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Items: 1 to 50 of 65

1.

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer's Disease.

Toublet FX, Lecoutey C, Lalut J, Hatat B, Davis A, Since M, Corvaisier S, Freret T, Sopkova de Oliveira Santos J, Claeysen S, Boulouard M, Dallemagne P, Rochais C.

Molecules. 2019 Jul 31;24(15). pii: E2786. doi: 10.3390/molecules24152786.

2.
3.

Program Director Perceptions of Subspecialty Tracking in Obstetrics and Gynecology Residency.

Hariton E, Freret TS, Nitecki R, Hinchcliff E, Stagg A.

J Grad Med Educ. 2018 Dec;10(6):665-670. doi: 10.4300/JGME-D-18-00096.1.

PMID:
30619524
4.

Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses.

Billard JM, Freret T.

J Neurochem. 2018 Nov;147(4):514-525. doi: 10.1111/jnc.14586. Epub 2018 Nov 6.

PMID:
30187927
5.

Evaluation of the impact of S-adenosylmethionine-dependent methyltransferase inhibitor, 3-deazaneplanocin A, on tissue injury and cognitive function in mice.

Lhuissier E, Aury-Landas J, Bouet V, Bazille C, Repesse Y, Freret T, Boumédiene K, Baugé C.

Oncotarget. 2018 Apr 17;9(29):20698-20708. doi: 10.18632/oncotarget.25062. eCollection 2018 Apr 17.

6.

Characterizing age-related decline of recognition memory and brain activation profile in mice.

Belblidia H, Leger M, Abdelmalek A, Quiedeville A, Calocer F, Boulouard M, Jozet-Alves C, Freret T, Schumann-Bard P.

Exp Gerontol. 2018 Jun;106:222-231. doi: 10.1016/j.exger.2018.03.006. Epub 2018 Mar 8.

PMID:
29524468
7.

Effects of a Short Video-Based Resident-as-Teacher Training Toolkit on Resident Teaching.

Ricciotti HA, Freret TS, Aluko A, McKeon BA, Haviland MJ, Newman LR.

Obstet Gynecol. 2017 Oct;130 Suppl 1:36S-41S. doi: 10.1097/AOG.0000000000002203.

PMID:
28937517
8.

Sitting With Fatima: How Longitudinal Learning Inspired My Passion for Obstetrics and Gynecology.

Freret TS.

Obstet Gynecol. 2017 Oct;130(4):878-880. doi: 10.1097/AOG.0000000000002205. No abstract available.

PMID:
28885422
9.

LP-211, a selective 5-HT7 receptor agonist, increases novelty-preference and promotes risk-prone behavior in rats.

Beaudet G, Paizanis E, Zoratto F, Lacivita E, Leopoldo M, Freret T, Laviola G, Boulouard M, Adriani W.

Synapse. 2017 Dec;71(12). doi: 10.1002/syn.21995. Epub 2017 Aug 17.

PMID:
28752923
10.

Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse.

Freret T, Lelong-Boulouard V, Lecouflet P, Hamidouche K, Dauphin F, Boulouard M.

Psychopharmacology (Berl). 2017 Aug;234(15):2365-2374. doi: 10.1007/s00213-017-4664-z. Epub 2017 Jun 19.

PMID:
28631100
11.

Twelve tips for implementation of "student-as-teacher" programs.

Freret T, Rana J, Schwartzstein RM, Gooding HC.

Med Teach. 2017 Dec;39(12):1221-1226. doi: 10.1080/0142159X.2017.1333591. Epub 2017 Jun 9.

PMID:
28598708
12.

Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate.

Schrantee A, Tremoleda JL, Wylezinska-Arridge M, Bouet V, Hesseling P, Meerhoff GF, de Bruin KM, Koeleman J, Freret T, Boulouard M, Desfosses E, Galineau L, Gozzi A, Dauphin F, Gsell W, Booij J, Lucassen PJ, Reneman L.

PLoS One. 2017 Feb 27;12(2):e0172776. doi: 10.1371/journal.pone.0172776. eCollection 2017.

13.

Deletion of the serotonin receptor type 7 disrupts the acquisition of allocentric but not egocentric navigation strategies in mice.

Beaudet G, Jozet-Alves C, Asselot R, Schumann-Bard P, Freret T, Boulouard M, Paizanis E.

Behav Brain Res. 2017 Mar 1;320:179-185. doi: 10.1016/j.bbr.2016.12.006. Epub 2016 Dec 8.

PMID:
27939340
14.

Long-Lasting Effects of Chronic Intermittent Alcohol Exposure in Adolescent Mice on Object Recognition and Hippocampal Neuronal Activity.

Beaudet G, Valable S, Bourgine J, Lelong-Boulouard V, Lanfumey L, Freret T, Boulouard M, Paizanis E.

Alcohol Clin Exp Res. 2016 Dec;40(12):2591-2603. doi: 10.1111/acer.13256. Epub 2016 Nov 1.

PMID:
27801508
15.

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT4R) partial agonist and 5-HT6R antagonist activities, as potential treatment of Alzheimer's disease.

Yahiaoui S, Hamidouche K, Ballandonne C, Davis A, de Oliveira Santos JS, Freret T, Boulouard M, Rochais C, Dallemagne P.

Eur J Med Chem. 2016 Oct 4;121:283-293. doi: 10.1016/j.ejmech.2016.05.048. Epub 2016 May 26.

PMID:
27266998
16.

Usefulness of Time-Point Serum Cortisol and ACTH Measurements for the Adjustment of Glucocorticoid Replacement in Adrenal Insufficiency.

Rousseau E, Joubert M, Trzepla G, Parienti JJ, Freret T, Vanthygem MC, Desailloud R, Lefebvre H, Coquerel A, Reznik Y; PHAD Study Group.

PLoS One. 2015 Aug 28;10(8):e0135975. doi: 10.1371/journal.pone.0135975. eCollection 2015.

17.

Effects of acute administration of melatonin on attentional, executive, and working memory processes in rats.

Liet C, Amenouche F, Freret T, Boulouard M, Mauvieux B, Lelong-Boulouard V, Bocca ML.

Fundam Clin Pharmacol. 2015 Oct;29(5):472-7. doi: 10.1111/fcp.12134. Epub 2015 Aug 11.

PMID:
26194194
18.

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances.

Quiedeville A, Boulouard M, Hamidouche K, Da Silva Costa-Aze V, Nee G, Rochais C, Dallemagne P, Fabis F, Freret T, Bouet V.

Behav Brain Res. 2015 Oct 15;293:10-7. doi: 10.1016/j.bbr.2015.07.020. Epub 2015 Jul 14.

PMID:
26187692
19.

Therapeutic Potential of 5-HT6 Receptor Agonists.

Karila D, Freret T, Bouet V, Boulouard M, Dallemagne P, Rochais C.

J Med Chem. 2015 Oct 22;58(20):7901-12. doi: 10.1021/acs.jmedchem.5b00179. Epub 2015 Jul 2. Review.

PMID:
26099069
20.

Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis.

van der Marel K, Bouet V, Meerhoff GF, Freret T, Boulouard M, Dauphin F, Klomp A, Lucassen PJ, Homberg JR, Dijkhuizen RM, Reneman L.

Neuroscience. 2015 Nov 19;309:243-58. doi: 10.1016/j.neuroscience.2015.04.044. Epub 2015 Apr 28.

PMID:
25934041
21.

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride.

Rochais C, Lecoutey C, Gaven F, Giannoni P, Hamidouche K, Hedou D, Dubost E, Genest D, Yahiaoui S, Freret T, Bouet V, Dauphin F, Sopkova de Oliveira Santos J, Ballandonne C, Corvaisier S, Malzert-Fréon A, Legay R, Boulouard M, Claeysen S, Dallemagne P.

J Med Chem. 2015 Apr 9;58(7):3172-87. doi: 10.1021/acs.jmedchem.5b00115. Epub 2015 Mar 31.

PMID:
25793650
22.

Time decay of object, place and temporal order memory in a paradigm assessing simultaneously episodic-like memory components in mice.

Belblidia H, Abdelouadoud A, Jozet-Alves C, Dumas H, Freret T, Leger M, Schumann-Bard P.

Behav Brain Res. 2015 Jun 1;286:80-4. doi: 10.1016/j.bbr.2015.02.043. Epub 2015 Feb 28.

PMID:
25732955
23.

Spatial memory deficit across aging: current insights of the role of 5-HT7 receptors.

Beaudet G, Bouet V, Jozet-Alves C, Schumann-Bard P, Dauphin F, Paizanis E, Boulouard M, Freret T.

Front Behav Neurosci. 2015 Jan 14;8:448. doi: 10.3389/fnbeh.2014.00448. eCollection 2014. Review.

24.

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

Fernandez MA, Klutkowski JA, Freret T, Wolfe MS.

J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19.

25.

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment.

Lecoutey C, Hedou D, Freret T, Giannoni P, Gaven F, Since M, Bouet V, Ballandonne C, Corvaisier S, Malzert Fréon A, Mignani S, Cresteil T, Boulouard M, Claeysen S, Rochais C, Dallemagne P.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3825-30. doi: 10.1073/pnas.1410315111. Epub 2014 Aug 25.

26.

Environmental Enrichment Duration Differentially Affects Behavior and Neuroplasticity in Adult Mice.

Leger M, Paizanis E, Dzahini K, Quiedeville A, Bouet V, Cassel JC, Freret T, Schumann-Bard P, Boulouard M.

Cereb Cortex. 2015 Nov;25(11):4048-61. doi: 10.1093/cercor/bhu119. Epub 2014 Jun 5.

PMID:
24904072
27.

Iron overload accelerates neuronal amyloid-β production and cognitive impairment in transgenic mice model of Alzheimer's disease.

Becerril-Ortega J, Bordji K, Fréret T, Rush T, Buisson A.

Neurobiol Aging. 2014 Oct;35(10):2288-301. doi: 10.1016/j.neurobiolaging.2014.04.019. Epub 2014 May 1.

PMID:
24863668
28.

Dual histamine H3R/serotonin 5-HT4R ligands with antiamnesic properties: pharmacophore-based virtual screening and polypharmacology.

Lepailleur A, Freret T, Lemaître S, Boulouard M, Dauphin F, Hinschberger A, Dulin F, Lesnard A, Bureau R, Rault S.

J Chem Inf Model. 2014 Jun 23;54(6):1773-84. doi: 10.1021/ci500157n. Epub 2014 Jun 10.

PMID:
24857631
29.

5-HT6 receptor antagonists as treatment for age-related cognitive decline.

Quiedeville A, Boulouard M, Da Silva Costa-Aze V, Dauphin F, Bouet V, Freret T.

Rev Neurosci. 2014;25(3):417-27. doi: 10.1515/revneuro-2014-0013.

PMID:
24622786
30.

Benzodiazepines increase the reward effects of buprenorphine in a conditioned place preference test in the mouse.

Ma LL, Freret T, Lange M, Bourgine J, Coquerel A, Lelong-Boulouard V.

Fundam Clin Pharmacol. 2014 Dec;28(6):681-9. doi: 10.1111/fcp.12072. Epub 2014 Apr 17.

PMID:
24617653
31.

Mechanisms underlying the neuroprotective effect of brain reserve against late life depression.

Freret T, Gaudreau P, Schumann-Bard P, Billard JM, Popa-Wagner A.

J Neural Transm (Vienna). 2015 Aug;122 Suppl 1:S55-61. doi: 10.1007/s00702-013-1154-2. Epub 2014 Jan 5. Review.

PMID:
24390152
32.

Object recognition test in mice.

Leger M, Quiedeville A, Bouet V, Haelewyn B, Boulouard M, Schumann-Bard P, Freret T.

Nat Protoc. 2013 Dec;8(12):2531-7. doi: 10.1038/nprot.2013.155. Epub 2013 Nov 21.

PMID:
24263092
33.

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: synthesis and antinociceptive evaluation.

Since M, Freret T, Nee G, Terme T, Vanelle P, Boulouard M.

Eur J Med Chem. 2013 Nov;69:728-34. doi: 10.1016/j.ejmech.2013.08.041. Epub 2013 Sep 13.

PMID:
24095764
34.

Modulation of 5-HT7 receptor: effect on object recognition performances in mice.

Freret T, Paizanis E, Beaudet G, Gusmao-Montaigne A, Nee G, Dauphin F, Bouet V, Boulouard M.

Psychopharmacology (Berl). 2014 Jan;231(2):393-400. doi: 10.1007/s00213-013-3247-x. Epub 2013 Aug 31.

PMID:
23995300
35.

Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging.

Paban V, Billard JM, Bouet V, Freret T, Boulouard M, Chambon C, Loriod B, Alescio-Lautier B.

Brain Struct Funct. 2013 Nov;218(6):1501-12. doi: 10.1007/s00429-012-0472-8. Epub 2012 Nov 10.

PMID:
23143343
36.

Environmental enrichment enhances episodic-like memory in association with a modified neuronal activation profile in adult mice.

Leger M, Quiedeville A, Paizanis E, Natkunarajah S, Freret T, Boulouard M, Schumann-Bard P.

PLoS One. 2012;7(10):e48043. doi: 10.1371/journal.pone.0048043. Epub 2012 Oct 22.

37.

Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.

Danglot L, Freret T, Le Roux N, Narboux Nême N, Burgo A, Hyenne V, Roumier A, Contremoulins V, Dauphin F, Bizot JC, Vodjdani G, Gaspar P, Boulouard M, Poncer JC, Galli T, Simmler MC.

J Neurosci. 2012 Jun 27;32(26):9007-22. doi: 10.1523/JNEUROSCI.3084-11.2012.

38.

Spatial and non-spatial performance in mutant mice devoid of otoliths.

Machado ML, Kroichvili N, Freret T, Philoxène B, Lelong-Boulouard V, Denise P, Besnard S.

Neurosci Lett. 2012 Jul 26;522(1):57-61. doi: 10.1016/j.neulet.2012.06.016. Epub 2012 Jun 15.

PMID:
22705908
39.

Influence of anxiety in spatial memory impairments related to the loss of vestibular function in rat.

Machado ML, Lelong-Boulouard V, Smith PF, Freret T, Philoxene B, Denise P, Besnard S.

Neuroscience. 2012 Aug 30;218:161-9. doi: 10.1016/j.neuroscience.2012.05.029. Epub 2012 May 24.

PMID:
22633950
40.

A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat.

Hotte M, Dauphin F, Freret T, Boulouard M, Levallet G.

PLoS One. 2012;7(2):e32244. doi: 10.1371/journal.pone.0032244. Epub 2012 Feb 16.

41.

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Freret T, Bouet V, Quiedeville A, Nee G, Dallemagne P, Rochais C, Boulouard M.

Behav Brain Res. 2012 Apr 21;230(1):304-8. doi: 10.1016/j.bbr.2012.02.012. Epub 2012 Feb 14.

PMID:
22348892
42.

Post-stroke depression: mechanisms, translation and therapy.

Loubinoux I, Kronenberg G, Endres M, Schumann-Bard P, Freret T, Filipkowski RK, Kaczmarek L, Popa-Wagner A.

J Cell Mol Med. 2012 Sep;16(9):1961-9. doi: 10.1111/j.1582-4934.2012.01555.x. Review.

43.

Repeated mild hypoxic exposures decrease anxiety-like behavior in the adult mouse together with an increased brain adrenomedullin gene expression.

Leconte C, Léger M, Boulouard M, Tixier E, Fréret T, Bernaudin M, Schumann-Bard P.

Behav Brain Res. 2012 Apr 21;230(1):78-84. doi: 10.1016/j.bbr.2012.01.054. Epub 2012 Feb 7.

PMID:
22326698
44.

Age-dependent effects of chronic fluoxetine treatment on the serotonergic system one week following treatment.

Bouet V, Klomp A, Freret T, Wylezinska-Arridge M, Lopez-Tremoleda J, Dauphin F, Boulouard M, Booij J, Gsell W, Reneman L.

Psychopharmacology (Berl). 2012 May;221(2):329-39. doi: 10.1007/s00213-011-2580-1. Epub 2011 Dec 24.

PMID:
22205158
45.

Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice.

Leger M, Bouet V, Freret T, Darmaillacq AS, Dacher M, Dauphin F, Boulouard M, Schumann-Bard P.

Behav Brain Res. 2012 Mar 1;228(1):22-9. doi: 10.1016/j.bbr.2011.11.022. Epub 2011 Nov 28.

PMID:
22138509
46.

Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia-ischemia: sequential MRI and behavioral investigations.

Letourneur A, Freret T, Roussel S, Boulouard M, Divoux D, Toutain J, Bernaudin M, Schumann-Bard P, Bouet V, Touzani O.

Exp Neurol. 2012 Jan;233(1):264-72. doi: 10.1016/j.expneurol.2011.10.014. Epub 2011 Oct 25.

PMID:
22051176
47.

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan.

Freret T, Billard JM, Schumann-Bard P, Dutar P, Dauphin F, Boulouard M, Bouet V.

Neurobiol Aging. 2012 May;33(5):1005.e1-10. doi: 10.1016/j.neurobiolaging.2011.09.028. Epub 2011 Oct 27.

PMID:
22035592
48.

On the importance of long-term functional assessment after stroke to improve translation from bench to bedside.

Freret T, Schumann-Bard P, Boulouard M, Bouet V.

Exp Transl Stroke Med. 2011 Jun 18;3:6. doi: 10.1186/2040-7378-3-6.

49.

Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors.

Besnard S, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V.

Hippocampus. 2012 Apr;22(4):814-26. doi: 10.1002/hipo.20942. Epub 2011 Apr 27.

PMID:
21538662
50.

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals.

Bouet V, Freret T, Dutar P, Billard JM, Boulouard M.

Mech Ageing Dev. 2011 May;132(5):240-8. doi: 10.1016/j.mad.2011.04.006. Epub 2011 Apr 17.

PMID:
21530571

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