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Items: 1 to 50 of 54

1.

StarPEG/heparin-hydrogel based in vivo engineering of stable bizonal cartilage with a calcified bottom layer.

Kunisch E, Knauf AK, Hesse E, Freudenberg U, Werner C, Bothe F, Diederichs S, Richter W.

Biofabrication. 2018 Oct 30;11(1):015001. doi: 10.1088/1758-5090/aae75a.

PMID:
30376451
2.

In situ-forming, cell-instructive hydrogels based on glycosaminoglycans with varied sulfation patterns.

Atallah P, Schirmer L, Tsurkan M, Putra Limasale YD, Zimmermann R, Werner C, Freudenberg U.

Biomaterials. 2018 Oct;181:227-239. doi: 10.1016/j.biomaterials.2018.07.056. Epub 2018 Jul 30.

PMID:
30092371
3.

3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity.

Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He S, Antos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C.

Dev Cell. 2018 Jul 2;46(1):85-101.e8. doi: 10.1016/j.devcel.2018.06.005.

PMID:
29974866
4.

Defined Geldrop Cultures Maintain Neural Precursor Cells.

Vogler S, Prokoph S, Freudenberg U, Binner M, Tsurkan M, Werner C, Kempermann G.

Sci Rep. 2018 May 30;8(1):8433. doi: 10.1038/s41598-018-26417-1.

5.

Solvent-Assisted Micromolding of Biohybrid Hydrogels to Maintain Human Hematopoietic Stem and Progenitor Cells Ex Vivo.

Müller E, Pompe T, Freudenberg U, Werner C.

Adv Mater. 2017 Nov;29(42). doi: 10.1002/adma.201703489. Epub 2017 Sep 28.

PMID:
28960524
6.

Hydrogel-Based In Vitro Models of Tumor Angiogenesis.

Bray LJ, Binner M, Freudenberg U, Werner C.

Methods Mol Biol. 2017;1612:39-63. doi: 10.1007/978-1-4939-7021-6_4.

PMID:
28634934
7.

Combined influence of biophysical and biochemical cues on maintenance and proliferation of hematopoietic stem cells.

Gvaramia D, Müller E, Müller K, Atallah P, Tsurkan M, Freudenberg U, Bornhäuser M, Werner C.

Biomaterials. 2017 Sep;138:108-117. doi: 10.1016/j.biomaterials.2017.05.023. Epub 2017 May 24.

PMID:
28554007
8.

Heparin-based hydrogels induce human renal tubulogenesis in vitro.

Weber HM, Tsurkan MV, Magno V, Freudenberg U, Werner C.

Acta Biomater. 2017 Jul 15;57:59-69. doi: 10.1016/j.actbio.2017.05.035. Epub 2017 May 17.

PMID:
28526628
9.

Adaptive release of heparin from anticoagulant hydrogels triggered by different blood coagulation factors.

Maitz MF, Zitzmann J, Hanke J, Renneberg C, Tsurkan MV, Sperling C, Freudenberg U, Werner C.

Biomaterials. 2017 Aug;135:53-61. doi: 10.1016/j.biomaterials.2017.04.044. Epub 2017 Apr 26.

PMID:
28486148
10.

Glycosaminoglycan-based hydrogels capture inflammatory chemokines and rescue defective wound healing in mice.

Lohmann N, Schirmer L, Atallah P, Wandel E, Ferrer RA, Werner C, Simon JC, Franz S, Freudenberg U.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaai9044. doi: 10.1126/scitranslmed.aai9044.

PMID:
28424334
11.

[The emerging technology of tissue engineering : Focus on stem cell niche].

Schlötzer-Schrehardt U, Freudenberg U, Kruse FE.

Ophthalmologe. 2017 Apr;114(4):327-340. doi: 10.1007/s00347-017-0468-0. Review. German.

PMID:
28243750
12.

Cell-instructive starPEG-heparin-collagen composite matrices.

Binner M, Bray LJ, Friedrichs J, Freudenberg U, Tsurkan MV, Werner C.

Acta Biomater. 2017 Apr 15;53:70-80. doi: 10.1016/j.actbio.2017.01.086. Epub 2017 Feb 16.

PMID:
28216298
13.

Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy.

Aliperta R, Welzel PB, Bergmann R, Freudenberg U, Berndt N, Feldmann A, Arndt C, Koristka S, Stanzione M, Cartellieri M, Ehninger A, Ehninger G, Werner C, Pietzsch J, Steinbach J, Bornhäuser M, Bachmann MP.

Sci Rep. 2017 Feb 16;7:42855. doi: 10.1038/srep42855.

14.

Peptide-functionalized starPEG/heparin hydrogels direct mitogenicity, cell morphology and cartilage matrix distribution in vitro and in vivo.

Hesse E, Freudenberg U, Niemietz T, Greth C, Weisser M, Hagmann S, Binner M, Werner C, Richter W.

J Tissue Eng Regen Med. 2018 Jan;12(1):229-239. doi: 10.1002/term.2404. Epub 2017 Jun 4.

PMID:
28083992
15.

StarPEG-Heparin Hydrogels to Protect and Sustainably Deliver IL-4.

Schirmer L, Atallah P, Werner C, Freudenberg U.

Adv Healthc Mater. 2016 Dec;5(24):3157-3164. doi: 10.1002/adhm.201600797. Epub 2016 Nov 8.

PMID:
27860466
16.

Glycosaminoglycan-Based Biohybrid Hydrogels: A Sweet and Smart Choice for Multifunctional Biomaterials.

Freudenberg U, Liang Y, Kiick KL, Werner C.

Adv Mater. 2016 Oct;28(40):8861-8891. doi: 10.1002/adma.201601908. Epub 2016 Jul 27. Review.

17.

Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro.

Nowak M, Freudenberg U, Tsurkan MV, Werner C, Levental KR.

Biomaterials. 2017 Jan;112:20-30. doi: 10.1016/j.biomaterials.2016.10.007. Epub 2016 Oct 6.

18.

Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells.

Borg DJ, Welzel PB, Grimmer M, Friedrichs J, Weigelt M, Wilhelm C, Prewitz M, Stißel A, Hommel A, Kurth T, Freudenberg U, Bonifacio E, Werner C.

Acta Biomater. 2016 Oct 15;44:178-87. doi: 10.1016/j.actbio.2016.08.007. Epub 2016 Aug 6.

PMID:
27506126
19.

Functional Interference in the Bone Marrow Microenvironment by Disseminated Breast Cancer Cells.

Dhawan A, von Bonin M, Bray LJ, Freudenberg U, Pishali Bejestani E, Werner C, Hofbauer LC, Wobus M, Bornhäuser M.

Stem Cells. 2016 Aug;34(8):2224-35. doi: 10.1002/stem.2384. Epub 2016 May 18.

20.

3D extracellular matrix interactions modulate tumour cell growth, invasion and angiogenesis in engineered tumour microenvironments.

Taubenberger AV, Bray LJ, Haller B, Shaposhnykov A, Binner M, Freudenberg U, Guck J, Werner C.

Acta Biomater. 2016 May;36:73-85. doi: 10.1016/j.actbio.2016.03.017. Epub 2016 Mar 10.

PMID:
26971667
21.

Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds.

Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C.

J Control Release. 2015 Dec 28;220(Pt A):79-88. doi: 10.1016/j.jconrel.2015.10.028. Epub 2015 Oct 22.

PMID:
26478015
22.

Tackling Cell Transplantation Anoikis: An Injectable, Shape Memory Cryogel Microcarrier Platform Material for Stem Cell and Neuronal Cell Growth.

Newland B, Welzel PB, Newland H, Renneberg C, Kolar P, Tsurkan M, Rosser A, Freudenberg U, Werner C.

Small. 2015 Oct;11(38):5047-53. doi: 10.1002/smll.201500898. Epub 2015 Aug 3.

23.

Neurotropic growth factors and glycosaminoglycan based matrices to induce dopaminergic tissue formation.

Schurig K, Zieris A, Hermann A, Freudenberg U, Heidel S, Grimmer M, Storch A, Werner C.

Biomaterials. 2015 Oct;67:205-13. doi: 10.1016/j.biomaterials.2015.07.029. Epub 2015 Jul 21.

PMID:
26222283
24.

TGFβ functionalized starPEG-heparin hydrogels modulate human dermal fibroblast growth and differentiation.

Watarai A, Schirmer L, Thönes S, Freudenberg U, Werner C, Simon JC, Anderegg U.

Acta Biomater. 2015 Oct;25:65-75. doi: 10.1016/j.actbio.2015.07.036. Epub 2015 Jul 26.

PMID:
26219861
25.

Multilayer hydrogel coatings to combine hemocompatibility and antimicrobial activity.

Fischer M, Vahdatzadeh M, Konradi R, Friedrichs J, Maitz MF, Freudenberg U, Werner C.

Biomaterials. 2015 Jul;56:198-205. doi: 10.1016/j.biomaterials.2015.03.056. Epub 2015 Apr 17.

PMID:
25934292
26.

Multi-parametric hydrogels support 3D in vitro bioengineered microenvironment models of tumour angiogenesis.

Bray LJ, Binner M, Holzheu A, Friedrichs J, Freudenberg U, Hutmacher DW, Werner C.

Biomaterials. 2015;53:609-20. doi: 10.1016/j.biomaterials.2015.02.124. Epub 2015 Mar 24.

PMID:
25890757
27.

Biohybrid networks of selectively desulfated glycosaminoglycans for tunable growth factor delivery.

Zieris A, Dockhorn R, Röhrich A, Zimmermann R, Müller M, Welzel PB, Tsurkan MV, Sommer JU, Freudenberg U, Werner C.

Biomacromolecules. 2014 Dec 8;15(12):4439-46. doi: 10.1021/bm5012294. Epub 2014 Nov 5.

PMID:
25329425
28.

Photopatterning of multifunctional hydrogels to direct adult neural precursor cells.

Tsurkan MV, Wetzel R, Pérez-Hernández HR, Chwalek K, Kozlova A, Freudenberg U, Kempermann G, Zhang Y, Lasagni AF, Werner C.

Adv Healthc Mater. 2015 Mar 11;4(4):516-21. doi: 10.1002/adhm.201400395. Epub 2014 Oct 16.

PMID:
25323149
29.

Chemoselective peptide functionalization of starPEG-GAG hydrogels.

Tsurkan MV, Chwalek K, Schoder M, Freudenberg U, Werner C.

Bioconjug Chem. 2014 Nov 19;25(11):1942-50. doi: 10.1021/bc500217z. Epub 2014 Oct 9.

PMID:
25297697
30.

Cryogel micromechanics unraveled by atomic force microscopy-based nanoindentation.

Welzel PB, Friedrichs J, Grimmer M, Vogler S, Freudenberg U, Werner C.

Adv Healthc Mater. 2014 Nov;3(11):1849-53. doi: 10.1002/adhm.201400102. Epub 2014 Apr 14.

PMID:
24729299
31.

Glycosaminoglycan-based hydrogels to modulate heterocellular communication in in vitro angiogenesis models.

Chwalek K, Tsurkan MV, Freudenberg U, Werner C.

Sci Rep. 2014 Mar 19;4:4414. doi: 10.1038/srep04414.

32.

Geometry-driven cell organization determines tissue growths in scaffold pores: consequences for fibronectin organization.

Joly P, Duda GN, Schöne M, Welzel PB, Freudenberg U, Werner C, Petersen A.

PLoS One. 2013 Sep 5;8(9):e73545. doi: 10.1371/journal.pone.0073545. eCollection 2013.

33.

Bio-responsive polymer hydrogels homeostatically regulate blood coagulation.

Maitz MF, Freudenberg U, Tsurkan MV, Fischer M, Beyrich T, Werner C.

Nat Commun. 2013;4:2168. doi: 10.1038/ncomms3168.

34.

Characterization of polymer membranes by MALDI mass-spectrometric imaging techniques.

Krueger K, Terne C, Werner C, Freudenberg U, Jankowski V, Zidek W, Jankowski J.

Anal Chem. 2013 May 21;85(10):4998-5004. doi: 10.1021/ac4002063. Epub 2013 May 1.

PMID:
23594377
35.

Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ.

Tsurkan MV, Chwalek K, Prokoph S, Zieris A, Levental KR, Freudenberg U, Werner C.

Adv Mater. 2013 May 14;25(18):2606-10. doi: 10.1002/adma.201300691. Epub 2013 Apr 10.

PMID:
23576312
36.

Growth factor delivery from hydrogel particle aggregates to promote tubular regeneration after acute kidney injury.

Tsurkan MV, Hauser PV, Zieris A, Carvalhosa R, Bussolati B, Freudenberg U, Camussi G, Werner C.

J Control Release. 2013 May 10;167(3):248-55. doi: 10.1016/j.jconrel.2013.01.030. Epub 2013 Feb 8.

37.

Minimal peptide motif for non-covalent peptide-heparin hydrogels.

Wieduwild R, Tsurkan M, Chwalek K, Murawala P, Nowak M, Freudenberg U, Neinhuis C, Werner C, Zhang Y.

J Am Chem Soc. 2013 Feb 27;135(8):2919-22. doi: 10.1021/ja312022u. Epub 2013 Feb 12.

PMID:
23388040
38.

Electrokinetic analysis to reveal composition and structure of biohybrid hydrogels.

Zimmermann R, Bartsch S, Freudenberg U, Werner C.

Anal Chem. 2012 Nov 6;84(21):9592-5. doi: 10.1021/ac302538j. Epub 2012 Oct 16. Erratum in: Anal Chem. 2013 Jan 15;85(2):1256.

PMID:
23030581
39.

Macroporous starPEG-heparin cryogels.

Welzel PB, Grimmer M, Renneberg C, Naujox L, Zschoche S, Freudenberg U, Werner C.

Biomacromolecules. 2012 Aug 13;13(8):2349-58. doi: 10.1021/bm300605s. Epub 2012 Jul 3.

PMID:
22758219
40.

A novel, biased-like SDF-1 derivative acts synergistically with starPEG-based heparin hydrogels and improves eEPC migration in vitro.

Baumann L, Prokoph S, Gabriel C, Freudenberg U, Werner C, Beck-Sickinger AG.

J Control Release. 2012 Aug 20;162(1):68-75. doi: 10.1016/j.jconrel.2012.04.049. Epub 2012 May 22.

PMID:
22634073
41.

Sustained delivery of SDF-1α from heparin-based hydrogels to attract circulating pro-angiogenic cells.

Prokoph S, Chavakis E, Levental KR, Zieris A, Freudenberg U, Dimmeler S, Werner C.

Biomaterials. 2012 Jun;33(19):4792-800. doi: 10.1016/j.biomaterials.2012.03.039. Epub 2012 Apr 6.

PMID:
22483246
42.

Two-tier hydrogel degradation to boost endothelial cell morphogenesis.

Chwalek K, Levental KR, Tsurkan MV, Zieris A, Freudenberg U, Werner C.

Biomaterials. 2011 Dec;32(36):9649-57. doi: 10.1016/j.biomaterials.2011.08.078. Epub 2011 Sep 19.

PMID:
21937106
43.

Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels.

Zieris A, Chwalek K, Prokoph S, Levental KR, Welzel PB, Freudenberg U, Werner C.

J Control Release. 2011 Nov 30;156(1):28-36. doi: 10.1016/j.jconrel.2011.06.042. Epub 2011 Jul 6.

PMID:
21763368
44.

Modular StarPEG-Heparin Gels with Bifunctional Peptide Linkers.

Tsurkan MV, Chwalek K, Levental KR, Freudenberg U, Werner C.

Macromol Rapid Commun. 2010 Sep 1;31(17):1529-33. doi: 10.1002/marc.201000155. Epub 2010 Aug 16.

PMID:
21567562
45.

FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis.

Zieris A, Prokoph S, Levental KR, Welzel PB, Grimmer M, Freudenberg U, Werner C.

Biomaterials. 2010 Nov;31(31):7985-94. doi: 10.1016/j.biomaterials.2010.07.021. Epub 2010 Aug 3.

PMID:
20674970
46.

Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties.

Tsurkan MV, Levental KR, Freudenberg U, Werner C.

Chem Commun (Camb). 2010 Feb 21;46(7):1141-3. doi: 10.1039/b921616b. Epub 2009 Dec 16.

PMID:
20126740
47.

Directed growth of adult human white matter stem cell-derived neurons on aligned fibrillar collagen.

Lanfer B, Hermann A, Kirsch M, Freudenberg U, Reuner U, Werner C, Storch A.

Tissue Eng Part A. 2010 Apr;16(4):1103-13. doi: 10.1089/ten.TEA.2009.0282.

PMID:
19860550
48.

Analytical approaches to uptake and release of hydrogel-associated FGF-2.

Zieris A, Prokoph S, Welzel PB, Grimmer M, Levental KR, Panyanuwat W, Freudenberg U, Werner C.

J Mater Sci Mater Med. 2010 Mar;21(3):915-23. doi: 10.1007/s10856-009-3913-z. Epub 2009 Oct 23.

PMID:
19851836
49.

The growth and differentiation of mesenchymal stem and progenitor cells cultured on aligned collagen matrices.

Lanfer B, Seib FP, Freudenberg U, Stamov D, Bley T, Bornhäuser M, Werner C.

Biomaterials. 2009 Oct;30(30):5950-8. doi: 10.1016/j.biomaterials.2009.07.039. Epub 2009 Aug 11.

PMID:
19674785
50.

A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases.

Freudenberg U, Hermann A, Welzel PB, Stirl K, Schwarz SC, Grimmer M, Zieris A, Panyanuwat W, Zschoche S, Meinhold D, Storch A, Werner C.

Biomaterials. 2009 Oct;30(28):5049-60. doi: 10.1016/j.biomaterials.2009.06.002. Epub 2009 Jun 27.

PMID:
19560816

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