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Items: 41

1.

Sustained release and improved bioavailability in mice after subcutaneous administration of griseofulvin as nano- and microcrystals.

Sigfridsson K, Xue A, Goodwin K, Fretland AJ, Arvidsson T.

Int J Pharm. 2019 Jul 20;566:565-572. doi: 10.1016/j.ijpharm.2019.06.015. Epub 2019 Jun 7.

PMID:
31181305
2.

Development of a quantification method for adenosine in tumors by LC-MS/MS with dansyl chloride derivatization.

Goodwin KJ, Gangl E, Sarkar U, Pop-Damkov P, Jones N, Borodovsky A, Woessner R, Fretland AJ.

Anal Biochem. 2019 Mar 1;568:78-88. doi: 10.1016/j.ab.2018.11.004. Epub 2018 Nov 5.

PMID:
30408457
3.

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.

Estridge TB, Dey AB, Reidy C, Yu X, Zhang Y, Hartley M, Milligan PL, Jin N, Kowala MC, Leohr JK, Fretland AJ, Mabry TE, Luffer-Atlas D, Luo MJ.

J Pharmacol Exp Ther. 2017 Jul;362(1):108-118. doi: 10.1124/jpet.117.240242. Epub 2017 May 2.

PMID:
28465372
4.

Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.

Kuklish SL, Antonysamy S, Bhattachar SN, Chandrasekhar S, Fisher MJ, Fretland AJ, Gooding K, Harvey A, Hughes NE, Luz JG, Manninen PR, McGee JE, Navarro A, Norman BH, Partridge KM, Quimby SJ, Schiffler MA, Sloan AV, Warshawsky AM, York JS, Yu XP.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4824-4828. doi: 10.1016/j.bmcl.2016.08.023. Epub 2016 Aug 10.

PMID:
27554445
5.

Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans.

Glenn KJ, Yu LJ, Reddy MB, Fretland AJ, Parrott N, Hussain S, Palacios M, Vazvaei F, Zhi J, Tuerck D.

Xenobiotica. 2016 Aug;46(8):667-76. doi: 10.3109/00498254.2015.1110761. Epub 2015 Nov 19.

PMID:
26586447
6.

Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.

Kester RF, Donnell AF, Lou Y, Remiszewski SW, Lombardo LJ, Chen S, Le NT, Lo J, Moliterni JA, Han X, Hogg JH, Liang W, Michoud C, Rupert KC, Mischke S, Le K, Weisel M, Janson CA, Lukacs CM, Fretland AJ, Hong K, Polonskaia A, Gao L, Li S, Solis DS, Aguilar D, Tardell C, Dvorozniak M, Tannu S, Lee EC, Schutt AD, Goggin B.

J Med Chem. 2013 Oct 24;56(20):7788-803. doi: 10.1021/jm400732v. Epub 2013 Oct 7.

PMID:
24093940
7.

Authors' response to letter to the editor on "image cytometry protocols".

Garrido R, Zabka TS, Tao J, Fielden MR, Fretland AJ, Albassam M.

J Histochem Cytochem. 2013 Oct;61(10):761-2. doi: 10.1369/0022155413502057. No abstract available.

8.

Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.

Donnell AF, Michoud C, Rupert KC, Han X, Aguilar D, Frank KB, Fretland AJ, Gao L, Goggin B, Hogg JH, Hong K, Janson CA, Kester RF, Kong N, Le K, Li S, Liang W, Lombardo LJ, Lou Y, Lukacs CM, Mischke S, Moliterni JA, Polonskaia A, Schutt AD, Solis DS, Specian A, Taylor RT, Weisel M, Remiszewski SW.

J Med Chem. 2013 Oct 24;56(20):7772-87. doi: 10.1021/jm400731m. Epub 2013 Oct 1.

PMID:
24083782
9.

Discovery of highly selective and orally active lysophosphatidic acid receptor-1 antagonists with potent activity on human lung fibroblasts.

Qian Y, Hamilton M, Sidduri A, Gabriel S, Ren Y, Peng R, Kondru R, Narayanan A, Truitt T, Hamid R, Chen Y, Zhang L, Fretland AJ, Sanchez RA, Chang KC, Lucas M, Schoenfeld RC, Laine D, Fuentes ME, Stevenson CS, Budd DC.

J Med Chem. 2012 Sep 13;55(17):7920-39. doi: 10.1021/jm301022v. Epub 2012 Aug 29.

PMID:
22894757
10.

Determination of time-dependent inactivation of CYP3A4 in cryopreserved human hepatocytes and assessment of human drug-drug interactions.

Chen Y, Liu L, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2011 Nov;39(11):2085-92. doi: 10.1124/dmd.111.040634. Epub 2011 Aug 11.

PMID:
21835977
11.

Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: anticipated thyroid effects and unique pituitary gland findings.

Zabka TS, Fielden MR, Garrido R, Tao J, Fretland AJ, Fretland JL, Albassam MA, Singer T, Kolaja KL.

Toxicol Pathol. 2011 Jun;39(4):664-77. doi: 10.1177/0192623311406934. Epub 2011 May 5.

PMID:
21551028
12.

Utility of intersystem extrapolation factors in early reaction phenotyping and the quantitative extrapolation of human liver microsomal intrinsic clearance using recombinant cytochromes P450.

Chen Y, Liu L, Nguyen K, Fretland AJ.

Drug Metab Dispos. 2011 Mar;39(3):373-82. doi: 10.1124/dmd.110.035147. Epub 2010 Dec 8.

PMID:
21148079
13.

Effect of hepatitis C virus infection on the mRNA expression of drug transporters and cytochrome p450 enzymes in chimeric mice with humanized liver.

Kikuchi R, McCown M, Olson P, Tateno C, Morikawa Y, Katoh Y, Bourdet DL, Monshouwer M, Fretland AJ.

Drug Metab Dispos. 2010 Nov;38(11):1954-61. doi: 10.1124/dmd.109.031732. Epub 2010 Aug 6.

PMID:
20693416
14.

The in vitro metabolism of bupropion revisited: concentration dependent involvement of cytochrome P450 2C19.

Chen Y, Liu HF, Liu L, Nguyen K, Jones EB, Fretland AJ.

Xenobiotica. 2010 Aug;40(8):536-46. doi: 10.3109/00498254.2010.492880.

PMID:
20528624
18.

Metabolic activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus.

Fretland AJ, Devanaboyina US, Doll MA, Zhao S, Xiao GH, Hein DW.

Toxicol Sci. 2003 Aug;74(2):253-9. Epub 2003 May 28.

PMID:
12773763
20.

Acetylator phenotype and genotype in HIV-infected patients with and without sulfonamide hypersensitivity.

O'Neil WM, MacArthur RD, Farrough MJ, Doll MA, Fretland AJ, Hein DW, Crane LR, Svensson CK.

J Clin Pharmacol. 2002 Jun;42(6):613-9.

PMID:
12043950
21.

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas.

Ishibe N, Sinha R, Hein DW, Kulldorff M, Strickland P, Fretland AJ, Chow WH, Kadlubar FF, Lang NP, Rothman N.

Pharmacogenetics. 2002 Mar;12(2):145-50.

PMID:
11875368
22.

Functional characterization of nucleotide polymorphisms in the coding region of N-acetyltransferase 1.

Fretland AJ, Doll MA, Leff MA, Hein DW.

Pharmacogenetics. 2001 Aug;11(6):511-20.

PMID:
11505221
23.

Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms.

Fretland AJ, Leff MA, Doll MA, Hein DW.

Pharmacogenetics. 2001 Apr;11(3):207-15.

PMID:
11337936
24.

DNA adduct levels and absence of tumors in female rapid and slow acetylator congenic hamsters administered the rat mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine.

Fretland AJ, Devanaboyina US, Nangju NA, Leff MA, Xiao GH, Webb SJ, Doll MA, Hein DW.

J Biochem Mol Toxicol. 2001;15(1):26-33.

PMID:
11170312
25.
26.

Epoxide hydrolases: biochemistry and molecular biology.

Fretland AJ, Omiecinski CJ.

Chem Biol Interact. 2000 Dec 1;129(1-2):41-59. Review.

PMID:
11154734
27.
28.
29.

Acetylator phenotype and genotype in patients infected with HIV: discordance between methods for phenotype determination and genotype.

O'Neil WM, Drobitch RK, MacArthur RD, Farrough MJ, Doll MA, Fretland AJ, Hein DW, Crane LR, Svensson CK.

Pharmacogenetics. 2000 Mar;10(2):171-82.

PMID:
10762005
30.
31.

Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms.

Hein DW, Doll MA, Fretland AJ, Leff MA, Webb SJ, Xiao GH, Devanaboyina US, Nangju NA, Feng Y.

Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42. Review.

32.

Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype.

Leff MA, Fretland AJ, Doll MA, Hein DW.

J Biol Chem. 1999 Dec 3;274(49):34519-22.

33.

Prostate-specific human N-acetyltransferase 2 (NAT2) expression in the mouse.

Leff MA, Epstein PN, Doll MA, Fretland AJ, Devanaboyina US, Rustan TD, Hein DW.

J Pharmacol Exp Ther. 1999 Jul;290(1):182-7.

PMID:
10381774
34.

Dietary selenium reduces the formation of aberrant crypts in rats administered 3,2'-dimethyl-4-aminobiphenyl.

Feng Y, Finley JW, Davis CD, Becker WK, Fretland AJ, Hein DW.

Toxicol Appl Pharmacol. 1999 May 15;157(1):36-42.

PMID:
10329505
35.

A rapid and sensitive method for detection of urinary bladder tumors in rodents.

Feng Y, Rustan TD, Fretland AJ, Cooley AM, Lee KJ, Becker WK, Hein DW.

Proc West Pharmacol Soc. 1998;41:11-3. No abstract available.

PMID:
9836226
36.

Higher frequency of aberrant crypt foci in rapid than slow acetylator inbred rats administered the colon carcinogen 3,2'-dimethyl-4-aminobiphenyl.

Feng Y, Fretland AJ, Rustan TD, Jiang W, Becker WK, Hein DW.

Toxicol Appl Pharmacol. 1997 Nov;147(1):56-62.

PMID:
9356307
37.

Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases.

Hein DW, Doll MA, Fretland AJ, Gray K, Deitz AC, Feng Y, Jiang W, Rustan TD, Satran SL, Wilkie TR Sr.

Mutat Res. 1997 May 12;376(1-2):101-6.

PMID:
9202744
39.

DNA adduct levels in rapid and slow acetylator inbred rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

Fretland AJ, Feng Y, Hein DW.

Proc West Pharmacol Soc. 1997;40:9-12. No abstract available.

PMID:
9436199
40.

Acetylator genotype (NAT2)-dependent formation of aberrant crypts in congenic Syrian hamsters administered 3,2'-dimethyl-4-aminobiphenyl.

Feng Y, Wagner RJ, Fretland AJ, Becker WK, Cooley AM, Pretlow TP, Lee KJ, Hein DW.

Cancer Res. 1996 Feb 1;56(3):527-31.

41.

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