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Items: 1 to 50 of 150

1.

Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.

Sherman MB, Williams AN, Smith HQ, Nelson C, Wilen CB, Fremont DH, Virgin HW, Smith TJ.

J Virol. 2019 Jul 24. pii: JVI.00970-19. doi: 10.1128/JVI.00970-19. [Epub ahead of print]

PMID:
31341042
2.

Neutralizing antibodies against Mayaro virus require Fc effector functions for protective activity.

Earnest JT, Basore K, Roy V, Bailey AL, Wang D, Alter G, Fremont DH, Diamond MS.

J Exp Med. 2019 Jul 23. pii: jem.20190736. doi: 10.1084/jem.20190736. [Epub ahead of print]

PMID:
31337735
3.

Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor.

Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH.

Cell. 2019 Jun 13;177(7):1725-1737.e16. doi: 10.1016/j.cell.2019.04.006. Epub 2019 May 9.

PMID:
31080061
4.

Molluscum contagiosum virus MC80 sabotages MHC-I antigen presentation by targeting tapasin for ER-associated degradation.

Harvey IB, Wang X, Fremont DH.

PLoS Pathog. 2019 Apr 29;15(4):e1007711. doi: 10.1371/journal.ppat.1007711. eCollection 2019 Apr.

5.

Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes.

Fox JM, Roy V, Gunn BM, Huang L, Edeling MA, Mack M, Fremont DH, Doranz BJ, Johnson S, Alter G, Diamond MS.

Sci Immunol. 2019 Feb 22;4(32). pii: eaav5062. doi: 10.1126/sciimmunol.aav5062.

6.

Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.

Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE Jr, Screaton GR, Diamond MS.

Cell Rep. 2019 Feb 5;26(6):1585-1597.e4. doi: 10.1016/j.celrep.2019.01.052.

7.

A herpesvirus encoded Qa-1 mimic inhibits natural killer cell cytotoxicity through CD94/NKG2A receptor engagement.

Wang X, Piersma SJ, Nelson CA, Dai YN, Christensen T, Lazear E, Yang L, Sluijter M, van Hall T, Hansen TH, Yokoyama WM, Fremont DH.

Elife. 2018 Dec 21;7. pii: e38667. doi: 10.7554/eLife.38667.

8.

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.

Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS.

Nat Microbiol. 2019 Jan;4(1):187-197. doi: 10.1038/s41564-018-0286-4. Epub 2018 Nov 19.

9.

Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor.

Nelson CA, Wilen CB, Dai YN, Orchard RC, Kim AS, Stegeman RA, Hsieh LL, Smith TJ, Virgin HW, Fremont DH.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9201-E9210. doi: 10.1073/pnas.1805797115. Epub 2018 Sep 7.

10.

Mxra8 is a receptor for multiple arthritogenic alphaviruses.

Zhang R, Kim AS, Fox JM, Nair S, Basore K, Klimstra WB, Rimkunas R, Fong RH, Lin H, Poddar S, Crowe JE Jr, Doranz BJ, Fremont DH, Diamond MS.

Nature. 2018 May;557(7706):570-574. doi: 10.1038/s41586-018-0121-3. Epub 2018 May 16.

11.

Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.

Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM.

J Exp Med. 2018 May 7;215(5):1417-1435. doi: 10.1084/jem.20171784. Epub 2018 Mar 23.

12.

Mouse and Human Monoclonal Antibodies Protect against Infection by Multiple Genotypes of Japanese Encephalitis Virus.

Fernandez E, Kose N, Edeling MA, Adhikari J, Sapparapu G, Lazarte SM, Nelson CA, Govero J, Gross ML, Fremont DH, Crowe JE Jr, Diamond MS.

MBio. 2018 Feb 27;9(1). pii: e00008-18. doi: 10.1128/mBio.00008-18.

13.

Cross-priming induces immunodomination in the presence of viral MHC class I inhibition.

Lauron EJ, Yang L, Elliott JI, Gainey MD, Fremont DH, Yokoyama WM.

PLoS Pathog. 2018 Feb 14;14(2):e1006883. doi: 10.1371/journal.ppat.1006883. eCollection 2018 Feb.

14.

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses.

Tai W, He L, Wang Y, Sun S, Zhao G, Luo C, Li P, Zhao H, Fremont DH, Li F, Jiang S, Zhou Y, Du L.

Emerg Microbes Infect. 2018 Jan 24;7(1):7. doi: 10.1038/s41426-017-0007-8.

15.

Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.

Scott JM, Lebratti TJ, Richner JM, Jiang X, Fernandez E, Zhao H, Fremont DH, Diamond MS, Shin H.

J Virol. 2018 Mar 14;92(7). pii: e00038-18. doi: 10.1128/JVI.00038-18. Print 2018 Apr 1.

16.

Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.

Barrow AD, Edeling MA, Trifonov V, Luo J, Goyal P, Bohl B, Bando JK, Kim AH, Walker J, Andahazy M, Bugatti M, Melocchi L, Vermi W, Fremont DH, Cox S, Cella M, Schmedt C, Colonna M.

Cell. 2018 Jan 25;172(3):534-548.e19. doi: 10.1016/j.cell.2017.11.037. Epub 2017 Dec 21.

17.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Nasamu AS, Glushakova S, Russo I, Vaupel B, Oksman A, Kim AS, Fremont DH, Tolia N, Beck JR, Meyers MJ, Niles JC, Zimmerberg J, Goldberg DE.

Science. 2017 Oct 27;358(6362):518-522. doi: 10.1126/science.aan1478.

18.

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.

Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.

19.

Targeting of IL-2 to cytotoxic lymphocytes as an improved method of cytokine-driven immunotherapy.

Lazear E, Ghasemi R, Hein SM, Westwick J, Watkins D, Fremont DH, Krupnick AS.

Oncoimmunology. 2017 Jan 10;6(2):e1265721. doi: 10.1080/2162402X.2016.1265721. eCollection 2017.

20.

A Murine Herpesvirus Closely Related to Ubiquitous Human Herpesviruses Causes T-Cell Depletion.

Patel SJ, Zhao G, Penna VR, Park E, Lauron EJ, Harvey IB, Beatty WL, Plougastel-Douglas B, Poursine-Laurent J, Fremont DH, Wang D, Yokoyama WM.

J Virol. 2017 Apr 13;91(9). pii: e02463-16. doi: 10.1128/JVI.02463-16. Print 2017 May 1.

21.

Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice.

Sapparapu G, Fernandez E, Kose N, Bin Cao, Fox JM, Bombardi RG, Zhao H, Nelson CA, Bryan AL, Barnes T, Davidson E, Mysorekar IU, Fremont DH, Doranz BJ, Diamond MS, Crowe JE.

Nature. 2016 Dec 15;540(7633):443-447. doi: 10.1038/nature20564. Epub 2016 Nov 7.

22.

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy.

Ghasemi R, Lazear E, Wang X, Arefanian S, Zheleznyak A, Carreno BM, Higashikubo R, Gelman AE, Kreisel D, Fremont DH, Krupnick AS.

Nat Commun. 2016 Sep 21;7:12878. doi: 10.1038/ncomms12878.

23.

A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I.

Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS.

J Virol. 2016 Nov 14;90(23):10499-10512. doi: 10.1128/JVI.01011-16. Print 2016 Dec 1.

24.

Discovery of a proteinaceous cellular receptor for a norovirus.

Orchard RC, Wilen CB, Doench JG, Baldridge MT, McCune BT, Lee YC, Lee S, Pruett-Miller SM, Nelson CA, Fremont DH, Virgin HW.

Science. 2016 Aug 26;353(6302):933-6. doi: 10.1126/science.aaf1220. Epub 2016 Aug 18.

25.

Structural Basis of Zika Virus-Specific Antibody Protection.

Zhao H, Fernandez E, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS, Fremont DH.

Cell. 2016 Aug 11;166(4):1016-1027. doi: 10.1016/j.cell.2016.07.020. Epub 2016 Jul 27.

26.

Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors.

Lubman OY, Fremont DH.

Structure. 2016 Jan 5;24(1):57-69. doi: 10.1016/j.str.2015.10.018. Epub 2015 Dec 3.

27.

Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress.

Fox JM, Long F, Edeling MA, Lin H, van Duijl-Richter MKS, Fong RH, Kahle KM, Smit JM, Jin J, Simmons G, Doranz BJ, Crowe JE Jr, Fremont DH, Rossmann MG, Diamond MS.

Cell. 2015 Nov 19;163(5):1095-1107. doi: 10.1016/j.cell.2015.10.050. Epub 2015 Nov 6.

28.

Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily.

Nelson CA, Epperson ML, Singh S, Elliott JI, Fremont DH.

Viruses. 2015 Aug 28;7(9):4878-98. doi: 10.3390/v7092848. Review.

29.

Functional Heterogeneity and Antimycobacterial Effects of Mouse Mucosal-Associated Invariant T Cells Specific for Riboflavin Metabolites.

Sakala IG, Kjer-Nielsen L, Eickhoff CS, Wang X, Blazevic A, Liu L, Fairlie DP, Rossjohn J, McCluskey J, Fremont DH, Hansen TH, Hoft DF.

J Immunol. 2015 Jul 15;195(2):587-601. doi: 10.4049/jimmunol.1402545. Epub 2015 Jun 10.

30.

Correlating RANK ligand/RANK binding kinetics with osteoclast formation and function.

Warren JT, Zou W, Decker CE, Rohatgi N, Nelson CA, Fremont DH, Teitelbaum SL.

J Cell Biochem. 2015 Nov;116(11):2476-83. doi: 10.1002/jcb.25191.

31.

Manipulation of receptor oligomerization as a strategy to inhibit signaling by TNF superfamily members.

Warren JT, Nelson CA, Decker CE, Zou W, Fremont DH, Teitelbaum SL.

Sci Signal. 2014 Aug 19;7(339):ra80. doi: 10.1126/scisignal.2004948.

32.

Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement.

Edeling MA, Austin SK, Shrestha B, Dowd KA, Mukherjee S, Nelson CA, Johnson S, Mabila MN, Christian EA, Rucker J, Pierson TC, Diamond MS, Fremont DH.

PLoS Pathog. 2014 Apr 17;10(4):e1004072. doi: 10.1371/journal.ppat.1004072. eCollection 2014 Apr.

33.

Structural basis of Flavivirus NS1 assembly and antibody recognition.

Edeling MA, Diamond MS, Fremont DH.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4285-90. doi: 10.1073/pnas.1322036111. Epub 2014 Mar 4.

34.

Oxidative refolding from inclusion bodies.

Nelson CA, Lee CA, Fremont DH.

Methods Mol Biol. 2014;1140:145-57. doi: 10.1007/978-1-4939-0354-2_11.

PMID:
24590715
35.

Eukaryotic expression systems for structural studies.

Nelson CA, McCoy WH, Fremont DH.

Methods Mol Biol. 2014;1140:107-16. doi: 10.1007/978-1-4939-0354-2_8.

PMID:
24590712
36.

Target selection for structural genomics of infectious diseases.

Yeats C, Dessailly BH, Glass EM, Fremont DH, Orengo CA.

Methods Mol Biol. 2014;1140:35-51. doi: 10.1007/978-1-4939-0354-2_3.

PMID:
24590707
37.

MMTV superantigens coerce an unconventional topology between the TCR and MHC class II.

Fortin JS, Genève L, Gauthier C, Shoukry NH, Azar GA, Younes S, Yassine-Diab B, Sékaly RP, Fremont DH, Thibodeau J.

J Immunol. 2014 Feb 15;192(4):1896-906. doi: 10.4049/jimmunol.1203130. Epub 2014 Jan 22.

38.

Rodent herpesvirus Peru encodes a secreted chemokine decoy receptor.

Lubman OY, Cella M, Wang X, Monte K, Lenschow DJ, Huang YH, Fremont DH.

J Virol. 2014 Jan;88(1):538-46. doi: 10.1128/JVI.02729-13. Epub 2013 Oct 30.

39.

The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states.

Lee PD, Mukherjee S, Edeling MA, Dowd KA, Austin SK, Manhart CJ, Diamond MS, Fremont DH, Pierson TC.

J Virol. 2013 Dec;87(24):13729-40. doi: 10.1128/JVI.02340-13. Epub 2013 Oct 9.

40.

The unusual dynamics of parasite actin result from isodesmic polymerization.

Skillman KM, Ma CI, Fremont DH, Diraviyam K, Cooper JA, Sept D, Sibley LD.

Nat Commun. 2013;4:2285. doi: 10.1038/ncomms3285.

41.

Functional analysis of antibodies against dengue virus type 4 reveals strain-dependent epitope exposure that impacts neutralization and protection.

Sukupolvi-Petty S, Brien JD, Austin SK, Shrestha B, Swayne S, Kahle K, Doranz BJ, Johnson S, Pierson TC, Fremont DH, Diamond MS.

J Virol. 2013 Aug;87(16):8826-42. doi: 10.1128/JVI.01314-13. Epub 2013 Jun 19.

42.

Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus.

Pal P, Dowd KA, Brien JD, Edeling MA, Gorlatov S, Johnson S, Lee I, Akahata W, Nabel GJ, Richter MK, Smit JM, Fremont DH, Pierson TC, Heise MT, Diamond MS.

PLoS Pathog. 2013;9(4):e1003312. doi: 10.1371/journal.ppat.1003312. Epub 2013 Apr 18.

43.

The mechanism of differential neutralization of dengue serotype 3 strains by monoclonal antibody 8A1.

Zhou Y, Austin SK, Fremont DH, Yount BL, Huynh JP, de Silva AM, Baric RS, Messer WB.

Virology. 2013 Apr 25;439(1):57-64. doi: 10.1016/j.virol.2013.01.022. Epub 2013 Feb 28.

44.

Cowpox virus employs a two-pronged strategy to outflank MHCI antigen presentation.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH.

Mol Immunol. 2013 Sep;55(2):156-8. doi: 10.1016/j.molimm.2012.11.011. Epub 2013 Jan 10. Review.

45.

Structural mechanism of ER retrieval of MHC class I by cowpox.

McCoy WH 4th, Wang X, Yokoyama WM, Hansen TH, Fremont DH.

PLoS Biol. 2012;10(11):e1001432. doi: 10.1371/journal.pbio.1001432. Epub 2012 Nov 27.

46.

Structure of the St. Louis encephalitis virus postfusion envelope trimer.

Luca VC, Nelson CA, Fremont DH.

J Virol. 2013 Jan;87(2):818-28. doi: 10.1128/JVI.01950-12. Epub 2012 Oct 31.

47.

Crystal structure of the cowpox virus-encoded NKG2D ligand OMCP.

Lazear E, Peterson LW, Nelson CA, Fremont DH.

J Virol. 2013 Jan;87(2):840-50. doi: 10.1128/JVI.01948-12. Epub 2012 Oct 31.

48.

Immunoglobulin-like transcript receptors on human dermal CD14+ dendritic cells act as a CD8-antagonist to control cytotoxic T cell priming.

Banchereau J, Zurawski S, Thompson-Snipes L, Blanck JP, Clayton S, Munk A, Cao Y, Wang Z, Khandelwal S, Hu J, McCoy WH 4th, Palucka KA, Reiter Y, Fremont DH, Zurawski G, Colonna M, Shaw AS, Klechevsky E.

Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18885-90. doi: 10.1073/pnas.1205785109. Epub 2012 Oct 29.

49.

Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope.

Austin SK, Dowd KA, Shrestha B, Nelson CA, Edeling MA, Johnson S, Pierson TC, Diamond MS, Fremont DH.

PLoS Pathog. 2012;8(10):e1002930. doi: 10.1371/journal.ppat.1002930. Epub 2012 Oct 4.

50.

Subversion of cytokine networks by virally encoded decoy receptors.

Epperson ML, Lee CA, Fremont DH.

Immunol Rev. 2012 Nov;250(1):199-215. doi: 10.1111/imr.12009. Review.

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