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HFD refeeding in mice after fasting impairs learning by activating caspase-1 in the brain.

Towers AE, Oelschlager ML, Juda MB, Jain S, Gainey SJ, Freund GG.

Metabolism. 2020 Jan;102:153989. doi: 10.1016/j.metabol.2019.153989. Epub 2019 Nov 5.


Nutritional psychoneuroimmunology: Is the inflammasome a critical convergence point for stress and nutritional dysregulation?

Towers AE, Freund GG.

Curr Opin Behav Sci. 2019 Aug;28:20-24. doi: 10.1016/j.cobeha.2019.01.014. Epub 2019 Feb 23.


Handling stress impairs learning through a mechanism involving caspase-1 activation and adenosine signaling.

Towers AE, Oelschlager ML, Lorenz M, Gainey SJ, McCusker RH, Krauklis SA, Freund GG.

Brain Behav Immun. 2019 Aug;80:763-776. doi: 10.1016/j.bbi.2019.05.025. Epub 2019 May 17.


Indoleamine 2,3-dioxygenase 1 deletion promotes Theiler's virus-induced seizures in C57BL/6J mice.

Juda MB, Brooks AK, Towers AE, Freund GG, McCusker RH, Steelman AJ.

Epilepsia. 2019 Apr;60(4):626-635. doi: 10.1111/epi.14675. Epub 2019 Feb 15.


Exposure to a firefighting overhaul environment without respiratory protection increases immune dysregulation and lung disease risk.

Gainey SJ, Horn GP, Towers AE, Oelschlager ML, Tir VL, Drnevich J, Fent KW, Kerber S, Smith DL, Freund GG.

PLoS One. 2018 Aug 21;13(8):e0201830. doi: 10.1371/journal.pone.0201830. eCollection 2018.


Switching from a high-fat cellulose diet to a high-fat pectin diet reverses certain obesity-related morbidities.

Bray JK, Chiu GS, McNeil LK, Moon ML, Wall R, Towers AE, Freund GG.

Nutr Metab (Lond). 2018 Aug 6;15:55. doi: 10.1186/s12986-018-0294-7. eCollection 2018.


Mouse Testing Methods in Psychoneuroimmunology 2.0: Measuring Behavioral Responses.

Towers AE, York JM, Baynard T, Gainey SJ, Freund GG.

Methods Mol Biol. 2018;1781:221-258. doi: 10.1007/978-1-4939-7828-1_13. Review.


Glial and tissue-specific regulation of Kynurenine Pathway dioxygenases by acute stress of mice.

Dostal CR, Carson Sulzer M, Kelley KW, Freund GG, McCusker RH.

Neurobiol Stress. 2017 Feb 12;7:1-15. doi: 10.1016/j.ynstr.2017.02.002. eCollection 2017 Dec.


Influenza infection triggers disease in a genetic model of experimental autoimmune encephalomyelitis.

Blackmore S, Hernandez J, Juda M, Ryder E, Freund GG, Johnson RW, Steelman AJ.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6107-E6116. doi: 10.1073/pnas.1620415114. Epub 2017 Jul 10.


Acute fasting inhibits central caspase-1 activity reducing anxiety-like behavior and increasing novel object and object location recognition.

Towers AE, Oelschlager ML, Patel J, Gainey SJ, McCusker RH, Freund GG.

Metabolism. 2017 Jun;71:70-82. doi: 10.1016/j.metabol.2017.03.005. Epub 2017 Mar 9.


Short-Term High-Fat Diet (HFD) Induced Anxiety-Like Behaviors and Cognitive Impairment Are Improved with Treatment by Glyburide.

Gainey SJ, Kwakwa KA, Bray JK, Pillote MM, Tir VL, Towers AE, Freund GG.

Front Behav Neurosci. 2016 Aug 11;10:156. doi: 10.3389/fnbeh.2016.00156. eCollection 2016.


IL-4 Knock Out Mice Display Anxiety-Like Behavior.

Moon ML, Joesting JJ, Blevins NA, Lawson MA, Gainey SJ, Towers AE, McNeil LK, Freund GG.

Behav Genet. 2015 Jul;45(4):451-60. doi: 10.1007/s10519-015-9714-x. Epub 2015 Mar 14.


Modulation of neuroimmunity by adenosine and its receptors: metabolism to mental illness.

Chiu GS, Freund GG.

Metabolism. 2014 Dec;63(12):1491-8. doi: 10.1016/j.metabol.2014.09.003. Epub 2014 Sep 26. Review.


Effect of obesity on acute hemostatic responses to live-fire training drills.

Smith DL, Horn GP, Petruzzello SJ, Freund GG, Woods JA, Cook MD, Goldstein E, Fernhall B.

Am J Cardiol. 2014 Dec 1;114(11):1768-71. doi: 10.1016/j.amjcard.2014.08.046. Epub 2014 Sep 16.


Fasting Induces IL-1 Resistance and Free-Fatty Acid-Mediated Up-Regulation of IL-1R2 and IL-1RA.

Joesting JJ, Moon ML, Gainey SJ, Tisza BL, Blevins NA, Freund GG.

Front Immunol. 2014 Jul 9;5:315. doi: 10.3389/fimmu.2014.00315. eCollection 2014.


The saturated fatty acid, palmitic acid, induces anxiety-like behavior in mice.

Moon ML, Joesting JJ, Lawson MA, Chiu GS, Blevins NA, Kwakwa KA, Freund GG.

Metabolism. 2014 Sep;63(9):1131-40. doi: 10.1016/j.metabol.2014.06.002. Epub 2014 Jun 9.


Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety.

Chiu GS, Darmody PT, Walsh JP, Moon ML, Kwakwa KA, Bray JK, McCusker RH, Freund GG.

Brain Behav Immun. 2014 Oct;41:218-31. doi: 10.1016/j.bbi.2014.05.018. Epub 2014 Jun 4.


Mouse short- and long-term locomotor activity analyzed by video tracking software.

York JM, Blevins NA, McNeil LK, Freund GG.

J Vis Exp. 2013 Jun 20;(76). doi: 10.3791/50252.


Methylphenidate prevents high-fat diet (HFD)-induced learning/memory impairment in juvenile mice.

Kaczmarczyk MM, Machaj AS, Chiu GS, Lawson MA, Gainey SJ, York JM, Meling DD, Martin SA, Kwakwa KA, Newman AF, Woods JA, Kelley KW, Wang Y, Miller MJ, Freund GG.

Psychoneuroendocrinology. 2013 Sep;38(9):1553-64. doi: 10.1016/j.psyneuen.2013.01.004. Epub 2013 Feb 11.


Central inhibition of interleukin-6 trans-signaling during peripheral infection reduced neuroinflammation and sickness in aged mice.

Burton MD, Rytych JL, Freund GG, Johnson RW.

Brain Behav Immun. 2013 May;30:66-72. doi: 10.1016/j.bbi.2013.01.002. Epub 2013 Jan 23.


IL-1 receptor 2 (IL-1R2) and its role in immune regulation.

Peters VA, Joesting JJ, Freund GG.

Brain Behav Immun. 2013 Aug;32:1-8. doi: 10.1016/j.bbi.2012.11.006. Epub 2012 Nov 27. Review.


Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Chiu GS, Chatterjee D, Darmody PT, Walsh JP, Meling DD, Johnson RW, Freund GG.

J Neurosci. 2012 Oct 3;32(40):13945-55. doi: 10.1523/JNEUROSCI.0704-12.2012.


Development of a Lactobacillus specific T-RFLP method to determine lactobacilli diversity in complex samples.

Chen L, Teasdale MT, Kaczmarczyk MM, Freund GG, Miller MJ.

J Microbiol Methods. 2012 Nov;91(2):262-8. doi: 10.1016/j.mimet.2012.08.005. Epub 2012 Aug 17.


Mouse testing methods in psychoneuroimmunology: an overview of how to measure sickness, depressive/anxietal, cognitive, and physical activity behaviors.

York JM, Blevins NA, Baynard T, Freund GG.

Methods Mol Biol. 2012;934:243-76. doi: 10.1007/978-1-62703-071-7_13. Review.


Individually ventilated cages cause chronic low-grade hypoxia impacting mice hematologically and behaviorally.

York JM, McDaniel AW, Blevins NA, Guillet RR, Allison SO, Cengel KA, Freund GG.

Brain Behav Immun. 2012 Aug;26(6):951-8. doi: 10.1016/j.bbi.2012.04.008. Epub 2012 May 3.


The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer.

Kaczmarczyk MM, Miller MJ, Freund GG.

Metabolism. 2012 Aug;61(8):1058-66. doi: 10.1016/j.metabol.2012.01.017. Epub 2012 Mar 7. Review.


The biobehavioral and neuroimmune impact of low-dose ionizing radiation.

York JM, Blevins NA, Meling DD, Peterlin MB, Gridley DS, Cengel KA, Freund GG.

Brain Behav Immun. 2012 Feb;26(2):218-27. doi: 10.1016/j.bbi.2011.09.006. Epub 2011 Sep 21.


Macrophages make me sick: how macrophage activation states influence sickness behavior.

Moon ML, McNeil LK, Freund GG.

Psychoneuroendocrinology. 2011 Nov;36(10):1431-40. doi: 10.1016/j.psyneuen.2011.07.002. Epub 2011 Aug 19. Review.


Acute hypoglycemia causes depressive-like behaviors in mice.

Park MJ, Yoo SW, Choe BS, Dantzer R, Freund GG.

Metabolism. 2012 Feb;61(2):229-36. doi: 10.1016/j.metabol.2011.06.013. Epub 2011 Aug 4.


Fasting induces an anti-inflammatory effect on the neuroimmune system which a high-fat diet prevents.

Lavin DN, Joesting JJ, Chiu GS, Moon ML, Meng J, Dilger RN, Freund GG.

Obesity (Silver Spring). 2011 Aug;19(8):1586-94. doi: 10.1038/oby.2011.73. Epub 2011 Apr 28.


Effect of live-fire training drills on firefighters' platelet number and function.

Smith DL, Petruzzello SJ, Goldstein E, Ahmad U, Tangella K, Freund GG, Horn GP.

Prehosp Emerg Care. 2011 Apr-Jun;15(2):233-9. doi: 10.3109/10903127.2010.545477.


Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization.

Sherry CL, Kim SS, Dilger RN, Bauer LL, Moon ML, Tapping RI, Fahey GC Jr, Tappenden KA, Freund GG.

Brain Behav Immun. 2010 May;24(4):631-40. doi: 10.1016/j.bbi.2010.01.015. Epub 2010 Feb 6.


Market survey predictions on the future of US Pap testing.

Austin RM, Benstein B, Bentz J, Bigner S, Freund GG, Rocco GL, Ramzy I, Savaloja L, Shidham VB.

Cytojournal. 2009 Sep 18;6:17. doi: 10.4103/1742-6413.55885. No abstract available.


Collection of the BD SurePath Pap Test with a broom device plus endocervical brush improves disease detection when compared to the broom device alone or the spatula plus endocervical brush combination.

Davis-Devine S, Day SJ, Anderson A, French A, Madison-Henness D, Mohar N, Tansy D, Hiremath A, Douglas JA, Freund GG.

Cytojournal. 2008 Feb 12;6:4. doi: 10.4103/1742-6413.45495.


Psychoneuroimmune implications of type 2 diabetes: redux.

O'Connor JC, Johnson DR, Freund GG.

Immunol Allergy Clin North Am. 2009 May;29(2):339-58. doi: 10.1016/j.iac.2009.02.004.


Psychoneuroimmunology. Preface.

Freund GG.

Immunol Allergy Clin North Am. 2009 May;29(2):xv-xvi. doi: 10.1016/j.iac.2009.03.001. No abstract available.


Accelerated recovery from acute hypoxia in obese mice is due to obesity-associated up-regulation of interleukin-1 receptor antagonist.

Sherry CL, Kim SS, Freund GG.

Endocrinology. 2009 Jun;150(6):2660-7. doi: 10.1210/en.2008-1622. Epub 2009 Feb 12.


Behavioral recovery from acute hypoxia is reliant on leptin.

Sherry CL, Kramer JM, York JM, Freund GG.

Brain Behav Immun. 2009 Feb;23(2):169-75. doi: 10.1016/j.bbi.2008.09.011. Epub 2008 Sep 27.


Blocking of beta-2 adrenergic receptors hastens recovery from hypoglycemia-associated social withdrawal.

Park MJ, Guest CB, Barnes MB, Martin J, Ahmad U, York JM, Freund GG.

Psychoneuroendocrinology. 2008 Nov;33(10):1411-8. doi: 10.1016/j.psyneuen.2008.08.005. Epub 2008 Sep 23.


Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.

Guest CB, Chakour KS, Freund GG.

BMC Immunol. 2008 Jul 30;9:42. doi: 10.1186/1471-2172-9-42.


The implication of proinflammatory cytokines in type 2 diabetes.

Guest CB, Park MJ, Johnson DR, Freund GG.

Front Biosci. 2008 May 1;13:5187-94. Review.


Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.

Guest CB, Deszo EL, Hartman ME, York JM, Kelley KW, Freund GG.

PLoS One. 2008 Feb 13;3(2):e1606. doi: 10.1371/journal.pone.0001606.


From inflammation to sickness and depression: when the immune system subjugates the brain.

Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW.

Nat Rev Neurosci. 2008 Jan;9(1):46-56. Review.


Acute hypoxia, diabetes, and neuroimmune dysregulation: converging mechanisms in the brain.

Johnson DR, Sherry CL, York JM, Freund GG.

Neuroscientist. 2008 Jun;14(3):235-9. Epub 2007 Nov 13. Review.


Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system.

Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW.

Brain Behav Immun. 2008 Mar;22(3):301-11. Epub 2007 Oct 24.


Detection of Chlamydia trachomatis and Neisseria gonorrhoeae infections in North American women by testing SurePath liquid-based Pap specimens in APTIMA assays.

Chernesky M, Freund GG, Hook E 3rd, Leone P, D'Ascoli P, Martens M.

J Clin Microbiol. 2007 Aug;45(8):2434-8. Epub 2007 Jun 20.


Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts.

Strle K, McCusker RH, Tran L, King A, Johnson RW, Freund GG, Dantzer R, Kelley KW.

J Neuroimmunol. 2007 Aug;188(1-2):48-55. Epub 2007 Jun 18.


Phagocytosis of cholesteryl ester is amplified in diabetic mouse macrophages and is largely mediated by CD36 and SR-A.

Guest CB, Hartman ME, O'Connor JC, Chakour KS, Sovari AA, Freund GG.

PLoS One. 2007 Jun 6;2(6):e511.


LPS-dependent suppression of social exploration is augmented in type 1 diabetic mice.

Lin KI, Johnson DR, Freund GG.

Brain Behav Immun. 2007 Aug;21(6):775-82. Epub 2007 Feb 23.


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