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Items: 1 to 50 of 105

1.

Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells.

Straub T, Freudenberg MA, Schleicher U, Bogdan C, Gasteiger G, Pircher H.

Nat Commun. 2018 Oct 8;9(1):4117. doi: 10.1038/s41467-018-06609-z.

2.

Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor.

Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA, Plückthun A, May T, Köster M, Fejer G, Greber UF.

PLoS Pathog. 2018 Mar 9;14(3):e1006914. doi: 10.1371/journal.ppat.1006914. eCollection 2018 Mar.

3.

Erratum for Maler et al., "Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages".

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WW, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Sep 26;8(5). pii: e01445-17. doi: 10.1128/mBio.01445-17. No abstract available.

4.

Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.

Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I, Huber M, Müller-Quernheim J, Schamel WWA, Gordon S, Jakob T, Martin SF, Jahnen-Dechent W, Greber UF, Freudenberg MA, Fejer G.

MBio. 2017 Aug 1;8(4). pii: e00670-17. doi: 10.1128/mBio.00670-17. Erratum in: MBio. 2017 Sep 26;8(5):.

5.

Immune response to Propionibacterium acnes in patients with sarcoidosis--in vivo and in vitro.

Schupp JC, Tchaptchet S, Lützen N, Engelhard P, Müller-Quernheim J, Freudenberg MA, Prasse A.

BMC Pulm Med. 2015 Jul 24;15:75. doi: 10.1186/s12890-015-0070-7.

6.

TNFR2 maintains adequate IL-12 production by dendritic cells in inflammatory responses by regulating endogenous TNF levels.

Martin EM, Remke A, Pfeifer E, Polz J, Pietryga-Krieger A, Steffens-Weber D, Freudenberg MA, Mostböck S, Männel DN.

Innate Immun. 2014 Oct;20(7):712-20. doi: 10.1177/1753425913506949. Epub 2013 Oct 11.

PMID:
24122297
7.

Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.

Gülden E, Ihira M, Ohashi A, Reinbeck AL, Freudenberg MA, Kolb H, Burkart V.

PLoS One. 2013 Sep 23;8(9):e75385. doi: 10.1371/journal.pone.0075385. eCollection 2013.

8.

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions.

Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Schneider R, Apte RN, Galanos C, Freudenberg MA.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2191-8. doi: 10.1073/pnas.1302877110. Epub 2013 May 24.

9.

Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation.

Esser PR, Wölfle U, Dürr C, von Loewenich FD, Schempp CM, Freudenberg MA, Jakob T, Martin SF.

PLoS One. 2012;7(7):e41340. doi: 10.1371/journal.pone.0041340. Epub 2012 Jul 25.

10.

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Hölscher C, Kirschning CJ, Lamers M, Galanos C, Freudenberg MA.

PLoS One. 2012;7(6):e39155. doi: 10.1371/journal.pone.0039155. Epub 2012 Jun 22.

11.

Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.

Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.

J Immunol. 2012 Jul 1;189(1):328-36. doi: 10.4049/jimmunol.1103258. Epub 2012 May 25.

12.

Animal models for nickel allergy.

Schmidt M, Martin SF, Freudenberg MA, Goebeler M.

Nat Nanotechnol. 2011 Sep 6;6(9):533; author reply 533. doi: 10.1038/nnano.2011.143. No abstract available.

PMID:
21897378
13.

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis.

Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M.

Allergy. 2011 Sep;66(9):1152-63. doi: 10.1111/j.1398-9995.2011.02652.x. Epub 2011 May 21. Review.

PMID:
21599706
14.

Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells.

Keck S, Müller I, Fejer G, Savic I, Tchaptchet S, Nielsen PJ, Galanos C, Huber M, Freudenberg MA.

J Immunol. 2011 May 1;186(9):5478-88. doi: 10.4049/jimmunol.1000458. Epub 2011 Mar 25.

15.

Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC.

Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber CA, Fejer G, Freudenberg MA, Davey GM, Vremec D, Kallies A, Wu L, Shortman K, Chaplin P, Suter M, O'Keeffe M, Hochrein H.

J Exp Med. 2010 Nov 22;207(12):2703-17. doi: 10.1084/jem.20092720. Epub 2010 Oct 25.

16.

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.

Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M.

Nat Immunol. 2010 Sep;11(9):814-9. doi: 10.1038/ni.1919. Epub 2010 Aug 15.

PMID:
20711192
17.

Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes.

Tchaptchet S, Kirberg J, Freudenberg N, Schamel WW, Galanos C, Freudenberg MA.

Eur J Immunol. 2010 Sep;40(9):2506-16. doi: 10.1002/eji.200939860.

18.

MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease.

Heimesaat MM, Nogai A, Bereswill S, Plickert R, Fischer A, Loddenkemper C, Steinhoff U, Tchaptchet S, Thiel E, Freudenberg MA, Göbel UB, Uharek L.

Gut. 2010 Aug;59(8):1079-87. doi: 10.1136/gut.2009.197434.

PMID:
20639251
19.

Tumour Biology: tumour-associated inflammation versus antitumor immunity.

Müller-Hübenthal B, Azemar M, Lorenzen D, Huber M, Freudenberg MA, Galanos C, Unger C, Hildenbrand B.

Anticancer Res. 2009 Nov;29(11):4795-805. Review.

20.

Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis.

Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg MA, Fejer G, Büttner M, Köhler G, Kirschning CJ, Sparwasser T, Alber G.

J Virol. 2009 Sep;83(18):9411-22. doi: 10.1128/JVI.02362-08. Epub 2009 Jul 1.

21.

Innate and adaptive immune responses in contact dermatitis: analogy with infections.

Freudenberg MA, Esser PR, Jakob T, Galanos C, Martin SF.

G Ital Dermatol Venereol. 2009 Apr;144(2):173-85. Review.

PMID:
19357624
22.

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo.

Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N, Greber UF, Keck S, Hildenbrand B, Krug A, Bogdan C, Freudenberg MA.

PLoS Pathog. 2008 Nov;4(11):e1000208. doi: 10.1371/journal.ppat.1000208. Epub 2008 Nov 14.

23.

Bruton's tyrosine kinase is dispensable for the Toll-like receptor-mediated activation of mast cells.

Zorn CN, Keck S, Hendriks RW, Leitges M, Freudenberg MA, Huber M.

Cell Signal. 2009 Jan;21(1):79-86. doi: 10.1016/j.cellsig.2008.09.010. Epub 2008 Sep 26.

PMID:
18848985
24.

Enhanced B-cell activation mediated by TLR4 and BCR crosstalk.

Minguet S, Dopfer EP, Pollmer C, Freudenberg MA, Galanos C, Reth M, Huber M, Schamel WW.

Eur J Immunol. 2008 Sep;38(9):2475-87. doi: 10.1002/eji.200738094.

25.

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity.

Martin SF, Dudda JC, Bachtanian E, Lembo A, Liller S, Dürr C, Heimesaat MM, Bereswill S, Fejer G, Vassileva R, Jakob T, Freudenberg N, Termeer CC, Johner C, Galanos C, Freudenberg MA.

J Exp Med. 2008 Sep 1;205(9):2151-62. doi: 10.1084/jem.20070509. Epub 2008 Aug 25.

26.

MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection.

Cramer JP, Lepenies B, Kamena F, Hölscher C, Freudenberg MA, Burchard GD, Wagner H, Kirschning CJ, Liu X, Seeberger PH, Jacobs T.

Microbes Infect. 2008 Oct;10(12-13):1259-65. doi: 10.1016/j.micinf.2008.07.024. Epub 2008 Jul 22.

PMID:
18692153
27.

IFN-y enhances T(H)1 polarisation of monocyte-derived dendritic cells matured with clinical-grade cytokines using serum-free conditions.

Hildenbrand B, Lorenzen D, Sauer B, Hertkorn C, Freudenberg MA, Peters JH, Nesselhut T, Unger C, Azemar M.

Anticancer Res. 2008 May-Jun;28(3A):1467-76.

28.

Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity.

Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schütze N, Beutler B, Galanos C.

Immunobiology. 2008;213(3-4):193-203. doi: 10.1016/j.imbio.2007.11.008. Epub 2007 Dec 27. Review.

PMID:
18406367
29.

Production of IL-12, IL-23 and IL-27p28 by bone marrow-derived conventional dendritic cells rather than macrophages after LPS/TLR4-dependent induction by Salmonella Enteritidis.

Siegemund S, Schütze N, Freudenberg MA, Lutz MB, Straubinger RK, Alber G.

Immunobiology. 2007;212(9-10):739-50. Epub 2007 Nov 9.

PMID:
18086375
30.

Immunotherapy of patients with hormone-refractory prostate carcinoma pre-treated with interferon-gamma and vaccinated with autologous PSA-peptide loaded dendritic cells--a pilot study.

Hildenbrand B, Sauer B, Kalis O, Stoll C, Freudenberg MA, Niedermann G, Giesler JM, Jüttner E, Peters JH, Häring B, Leo R, Unger C, Azemar M.

Prostate. 2007 Apr 1;67(5):500-8.

PMID:
17262804
31.

Cytotoxic efficacy and influence on cellular phospholipid metabolism of 2-hydroxy- and 2-O-acetyl-octadecylphosphocholines.

Hildenbrand B, Kley JT, Haberstroh F, Freudenberg MA, Azemar M, Unger C, Massing U.

Anticancer Res. 2006 Nov-Dec;26(6B):4255-62.

32.

Stage of primary infection with lymphocytic choriomeningitis virus determines predisposition or resistance of mice to secondary bacterial infections.

Gumenscheimer M, Balkow S, Simon MM, Jirillo E, Galanos C, Freudenberg MA.

Med Microbiol Immunol. 2007 Jun;196(2):79-88. Epub 2006 Nov 29.

PMID:
17136407
33.

TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease.

Liu B, Yang Y, Dai J, Medzhitov R, Freudenberg MA, Zhang PL, Li Z.

J Immunol. 2006 Nov 15;177(10):6880-8.

34.

R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells.

Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Beutler B, Galanos C, Freudenberg MA.

Eur J Immunol. 2006 Mar;36(3):701-11.

36.

IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella enteritidis and the impact of IL-10 in bone marrow-derived macrophages.

Schuetze N, Schoeneberger S, Mueller U, Freudenberg MA, Alber G, Straubinger RK.

Int Immunol. 2005 May;17(5):649-59. Epub 2005 Apr 18.

PMID:
15837713
37.

Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.

Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, Akira S, Galanos C, Freudenberg MA.

J Immunol. 2005 Apr 1;174(7):4295-300.

38.

Chemokine gene expression in toll-like receptor-competent and -deficient mice infected with Leishmania major.

Antoniazi S, Price HP, Kropf P, Freudenberg MA, Galanos C, Smith DF, Müller I.

Infect Immun. 2004 Sep;72(9):5168-74.

39.

Toll-like receptor 4 contributes to efficient control of infection with the protozoan parasite Leishmania major.

Kropf P, Freudenberg MA, Modolell M, Price HP, Herath S, Antoniazi S, Galanos C, Smith DF, Müller I.

Infect Immun. 2004 Apr;72(4):1920-8.

40.

Treatment of experimental sepsis-induced immunoparalysis with TNF.

Echtenacher B, Urbaschek R, Weigl K, Freudenberg MA, Männel DN.

Immunobiology. 2003;208(4):381-9.

PMID:
14748511
41.

Role of interferons in LPS hypersensitivity.

Freudenberg MA, Kalis C, Chvatchko Y, Merlin T, Gumenscheimer M, Galanos C.

J Endotoxin Res. 2003;9(5):308-12. Review.

PMID:
14577847
42.

Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice.

Lembo A, Kalis C, Kirschning CJ, Mitolo V, Jirillo E, Wagner H, Galanos C, Freudenberg MA.

Infect Immun. 2003 Oct;71(10):6058-62.

43.

Toll-like receptor 4 expression levels determine the degree of LPS-susceptibility in mice.

Kalis C, Kanzler B, Lembo A, Poltorak A, Galanos C, Freudenberg MA.

Eur J Immunol. 2003 Mar;33(3):798-805.

44.
45.
46.

Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria.

Freudenberg MA, Merlin T, Gumenscheimer M, Kalis C, Landmann R, Galanos C.

Microbes Infect. 2001 Nov-Dec;3(14-15):1213-22. Review.

PMID:
11755409
47.

Differential clearance and induction of host responses by various administered or released lipopolysaccharides.

Hasunuma R, Morita H, Tanaka S, Ryll R, Freudenberg MA, Galanos C, Kumazawa Y.

J Endotoxin Res. 2001;7(6):421-9.

PMID:
11753211
48.

Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis.

Echtenacher B, Freudenberg MA, Jack RS, Männel DN.

Infect Immun. 2001 Dec;69(12):7271-6.

49.
50.

A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.

Poltorak A, Merlin T, Nielsen PJ, Sandra O, Smirnova I, Schupp I, Boehm T, Galanos C, Freudenberg MA.

J Immunol. 2001 Aug 15;167(4):2106-11.

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