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Items: 1 to 50 of 187

1.

Generation of genetically matched hiPSC lines from two mosaic facioscapulohumeral dystrophy type 1 patients.

van der Wal E, den Hamer B, van der Vliet PJ, Tok M, Brands T, Eussen B, Lemmers RJLF, Freund C, de Klein A, Buijsen RAM, van Roon-Mom WMC, Tawil R, van der Maarel SM, de Greef JC.

Stem Cell Res. 2019 Oct;40:101560. doi: 10.1016/j.scr.2019.101560. Epub 2019 Aug 28.

2.

Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations.

Rödel CJ, Otten C, Donat S, Lourenco M, Fischer D, Kuropka B, Paolini A, Freund C, Abdelilah-Seyfried S.

Circ Res. 2019 Sep 9. doi: 10.1161/CIRCRESAHA.119.315076. [Epub ahead of print]

PMID:
31495257
3.

Generation of 5 induced pluripotent stem cell lines, LUMCi007-A and B and LUMCi008-A, B and C, from 2 patients with Huntington disease.

van der Graaf LM, Gardiner SL, Tok M, Brands T, Boogaard MW, Pepers BA, Eussen B, de Klein A, Aziz NA, Freund C, Buijsen RAM, van Roon-Mom WMC.

Stem Cell Res. 2019 Aug;39:101498. doi: 10.1016/j.scr.2019.101498. Epub 2019 Jul 12.

4.

Exon Inclusion Modulates Conformational Plasticity and Autoinhibition of the Intersectin 1 SH3A Domain.

Gerth F, Jäpel M, Sticht J, Kuropka B, Schmitt XJ, Driller JH, Loll B, Wahl MC, Pagel K, Haucke V, Freund C.

Structure. 2019 Jun 4;27(6):977-987.e5. doi: 10.1016/j.str.2019.03.020. Epub 2019 Apr 25.

PMID:
31031201
5.

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5.

Quinn PM, Buck TM, Mulder AA, Ohonin C, Alves CH, Vos RM, Bialecka M, van Herwaarden T, van Dijk EHC, Talib M, Freund C, Mikkers HMM, Hoeben RC, Goumans MJ, Boon CJF, Koster AJ, Chuva de Sousa Lopes SM, Jost CR, Wijnholds J.

Stem Cell Reports. 2019 May 14;12(5):906-919. doi: 10.1016/j.stemcr.2019.03.002. Epub 2019 Apr 4.

6.

Intramolecular domain dynamics regulate synaptic MAGUK protein interactions.

Rademacher N, Kuropka B, Kunde SA, Wahl MC, Freund C, Shoichet SA.

Elife. 2019 Mar 13;8. pii: e41299. doi: 10.7554/eLife.41299.

7.

Phosphorylation of the Bruchpilot N-terminus in Drosophila unlocks axonal transport of active zone building blocks.

Driller JH, Lützkendorf J, Depner H, Siebert M, Kuropka B, Weise C, Piao C, Petzoldt AG, Lehmann M, Stelzl U, Zahedi R, Sickmann A, Freund C, Sigrist SJ, Wahl MC.

J Cell Sci. 2019 Mar 18;132(6). pii: jcs225151. doi: 10.1242/jcs.225151.

8.

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells.

Kroczek AL, Hartung E, Gurka S, Becker M, Reeg N, Mages HW, Voigt S, Freund C, Kroczek RA.

Front Immunol. 2018 Dec 13;9:2806. doi: 10.3389/fimmu.2018.02806. eCollection 2018.

9.

Generation of 3 human induced pluripotent stem cell lines LUMCi005-A, B and C from a Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch type patient.

Daoutsali E, Buijsen RAM, van de Pas S, Jong A', Mikkers H, Brands T, Eussen B, de Klein A, van der Graaf LM, Pepers BA, Freund C, Terwindt GM, Orlova VV, van Roon-Mom WMC.

Stem Cell Res. 2019 Jan;34:101359. doi: 10.1016/j.scr.2018.101359. Epub 2018 Dec 14.

10.

Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.

Waldt N, Seifert A, Demiray YE, Devroe E, Turk BE, Reichardt P, Mix C, Reinhold A, Freund C, Müller AJ, Schraven B, Stork O, Kliche S.

Front Immunol. 2018 Dec 4;9:2852. doi: 10.3389/fimmu.2018.02852. eCollection 2018.

11.

FBP21's C-Terminal Domain Remains Dynamic When Wrapped around the c-Sec63 Unit of Brr2 Helicase.

Sticht J, Bertazzon M, Henning LM, Licha JR, Abualrous ET, Freund C.

Biophys J. 2019 Feb 5;116(3):406-418. doi: 10.1016/j.bpj.2018.11.3123. Epub 2018 Nov 29.

PMID:
30558886
12.

Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation.

Álvaro-Benito M, Morrison E, Ebner F, Abualrous ET, Urbicht M, Wieczorek M, Freund C.

Cell Mol Immunol. 2018 Nov 22. doi: 10.1038/s41423-018-0181-1. [Epub ahead of print]

PMID:
30467419
13.

The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells.

Werno MW, Wilhelmi I, Kuropka B, Ebert F, Freund C, Schürmann A.

Biochem Biophys Res Commun. 2018 Nov 17;506(1):259-265. doi: 10.1016/j.bbrc.2018.10.092. Epub 2018 Oct 19.

14.

Understanding the elusive protein corona of thermoresponsive nanogels.

Miceli E, Kuropka B, Rosenauer C, Osorio Blanco ER, Theune LE, Kar M, Weise C, Morsbach S, Freund C, Calderón M.

Nanomedicine (Lond). 2018 Oct;13(20):2657-2668. doi: 10.2217/nnm-2018-0217. Epub 2018 Oct 18.

PMID:
30334470
15.

Quantification of HLA-DM-Dependent Major Histocompatibility Complex of Class II Immunopeptidomes by the Peptide Landscape Antigenic Epitope Alignment Utility.

Álvaro-Benito M, Morrison E, Abualrous ET, Kuropka B, Freund C.

Front Immunol. 2018 May 3;9:872. doi: 10.3389/fimmu.2018.00872. eCollection 2018.

16.

Dispatch from the field II: the mystery of the red and blue Opadometa male (Araneae, Tetragnathidae, Opadometa sarawakensis).

Miller JA, Freund C, Rambonnet L, Koets L, Barth N, van der Linden C, Geml J, Schilthuizen M, Burger R, Goossens B.

Biodivers Data J. 2018 Apr 3;(6):e24777. doi: 10.3897/BDJ.6.e24777. eCollection 2018.

17.

Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Halaidych OV, Freund C, van den Hil F, Salvatori DCF, Riminucci M, Mummery CL, Orlova VV.

Stem Cell Reports. 2018 May 8;10(5):1642-1656. doi: 10.1016/j.stemcr.2018.03.012. Epub 2018 Apr 12.

18.

Generation of 3 spinocerebellar ataxia type 1 (SCA1) patient-derived induced pluripotent stem cell lines LUMCi002-A, B, and C and 2 unaffected sibling control induced pluripotent stem cell lines LUMCi003-A and B.

Buijsen RAM, Gardiner SL, Bouma MJ, van der Graaf LM, Boogaard MW, Pepers BA, Eussen B, de Klein A, Freund C, van Roon-Mom WMC.

Stem Cell Res. 2018 May;29:125-128. doi: 10.1016/j.scr.2018.03.018. Epub 2018 Apr 5.

19.

Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F.

Nat Commun. 2018 Mar 9;9(1):1073. doi: 10.1038/s41467-018-03452-0.

20.

Intrinsically Disordered Protein Ntr2 Modulates the Spliceosomal RNA Helicase Brr2.

Wollenhaupt J, Henning LM, Sticht J, Becke C, Freund C, Santos KF, Wahl MC.

Biophys J. 2018 Feb 27;114(4):788-799. doi: 10.1016/j.bpj.2017.12.033.

21.

Stent-Assisted Coil Embolization of 2 Complex Juxtarenal Penetrating Aortic Ulcers: An Unconventional Solution.

Frech A, Gorny O, Fraedrich G, Jaschke W, Klocker J, Freund CM.

J Vasc Interv Radiol. 2018 Jan;29(1):132-133. doi: 10.1016/j.jvir.2017.07.030. No abstract available.

PMID:
29258654
22.

A Coincidence Detection Mechanism Controls PX-BAR Domain-Mediated Endocytic Membrane Remodeling via an Allosteric Structural Switch.

Lo WT, Vujičić Žagar A, Gerth F, Lehmann M, Puchkov D, Krylova O, Freund C, Scapozza L, Vadas O, Haucke V.

Dev Cell. 2017 Nov 20;43(4):522-529.e4. doi: 10.1016/j.devcel.2017.10.019.

23.

Intersectin associates with synapsin and regulates its nanoscale localization and function.

Gerth F, Jäpel M, Pechstein A, Kochlamazashvili G, Lehmann M, Puchkov D, Onofri F, Benfenati F, Nikonenko AG, Fredrich K, Shupliakov O, Maritzen T, Freund C, Haucke V.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12057-12062. doi: 10.1073/pnas.1715341114. Epub 2017 Oct 23. Erratum in: Proc Natl Acad Sci U S A. 2017 Dec 11;:.

24.

Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F.

Nat Commun. 2017 Oct 23;8(1):1095. doi: 10.1038/s41467-017-01163-6. Erratum in: Nat Commun. 2018 Mar 9;9(1):1073.

25.

A new role for FBP21 as regulator of Brr2 helicase activity.

Henning LM, Santos KF, Sticht J, Jehle S, Lee CT, Wittwer M, Urlaub H, Stelzl U, Wahl MC, Freund C.

Nucleic Acids Res. 2017 Jul 27;45(13):7922-7937. doi: 10.1093/nar/gkx535.

26.

Key steps in unconventional secretion of fibroblast growth factor 2 reconstituted with purified components.

Steringer JP, Lange S, Čujová S, Šachl R, Poojari C, Lolicato F, Beutel O, Müller HM, Unger S, Coskun Ü, Honigmann A, Vattulainen I, Hof M, Freund C, Nickel W.

Elife. 2017 Jul 19;6. pii: e28985. doi: 10.7554/eLife.28985.

27.

The Guanine-Nucleotide Exchange Factor Caldag Gefi Fine-Tunes Functional Properties of Regulatory T Cells.

Niemz J, Kliche S, Pils MC, Morrison E, Manns A, Freund C, Crittenden JR, Graybiel AM, Galla M, Jänsch L, Huehn J.

Eur J Microbiol Immunol (Bp). 2017 May 22;7(2):112-126. doi: 10.1556/1886.2017.00007. eCollection 2017 Jun.

28.

Identification of sortase substrates by specificity profiling.

Schmohl L, Bierlmeier J, von Kügelgen N, Kurz L, Reis P, Barthels F, Mach P, Schutkowski M, Freund C, Schwarzer D.

Bioorg Med Chem. 2017 Sep 15;25(18):5002-5007. doi: 10.1016/j.bmc.2017.06.033. Epub 2017 Jun 22.

PMID:
28684010
29.

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.

Bouma MJ, van Iterson M, Janssen B, Mummery CL, Salvatori DCF, Freund C.

Stem Cell Reports. 2017 May 9;8(5):1340-1353. doi: 10.1016/j.stemcr.2017.03.009.

30.

Vitamin A deficiency in chronic cholestatic liver disease: Is vitamin A therapy beneficial?

Freund C, Gotthardt DN.

Liver Int. 2017 Dec;37(12):1752-1758. doi: 10.1111/liv.13433. Epub 2017 Jul 29. Review.

PMID:
28371374
31.

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.

Wieczorek M, Abualrous ET, Sticht J, Álvaro-Benito M, Stolzenberg S, Noé F, Freund C.

Front Immunol. 2017 Mar 17;8:292. doi: 10.3389/fimmu.2017.00292. eCollection 2017. Review.

32.

The differentiation and plasticity of Tc17 cells are regulated by CTLA-4-mediated effects on STATs.

Arra A, Lingel H, Kuropka B, Pick J, Schnoeder T, Fischer T, Freund C, Pierau M, Brunner-Weinzierl MC.

Oncoimmunology. 2017 Jan 20;6(2):e1273300. doi: 10.1080/2162402X.2016.1273300. eCollection 2017.

33.

Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease.

Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL.

J Nucl Med. 2017 Jun;58(6):1003-1008. doi: 10.2967/jnumed.116.186007. Epub 2017 Feb 16.

34.

Engineering sortase A by screening a second-generation library using phage display.

Schmohl L, Bierlmeier J, Gerth F, Freund C, Schwarzer D.

J Pept Sci. 2017 Jul;23(7-8):631-635. doi: 10.1002/psc.2980. Epub 2017 Feb 10.

PMID:
28185387
35.

D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00509-16. doi: 10.1128/MCB.00509-16. Print 2017 Apr 1.

36.

Ten years of orangutan-related wildlife crime investigation in West Kalimantan, Indonesia.

Freund C, Rahman E, Knott C.

Am J Primatol. 2017 Nov;79(11). doi: 10.1002/ajp.22620. Epub 2016 Dec 13.

PMID:
27960033
37.

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.

Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD, Bhuiyan ZA, Passier R.

EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. doi: 10.15252/emmm.201505719. Print 2016 Dec.

38.

MHC class II complexes sample intermediate states along the peptide exchange pathway.

Wieczorek M, Sticht J, Stolzenberg S, Günther S, Wehmeyer C, El Habre Z, Álvaro-Benito M, Noé F, Freund C.

Nat Commun. 2016 Nov 9;7:13224. doi: 10.1038/ncomms13224.

39.

Human leukocyte Antigen-DM polymorphisms in autoimmune diseases.

Alvaro-Benito M, Morrison E, Wieczorek M, Sticht J, Freund C.

Open Biol. 2016 Aug;6(8). pii: 160165. doi: 10.1098/rsob.160165. Review.

40.

Tyrosine-phosphorylation of the scaffold protein ADAP and its role in T cell signaling.

Kuropka B, Schraven B, Kliche S, Krause E, Freund C.

Expert Rev Proteomics. 2016 Jun;13(6):545-54. doi: 10.1080/14789450.2016.1187565. Review.

PMID:
27258783
41.

An assessment of adherence to basic ecological principles by payments for ecosystem service projects.

Prager CM, Varga A, Olmsted P, Ingram JC, Cattau M, Freund C, Wynn-Grant R, Naeem S.

Conserv Biol. 2016 Aug;30(4):836-45. doi: 10.1111/cobi.12648. Epub 2016 Feb 22.

PMID:
26502915
42.

Analysis of Phosphorylation-dependent Protein Interactions of Adhesion and Degranulation Promoting Adaptor Protein (ADAP) Reveals Novel Interaction Partners Required for Chemokine-directed T cell Migration.

Kuropka B, Witte A, Sticht J, Waldt N, Majkut P, Hackenberger CP, Schraven B, Krause E, Kliche S, Freund C.

Mol Cell Proteomics. 2015 Nov;14(11):2961-72. doi: 10.1074/mcp.M115.048249. Epub 2015 Aug 5.

43.

Peptide-polymer ligands for a tandem WW-domain, an adaptive multivalent protein-protein interaction: lessons on the thermodynamic fitness of flexible ligands.

Koschek K, Durmaz V, Krylova O, Wieczorek M, Gupta S, Richter M, Bujotzek A, Fischer C, Haag R, Freund C, Weber M, Rademann J.

Beilstein J Org Chem. 2015 May 18;11:837-47. doi: 10.3762/bjoc.11.93. eCollection 2015.

44.

Exploring monovalent and multivalent peptides for the inhibition of FBP21-tWW.

Henning LM, Bhatia S, Bertazzon M, Marczynke M, Seitz O, Volkmer R, Haag R, Freund C.

Beilstein J Org Chem. 2015 May 11;11:701-706. doi: 10.3762/bjoc.11.80. eCollection 2015.

45.

Quantitative analysis of the human T cell palmitome.

Morrison E, Kuropka B, Kliche S, Brügger B, Krause E, Freund C.

Sci Rep. 2015 Jun 26;5:11598. doi: 10.1038/srep11598.

46.

The GYF domain protein CD2BP2 is critical for embryogenesis and podocyte function.

Albert GI, Schell C, Kirschner KM, Schäfer S, Naumann R, Müller A, Kretz O, Kuropka B, Girbig M, Hübner N, Krause E, Scholz H, Huber TB, Knobeloch KP, Freund C.

J Mol Cell Biol. 2015 Oct;7(5):402-14. doi: 10.1093/jmcb/mjv039. Epub 2015 Jun 16.

PMID:
26082520
47.

A modular toolkit to inhibit proline-rich motif-mediated protein-protein interactions.

Opitz R, Müller M, Reuter C, Barone M, Soicke A, Roske Y, Piotukh K, Huy P, Beerbaum M, Wiesner B, Beyermann M, Schmieder P, Freund C, Volkmer R, Oschkinat H, Schmalz HG, Kühne R.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5011-6. doi: 10.1073/pnas.1422054112. Epub 2015 Apr 6.

48.

Environment and Development. Get the science right when paying for nature's services.

Naeem S, Ingram JC, Varga A, Agardy T, Barten P, Bennett G, Bloomgarden E, Bremer LL, Burkill P, Cattau M, Ching C, Colby M, Cook DC, Costanza R, DeClerck F, Freund C, Gartner T, Goldman-Benner R, Gunderson J, Jarrett D, Kinzig AP, Kiss A, Koontz A, Kumar P, Lasky JR, Masozera M, Meyers D, Milano F, Naughton-Treves L, Nichols E, Olander L, Olmsted P, Perge E, Perrings C, Polasky S, Potent J, Prager C, Quétier F, Redford K, Saterson K, Thoumi G, Vargas MT, Vickerman S, Weisser W, Wilkie D, Wunder S.

Science. 2015 Mar 13;347(6227):1206-7. doi: 10.1126/science.aaa1403. Epub 2015 Mar 12. No abstract available.

PMID:
25766222
49.

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI).

Andrews PW, Baker D, Benvinisty N, Miranda B, Bruce K, Brüstle O, Choi M, Choi YM, Crook JM, de Sousa PA, Dvorak P, Freund C, Firpo M, Furue MK, Gokhale P, Ha HY, Han E, Haupt S, Healy L, Hei DJ, Hovatta O, Hunt C, Hwang SM, Inamdar MS, Isasi RM, Jaconi M, Jekerle V, Kamthorn P, Kibbey MC, Knezevic I, Knowles BB, Koo SK, Laabi Y, Leopoldo L, Liu P, Lomax GP, Loring JF, Ludwig TE, Montgomery K, Mummery C, Nagy A, Nakamura Y, Nakatsuji N, Oh S, Oh SK, Otonkoski T, Pera M, Peschanski M, Pranke P, Rajala KM, Rao M, Ruttachuk R, Reubinoff B, Ricco L, Rooke H, Sipp D, Stacey GN, Suemori H, Takahashi TA, Takada K, Talib S, Tannenbaum S, Yuan BZ, Zeng F, Zhou Q.

Regen Med. 2015;10(2 Suppl):1-44. doi: 10.2217/rme.14.93. No abstract available.

PMID:
25675265
50.

Vesicle uncoating regulated by SH3-SH3 domain-mediated complex formation between endophilin and intersectin at synapses.

Pechstein A, Gerth F, Milosevic I, Jäpel M, Eichhorn-Grünig M, Vorontsova O, Bacetic J, Maritzen T, Shupliakov O, Freund C, Haucke V.

EMBO Rep. 2015 Feb;16(2):232-9. doi: 10.15252/embr.201439260. Epub 2014 Dec 17.

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