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Inoculating a New Generation: Immunology in Medical Education.

Haidaris CG, Frelinger JG.

Front Immunol. 2019 Nov 1;10:2548. doi: 10.3389/fimmu.2019.02548. eCollection 2019.


Early Events in Coccidioidomycosis.

Donovan FM, Shubitz L, Powell D, Orbach M, Frelinger J, Galgiani JN.

Clin Microbiol Rev. 2019 Oct 16;33(1). pii: e00112-19. doi: 10.1128/CMR.00112-19. Print 2019 Dec 18. Review.


The Commensal Neisseria musculi Modulates Host Innate Immunity To Promote Oral Colonization.

Powell DA, Ma M, So M, Frelinger JA.

Immunohorizons. 2018 Oct 31;2(9):305-313. doi: 10.4049/immunohorizons.1800070.


Development of an Interleukin-12 Fusion Protein That Is Activated by Cleavage with Matrix Metalloproteinase 9.

Skrombolas D, Sullivan M, Frelinger JG.

J Interferon Cytokine Res. 2019 Apr;39(4):233-245. doi: 10.1089/jir.2018.0129. Epub 2019 Mar 8.


Lifelong CMV infection improves immune defense in old mice by broadening the mobilized TCR repertoire against third-party infection.

Smithey MJ, Venturi V, Davenport MP, Buntzman AS, Vincent BG, Frelinger JA, Nikolich-Žugich J.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6817-E6825. doi: 10.1073/pnas.1719451115. Epub 2018 Jul 2.


Viable spores of Coccidioides posadasii Δcps1 are required for vaccination and provide long lasting immunity.

Shubitz LF, Powell DA, Trinh HT, Lewis ML, Orbach MJ, Frelinger JA, Galgiani JN.

Vaccine. 2018 May 31;36(23):3375-3380. doi: 10.1016/j.vaccine.2018.04.026. Epub 2018 Apr 30.


Adaptive Immunity to Francisella tularensis and Considerations for Vaccine Development.

Roberts LM, Powell DA, Frelinger JA.

Front Cell Infect Microbiol. 2018 Apr 6;8:115. doi: 10.3389/fcimb.2018.00115. eCollection 2018. Review.


A Natural Mouse Model for Neisseria Colonization.

Ma M, Powell DA, Weyand NJ, Rhodes KA, Rendón MA, Frelinger JA, So M.

Infect Immun. 2018 Apr 23;86(5). pii: e00839-17. doi: 10.1128/IAI.00839-17. Print 2018 May.


Efficacy of Resistance to Francisella Imparted by ITY/NRAMP/SLC11A1 Depends on Route of Infection.

Powell DA, Frelinger JA.

Front Immunol. 2017 Mar 15;8:206. doi: 10.3389/fimmu.2017.00206. eCollection 2017.


A Coccidioides posadasii CPS1 Deletion Mutant Is Avirulent and Protects Mice from Lethal Infection.

Narra HP, Shubitz LF, Mandel MA, Trinh HT, Griffin K, Buntzman AS, Frelinger JA, Galgiani JN, Orbach MJ.

Infect Immun. 2016 Sep 19;84(10):3007-16. doi: 10.1128/IAI.00633-16. Print 2016 Oct.


Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy.

Mikucki ME, Skitzki JJ, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS.

Oncoimmunology. 2016 Feb 11;5(5):e1116675. doi: 10.1080/2162402X.2015.1116675. eCollection 2016 May.


Big Data, Big Opportunities, and Big Challenges.

Frelinger JA.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):33-5. doi: 10.1038/jidsymp.2015.38. Review.


From Targets to Treatments: Bridging Autoimmune Research to Advance Understanding of Alopecia Areata.

Kranz D, Ellison A, Frelinger JA, Mackay-Wiggan J, Norris DA.

J Investig Dermatol Symp Proc. 2015 Nov;17(2):1-5. doi: 10.1038/jidsymp.2015.29.


iWAS--A novel approach to analyzing Next Generation Sequence data for immunology.

Vincent B, Buntzman A, Hopson B, McEwen C, Cowell L, Akoglu A, Zhang H, Frelinger J.

Cell Immunol. 2016 Jan;299:6-13. doi: 10.1016/j.cellimm.2015.10.012. Epub 2015 Nov 2.


Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants.

Powell DA, Roberts LM, Ledvina HE, Sempowski GD, Curtiss R 3rd, Frelinger JA.

Cell Immunol. 2016 Jan;299:42-9. doi: 10.1016/j.cellimm.2015.10.002. Epub 2015 Oct 22.


Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints.

Mikucki ME, Fisher DT, Matsuzaki J, Skitzki JJ, Gaulin NB, Muhitch JB, Ku AW, Frelinger JG, Odunsi K, Gajewski TF, Luster AD, Evans SS.

Nat Commun. 2015 Jun 25;6:7458. doi: 10.1038/ncomms8458.


Depletion of alveolar macrophages in CD11c diphtheria toxin receptor mice produces an inflammatory response.

Roberts LM, Ledvina HE, Tuladhar S, Rana D, Steele SP, Sempowski GD, Frelinger JA.

Immun Inflamm Dis. 2015 Jun;3(2):71-81. doi: 10.1002/iid3.51. Epub 2015 Mar 23.


Characterization of an IL-12 p40/p35 Truncated Fusion Protein That can Inhibit the Action of IL-12.

Skrombolas D, Wylie I, Maharaj S, Frelinger JG.

J Interferon Cytokine Res. 2015 Sep;35(9):690-7. doi: 10.1089/jir.2014.0176. Epub 2015 May 4.


Identification and visualization of multidimensional antigen-specific T-cell populations in polychromatic cytometry data.

Lin L, Frelinger J, Jiang W, Finak G, Seshadri C, Bart PA, Pantaleo G, McElrath J, DeRosa S, Gottardo R.

Cytometry A. 2015 Jul;87(7):675-82. doi: 10.1002/cyto.a.22623. Epub 2015 Apr 23.


Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects.

Arjomandi M, Wong H, Donde A, Frelinger J, Dalton S, Ching W, Power K, Balmes JR.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1499-509. doi: 10.1152/ajpheart.00849.2014. Epub 2015 Apr 10.


Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire.

Hunsucker SA, McGary CS, Vincent BG, Enyenihi AA, Waugh JP, McKinnon KP, Bixby LM, Ropp PA, Coghill JM, Wood WA, Gabriel DA, Sarantopoulos S, Shea TC, Serody JS, Alatrash G, Rodriguez-Cruz T, Lizée G, Buntzman AS, Frelinger JA, Glish GL, Armistead PM.

Cancer Immunol Res. 2015 Mar;3(3):228-35. doi: 10.1158/2326-6066.CIR-14-0001. Epub 2015 Jan 9.


Elimination of Pasteurella pneumotropica from a mouse barrier facility by using a modified enrofloxacin treatment regimen.

Towne JW, Wagner AM, Griffin KJ, Buntzman AS, Frelinger JA, Besselsen DG.

J Am Assoc Lab Anim Sci. 2014 Sep;53(5):517-22.


TLR2 Signaling is Required for the Innate, but Not Adaptive Response to LVS clpB.

Roberts LM, Ledvina HE, Sempowski GD, Frelinger JA.

Front Immunol. 2014 Sep 5;5:426. doi: 10.3389/fimmu.2014.00426. eCollection 2014.


OpenCyto: an open source infrastructure for scalable, robust, reproducible, and automated, end-to-end flow cytometry data analysis.

Finak G, Frelinger J, Jiang W, Newell EW, Ramey J, Davis MM, Kalams SA, De Rosa SC, Gottardo R.

PLoS Comput Biol. 2014 Aug 28;10(8):e1003806. doi: 10.1371/journal.pcbi.1003806. eCollection 2014 Aug.


IFN-γ, but not IL-17A, is required for survival during secondary pulmonary Francisella tularensis Live Vaccine Stain infection.

Roberts LM, Davies JS, Sempowski GD, Frelinger JA.

Vaccine. 2014 Jun 17;32(29):3595-603. doi: 10.1016/j.vaccine.2014.05.013. Epub 2014 May 14.


Setting objective thresholds for rare event detection in flow cytometry.

Richards AJ, Staats J, Enzor J, McKinnon K, Frelinger J, Denny TN, Weinhold KJ, Chan C.

J Immunol Methods. 2014 Jul;409:54-61. doi: 10.1016/j.jim.2014.04.002. Epub 2014 Apr 12.


Identification of early interactions between Francisella and the host.

Roberts LM, Tuladhar S, Steele SP, Riebe KJ, Chen CJ, Cumming RI, Seay S, Frothingham R, Sempowski GD, Kawula TH, Frelinger JA.

Infect Immun. 2014 Jun;82(6):2504-10. doi: 10.1128/IAI.01654-13. Epub 2014 Mar 31.


Flagellin treatment prevents increased susceptibility to systemic bacterial infection after injury by inhibiting anti-inflammatory IL-10+ IL-12- neutrophil polarization.

Neely CJ, Kartchner LB, Mendoza AE, Linz BM, Frelinger JA, Wolfgang MC, Maile R, Cairns BA.

PLoS One. 2014 Jan 15;9(1):e85623. doi: 10.1371/journal.pone.0085623. eCollection 2014.


Challenges and developing solutions for increasing the benefits of IL-2 treatment in tumor therapy.

Skrombolas D, Frelinger JG.

Expert Rev Clin Immunol. 2014 Feb;10(2):207-17. doi: 10.1586/1744666X.2014.875856. Review.


Using the emerging Collaborative Cross to probe the immune system.

Phillippi J, Xie Y, Miller DR, Bell TA, Zhang Z, Lenarcic AB, Aylor DL, Krovi SH, Threadgill DW, de Villena FP, Wang W, Valdar W, Frelinger JA.

Genes Immun. 2014 Jan;15(1):38-46. doi: 10.1038/gene.2013.59. Epub 2013 Nov 7.


Deletion of naïve T cells recognizing the minor histocompatibility antigen HY with toxin-coupled peptide-MHC class I tetramers inhibits cognate CTL responses and alters immunodominance.

Hess SM, Young EF, Miller KR, Vincent BG, Buntzman AS, Collins EJ, Frelinger JA, Hess PR.

Transpl Immunol. 2013 Dec;29(1-4):138-45. doi: 10.1016/j.trim.2013.10.005. Epub 2013 Oct 23.


Generation of a dual-functioning antitumor immune response in the peritoneal cavity.

Sedlacek AL, Gerber SA, Randall TD, van Rooijen N, Frelinger JG, Lord EM.

Am J Pathol. 2013 Oct;183(4):1318-1328. doi: 10.1016/j.ajpath.2013.06.030. Epub 2013 Aug 8.


Changes in ovarian tumor cell number, tumor vasculature, and T cell function monitored in vivo using a novel xenograft model.

Yokota SJ, Facciponte JG, Kelleher RJ Jr, Shultz LD, Loyall JL, Parsons RR, Odunsi K, Frelinger JG, Lord EM, Gerber SA, Balu-Iyer SV, Bankert RB.

Cancer Immun. 2013 May 31;13:11. Print 2013.


Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples.

Cron A, Gouttefangeas C, Frelinger J, Lin L, Singh SK, Britten CM, Welters MJ, van der Burg SH, West M, Chan C.

PLoS Comput Biol. 2013;9(7):e1003130. doi: 10.1371/journal.pcbi.1003130. Epub 2013 Jul 11.


Recent advances in our understanding of the environmental, epidemiological, immunological, and clinical dimensions of coccidioidomycosis.

Nguyen C, Barker BM, Hoover S, Nix DE, Ampel NM, Frelinger JA, Orbach MJ, Galgiani JN.

Clin Microbiol Rev. 2013 Jul;26(3):505-25. doi: 10.1128/CMR.00005-13. Review.


Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.

Holmes JC, Holmer SG, Ross P, Buntzman AS, Frelinger JA, Hess PR.

Immunogenetics. 2013 Sep;65(9):675-89. doi: 10.1007/s00251-013-0711-z. Epub 2013 Jun 30.


IFN-γ mediates the antitumor effects of radiation therapy in a murine colon tumor.

Gerber SA, Sedlacek AL, Cron KR, Murphy SP, Frelinger JG, Lord EM.

Am J Pathol. 2013 Jun;182(6):2345-54. doi: 10.1016/j.ajpath.2013.02.041. Epub 2013 Apr 12.


Infection with Francisella tularensis LVS clpB leads to an altered yet protective immune response.

Barrigan LM, Tuladhar S, Brunton JC, Woolard MD, Chen CJ, Saini D, Frothingham R, Sempowski GD, Kawula TH, Frelinger JA.

Infect Immun. 2013 Jun;81(6):2028-42. doi: 10.1128/IAI.00207-13. Epub 2013 Mar 25.


Identification of Francisella novicida mutants that fail to induce prostaglandin E(2) synthesis by infected macrophages.

Woolard MD, Barrigan LM, Fuller JR, Buntzman AS, Bryan J, Manoil C, Kawula TH, Frelinger JA.

Front Microbiol. 2013 Feb 11;4:16. doi: 10.3389/fmicb.2013.00016. eCollection 2013.


Local expression of interleukin-2 by B16 melanoma cells results in decreased tumour growth and long-term tumour dormancy.

Gerber SA, Sorensen EW, Sedlacek AL, Lim JY, Skrombolas D, Frelinger JG, Lord EM.

Immunology. 2013 Mar;138(3):280-92. doi: 10.1111/imm.12037.


Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production.

Holl EK, Roney KE, Allen IC, Steinbach E, Arthur JC, Buntzman A, Plevy S, Frelinger J, Ting JP.

PLoS One. 2012;7(8):e43333. doi: 10.1371/journal.pone.0043333. Epub 2012 Aug 15.


The LCMV gp33-specific memory T cell repertoire narrows with age.

Bunztman A, Vincent BG, Krovi H, Steele S, Frelinger JA.

Immun Ageing. 2012 Aug 15;9(1):17. doi: 10.1186/1742-4933-9-17.


Allelic diversity at the DLA-88 locus in Golden Retriever and Boxer breeds is limited.

Ross P, Buntzman AS, Vincent BG, Grover EN, Gojanovich GS, Collins EJ, Frelinger JA, Hess PR.

Tissue Antigens. 2012 Aug;80(2):175-83. doi: 10.1111/j.1399-0039.2012.01889.x. Epub 2012 May 10.


Allergen and ozone exacerbate serotonin-induced increases in airway smooth muscle contraction in a model of childhood asthma.

Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES.

Respiration. 2012;83(6):529-42. doi: 10.1159/000336835. Epub 2012 Apr 13.


Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

Donde A, Wong H, Frelinger J, Power K, Balmes JR, Arjomandi M.

J Occup Environ Med. 2012 Apr;54(4):466-70. doi: 10.1097/JOM.0b013e318246f1d4.


Secreted osteopontin is highly polymerized in human airways and fragmented in asthmatic airway secretions.

Arjomandi M, Frelinger J, Donde A, Wong H, Yellamilli A, Raymond W.

PLoS One. 2011;6(10):e25678. doi: 10.1371/journal.pone.0025678. Epub 2011 Oct 21.


A broadly applicable approach to T cell epitope identification: application to improving tumor associated epitopes and identifying epitopes in complex pathogens.

Valentino MD, Abdul-Alim CS, Maben ZJ, Skrombolas D, Hensley LL, Kawula TH, Dziejman M, Lord EM, Frelinger JA, Frelinger JG.

J Immunol Methods. 2011 Oct 28;373(1-2):111-26. doi: 10.1016/j.jim.2011.08.007. Epub 2011 Aug 18.


HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/γc(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.

Whitfield-Larry F, Young EF, Talmage G, Fudge E, Azam A, Patel S, Largay J, Byrd W, Buse J, Calikoglu AS, Shultz LD, Frelinger JA.

Diabetes. 2011 Jun;60(6):1726-33. doi: 10.2337/db10-1287. Epub 2011 Apr 26.


Development of an attenuated interleukin-2 fusion protein that can be activated by tumour-expressed proteases.

Puskas J, Skrombolas D, Sedlacek A, Lord E, Sullivan M, Frelinger J.

Immunology. 2011 Jun;133(2):206-20. doi: 10.1111/j.1365-2567.2011.03428.x. Epub 2011 Mar 23.


Genetic analysis of complex traits in the emerging Collaborative Cross.

Aylor DL, Valdar W, Foulds-Mathes W, Buus RJ, Verdugo RA, Baric RS, Ferris MT, Frelinger JA, Heise M, Frieman MB, Gralinski LE, Bell TA, Didion JD, Hua K, Nehrenberg DL, Powell CL, Steigerwalt J, Xie Y, Kelada SN, Collins FS, Yang IV, Schwartz DA, Branstetter LA, Chesler EJ, Miller DR, Spence J, Liu EY, McMillan L, Sarkar A, Wang J, Wang W, Zhang Q, Broman KW, Korstanje R, Durrant C, Mott R, Iraqi FA, Pomp D, Threadgill D, de Villena FP, Churchill GA.

Genome Res. 2011 Aug;21(8):1213-22. doi: 10.1101/gr.111310.110. Epub 2011 Mar 15.

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