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Items: 13

1.

Novel model of secreted human tau protein reveals the impact of the abnormal N-glycosylation of tau on its aggregation propensity.

Losev Y, Paul A, Frenkel-Pinter M, Abu-Hussein M, Khalaila I, Gazit E, Segal D.

Sci Rep. 2019 Feb 19;9(1):2254. doi: 10.1038/s41598-019-39218-x.

2.

Distinct Effects of O-GlcNAcylation and Phosphorylation of a Tau-Derived Amyloid Peptide on Aggregation of the Native Peptide.

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S, Segal D.

Chemistry. 2018 Sep 20;24(53):14039-14043. doi: 10.1002/chem.201802209. Epub 2018 Aug 24.

PMID:
30144161
3.

Interplay between protein glycosylation pathways in Alzheimer's disease.

Frenkel-Pinter M, Shmueli MD, Raz C, Yanku M, Zilberzwige S, Gazit E, Segal D.

Sci Adv. 2017 Sep 15;3(9):e1601576. doi: 10.1126/sciadv.1601576. eCollection 2017 Sep.

4.

Altered protein glycosylation predicts Alzheimer's disease and modulates its pathology in disease model Drosophila.

Frenkel-Pinter M, Stempler S, Tal-Mazaki S, Losev Y, Singh-Anand A, Escobar-Álvarez D, Lezmy J, Gazit E, Ruppin E, Segal D.

Neurobiol Aging. 2017 Aug;56:159-171. doi: 10.1016/j.neurobiolaging.2017.04.020. Epub 2017 May 3.

PMID:
28552182
5.

Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro-Substituted Analogues.

Chemerovski-Glikman M, Frenkel-Pinter M, Mdah R, Abu-Mokh A, Gazit E, Segal D.

Chemistry. 2017 Jul 18;23(40):9618-9624. doi: 10.1002/chem.201701218. Epub 2017 Jun 27.

PMID:
28544138
6.

Cl-NQTrp Alleviates Tauopathy Symptoms in a Model Organism through the Inhibition of Tau Aggregation-Engendered Toxicity.

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E, Segal D.

Neurodegener Dis. 2017;17(2-3):73-82. doi: 10.1159/000448518. Epub 2016 Oct 20.

PMID:
27760426
7.

Selective Inhibition of Aggregation and Toxicity of a Tau-Derived Peptide using Its Glycosylated Analogues.

Frenkel-Pinter M, Richman M, Belostozky A, Abu-Mokh A, Gazit E, Rahimipour S, Segal D.

Chemistry. 2016 Apr 18;22(17):5945-52. doi: 10.1002/chem.201504950. Epub 2016 Feb 18.

PMID:
26891276
8.

Naphthoquinone-Tryptophan Hybrid Inhibits Aggregation of the Tau-Derived Peptide PHF6 and Reduces Neurotoxicity.

Frenkel-Pinter M, Tal S, Scherzer-Attali R, Abu-Hussien M, Alyagor I, Eisenbaum T, Gazit E, Segal D.

J Alzheimers Dis. 2016;51(1):165-78. doi: 10.3233/JAD-150927.

PMID:
26836184
9.

A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD).

Shaltiel-Karyo R, Frenkel-Pinter M, Rockenstein E, Patrick C, Levy-Sakin M, Schiller A, Egoz-Matia N, Masliah E, Segal D, Gazit E.

J Biol Chem. 2013 Jun 14;288(24):17579-88. doi: 10.1074/jbc.M112.434787. Epub 2013 May 1.

10.

A novel, sensitive assay for behavioral defects in Parkinson's disease model Drosophila.

Shaltiel-Karyo R, Davidi D, Menuchin Y, Frenkel-Pinter M, Marcus-Kalish M, Ringo J, Gazit E, Segal D.

Parkinsons Dis. 2012;2012:697564. doi: 10.1155/2012/697564. Epub 2012 Jul 25.

11.

Differential inhibition of α-synuclein oligomeric and fibrillar assembly in parkinson's disease model by cinnamon extract.

Shaltiel-Karyo R, Davidi D, Frenkel-Pinter M, Ovadia M, Segal D, Gazit E.

Biochim Biophys Acta. 2012 Oct;1820(10):1628-35. doi: 10.1016/j.bbagen.2012.04.021. Epub 2012 May 2.

PMID:
22575665
12.

Enhanced bioavailability of polyaromatic hydrocarbons in the form of mucin complexes.

Drug E, Landesman-Milo D, Belgorodsky B, Ermakov N, Frenkel-Pinter M, Fadeev L, Peer D, Gozin M.

Chem Res Toxicol. 2011 Mar 21;24(3):314-20. doi: 10.1021/tx100426s. Epub 2011 Feb 18.

PMID:
21332130
13.

Inhibiting α-synuclein oligomerization by stable cell-penetrating β-synuclein fragments recovers phenotype of Parkinson's disease model flies.

Shaltiel-Karyo R, Frenkel-Pinter M, Egoz-Matia N, Frydman-Marom A, Shalev DE, Segal D, Gazit E.

PLoS One. 2010 Nov 10;5(11):e13863. doi: 10.1371/journal.pone.0013863.

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