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DDR1 autophosphorylation is a result of aggregation into dense clusters.

Corcoran DS, Juskaite V, Xu Y, Görlitz F, Alexandrov Y, Dunsby C, French PMW, Leitinger B.

Sci Rep. 2019 Nov 19;9(1):17104. doi: 10.1038/s41598-019-53176-4.


Multidimensional luminescence microscope for imaging defect colour centres in diamond.

Jones DC, Kumar S, Lanigan PMP, McGuinness CD, Dale MW, Twitchen DJ, Fisher D, Martineau PM, Neil MAA, Dunsby C, French PMW.

Methods Appl Fluoresc. 2019 Nov 12;8(1):014004. doi: 10.1088/2050-6120/ab4eac.


Convolutional neural networks for reconstruction of undersampled optical projection tomography data applied to in vivo imaging of zebrafish.

Davis SPX, Kumar S, Alexandrov Y, Bhargava A, da Silva Xavier G, Rutter GA, Frankel P, Sahai E, Flaxman S, French PMW, McGinty J.

J Biophotonics. 2019 Dec;12(12):e201900128. doi: 10.1002/jbio.201900128. Epub 2019 Aug 29.


In vivo label-free optical monitoring of structural and metabolic remodeling of myocardium following infarction.

Lagarto JL, Dyer BT, Peters NS, French PMW, Dunsby C, Lyon AR.

Biomed Opt Express. 2019 Jun 21;10(7):3506-3521. doi: 10.1364/BOE.10.003506. eCollection 2019 Jul 1.


Accelerating single molecule localization microscopy through parallel processing on a high-performance computing cluster.

Munro I, García E, Yan M, Guldbrand S, Kumar S, Kwakwa K, Dunsby C, Neil MAA, French PMW.

J Microsc. 2019 Feb;273(2):148-160. doi: 10.1111/jmi.12772. Epub 2018 Dec 3.


Slice-illuminated optical projection tomography.

Davis SPX, Wisniewski L, Kumar S, Correia T, Arridge SR, Frankel P, McGinty J, French PMW.

Opt Lett. 2018 Nov 15;43(22):5555-5558. doi: 10.1364/OL.43.005555.


Characterization of NAD(P)H and FAD autofluorescence signatures in a Langendorff isolated-perfused rat heart model.

Lagarto JL, Dyer BT, Talbot CB, Peters NS, French PMW, Lyon AR, Dunsby C.

Biomed Opt Express. 2018 Sep 21;9(10):4961-4978. doi: 10.1364/BOE.9.004961. eCollection 2018 Oct 1.


easySLM-STED: Stimulated emission depletion microscopy with aberration correction, extended field of view and multiple beam scanning.

Görlitz F, Guldbrand S, Runcorn TH, Murray RT, Jaso-Tamame AL, Sinclair HG, Martinez-Perez E, Taylor JR, Neil MAA, Dunsby C, French PMW.

J Biophotonics. 2018 Nov;11(11):e201800087. doi: 10.1002/jbio.201800087. Epub 2018 Jul 31.


Quantitative time domain analysis of lifetime-based Förster resonant energy transfer measurements with fluorescent proteins: Static random isotropic fluorophore orientation distributions.

Alexandrov Y, Nikolic DS, Dunsby C, French PMW.

J Biophotonics. 2018 Jul;11(7):e201700366. doi: 10.1002/jbio.201700366. Epub 2018 May 2.


In vivo multiphoton microscopy using a handheld scanner with lateral and axial motion compensation.

Sherlock B, Warren SC, Alexandrov Y, Yu F, Stone J, Knight J, Neil MAA, Paterson C, French PMW, Dunsby C.

J Biophotonics. 2018 Feb;11(2). doi: 10.1002/jbio.201700131. Epub 2017 Nov 15.


In vivo label-free mapping of the effect of a photosystem II inhibiting herbicide in plants using chlorophyll fluorescence lifetime.

Noble E, Kumar S, Görlitz FG, Stain C, Dunsby C, French PMW.

Plant Methods. 2017 Jun 15;13:48. doi: 10.1186/s13007-017-0201-7. eCollection 2017.


Development of Low-Cost Instrumentation for Single Point Autofluorescence Lifetime Measurements.

Lagarto J, Hares JD, Dunsby C, French PMW.

J Fluoresc. 2017 Sep;27(5):1643-1654. doi: 10.1007/s10895-017-2101-7. Epub 2017 May 25.


Open Source High Content Analysis Utilizing Automated Fluorescence Lifetime Imaging Microscopy.

Görlitz F, Kelly DJ, Warren SC, Alibhai D, West L, Kumar S, Alexandrov Y, Munro I, Garcia E, McGinty J, Talbot C, Serwa RA, Thinon E, da Paola V, Murray EJ, Stuhmeier F, Neil MA, Tate EW, Dunsby C, French PM.

J Vis Exp. 2017 Jan 18;(119). doi: 10.3791/55119.


Characterisation of new gated optical image intensifiers for fluorescence lifetime imaging.

Sparks H, Görlitz F, Kelly DJ, Warren SC, Kellett PA, Garcia E, Dymoke-Bradshaw AK, Hares JD, Neil MA, Dunsby C, French PM.

Rev Sci Instrum. 2017 Jan;88(1):013707. doi: 10.1063/1.4973917.


Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults.

Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z, McGinty J, Paul EJ, Ungless MA, French PMW, Withers DJ, Uren A, Ferguson-Smith AC, Merkenschlager M, John RM, Fisher AG.

Cell Rep. 2017 Jan 31;18(5):1090-1099. doi: 10.1016/j.celrep.2017.01.010.


Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.

Perdios L, Lowe AR, Saladino G, Bunney TD, Thiyagarajan N, Alexandrov Y, Dunsby C, French PM, Chin JW, Gervasio FL, Tate EW, Katan M.

Sci Rep. 2017 Jan 3;7:39841. doi: 10.1038/srep39841.


Plasmonic Nanoprobes for Stimulated Emission Depletion Nanoscopy.

Cortés E, Huidobro PA, Sinclair HG, Guldbrand S, Peveler WJ, Davies T, Parrinello S, Görlitz F, Dunsby C, Neil MA, Sivan Y, Parkin IP, French PM, Maier SA.

ACS Nano. 2016 Nov 22;10(11):10454-10461. Epub 2016 Nov 3.


Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection.

Warren SC, Kim Y, Stone JM, Mitchell C, Knight JC, Neil MA, Paterson C, French PM, Dunsby C.

Opt Express. 2016 Sep 19;24(19):21474-84. doi: 10.1364/OE.24.021474.


Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).

Margineanu A, Chan JJ, Kelly DJ, Warren SC, Flatters D, Kumar S, Katan M, Dunsby CW, French PM.

Sci Rep. 2016 Sep 22;6:33621. doi: 10.1038/srep33621. No abstract available.


easySTORM: a robust, lower-cost approach to localisation and TIRF microscopy.

Kwakwa K, Savell A, Davies T, Munro I, Parrinello S, Purbhoo MA, Dunsby C, Neil MA, French PM.

J Biophotonics. 2016 Sep;9(9):948-57. doi: 10.1002/jbio.201500324. Epub 2016 Mar 11.


Imaging of Metabolic Status in 3D Cultures with an Improved AMPK FRET Biosensor for FLIM.

Chennell G, Willows RJ, Warren SC, Carling D, French PM, Dunsby C, Sardini A.

Sensors (Basel). 2016 Aug 19;16(8). pii: E1312. doi: 10.3390/s16081312.


Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).

Margineanu A, Chan JJ, Kelly DJ, Warren SC, Flatters D, Kumar S, Katan M, Dunsby CW, French PM.

Sci Rep. 2016 Jun 24;6:28186. doi: 10.1038/srep28186. Erratum in: Sci Rep. 2016 Sep 22;6:33621.


Quantitative in vivo optical tomography of cancer progression & vasculature development in adult zebrafish.

Kumar S, Lockwood N, Ramel MC, Correia T, Ellis M, Alexandrov Y, Andrews N, Patel R, Bugeon L, Dallman MJ, Brandner S, Arridge S, Katan M, McGinty J, Frankel P, French PM.

Oncotarget. 2016 Jul 12;7(28):43939-43948. doi: 10.18632/oncotarget.9756.


Tunable fibre-coupled multiphoton microscopy with a negative curvature fibre.

Sherlock B, Yu F, Stone J, Warren S, Paterson C, Neil MA, French PM, Knight J, Dunsby C.

J Biophotonics. 2016 Jul;9(7):715-20. doi: 10.1002/jbio.201500290. Epub 2016 Mar 15.


Visualising apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time.

Andrews N, Ramel MC, Kumar S, Alexandrov Y, Kelly DJ, Warren SC, Kerry L, Lockwood N, Frolov A, Frankel P, Bugeon L, McGinty J, Dallman MJ, French PM.

J Biophotonics. 2016 Apr;9(4):414-24. doi: 10.1002/jbio.201500258. Epub 2016 Jan 11.


Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1.

Perdios L, Bunney TD, Warren SC, Dunsby C, French PMW, Tate EW, Katan M.

Adv Biol Regul. 2016 Jan;60:6-13. doi: 10.1016/j.jbior.2015.09.002. Epub 2015 Sep 26.


Accelerated Optical Projection Tomography Applied to In Vivo Imaging of Zebrafish.

Correia T, Lockwood N, Kumar S, Yin J, Ramel MC, Andrews N, Katan M, Bugeon L, Dallman MJ, McGinty J, Frankel P, French PM, Arridge S.

PLoS One. 2015 Aug 26;10(8):e0136213. doi: 10.1371/journal.pone.0136213. eCollection 2015.


Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells.

Warren SC, Margineanu A, Katan M, Dunsby C, French PM.

Int J Mol Sci. 2015 Jun 30;16(7):14695-716. doi: 10.3390/ijms160714695.


Correction Approach for Delta Function Convolution Model Fitting of Fluorescence Decay Data in the Case of a Monoexponential Reference Fluorophore.

Talbot CB, Lagarto J, Warren S, Neil MA, French PM, Dunsby C.

J Fluoresc. 2015 Sep;25(5):1169-82. doi: 10.1007/s10895-015-1583-4. Epub 2015 Jun 11.


Mesoscopic in vivo 3-D tracking of sparse cell populations using angular multiplexed optical projection tomography.

Chen L, Alexandrov Y, Kumar S, Andrews N, Dallman MJ, French PM, McGinty J.

Biomed Opt Express. 2015 Mar 12;6(4):1253-61. doi: 10.1364/BOE.6.001253. eCollection 2015 Apr 1.


Application of time-resolved autofluorescence to label-free in vivo optical mapping of changes in tissue matrix and metabolism associated with myocardial infarction and heart failure.

Lagarto J, Dyer BT, Talbot C, Sikkel MB, Peters NS, French PM, Lyon AR, Dunsby C.

Biomed Opt Express. 2015 Jan 7;6(2):324-46. doi: 10.1364/BOE.6.000324. eCollection 2015 Feb 1.


Remote focal scanning optical projection tomography with an electrically tunable lens.

Chen L, Kumar S, Kelly D, Andrews N, Dallman MJ, French PM, McGinty J.

Biomed Opt Express. 2014 Sep 2;5(10):3367-75. doi: 10.1364/BOE.5.003367. eCollection 2014 Oct 1.


Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.

Mitchell RK, Mondragon A, Chen L, Mcginty JA, French PM, Ferrer J, Thorens B, Hodson DJ, Rutter GA, Da Silva Xavier G.

Hum Mol Genet. 2015 Mar 1;24(5):1390-9. doi: 10.1093/hmg/ddu553. Epub 2014 Oct 29.


Analysis of DNA binding and nucleotide flipping kinetics using two-color two-photon fluorescence lifetime imaging microscopy.

Robinson T, Valluri P, Kennedy G, Sardini A, Dunsby C, Neil MA, Baldwin GS, French PM, de Mello AJ.

Anal Chem. 2014 Nov 4;86(21):10732-40. doi: 10.1021/ac502732s. Epub 2014 Oct 20.


LKB1 and AMPK differentially regulate pancreatic β-cell identity.

Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, McGinty JA, Chen L, French PM, Birzele F, Hildebrandt T, Uphues I, Rutter GA.

FASEB J. 2014 Nov;28(11):4972-85. doi: 10.1096/fj.14-257667. Epub 2014 Jul 28.


Experimental proof of concept of nanoparticle-assisted STED.

Sonnefraud Y, Sinclair HG, Sivan Y, Foreman MR, Dunsby CW, Neil MA, French PM, Maier SA.

Nano Lett. 2014 Aug 13;14(8):4449-53. doi: 10.1021/nl5014103. Epub 2014 Jul 28.


Introduction: feature issue on optical molecular probes, imaging, and drug delivery.

Campagnola P, French PM, Georgakoudi I, Mycek MA.

Biomed Opt Express. 2014 Jan 29;5(2):643-4. doi: 10.1364/BOE.5.000643. eCollection 2014 Feb 1.


Fluorescence lifetime spectroscopy of tissue autofluorescence in normal and diseased colon measured ex vivo using a fiber-optic probe.

Coda S, Thompson AJ, Kennedy GT, Roche KL, Ayaru L, Bansi DS, Stamp GW, Thillainayagam AV, French PM, Dunsby C.

Biomed Opt Express. 2014 Jan 16;5(2):515-38. doi: 10.1364/BOE.5.000515. eCollection 2014 Feb 1.


SUMOylation inhibits FOXM1 activity and delays mitotic transition.

Myatt SS, Kongsema M, Man CW, Kelly DJ, Gomes AR, Khongkow P, Karunarathna U, Zona S, Langer JK, Dunsby CW, Coombes RC, French PM, Brosens JJ, Lam EW.

Oncogene. 2014 Aug 21;33(34):4316-29. doi: 10.1038/onc.2013.546. Epub 2013 Dec 23.


Rapid global fitting of large fluorescence lifetime imaging microscopy datasets.

Warren SC, Margineanu A, Alibhai D, Kelly DJ, Talbot C, Alexandrov Y, Munro I, Katan M, Dunsby C, French PM.

PLoS One. 2013 Aug 5;8(8):e70687. doi: 10.1371/journal.pone.0070687. Print 2013.


Multiphoton laser tomography and fluorescence lifetime imaging of melanoma: morphologic features and quantitative data for sensitive and specific non-invasive diagnostics.

Seidenari S, Arginelli F, Dunsby C, French PM, König K, Magnoni C, Talbot C, Ponti G.

PLoS One. 2013 Jul 26;8(7):e70682. doi: 10.1371/journal.pone.0070682. Print 2013.


3-D stimulated emission depletion microscopy with programmable aberration correction.

Lenz MO, Sinclair HG, Savell A, Clegg JH, Brown AC, Davis DM, Dunsby C, Neil MA, French PM.

J Biophotonics. 2014 Jan;7(1-2):29-36. doi: 10.1002/jbio.201300041. Epub 2013 Jun 21.


Animal models of GWAS-identified type 2 diabetes genes.

da Silva Xavier G, Bellomo EA, McGinty JA, French PM, Rutter GA.

J Diabetes Res. 2013;2013:906590. doi: 10.1155/2013/906590. Epub 2013 Apr 11. Review.


Simultaneous angular multiplexing optical projection tomography at shifted focal planes.

Chen L, Andrews N, Kumar S, Frankel P, McGinty J, French PM.

Opt Lett. 2013 Mar 15;38(6):851-3. doi: 10.1364/OL.38.000851.


Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation.

Alibhai D, Kelly DJ, Warren S, Kumar S, Margineau A, Serwa RA, Thinon E, Alexandrov Y, Murray EJ, Stuhmeier F, Tate EW, Neil MA, Dunsby C, French PM.

J Biophotonics. 2013 May;6(5):398-408. doi: 10.1002/jbio.201200185. Epub 2012 Nov 26.


Fluorescence lifetime readouts of Troponin-C-based calcium FRET sensors: a quantitative comparison of CFP and mTFP1 as donor fluorophores.

Laine R, Stuckey DW, Manning H, Warren SC, Kennedy G, Carling D, Dunsby C, Sardini A, French PM.

PLoS One. 2012;7(11):e49200. doi: 10.1371/journal.pone.0049200. Epub 2012 Nov 9.


Activity of PLCε contributes to chemotaxis of fibroblasts towards PDGF.

Martins M, Warren S, Kimberley C, Margineanu A, Peschard P, McCarthy A, Yeo M, Marshall CJ, Dunsby C, French PM, Katan M.

J Cell Sci. 2012 Dec 1;125(Pt 23):5758-69. doi: 10.1242/jcs.110007. Epub 2012 Sep 19.


Multiphoton multispectral fluorescence lifetime tomography for the evaluation of basal cell carcinomas.

Patalay R, Talbot C, Alexandrov Y, Lenz MO, Kumar S, Warren S, Munro I, Neil MA, König K, French PM, Chu A, Stamp GW, Dunsby C.

PLoS One. 2012;7(9):e43460. doi: 10.1371/journal.pone.0043460. Epub 2012 Sep 11.


Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.

da Silva Xavier G, Mondragon A, Sun G, Chen L, McGinty JA, French PM, Rutter GA.

Diabetologia. 2012 Oct;55(10):2667-2676. doi: 10.1007/s00125-012-2600-7. Epub 2012 Jun 21.


Incorporation of an experimentally determined MTF for spatial frequency filtering and deconvolution during optical projection tomography reconstruction.

Chen L, McGinty J, Taylor HB, Bugeon L, Lamb JR, Dallman MJ, French PM.

Opt Express. 2012 Mar 26;20(7):7323-37. doi: 10.1364/OE.20.007323.


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