M, Lehmann H, Brandt LP, Hejhal T, Catalano A, Busenhart P, Gonçalves AF, Brandt S, Bode PK, Bode-Lesniewska B, Wild PJ, Frew IJ.

J Clin Invest. 2015 Apr;125(4):1603-19. doi: 10.1172/JCI79743. Epub 2015 Mar 9.

15.

Hedgehog pathway inhibitors promote adaptive immune responses in basal cell carcinoma.

Otsuka A, Dreier J, Cheng PF, Nägeli M, Lehmann H, Felderer L, Frew IJ, Matsushita S, Levesque MP, Dummer R.

Clin Cancer Res. 2015 Mar 15;21(6):1289-97. doi: 10.1158/1078-0432.CCR-14-2110. Epub 2015 Jan 15.

16.

A clearer view of the molecular complexity of clear cell renal cell carcinoma.

Frew IJ, Moch H.

Annu Rev Pathol. 2015;10:263-89. doi: 10.1146/annurev-pathol-012414-040306. Epub 2014 Oct 27. Review.

PMID:
25387056
17.

KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation.

Ikenberg K, Valtcheva N, Brandt S, Zhong Q, Wong CE, Noske A, Rechsteiner M, Rueschoff JH, Caduff R, Dellas A, Obermann E, Fink D, Fuchs T, Krek W, Moch H, Frew IJ, Wild PJ.

J Pathol. 2014 Oct;234(2):239-52. doi: 10.1002/path.4390. Epub 2014 Jul 30.

PMID:
24930886
18.

Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.

Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, Georgiev S, Wild PJ, Moch H, Krek W, Frew IJ.

EMBO Mol Med. 2013 Jun;5(6):949-64. doi: 10.1002/emmm.201202231. Epub 2013 Apr 22.

19.

Genetic deletion of the long isoform of the von Hippel-Lindau tumour suppressor gene product alters microtubule dynamics.

Frew IJ, Smole Z, Thoma CR, Krek W.

Eur J Cancer. 2013 Jul;49(10):2433-40. doi: 10.1016/j.ejca.2013.02.024. Epub 2013 Mar 27.

PMID:
23541568
20.

p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans.

Wild PJ, Ikenberg K, Fuchs TJ, Rechsteiner M, Georgiev S, Fankhauser N, Noske A, Roessle M, Caduff R, Dellas A, Fink D, Moch H, Krek W, Frew IJ.

EMBO Mol Med. 2012 Aug;4(8):808-24. doi: 10.1002/emmm.201101063. Epub 2012 Jun 8.

21.

VHL loss causes spindle misorientation and chromosome instability.

Thoma CR, Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, Meraldi P, Krek W.

Nat Cell Biol. 2009 Aug;11(8):994-1001. doi: 10.1038/ncb1912. Epub 2009 Jul 20.

PMID:
19620968
22.

Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely reduced frequency of primary cilia.

Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W, Moch H.

Mod Pathol. 2009 Jan;22(1):31-6. doi: 10.1038/modpathol.2008.132. Epub 2008 Jul 25.

23.

pVHL: a multipurpose adaptor protein.

Frew IJ, Krek W.

Sci Signal. 2008 Jun 17;1(24):pe30. doi: 10.1126/scisignal.124pe30.

PMID:
18560019
24.

pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.

Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H, Krek W.

EMBO J. 2008 Jun 18;27(12):1747-57. doi: 10.1038/emboj.2008.96. Epub 2008 May 22.

25.

Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia.

Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO, Krek W.

Mol Cell Biol. 2008 Jul;28(14):4536-48. doi: 10.1128/MCB.02132-07. Epub 2008 May 12.

26.

Multitasking by pVHL in tumour suppression.

Frew IJ, Krek W.

Curr Opin Cell Biol. 2007 Dec;19(6):685-90. Epub 2007 Nov 19. Review.

PMID:
18006292
27.

The VHL tumor suppressor: riding tandem with GSK3beta in primary cilium maintenance.

Thoma CR, Frew IJ, Krek W.

Cell Cycle. 2007 Aug 1;6(15):1809-13. Epub 2007 May 25.

PMID:
17671433
28.

pVHL and GSK3beta are components of a primary cilium-maintenance signalling network.

Thoma CR, Frew IJ, Hoerner CR, Montani M, Moch H, Krek W.

Nat Cell Biol. 2007 May;9(5):588-95. Epub 2007 Apr 22.

PMID:
17450132
29.

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia.

Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z.

Cell. 2004 Jun 25;117(7):941-52.

30.

Osteopenia in Siah1a mutant mice.

Frew IJ, Sims NA, Quinn JM, Walkley CR, Purton LE, Bowtell DD, Gillespie MT.

J Biol Chem. 2004 Jul 9;279(28):29583-8. Epub 2004 May 3.

31.

Generation and analysis of Siah2 mutant mice.

Frew IJ, Hammond VE, Dickins RA, Quinn JM, Walkley CR, Sims NA, Schnall R, Della NG, Holloway AJ, Digby MR, Janes PW, Tarlinton DM, Purton LE, Gillespie MT, Bowtell DD.

Mol Cell Biol. 2003 Dec;23(24):9150-61.

32.

A binding motif for Siah ubiquitin ligase.

House CM, Frew IJ, Huang HL, Wiche G, Traficante N, Nice E, Catimel B, Bowtell DD.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3101-6. Epub 2003 Mar 7.

33.

Normal p53 function in primary cells deficient for Siah genes.

Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O'Connell MJ, Bowtell DD.

Mol Cell Biol. 2002 Dec;22(23):8155-64.

34.

Stress-induced decrease in TRAF2 stability is mediated by Siah2.

Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sassoon D, Bowtell DD, Ronai Z.

EMBO J. 2002 Nov 1;21(21):5756-65.

35.

The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.

Dickins RA, Frew IJ, House CM, O'Bryan MK, Holloway AJ, Haviv I, Traficante N, de Kretser DM, Bowtell DD.

Mol Cell Biol. 2002 Apr;22(7):2294-303.

36.

Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells.

Berven LA, Frew IJ, Crouch MF.

Biochem Biophys Res Commun. 1999 Dec 20;266(2):352-60.

PMID:
10600507
37.

Competition by second messenger systems for receptor interaction and activation: implications for tissue-specific responses and disease therapy.

Crouch MF, Frew IJ, Simson L, Davy DA.

Clin Exp Pharmacol Physiol. 1997 Aug;24(8):632-8. Review.

PMID:
9269540
38.

Betahistine hydrochloride in Méniére's disease.

Frew IJ, Menon GN.

Postgrad Med J. 1976 Aug;52(610):501-3.

39.

The familial association of neurofibromatosis, peroneal muscular atrophy, congenital deafness, partial albinism, and Axenfeld's defect.

Bradley WG, Richardson J, Frew IJ.

Brain. 1974 Sep;97(3):521-32. No abstract available.

PMID:
4213898
40.

Delayed conductive deafness.

Frew IJ.

J Laryngol Otol. 1970 Sep;84(9):939-41. No abstract available.

PMID:
5471898
41.

THE DIAGNOSIS OF MALIGNANCY OF THE MIDDLE EAR IN MIDDLE LIFE.

FREW IJ.

Geriatrics. 1965 Sep;20:759-60. No abstract available.

PMID:
14333674
42.

SEVERE EPISTAXIS.

FREW IJ.

Lancet. 1965 Jul 17;2(7403):101-2. No abstract available.

PMID:
14330028
43.

Tracheostomy and controlled respiration.

FREW IJ.

J Laryngol Otol. 1961 Feb;75:136-41. No abstract available.

PMID:
13701821
44.

The role of respiratory insufficiency in the mortality of severe head injuries.

MACIVER IN, FREW IJ, MATHESON JG.

Lancet. 1958 Feb 22;1(7017):390-3. No abstract available.

PMID:
13515227
45.

Tuberculosis of the oesophagus.

FREW IJ.

J Laryngol Otol. 1950 Dec;64(12):774-5. No abstract available.

PMID:
14784756

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