Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 224


The Commensal Neisseria musculi Modulates Host Innate Immunity To Promote Oral Colonization.

Powell DA, Ma M, So M, Frelinger JA.

Immunohorizons. 2018 Oct 31;2(9):305-313. doi: 10.4049/immunohorizons.1800070.


Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.

Smithey MJ, Venturi V, Davenport MP, Buntzman AS, Vincent BG, Frelinger JA, Nikolich-Žugich J.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6817-E6825. doi: 10.1073/pnas.1719451115. Epub 2018 Jul 2.


Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.

Shubitz LF, Powell DA, Trinh HT, Lewis ML, Orbach MJ, Frelinger JA, Galgiani JN.

Vaccine. 2018 May 31;36(23):3375-3380. doi: 10.1016/j.vaccine.2018.04.026. Epub 2018 Apr 30.


Adaptive Immunity to Francisella tularensis and Considerations for Vaccine Development.

Roberts LM, Powell DA, Frelinger JA.

Front Cell Infect Microbiol. 2018 Apr 6;8:115. doi: 10.3389/fcimb.2018.00115. eCollection 2018. Review.


A Natural Mouse Model for Neisseria Colonization.

Ma M, Powell DA, Weyand NJ, Rhodes KA, Rendón MA, Frelinger JA, So M.

Infect Immun. 2018 Apr 23;86(5). pii: e00839-17. doi: 10.1128/IAI.00839-17. Print 2018 May.


Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.

Powell DA, Frelinger JA.

Front Immunol. 2017 Mar 15;8:206. doi: 10.3389/fimmu.2017.00206. eCollection 2017.


A Coccidioides posadasii CPS1 Deletion Mutant Is Avirulent and Protects Mice from Lethal Infection.

Narra HP, Shubitz LF, Mandel MA, Trinh HT, Griffin K, Buntzman AS, Frelinger JA, Galgiani JN, Orbach MJ.

Infect Immun. 2016 Sep 19;84(10):3007-16. doi: 10.1128/IAI.00633-16. Print 2016 Oct.


Big Data, Big Opportunities, and Big Challenges.

Frelinger JA.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):33-5. doi: 10.1038/jidsymp.2015.38. Review.


From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata.

Kranz D, Ellison A, Frelinger JA, Mackay-Wiggan J, Norris DA.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):1-5. doi: 10.1038/jidsymp.2015.29.


Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.

Powell DA, Roberts LM, Ledvina HE, Sempowski GD, Curtiss R 3rd, Frelinger JA.

Cell Immunol. 2016 Jan;299:42-9. doi: 10.1016/j.cellimm.2015.10.002. Epub 2015 Oct 22.


Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.

Roberts LM, Ledvina HE, Tuladhar S, Rana D, Steele SP, Sempowski GD, Frelinger JA.

Immun Inflamm Dis. 2015 Jun;3(2):71-81. doi: 10.1002/iid3.51. Epub 2015 Mar 23.


Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire.

Hunsucker SA, McGary CS, Vincent BG, Enyenihi AA, Waugh JP, McKinnon KP, Bixby LM, Ropp PA, Coghill JM, Wood WA, Gabriel DA, Sarantopoulos S, Shea TC, Serody JS, Alatrash G, Rodriguez-Cruz T, Lizée G, Buntzman AS, Frelinger JA, Glish GL, Armistead PM.

Cancer Immunol Res. 2015 Mar;3(3):228-35. doi: 10.1158/2326-6066.CIR-14-0001. Epub 2015 Jan 9.


Elimination of Pasteurella pneumotropica from a mouse barrier facility by using a modified enrofloxacin treatment regimen.

Towne JW, Wagner AM, Griffin KJ, Buntzman AS, Frelinger JA, Besselsen DG.

J Am Assoc Lab Anim Sci. 2014 Sep;53(5):517-22.


TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.

Roberts LM, Ledvina HE, Sempowski GD, Frelinger JA.

Front Immunol. 2014 Sep 5;5:426. doi: 10.3389/fimmu.2014.00426. eCollection 2014.


IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.

Roberts LM, Davies JS, Sempowski GD, Frelinger JA.

Vaccine. 2014 Jun 17;32(29):3595-603. doi: 10.1016/j.vaccine.2014.05.013. Epub 2014 May 14.


Identification of early interactions between Francisella and the host.

Roberts LM, Tuladhar S, Steele SP, Riebe KJ, Chen CJ, Cumming RI, Seay S, Frothingham R, Sempowski GD, Kawula TH, Frelinger JA.

Infect Immun. 2014 Jun;82(6):2504-10. doi: 10.1128/IAI.01654-13. Epub 2014 Mar 31.


Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.

Neely CJ, Kartchner LB, Mendoza AE, Linz BM, Frelinger JA, Wolfgang MC, Maile R, Cairns BA.

PLoS One. 2014 Jan 15;9(1):e85623. doi: 10.1371/journal.pone.0085623. eCollection 2014.


Using the emerging Collaborative Cross to probe the immune system.

Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, de Villena FP, Wang W, Valdar W, Frelinger JA.

Genes Immun. 2014 Jan;15(1):38-46. doi: 10.1038/gene.2013.59. Epub 2013 Nov 7.


Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance.

Hess SM, Young EF, Miller KR, Vincent BG, Buntzman AS, Collins EJ, Frelinger JA, Hess PR.

Transpl Immunol. 2013 Dec;29(1-4):138-45. doi: 10.1016/j.trim.2013.10.005. Epub 2013 Oct 23.


Recent advances in our understanding of the environmental, epidemiological, immunological, and clinical dimensions of coccidioidomycosis.

Nguyen C, Barker BM, Hoover S, Nix DE, Ampel NM, Frelinger JA, Orbach MJ, Galgiani JN.

Clin Microbiol Rev. 2013 Jul;26(3):505-25. doi: 10.1128/CMR.00005-13. Review.


Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.

Holmes JC, Holmer SG, Ross P, Buntzman AS, Frelinger JA, Hess PR.

Immunogenetics. 2013 Sep;65(9):675-89. doi: 10.1007/s00251-013-0711-z. Epub 2013 Jun 30.


Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.

Barrigan LM, Tuladhar S, Brunton JC, Woolard MD, Chen CJ, Saini D, Frothingham R, Sempowski GD, Kawula TH, Frelinger JA.

Infect Immun. 2013 Jun;81(6):2028-42. doi: 10.1128/IAI.00207-13. Epub 2013 Mar 25.


Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages.

Woolard MD, Barrigan LM, Fuller JR, Buntzman AS, Bryan J, Manoil C, Kawula TH, Frelinger JA.

Front Microbiol. 2013 Feb 11;4:16. doi: 10.3389/fmicb.2013.00016. eCollection 2013.


The LCMV gp33-specific memory T cell repertoire narrows with age.

Bunztman A, Vincent BG, Krovi H, Steele S, Frelinger JA.

Immun Ageing. 2012 Aug 15;9(1):17. doi: 10.1186/1742-4933-9-17.


Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited.

Ross P, Buntzman AS, Vincent BG, Grover EN, Gojanovich GS, Collins EJ, Frelinger JA, Hess PR.

Tissue Antigens. 2012 Aug;80(2):175-83. doi: 10.1111/j.1399-0039.2012.01889.x. Epub 2012 May 10.


A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.

Valentino MD, Abdul-Alim CS, Maben ZJ, Skrombolas D, Hensley LL, Kawula TH, Dziejman M, Lord EM, Frelinger JA, Frelinger JG.

J Immunol Methods. 2011 Oct 28;373(1-2):111-26. doi: 10.1016/j.jim.2011.08.007. Epub 2011 Aug 18.


HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.

Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA.

Diabetes. 2011 Jun;60(6):1726-33. doi: 10.2337/db10-1287. Epub 2011 Apr 26.


Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA.

Genome Res. 2011 Aug;21(8):1213-22. doi: 10.1101/gr.111310.110. Epub 2011 Mar 15.


A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease.

Washburn ML, Bility MT, Zhang L, Kovalev GI, Buntzman A, Frelinger JA, Barry W, Ploss A, Rice CM, Su L.

Gastroenterology. 2011 Apr;140(4):1334-44. doi: 10.1053/j.gastro.2011.01.001. Epub 2011 Jan 13.


Identification of T-cell epitopes in Francisella tularensis using an ordered protein array of serological targets.

Valentino MD, Maben ZJ, Hensley LL, Woolard MD, Kawula TH, Frelinger JA, Frelinger JG.

Immunology. 2011 Mar;132(3):348-60. doi: 10.1111/j.1365-2567.2010.03387.x. Epub 2011 Jan 7.


Lung CD4-CD8- double-negative T cells are prominent producers of IL-17A and IFN-gamma during primary respiratory murine infection with Francisella tularensis live vaccine strain.

Cowley SC, Meierovics AI, Frelinger JA, Iwakura Y, Elkins KL.

J Immunol. 2010 May 15;184(10):5791-801. doi: 10.4049/jimmunol.1000362. Epub 2010 Apr 14.


Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.

Vincent BG, Young EF, Buntzman AS, Stevens R, Kepler TB, Tisch RM, Frelinger JA, Hess PR.

J Immunol. 2010 Apr 15;184(8):4196-204. doi: 10.4049/jimmunol.0903931. Epub 2010 Mar 10.


Heterotypic humoral and cellular immune responses following Norwalk virus infection.

Lindesmith LC, Donaldson E, Leon J, Moe CL, Frelinger JA, Johnston RE, Weber DJ, Baric RS.

J Virol. 2010 Feb;84(4):1800-15. doi: 10.1128/JVI.02179-09. Epub 2009 Dec 9.


beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.

Li L, He Q, Garland A, Yi Z, Aybar LT, Kepler TB, Frelinger JA, Wang B, Tisch R.

J Immunol. 2009 Dec 1;183(11):7585-91. doi: 10.4049/jimmunol.0901587. Epub 2009 Nov 16.


Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.

Young EF, Hess PR, Arnold LW, Tisch R, Frelinger JA.

Autoimmunity. 2009;42(8):678-91. doi: 10.3109/08916930903213993.


Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS.

Valentino MD, Hensley LL, Skrombolas D, McPherson PL, Woolard MD, Kawula TH, Frelinger JA, Frelinger JG.

Mol Immunol. 2009 May;46(8-9):1830-8. doi: 10.1016/j.molimm.2009.01.008. Epub 2009 Feb 23.


Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112.

Hall JD, Woolard MD, Gunn BM, Craven RR, Taft-Benz S, Frelinger JA, Kawula TH.

Infect Immun. 2008 Dec;76(12):5843-52. doi: 10.1128/IAI.01176-08. Epub 2008 Oct 13.


Novel epitope begets a novel pathway in type 1 diabetes progression.

Frelinger JA.

J Clin Invest. 2008 Oct;118(10):3268-71. doi: 10.1172/JCI37125.


Outsmarting the host: bacteria modulating the immune response.

Woolard MD, Frelinger JA.

Immunol Res. 2008;41(3):188-202. doi: 10.1007/s12026-008-8021-5.


T-cell promiscuity in autoimmune diabetes.

Li L, Wang B, Frelinger JA, Tisch R.

Diabetes. 2008 Aug;57(8):2099-106. doi: 10.2337/db08-0383. Epub 2008 May 20.


Rescue of cytotoxic function in the CD8alpha knockout mouse by removal of MHC class II.

Riddle DS, Miller PJ, Vincent BG, Kepler TB, Maile R, Frelinger JA, Collins EJ.

Eur J Immunol. 2008 Jun;38(6):1511-21. doi: 10.1002/eji.200737710.


Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells.

Woolard MD, Hensley LL, Kawula TH, Frelinger JA.

Infect Immun. 2008 Jun;76(6):2651-9. doi: 10.1128/IAI.01412-07. Epub 2008 Apr 7.


CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.

Tian S, Maile R, Collins EJ, Frelinger JA.

J Immunol. 2007 Sep 1;179(5):2952-60.


Francisella tularensis-infected macrophages release prostaglandin E2 that blocks T cell proliferation and promotes a Th2-like response.

Woolard MD, Wilson JE, Hensley LL, Jania LA, Kawula TH, Drake JR, Frelinger JA.

J Immunol. 2007 Feb 15;178(4):2065-74.


Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets.

Wong CP, Stevens R, Long B, Li L, Wang Y, Wallet MA, Goudy KS, Frelinger JA, Tisch R.

J Immunol. 2007 Feb 1;178(3):1388-95.


Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin.

Hess PR, Barnes C, Woolard MD, Johnson MD, Cullen JM, Collins EJ, Frelinger JA.

Blood. 2007 Apr 15;109(8):3300-7. Epub 2006 Dec 19.


The effect of burn injury on CD8+ and CD4+ T cells in an irradiation model of homeostatic proliferation.

Buchanan IB, Maile R, Frelinger JA, Fair JH, Meyer AA, Cairns BA.

J Trauma. 2006 Nov;61(5):1062-8.


Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice.

Zhang TP, Jin DY, Wardrop RM 3rd, Gui T, Maile R, Frelinger JA, Stafford DW, Monahan PE.

Gene Ther. 2007 Mar;14(5):429-40. Epub 2006 Oct 26.


Increased Toll-like receptor 4 expression on T cells may be a mechanism for enhanced T cell response late after burn injury.

Cairns B, Maile R, Barnes CM, Frelinger JA, Meyer AA.

J Trauma. 2006 Aug;61(2):293-8; discussion 298-9.


Lymphopenia-induced homeostatic proliferation of CD8+ T cells is a mechanism for effective allogeneic skin graft rejection following burn injury.

Maile R, Barnes CM, Nielsen AI, Meyer AA, Frelinger JA, Cairns BA.

J Immunol. 2006 Jun 1;176(11):6717-26.

Supplemental Content

Loading ...
Support Center