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Structural Determinants for Substrate Selectivity in Guanine Deaminase Enzymes of the Amidohydrolase Superfamily.

Shek R, Hilaire T, Sim J, French JB.

Biochemistry. 2019 Jul 30;58(30):3280-3292. doi: 10.1021/acs.biochem.9b00341. Epub 2019 Jul 19.


Vibrational spectroscopy of flavoproteins.

Iuliano JN, French JB, Tonge PJ.

Methods Enzymol. 2019;620:189-214. doi: 10.1016/bs.mie.2019.03.011. Epub 2019 Apr 10.


Structure-Based Design, Synthesis, and Biological Evaluation of Non-Acyl Sulfamate Inhibitors of the Adenylate-Forming Enzyme MenE.

Evans CE, Si Y, Matarlo JS, Yin Y, French JB, Tonge PJ, Tan DS.

Biochemistry. 2019 Apr 9;58(14):1918-1930. doi: 10.1021/acs.biochem.9b00003. Epub 2019 Mar 26.


Fast, volumetric live-cell imaging using high-resolution light-field microscopy.

Li H, Guo C, Kim-Holzapfel D, Li W, Altshuller Y, Schroeder B, Liu W, Meng Y, French JB, Takamaru KI, Frohman MA, Jia S.

Biomed Opt Express. 2018 Dec 4;10(1):29-49. doi: 10.1364/BOE.10.000029. eCollection 2019 Jan 1.


Crystal structure of E. coli PRPP synthetase.

Zhou W, Tsai A, Dattmore DA, Stives DP, Chitrakar I, D'alessandro AM, Patil S, Hicks KA, French JB.

BMC Struct Biol. 2019 Jan 15;19(1):1. doi: 10.1186/s12900-019-0100-4.


Discovery and Characterization of Two Classes of Selective Inhibitors of the Suppressor of the TCR Signaling Family of Proteins.

Zhou W, Yin Y, Smith E, Chou J, Shumate J, Scampavia L, Spicer TP, Carpino N, French JB.

ACS Infect Dis. 2019 Feb 8;5(2):250-259. doi: 10.1021/acsinfecdis.8b00238. Epub 2018 Dec 14.


Correction: Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT.

PLoS Pathog. 2018 Sep 25;14(9):e1007319. doi: 10.1371/journal.ppat.1007319. eCollection 2018 Sep.


Endoscopic repair of complete bile duct transection by use of transpapillary cholangioperitoneoscopy.

Runge TM, French JB, Grimm IS, Baron TH.

VideoGIE. 2017 Nov 6;3(1):11-12. doi: 10.1016/j.vgie.2017.09.007. eCollection 2018 Jan. No abstract available.


Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice.

Van Skike ND, Minkah NK, Hogan CH, Wu G, Benziger PT, Oldenburg DG, Kara M, Kim-Holzapfel DM, White DW, Tibbetts SA, French JB, Krug LT.

PLoS Pathog. 2018 Feb 1;14(2):e1006843. doi: 10.1371/journal.ppat.1006843. eCollection 2018 Feb. Erratum in: PLoS Pathog. 2018 Sep 25;14(9):e1007319.


Variation in LOV Photoreceptor Activation Dynamics Probed by Time-Resolved Infrared Spectroscopy.

Iuliano JN, Gil AA, Laptenok SP, Hall CR, Tolentino Collado J, Lukacs A, Hag Ahmed SA, Abyad J, Daryaee T, Greetham GM, Sazanovich IV, Illarionov B, Bacher A, Fischer M, Towrie M, French JB, Meech SR, Tonge PJ.

Biochemistry. 2018 Feb 6;57(5):620-630. doi: 10.1021/acs.biochem.7b01040. Epub 2018 Jan 4.


Structural and Functional Basis for Targeting Campylobacter jejuni Agmatine Deiminase To Overcome Antibiotic Resistance.

Shek R, Dattmore DA, Stives DP, Jackson AL, Chatfield CH, Hicks KA, French JB.

Biochemistry. 2017 Dec 26;56(51):6734-6742. doi: 10.1021/acs.biochem.7b00982. Epub 2017 Dec 14.


Photoactivation of the BLUF Protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues.

Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon GE, Brust R, Greetham GM, Towrie M, French JB, Meech SR, Tonge PJ.

J Am Chem Soc. 2017 Oct 18;139(41):14638-14648. doi: 10.1021/jacs.7b07849. Epub 2017 Oct 5.


Health Quality Measures Addressing Disparities in Culturally and Linguistically Appropriate Services: What are Current Gaps?

Ng JH, Tirodkar MA, French JB, Spalt HE, Ward LM, Haffer SC, Hewitt N, Rey D, Scholle SH.

J Health Care Poor Underserved. 2017;28(3):1012-1029. doi: 10.1353/hpu.2017.0093.


Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2.

Zhou W, Yin Y, Weinheimer AS, Kaur N, Carpino N, French JB.

Biochemistry. 2017 Sep 5;56(35):4637-4645. doi: 10.1021/acs.biochem.7b00638. Epub 2017 Aug 21.


Higher order structures in purine and pyrimidine metabolism.

Chitrakar I, Kim-Holzapfel DM, Zhou W, French JB.

J Struct Biol. 2017 Mar;197(3):354-364. doi: 10.1016/j.jsb.2017.01.003. Epub 2017 Jan 21. Review.


Femtosecond to Millisecond Dynamics of Light Induced Allostery in the Avena sativa LOV Domain.

Gil AA, Laptenok SP, French JB, Iuliano JN, Lukacs A, Hall CR, Sazanovich IV, Greetham GM, Bacher A, Illarionov B, Fischer M, Tonge PJ, Meech SR.

J Phys Chem B. 2017 Feb 9;121(5):1010-1019. doi: 10.1021/acs.jpcb.7b00088. Epub 2017 Jan 25.


Somatostatinoma of the Ampulla: An Incidental Postoperative Finding Following Colorectal Cancer Resection.

French JB, Pawa R.

ACG Case Rep J. 2016 Jan 20;3(2):109-11. doi: 10.14309/crj.2016.16. eCollection 2016 Jan.


Endoscopic ultrasound-guided choledochoduodenostomy with a lumen-apposing, self-expandable fully covered metal stent for palliative biliary drainage.

French JB, Coe AW, Pawa R.

Clin J Gastroenterol. 2016 Apr;9(2):79-85. doi: 10.1007/s12328-016-0634-y. Epub 2016 Mar 8.


Spatial colocalization and functional link of purinosomes with mitochondria.

French JB, Jones SA, Deng H, Pedley AM, Kim D, Chan CY, Hu H, Pugh RJ, Zhao H, Zhang Y, Huang TJ, Fang Y, Zhuang X, Benkovic SJ.

Science. 2016 Feb 12;351(6274):733-7. doi: 10.1126/science.aac6054.


Hepatotoxicity Associated with the Use of Anti-TNF-α Agents.

French JB, Bonacini M, Ghabril M, Foureau D, Bonkovsky HL.

Drug Saf. 2016 Mar;39(3):199-208. doi: 10.1007/s40264-015-0366-9. Review.


Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.

Matarlo JS, Evans CE, Sharma I, Lavaud LJ, Ngo SC, Shek R, Rajashankar KR, French JB, Tan DS, Tonge PJ.

Biochemistry. 2015 Oct 27;54(42):6514-6524. doi: 10.1021/acs.biochem.5b00966. Epub 2015 Oct 15.


Precise Manipulation and Patterning of Protein Crystals for Macromolecular Crystallography Using Surface Acoustic Waves.

Guo F, Zhou W, Li P, Mao Z, Yennawar NH, French JB, Huang TJ.

Small. 2015 Jun;11(23):2733-7. doi: 10.1002/smll.201403262. Epub 2015 Feb 1.


Quantitative analysis of purine nucleotides indicates that purinosomes increase de novo purine biosynthesis.

Zhao H, Chiaro CR, Zhang L, Smith PB, Chan CY, Pedley AM, Pugh RJ, French JB, Patterson AD, Benkovic SJ.

J Biol Chem. 2015 Mar 13;290(11):6705-13. doi: 10.1074/jbc.M114.628701. Epub 2015 Jan 20.


Controlling cell-cell interactions using surface acoustic waves.

Guo F, Li P, French JB, Mao Z, Zhao H, Li S, Nama N, Fick JR, Benkovic SJ, Huang TJ.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):43-8. doi: 10.1073/pnas.1422068112. Epub 2014 Dec 22.


Acoustofluidic chemical waveform generator and switch.

Ahmed D, Muddana HS, Lu M, French JB, Ozcelik A, Fang Y, Butler PJ, Benkovic SJ, Manz A, Huang TJ.

Anal Chem. 2014 Dec 2;86(23):11803-10. doi: 10.1021/ac5033676. Epub 2014 Nov 18.


Probing the electrostatics of active site microenvironments along the catalytic cycle for Escherichia coli dihydrofolate reductase.

Liu CT, Layfield JP, Stewart RJ 3rd, French JB, Hanoian P, Asbury JB, Hammes-Schiffer S, Benkovic SJ.

J Am Chem Soc. 2014 Jul 23;136(29):10349-60. doi: 10.1021/ja5038947. Epub 2014 Jul 11.


Gastrointestinal bleeding in patients with ventricular assist devices is highest immediately after implantation.

French JB, Pamboukian SV, George JF, Smallfield GB, Tallaj JA, Brown RN, Smallfield MC, Kirklin JK, Holman WL, Peter S.

ASAIO J. 2013 Sep-Oct;59(5):480-5. doi: 10.1097/MAT.0b013e3182a4b434.


Probing cell-cell communication with microfluidic devices.

Guo F, French JB, Li P, Zhao H, Chan CY, Fick JR, Benkovic SJ, Huang TJ.

Lab Chip. 2013 Aug 21;13(16):3152-62. doi: 10.1039/c3lc90067c. Epub 2013 Jul 10. Review.


Toxic exposure of songbirds to lead in the Southeast Missouri Lead Mining District.

Beyer WN, Franson JC, French JB, May T, Rattner BA, Shearn-Bochsler VI, Warner SE, Weber J, Mosby D.

Arch Environ Contam Toxicol. 2013 Oct;65(3):598-610. doi: 10.1007/s00244-013-9923-3. Epub 2013 Jun 15.


Functional significance of evolving protein sequence in dihydrofolate reductase from bacteria to humans.

Liu CT, Hanoian P, French JB, Pringle TH, Hammes-Schiffer S, Benkovic SJ.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10159-64. doi: 10.1073/pnas.1307130110. Epub 2013 Jun 3.


Lab-on-a-chip technologies for single-molecule studies.

Zhao Y, Chen D, Yue H, French JB, Rufo J, Benkovic SJ, Huang TJ.

Lab Chip. 2013 Jun 21;13(12):2183-98. doi: 10.1039/c3lc90042h. Epub 2013 May 14.


The purinosome, a multi-protein complex involved in the de novo biosynthesis of purines in humans.

Zhao H, French JB, Fang Y, Benkovic SJ.

Chem Commun (Camb). 2013 May 18;49(40):4444-52. doi: 10.1039/c3cc41437j. Epub 2013 Apr 11.


Hsp70/Hsp90 chaperone machinery is involved in the assembly of the purinosome.

French JB, Zhao H, An S, Niessen S, Deng Y, Cravatt BF, Benkovic SJ.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2528-33. doi: 10.1073/pnas.1300173110. Epub 2013 Jan 28.


Mapping protein-protein proximity in the purinosome.

Deng Y, Gam J, French JB, Zhao H, An S, Benkovic SJ.

J Biol Chem. 2012 Oct 19;287(43):36201-7. doi: 10.1074/jbc.M112.407056. Epub 2012 Sep 6.


Structure of trifunctional THI20 from yeast.

French JB, Begley TP, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):784-91. doi: 10.1107/S0907444911024814. Epub 2011 Aug 9.


Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae.

French JB, Ealick SE.

Acta Crystallogr D Biol Crystallogr. 2011 Aug;67(Pt 8):671-7. doi: 10.1107/S090744491101746X. Epub 2011 Jul 12.


Characterization of the structure and function of Klebsiella pneumoniae allantoin racemase.

French JB, Neau DB, Ealick SE.

J Mol Biol. 2011 Jul 15;410(3):447-60. doi: 10.1016/j.jmb.2011.05.016. Epub 2011 May 17.


The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization.

French JB, Yates PA, Soysa DR, Boitz JM, Carter NS, Chang B, Ullman B, Ealick SE.

J Biol Chem. 2011 Jun 10;286(23):20930-41. doi: 10.1074/jbc.M111.228213. Epub 2011 Apr 19.


Toxic effects of dietary methylmercury on immune system development in nestling American kestrels (Falco sparverius).

Fallacara DM, Halbrook RS, French JB.

Environ Toxicol Chem. 2011 Jun;30(6):1328-37. doi: 10.1002/etc.519. Epub 2011 Apr 4.


Toxic effects of dietary methylmercury on immune function and hematology in American kestrels (Falco sparverius).

Fallacara DM, Halbrook RS, French JB.

Environ Toxicol Chem. 2011 Jun;30(6):1320-7. doi: 10.1002/etc.494. Epub 2011 Mar 28.


Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism.

French JB, Cen Y, Vrablik TL, Xu P, Allen E, Hanna-Rose W, Sauve AA.

Biochemistry. 2010 Dec 14;49(49):10421-39. doi: 10.1021/bi1012518. Epub 2010 Nov 15.


Mercury in the blood and eggs of American kestrels fed methylmercury chloride.

French JB Jr, Bennett RS, Rossmann R.

Environ Toxicol Chem. 2010 Oct;29(10):2206-10. doi: 10.1002/etc.284.


Structural and mechanistic studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.

French JB, Ealick SE.

J Biol Chem. 2010 Nov 12;285(46):35446-54. doi: 10.1074/jbc.M110.156034. Epub 2010 Sep 8.


A physiologically based toxicokinetic model for methylmercury in female American kestrels.

Nichols JW, Bennett RS, Rossmann R, French JB, Sappington KG.

Environ Toxicol Chem. 2010 Aug;29(8):1854-67. doi: 10.1002/etc.241.


Reducing disparities and improving quality: understanding the needs of small primary care practices.

Weinick RM, Byron SC, Han ES, French JB, Scholle SH.

Ethn Dis. 2010 Winter;20(1):58-63.


Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase.

French JB, Cen Y, Sauve AA.

Biochemistry. 2008 Sep 23;47(38):10227-39. doi: 10.1021/bi800767t. Epub 2008 Aug 26.


Dietary toxicity and tissue accumulation of methylmercury in American kestrels.

Bennett RS, French JB Jr, Rossmann R, Haebler R.

Arch Environ Contam Toxicol. 2009 Jan;56(1):149-56. doi: 10.1007/s00244-008-9168-8. Epub 2008 Apr 17.


Effects of methylmercury on reproduction in American kestrels.

Albers PH, Koterba MT, Rossmann R, Link WA, French JB, Bennett RS, Bauer WC.

Environ Toxicol Chem. 2007 Sep;26(9):1856-66.


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