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Research on sepsis biomarkers in the emergency department: What now, what next?

Philippon AL, Freund Y.

Emergencias. 2019 Oct;31(5):302-303. Spanish, English. No abstract available.


Prevalence of pulmonary embolism in emergency department patients with isolated syncope: a prospective cohort study.

Raynal PA, Cachanado M, Truchot J, Damas-Perrichet C, Feral-Pierssens AL, Goulet H, Deltour S, Boussouar S, Donciu V, Simon T, Freund Y, Philippon AL.

Eur J Emerg Med. 2019 Oct 11. doi: 10.1097/MEJ.0000000000000625. [Epub ahead of print]


Low compliance to guidelines in the management of acute heart failure in emergency elderly patients: a multicenter pilot prospective study.

Gorlicki J, Minka FH, Chouihed T, Desmettre T, Feral-Pierssens AL, Laribi S, Mebazaa A, Freund Y.

Eur J Emerg Med. 2019 Oct;26(5):379-380. doi: 10.1097/MEJ.0000000000000593. No abstract available.


A new hope.

Freund Y.

Eur J Emerg Med. 2019 Oct;26(5):311. doi: 10.1097/MEJ.0000000000000626. No abstract available.


Waterfalls and Handoffs: A Novel Physician Staffing Model to Decrease Handoffs in a Pediatric Emergency Department.

Freund Y, Bloom B.

Ann Emerg Med. 2019 Sep;74(3):467. doi: 10.1016/j.annemergmed.2019.04.027. No abstract available.


Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis.

Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J, Rosenthal PJ, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD.

Nat Commun. 2019 Jun 27;10(1):2816. doi: 10.1038/s41467-019-10687-y.


European Society of Emergency Medicine position paper on the 1-hour sepsis bundle of the Surviving Sepsis Campaign: expression of concern.

Freund Y, Khoury A, Möckel M, Karamercan M, Dodt C, Leach R, Bloom B, Garcia-Castrillo L.

Eur J Emerg Med. 2019 Aug;26(4):232-233. doi: 10.1097/MEJ.0000000000000603.


Time-pattern of adverse outcomes after an infection-triggered acute heart failure decompensation and the influence of early antibiotic administration and hospitalisation: results of the PAPRICA-3 study.

Miró Ò, Takagi K, Gayat É, Gil V, Llorens P, Martín-Sánchez FJ, Jacob J, Herrero-Puente P, Escoda R, Pilar López-Díez M, Valero A, Fuentes M, Garrido JM, Salvo E, Rizzi MA, Aguirre A, Travería Bécquer L, Domínguez-Rodríguez A, Padrosa J, Martínez G, Arrigo M, Freund Y, Mebazaa A.

Clin Res Cardiol. 2019 Apr 29. doi: 10.1007/s00392-019-01481-3. [Epub ahead of print]


An active texture-based digital atlas enables automated mapping of structures and markers across brains.

Chen Y, McElvain LE, Tolpygo AS, Ferrante D, Friedman B, Mitra PP, Karten HJ, Freund Y, Kleinfeld D.

Nat Methods. 2019 Apr;16(4):341-350. doi: 10.1038/s41592-019-0328-8. Epub 2019 Mar 11.


Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.

Jacobs RT, Lunde CS, Freund YR, Hernandez V, Li X, Xia Y, Carter DS, Berry PW, Halladay J, Rock F, Stefanakis R, Easom E, Plattner JJ, Ford L, Johnston KL, Cook DAN, Clare R, Cassidy A, Myhill L, Tyrer H, Gamble J, Guimaraes AF, Steven A, Lenz F, Ehrens A, Frohberger SJ, Koschel M, Hoerauf A, Hübner MP, McNamara CW, Bakowski MA, Turner JD, Taylor MJ, Ward SA.

J Med Chem. 2019 Mar 14;62(5):2521-2540. doi: 10.1021/acs.jmedchem.8b01854. Epub 2019 Feb 26.


Early and comprehensive care bundle in the elderly for acute heart failure in the emergency department: study protocol of the ELISABETH stepped-wedge cluster randomized trial.

Freund Y, Gorlicki J, Cachanado M, Salhi S, Lemaître V, Simon T, Mebazaa A.

Trials. 2019 Jan 31;20(1):95. doi: 10.1186/s13063-019-3188-8.


The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing.

Begolo D, Vincent IM, Giordani F, Pöhner I, Witty MJ, Rowan TG, Bengaly Z, Gillingwater K, Freund Y, Wade RC, Barrett MP, Clayton C.

PLoS Pathog. 2018 Sep 25;14(9):e1007315. doi: 10.1371/journal.ppat.1007315. eCollection 2018 Sep.


Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. doi: 10.1073/pnas.1807915115. Epub 2018 Sep 5.


Prognostic value of prehospital quick sequential organ failure assessment score among patients with suspected infection.

Vaittinada Ayar P, Delay M, Avondo A, Duchateau FX, Nadiras P, Lapostolle F, Chouihed T, Freund Y.

Eur J Emerg Med. 2019 Oct;26(5):329-333. doi: 10.1097/MEJ.0000000000000570.


The Health Care System Flies in the Face of Airline Security Concepts-Reply.

Freund Y, Bloom B, Philippon AL.

JAMA Intern Med. 2018 Aug 1;178(8):1143. doi: 10.1001/jamainternmed.2018.3553. No abstract available.


Safety of the Combination of PERC and YEARS Rules in Patients With Low Clinical Probability of Pulmonary Embolism: A Retrospective Analysis of Two Large European Cohorts.

Gorlicki J, Penaloza A, Germeau B, Moumneh T, Philippon AL, Truchot J, Douillet D, Steinier C, Soulié C, Bloom B, Cachanado M, Roy PM, Freund Y.

Acad Emerg Med. 2019 Jan;26(1):23-30. doi: 10.1111/acem.13508. Epub 2018 Aug 10.


Early variation of quick sequential organ failure assessment score to predict in-hospital mortality in emergency department patients with suspected infection.

Lemachatti N, Ortega M, Penaloza A, Le Borgne P, Claret PG, Occelli C, Truchot J, Dumas F, Feral-Pierssens AL, Andrianjafy H, Beaune S, Yordanov Y, Hausfater P, Riou B, Bloom B, Krastinova E, Freund Y; French Society of Emergency Medicine Collaborators Group and the INFURGSEMES Group.

Eur J Emerg Med. 2019 Aug;26(4):234-241. doi: 10.1097/MEJ.0000000000000551.


Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Steketee PC, Vincent IM, Achcar F, Giordani F, Kim DH, Creek DJ, Freund Y, Jacobs R, Rattigan K, Horn D, Field MC, MacLeod A, Barrett MP.

PLoS Negl Trop Dis. 2018 May 14;12(5):e0006450. doi: 10.1371/journal.pntd.0006450. eCollection 2018 May.


Effect of Systematic Physician Cross-checking on Reducing Adverse Events in the Emergency Department: The CHARMED Cluster Randomized Trial.

Freund Y, Goulet H, Leblanc J, Bokobza J, Ray P, Maignan M, Guinemer S, Truchot J, Féral-Pierssens AL, Yordanov Y, Philippon AL, Rouff E, Bloom B, Cachanado M, Rousseau A, Simon T, Riou B.

JAMA Intern Med. 2018 Jun 1;178(6):812-819. doi: 10.1001/jamainternmed.2018.0607.


Ethical and scientific misconduct: the beginner's experience.

Freund Y.

Eur J Emerg Med. 2018 Apr;25(2):77. doi: 10.1097/MEJ.0000000000000542. No abstract available.


Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial.

Freund Y, Cachanado M, Aubry A, Orsini C, Raynal PA, Féral-Pierssens AL, Charpentier S, Dumas F, Baarir N, Truchot J, Desmettre T, Tazarourte K, Beaune S, Leleu A, Khellaf M, Wargon M, Bloom B, Rousseau A, Simon T, Riou B; PROPER Investigator Group.

JAMA. 2018 Feb 13;319(6):559-566. doi: 10.1001/jama.2017.21904.


Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles.

Zhang N, Zoltner M, Leung KF, Scullion P, Hutchinson S, Del Pino RC, Vincent IM, Zhang YK, Freund YR, Alley MRK, Jacobs RT, Read KD, Barrett MP, Horn D, Field MC.

PLoS Pathog. 2018 Feb 9;14(2):e1006850. doi: 10.1371/journal.ppat.1006850. eCollection 2018 Feb.


Effects of the intensity of prehospital treatment on short-term outcomes in patients with acute heart failure: the SEMICA-2 study.

Miró Ò, Hazlitt M, Escalada X, Llorens P, Gil V, Martín-Sánchez FJ, Harjola P, Rico V, Herrero-Puente P, Jacob J, Cone DC, Möckel M, Christ M, Freund Y, di Somma S, Laribi S, Mebazaa A, Harjola VP; ICA-SEMES Research Group.

Clin Res Cardiol. 2018 Apr;107(4):347-361. doi: 10.1007/s00392-017-1190-2. Epub 2017 Dec 28.


Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).

Akama T, Zhang YK, Freund YR, Berry P, Lee J, Easom EE, Jacobs RT, Plattner JJ, Witty MJ, Peter R, Rowan TG, Gillingwater K, Brun R, Nare B, Mercer L, Xu M, Wang J, Liang H.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10. doi: 10.1016/j.bmcl.2017.11.028. Epub 2017 Nov 20.


[Remote-guided cardiopulmonary resuscitation: Are dispatchers bad judges but good coaches?]

Freund Y, Philippon AL.

Emergencias. 2017 Feb;29(1):3-4. Spanish. No abstract available.


[Sepsis and prediction of in-hospital mortality].

Freund Y, Ortega M.

Emergencias. 2017 Abr;29(2):79-80. Spanish. No abstract available.


Effect of emergency physician burnout on patient waiting times.

De Stefano C, Philippon AL, Krastinova E, Hausfater P, Riou B, Adnet F, Freund Y.

Intern Emerg Med. 2018 Apr;13(3):421-428. doi: 10.1007/s11739-017-1706-9. Epub 2017 Jul 4.


Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL, Rosenthal PJ, Campo B, Gamo FJ, Sanz LM, Cao J.

J Med Chem. 2017 Jul 13;60(13):5889-5908. doi: 10.1021/acs.jmedchem.7b00621. Epub 2017 Jun 29.


Use of the qSOFA Score in the Emergency Department-Reply.

Freund Y, Bloom B, Riou B.

JAMA. 2017 May 9;317(18):1910. doi: 10.1001/jama.2017.3511. No abstract available.


Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis.

Pickering JW, Than MP, Cullen L, Aldous S, Ter Avest E, Body R, Carlton EW, Collinson P, Dupuy AM, Ekelund U, Eggers KM, Florkowski CM, Freund Y, George P, Goodacre S, Greenslade JH, Jaffe AS, Lord SJ, Mokhtari A, Mueller C, Munro A, Mustapha S, Parsonage W, Peacock WF, Pemberton C, Richards AM, Sanchis J, Staub LP, Troughton R, Twerenbold R, Wildi K, Young J.

Ann Intern Med. 2017 May 16;166(10):715-724. doi: 10.7326/M16-2562. Epub 2017 Apr 18. Erratum in: Ann Intern Med. 2017 Oct 3;167(7):528.


A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.

Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ, DeRisi J, Freund YR, Fidock DA, Rosenthal PJ.

Nat Commun. 2017 Mar 6;8:14574. doi: 10.1038/ncomms14574.


Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA.

EMBO Mol Med. 2017 Mar;9(3):385-394. doi: 10.15252/emmm.201607370.


Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department.

Freund Y, Lemachatti N, Krastinova E, Van Laer M, Claessens YE, Avondo A, Occelli C, Feral-Pierssens AL, Truchot J, Ortega M, Carneiro B, Pernet J, Claret PG, Dami F, Bloom B, Riou B, Beaune S; French Society of Emergency Medicine Collaborators Group.

JAMA. 2017 Jan 17;317(3):301-308. doi: 10.1001/jama.2016.20329.


External validation of a clinical decision rule: we need events in a population in order to rule them out!

Freund Y, Philippon AL.

Scand J Trauma Resusc Emerg Med. 2017 Jan 13;25(1):3. doi: 10.1186/s13049-016-0346-9.


Agreement between arterial and venous lactate in emergency department patients: a prospective study of 157 consecutive patients.

Paquet AL, Valli V, Philippon AL, Devilliers C, Bloom B, Hausfater P, Riou B, Freund Y.

Eur J Emerg Med. 2018 Apr;25(2):92-96. doi: 10.1097/MEJ.0000000000000435.


Feral-Pierssens et al. Respond.

Feral-Pierssens AL, Aubry A, Freund Y.

Am J Public Health. 2016 Oct;106(10):e4-5. doi: 10.2105/AJPH.2016.303357. No abstract available.


The assessment of circulating volume using inferior vena cava collapse index and carotid Doppler velocity time integral in healthy volunteers: a pilot study.

Peachey T, Tang A, Baker EC, Pott J, Freund Y, Harris T.

Scand J Trauma Resusc Emerg Med. 2016 Sep 2;24(1):108. doi: 10.1186/s13049-016-0298-0.


Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.


Effect of simulated patient death on emergency worker's anxiety: a cluster randomized trial.

Philippon AL, Bokobza J, Bloom B, Hurbault A, Duguet A, Riou B, Freund Y.

Ann Intensive Care. 2016 Dec;6(1):60. doi: 10.1186/s13613-016-0163-3. Epub 2016 Jul 7.


Temporal trends in nitrate utilization for acute heart failure in elderly emergency patients: A single-centre observational study.

Lemachatti N, Philippon AL, Bloom B, Hausfater P, Riou B, Ray P, Freund Y.

Arch Cardiovasc Dis. 2016 Aug-Sep;109(8-9):449-56. doi: 10.1016/j.acvd.2016.01.014. Epub 2016 Jun 21.


Prognostic value of PCT, copeptin, MR-proADM, MR-proANP and CT-proET-1 for severe acute dyspnea in the emergency department: the BIODINER study.

Hausfater P, Claessens YE, Martinage A, Joly LM, Lardeur JY, Der Sahakian G, Lemanski C, Ray P, Freund Y, Riou B.

Biomarkers. 2017 Feb;22(1):28-34. doi: 10.1080/1354750X.2016.1201541. Epub 2016 Jun 29.


Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase.

Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR, DeRisi J, Cusack S, Rosenthal PJ.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4886-95. doi: 10.1128/AAC.00820-16. Print 2016 Aug.


Management of urinary stone disease in general practice: A French Delphi study.

Abergel S, Peyronnet B, Seguin P, Bensalah K, Traxer O, Freund Y.

Eur J Gen Pract. 2016 Jun;22(2):103-10. doi: 10.3109/13814788.2016.1149568. Epub 2016 Apr 19.


Emergency Care for Homeless Patients: A French Multicenter Cohort Study.

Feral-Pierssens AL, Aubry A, Truchot J, Raynal PA, Boiffier M, Hutin A, Leleu A, Debruyne G, Joly LM, Juvin P, Riou B, Freund Y; SECOURS Investigators.

Am J Public Health. 2016 May;106(5):893-8. doi: 10.2105/AJPH.2015.303038. Epub 2016 Mar 17.


Can transcutaneous carbon dioxide pressure be a surrogate of blood gas samples for spontaneously breathing emergency patients? The ERNESTO experience.

Peschanski N, Garcia L, Delasalle E, Mzabi L, Rouff E, Dautheville S, Renai F, Kieffer Y, Lefevre G, Freund Y, Ray P.

Emerg Med J. 2016 May;33(5):325-8. doi: 10.1136/emermed-2015-205203. Epub 2015 Dec 30.


PERC rule to exclude the diagnosis of pulmonary embolism in emergency low-risk patients: study protocol for the PROPER randomized controlled study.

Freund Y, Rousseau A, Guyot-Rousseau F, Claessens YE, Hugli O, Sanchez O, Simon T, Riou B.

Trials. 2015 Nov 25;16:537. doi: 10.1186/s13063-015-1049-7.


[Autoimmune hepatitis triggered by nitrofurantoin: A rare drug-induced toxicity].

Sorin B, Pineton de Chambrun M, Haroche J, Freund Y, Miyara M, Charlotte F, Lebrun-Vignes B, Amoura Z, Cohen Aubart F.

Rev Med Interne. 2016 Feb;37(2):131-4. doi: 10.1016/j.revmed.2015.07.003. Epub 2015 Sep 26. French.


Personality, preterm labor contractions, and psychological consequences.

Handelzalts JE, Krissi H, Levy S, Freund Y, Carmiel N, Ashwal E, Peled Y.

Arch Gynecol Obstet. 2016 Mar;293(3):575-82. doi: 10.1007/s00404-015-3898-4. Epub 2015 Sep 24.


Cross-checking to reduce adverse events resulting from medical errors in the emergency department: study protocol of the CHARMED cluster randomized study.

Freund Y, Rousseau A, Berard L, Goulet H, Ray P, Bloom B, Simon T, Riou B.

BMC Emerg Med. 2015 Sep 4;15:21. doi: 10.1186/s12873-015-0046-1.

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