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Items: 34

1.

Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.

Akakpo JY, Ramachandran A, Duan L, Schaich MA, Jaeschke MW, Freudenthal BD, Ding WX, Rumack BH, Jaeschke H.

Toxicol Sci. 2019 Jul 1;170(1):57-68. doi: 10.1093/toxsci/kfz077.

PMID:
30903181
2.

A guardian residue hinders insertion of a Fapy•dGTP analog by modulating the open-closed DNA polymerase transition.

Smith MR, Shock DD, Beard WA, Greenberg MM, Freudenthal BD, Wilson SH.

Nucleic Acids Res. 2019 Apr 8;47(6):3197-3207. doi: 10.1093/nar/gkz002.

3.

APE1: A skilled nucleic acid surgeon.

Whitaker AM, Freudenthal BD.

DNA Repair (Amst). 2018 Nov;71:93-100. doi: 10.1016/j.dnarep.2018.08.012. Epub 2018 Aug 23. Review.

4.

Apurinic/apyrimidinic (AP) endonuclease 1 processing of AP sites with 5' mismatches.

Fairlamb MS, Whitaker AM, Freudenthal BD.

Acta Crystallogr D Struct Biol. 2018 Aug 1;74(Pt 8):760-768. doi: 10.1107/S2059798318003340. Epub 2018 Jul 24.

5.

Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.

Whitaker AM, Flynn TS, Freudenthal BD.

Nat Commun. 2018 Jan 26;9(1):399. doi: 10.1038/s41467-017-02175-y.

6.

Specific mutations in the D1-D2 linker region of VCP/p97 enhance ATPase activity and confer resistance to VCP inhibitors.

Bastola P, Wang F, Schaich MA, Gan T, Freudenthal BD, Chou TF, Chien J.

Cell Death Discov. 2017 Nov 6;3:17065. doi: 10.1038/cddiscovery.2017.65. eCollection 2017.

7.

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1.

Liu L, Kong M, Gassman NR, Freudenthal BD, Prasad R, Zhen S, Watkins SC, Wilson SH, Van Houten B.

Nucleic Acids Res. 2017 Dec 15;45(22):12834-12847. doi: 10.1093/nar/gkx1047.

8.

Structures of a DNA Polymerase Inserting Therapeutic Nucleotide Analogues.

Schaich MA, Smith MR, Cloud AS, Holloran SM, Freudenthal BD.

Chem Res Toxicol. 2017 Nov 20;30(11):1993-2001. doi: 10.1021/acs.chemrestox.7b00173. Epub 2017 Sep 1.

9.

Modulating the DNA polymerase β reaction equilibrium to dissect the reverse reaction.

Shock DD, Freudenthal BD, Beard WA, Wilson SH.

Nat Chem Biol. 2017 Oct;13(10):1074-1080. doi: 10.1038/nchembio.2450. Epub 2017 Jul 31.

10.

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops.

Liu J, Ede C, Wright WD, Gore SK, Jenkins SS, Freudenthal BD, Todd Washington M, Veaute X, Heyer WD.

Elife. 2017 May 23;6. pii: e22195. doi: 10.7554/eLife.22195.

11.

Capturing a mammalian DNA polymerase extending from an oxidized nucleotide.

Whitaker AM, Smith MR, Schaich MA, Freudenthal BD.

Nucleic Acids Res. 2017 Jun 20;45(11):6934-6944. doi: 10.1093/nar/gkx293.

12.

Base excision repair of oxidative DNA damage: from mechanism to disease.

Whitaker AM, Schaich MA, Smith MR, Flynn TS, Freudenthal BD.

Front Biosci (Landmark Ed). 2017 Mar 1;22:1493-1522. Review.

13.

Revealing the role of the product metal in DNA polymerase β catalysis.

Perera L, Freudenthal BD, Beard WA, Pedersen LG, Wilson SH.

Nucleic Acids Res. 2017 Mar 17;45(5):2736-2745. doi: 10.1093/nar/gkw1363.

14.

Oxidative guanine base damage regulates human telomerase activity.

Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL.

Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. Epub 2016 Nov 7.

15.

Insertion of oxidized nucleotide triggers rapid DNA polymerase opening.

Kim T, Freudenthal BD, Beard WA, Wilson SH, Schlick T.

Nucleic Acids Res. 2016 May 19;44(9):4409-24. doi: 10.1093/nar/gkw174. Epub 2016 Mar 31.

16.

Capturing snapshots of APE1 processing DNA damage.

Freudenthal BD, Beard WA, Cuneo MJ, Dyrkheeva NS, Wilson SH.

Nat Struct Mol Biol. 2015 Nov;22(11):924-31. doi: 10.1038/nsmb.3105. Epub 2015 Oct 12.

17.

Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.

Perera L, Freudenthal BD, Beard WA, Shock DD, Pedersen LG, Wilson SH.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5228-36. doi: 10.1073/pnas.1511207112. Epub 2015 Sep 8.

18.

Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer.

Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang SC, Li D, Delaney JC, Wilson SH, Essigmann JM.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4571-80. doi: 10.1073/pnas.1507709112. Epub 2015 Aug 4.

19.

New structural snapshots provide molecular insights into the mechanism of high fidelity DNA synthesis.

Freudenthal BD, Beard WA, Wilson SH.

DNA Repair (Amst). 2015 Aug;32:3-9. doi: 10.1016/j.dnarep.2015.04.007. Epub 2015 Apr 30. Review.

20.

Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.

Tsutakawa SE, Yan C, Xu X, Weinacht CP, Freudenthal BD, Yang K, Zhuang Z, Washington MT, Tainer JA, Ivanov I.

Structure. 2015 Apr 7;23(4):724-733. doi: 10.1016/j.str.2015.02.008. Epub 2015 Mar 12.

21.

Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide.

Freudenthal BD, Beard WA, Perera L, Shock DD, Kim T, Schlick T, Wilson SH.

Nature. 2015 Jan 29;517(7536):635-9. doi: 10.1038/nature13886. Epub 2014 Nov 17.

22.

Suicidal cross-linking of PARP-1 to AP site intermediates in cells undergoing base excision repair.

Prasad R, Horton JK, Chastain PD 2nd, Gassman NR, Freudenthal BD, Hou EW, Wilson SH.

Nucleic Acids Res. 2014 Jun;42(10):6337-51. doi: 10.1093/nar/gku288. Epub 2014 Apr 25.

23.

Optimal and variant metal-ion routes in DNA polymerase β's conformational pathways.

Li Y, Freudenthal BD, Beard WA, Wilson SH, Schlick T.

J Am Chem Soc. 2014 Mar 5;136(9):3630-9. doi: 10.1021/ja412701f. Epub 2014 Feb 21.

PMID:
24511902
24.

Watching a DNA polymerase in action.

Freudenthal BD, Beard WA, Wilson SH.

Cell Cycle. 2014;13(5):691-2. doi: 10.4161/cc.27789. Epub 2014 Jan 14. No abstract available.

25.

Observing a DNA polymerase choose right from wrong.

Freudenthal BD, Beard WA, Shock DD, Wilson SH.

Cell. 2013 Jul 3;154(1):157-68. doi: 10.1016/j.cell.2013.05.048.

26.

DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion.

Freudenthal BD, Beard WA, Wilson SH.

Nucleic Acids Res. 2013 Feb 1;41(3):1848-58. doi: 10.1093/nar/gks1276. Epub 2012 Dec 24.

27.

Structures of dNTP intermediate states during DNA polymerase active site assembly.

Freudenthal BD, Beard WA, Wilson SH.

Structure. 2012 Nov 7;20(11):1829-37. doi: 10.1016/j.str.2012.08.008. Epub 2012 Sep 6.

28.

PCNA structure and function: insights from structures of PCNA complexes and post-translationally modified PCNA.

Dieckman LM, Freudenthal BD, Washington MT.

Subcell Biochem. 2012;62:281-99. doi: 10.1007/978-94-007-4572-8_15. Review.

29.

Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA.

Tsutakawa SE, Van Wynsberghe AW, Freudenthal BD, Weinacht CP, Gakhar L, Washington MT, Zhuang Z, Tainer JA, Ivanov I.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17672-7. doi: 10.1073/pnas.1110480108. Epub 2011 Oct 17.

30.

Crystal structure of SUMO-modified proliferating cell nuclear antigen.

Freudenthal BD, Brogie JE, Gakhar L, Kondratick CM, Washington MT.

J Mol Biol. 2011 Feb 11;406(1):9-17. doi: 10.1016/j.jmb.2010.12.015. Epub 2010 Dec 15.

31.

Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange.

Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT.

Nat Struct Mol Biol. 2010 Apr;17(4):479-84. doi: 10.1038/nsmb.1776. Epub 2010 Mar 21.

32.

Variations on a theme: eukaryotic Y-family DNA polymerases.

Washington MT, Carlson KD, Freudenthal BD, Pryor JM.

Biochim Biophys Acta. 2010 May;1804(5):1113-23. doi: 10.1016/j.bbapap.2009.07.004. Epub 2009 Jul 17. Review.

33.

A charged residue at the subunit interface of PCNA promotes trimer formation by destabilizing alternate subunit interactions.

Freudenthal BD, Gakhar L, Ramaswamy S, Washington MT.

Acta Crystallogr D Biol Crystallogr. 2009 Jun;65(Pt 6):560-6. doi: 10.1107/S0907444909011329. Epub 2009 May 15.

34.

Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis.

Freudenthal BD, Ramaswamy S, Hingorani MM, Washington MT.

Biochemistry. 2008 Dec 16;47(50):13354-61. doi: 10.1021/bi8017762.

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