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Regulation of Listeria monocytogenes Virulence.

Johansson J, Freitag NE.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0064-2019. Review.


Corrigendum to "PrfA activation in Listeria monocytogenes increases the sensitivity to class IIa bacteriocins despite impaired expression of the bacteriocin receptor" BBAGEN 2019 Aug 1863/8 Page 1283-1291.

Farizano JV, Masías E, Hsu FF, Salomón RA, Freitag NE, Hebert EM, Minahk C, Saavedra L.

Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129404. doi: 10.1016/j.bbagen.2019.07.013. Epub 2019 Aug 13. No abstract available.


PrfA activation in Listeria monocytogenes increases the sensitivity to class IIa bacteriocins despite impaired expression of the bacteriocin receptor.

Farizano JV, Masías E, Hsu FF, Salomón RA, Freitag NE, Hebert EM, Minahk C, Saavedra L.

Biochim Biophys Acta Gen Subj. 2019 Aug;1863(8):1283-1291. doi: 10.1016/j.bbagen.2019.04.021. Epub 2019 May 3. Erratum in: Biochim Biophys Acta Gen Subj. 2019 Nov;1863(11):129404.


Using a Bacterial Pathogen to Probe for Cellular and Organismic-level Host Responses.

Gayle P, Freitag NE, Strbo N, Schesser K.

J Vis Exp. 2019 Feb 22;(144). doi: 10.3791/58775.


Bacillus subtilis Biofilms: a Matter of Individual Choice.

Ryan-Payseur BK, Freitag NE.

mBio. 2018 Nov 27;9(6). pii: e02339-18. doi: 10.1128/mBio.02339-18.


The electrifying energy of gut microbes.

Cahoon LA, Freitag NE.

Nature. 2018 Oct;562(7725):43-44. doi: 10.1038/d41586-018-06180-z. No abstract available.


Vertical Transmission of Listeria monocytogenes: Probing the Balance between Protection from Pathogens and Fetal Tolerance.

Lamond NM, Freitag NE.

Pathogens. 2018 May 25;7(2). pii: E52. doi: 10.3390/pathogens7020052. Review.


Thioredoxin A Is Essential for Motility and Contributes to Host Infection of Listeria monocytogenes via Redox Interactions.

Cheng C, Dong Z, Han X, Wang H, Jiang L, Sun J, Yang Y, Ma T, Shao C, Wang X, Chen Z, Fang W, Freitag NE, Huang H, Song H.

Front Cell Infect Microbiol. 2017 Jun 28;7:287. doi: 10.3389/fcimb.2017.00287. eCollection 2017.


Propofol Sedation Exacerbates Kidney Pathology and Dissemination of Bacteria during Staphylococcus aureus Bloodstream Infections.

Visvabharathy L, Freitag NE.

Infect Immun. 2017 Jun 20;85(7). pii: e00097-17. doi: 10.1128/IAI.00097-17. Print 2017 Jul.


Apoptotic cells enhance pathogenesis of Listeria monocytogenes.

Pattabiraman G, Palasiewicz K, Visvabharathy L, Freitag NE, Ucker DS.

Microb Pathog. 2017 Apr;105:218-225. doi: 10.1016/j.micpath.2017.02.036. Epub 2017 Feb 24.


Transferase Versus Hydrolase: The Role of Conformational Flexibility in Reaction Specificity.

Light SH, Cahoon LA, Mahasenan KV, Lee M, Boggess B, Halavaty AS, Mobashery S, Freitag NE, Anderson WF.

Structure. 2017 Feb 7;25(2):295-304. doi: 10.1016/j.str.2016.12.007. Epub 2017 Jan 12.


Structure to function of an α-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis.

Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF.

Nat Microbiol. 2016 Nov 7;2:16202. doi: 10.1038/nmicrobiol.2016.202.


When being alone is enough: noncanonical functions of canonical bacterial quorum-sensing systems.

Xayarath B, Freitag NE.

Future Microbiol. 2016 Oct;11:1447-1459. Epub 2016 Oct 18. Review.


A structural comparison of Listeria monocytogenes protein chaperones PrsA1 and PrsA2 reveals molecular features required for virulence.

Cahoon LA, Freitag NE, Prehna G.

Mol Microbiol. 2016 Jul;101(1):42-61. doi: 10.1111/mmi.13367. Epub 2016 May 27.


Perforin-2 Protects Host Cells and Mice by Restricting the Vacuole to Cytosol Transitioning of a Bacterial Pathogen.

McCormack R, Bahnan W, Shrestha N, Boucher J, Barreto M, Barrera CM, Dauer EA, Freitag NE, Khan WN, Podack ER, Schesser K.

Infect Immun. 2016 Mar 24;84(4):1083-1091. doi: 10.1128/IAI.01434-15. Print 2016 Apr.


Propofol Increases Host Susceptibility to Microbial Infection by Reducing Subpopulations of Mature Immune Effector Cells at Sites of Infection.

Visvabharathy L, Xayarath B, Weinberg G, Shilling RA, Freitag NE.

PLoS One. 2015 Sep 18;10(9):e0138043. doi: 10.1371/journal.pone.0138043. eCollection 2015.


Identification of Conserved and Species-Specific Functions of the Listeria monocytogenes PrsA2 Secretion Chaperone.

Cahoon LA, Freitag NE.

Infect Immun. 2015 Oct;83(10):4028-41. doi: 10.1128/IAI.00504-15. Epub 2015 Jul 27.


Uncovering the Nonessential Nature of an Essential Second Messenger.

Xayarath B, Freitag NE.

Cell Host Microbe. 2015 Jun 10;17(6):731-2. doi: 10.1016/j.chom.2015.05.015.


Identification of a peptide-pheromone that enhances Listeria monocytogenes escape from host cell vacuoles.

Xayarath B, Alonzo F 3rd, Freitag NE.

PLoS Pathog. 2015 Mar 30;11(3):e1004707. doi: 10.1371/journal.ppat.1004707. eCollection 2015 Mar.


HMBPP-deficient Listeria mutant immunization alters pulmonary/systemic responses, effector functions, and memory polarization of Vγ2Vδ2 T cells.

Frencher JT, Shen H, Yan L, Wilson JO, Freitag NE, Rizzo AN, Chen CY, Chen ZW.

J Leukoc Biol. 2014 Dec;96(6):957-67. doi: 10.1189/jlb.6HI1213-632R. Epub 2014 Aug 11.


Listeria monocytogenes virulence factor secretion: don't leave the cell without a chaperone.

Cahoon LA, Freitag NE.

Front Cell Infect Microbiol. 2014 Feb 12;4:13. doi: 10.3389/fcimb.2014.00013. eCollection 2014. Review.


Roles of a novel Crp/Fnr family transcription factor Lmo0753 in soil survival, biofilm production and surface attachment to fresh produce of Listeria monocytogenes.

Salazar JK, Wu Z, Yang W, Freitag NE, Tortorello ML, Wang H, Zhang W.

PLoS One. 2013 Sep 16;8(9):e75736. doi: 10.1371/journal.pone.0075736. eCollection 2013.


γδ T cells exhibit multifunctional and protective memory in intestinal tissues.

Sheridan BS, Romagnoli PA, Pham QM, Fu HH, Alonzo F 3rd, Schubert WD, Freitag NE, Lefrançois L.

Immunity. 2013 Jul 25;39(1):184-95. doi: 10.1016/j.immuni.2013.06.015.


PrfA-like transcription factor gene lmo0753 contributes to L-rhamnose utilization in Listeria monocytogenes strains associated with human food-borne infections.

Salazar JK, Wu Z, McMullen PD, Luo Q, Freitag NE, Tortorello ML, Hu S, Zhang W.

Appl Environ Microbiol. 2013 Sep;79(18):5584-92. doi: 10.1128/AEM.01812-13. Epub 2013 Jul 8.


SHIV antigen immunization alters patterns of immune responses to SHIV/malaria coinfection and protects against life-threatening SHIV-related malaria.

Frencher JT, Ryan-Pasyeur BK, Huang D, Wang RC, McMullen PD, Letvin NL, Collins WE, Freitag NE, Malkovsky M, Chen CY, Shen L, Chen ZW.

J Infect Dis. 2013 Jul 15;208(2):260-70. doi: 10.1093/infdis/jit151. Epub 2013 Apr 8.


The Listeria monocytogenes ChiA chitinase enhances virulence through suppression of host innate immunity.

Chaudhuri S, Gantner BN, Ye RD, Cianciotto NP, Freitag NE.

mBio. 2013 Mar 19;4(2):e00617-12. doi: 10.1128/mBio.00617-12.


Smad7 inhibits autocrine expression of TGF-β2 in intestinal epithelial cells in baboon necrotizing enterocolitis.

Namachivayam K, Blanco CL, MohanKumar K, Jagadeeswaran R, Vasquez M, McGill-Vargas L, Garzon SA, Jain SK, Gill RK, Freitag NE, Weitkamp JH, Seidner SR, Maheshwari A.

Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G167-80. doi: 10.1152/ajpgi.00141.2012. Epub 2012 Nov 15.


Optimizing the balance between host and environmental survival skills: lessons learned from Listeria monocytogenes.

Xayarath B, Freitag NE.

Future Microbiol. 2012 Jul;7(7):839-52. doi: 10.2217/fmb.12.57. Review.


Genome sequence of Listeria monocytogenes 07PF0776, a cardiotropic serovar 4b strain.

McMullen PD, Gillaspy AF, Gipson J, Bobo LD, Skiest DJ, Freitag NE.

J Bacteriol. 2012 Jul;194(13):3552. doi: 10.1128/JB.00616-12.


Listeria monocytogenes adapts to long-term stationary phase survival without compromising bacterial virulence.

Bruno JC Jr, Freitag NE.

FEMS Microbiol Lett. 2011 Oct;323(2):171-9. doi: 10.1111/j.1574-6968.2011.02373.x. Epub 2011 Aug 24.


Probing the role of protein surface charge in the activation of PrfA, the central regulator of Listeria monocytogenes pathogenesis.

Xayarath B, Volz KW, Smart JI, Freitag NE.

PLoS One. 2011;6(8):e23502. doi: 10.1371/journal.pone.0023502. Epub 2011 Aug 12.


A novel C-terminal mutation resulting in constitutive activation of the Listeria monocytogenes central virulence regulatory factor PrfA.

Xayarath B, Smart JI, Mueller KJ, Freitag NE.

Microbiology. 2011 Nov;157(Pt 11):3138-3149. doi: 10.1099/mic.0.049957-0. Epub 2011 Aug 11.


Functional analysis of the Listeria monocytogenes secretion chaperone PrsA2 and its multiple contributions to bacterial virulence.

Alonzo F 3rd, Xayarath B, Whisstock JC, Freitag NE.

Mol Microbiol. 2011 Jun;80(6):1530-48. doi: 10.1111/j.1365-2958.2011.07665.x. Epub 2011 May 5.


Evidence for subpopulations of Listeria monocytogenes with enhanced invasion of cardiac cells.

Alonzo F 3rd, Bobo LD, Skiest DJ, Freitag NE.

J Med Microbiol. 2011 Apr;60(Pt 4):423-34. doi: 10.1099/jmm.0.027185-0. Epub 2011 Jan 25.


Actin polymerization drives septation of Listeria monocytogenes namA hydrolase mutants, demonstrating host correction of a bacterial defect.

Alonzo F 3rd, McMullen PD, Freitag NE.

Infect Immun. 2011 Apr;79(4):1458-70. doi: 10.1128/IAI.01140-10. Epub 2011 Jan 24.


Listeria monocytogenes PrsA2 is required for virulence factor secretion and bacterial viability within the host cell cytosol.

Alonzo F 3rd, Freitag NE.

Infect Immun. 2010 Nov;78(11):4944-57. doi: 10.1128/IAI.00532-10. Epub 2010 Sep 7.


Contribution of chitinases to Listeria monocytogenes pathogenesis.

Chaudhuri S, Bruno JC, Alonzo F 3rd, Xayarath B, Cianciotto NP, Freitag NE.

Appl Environ Microbiol. 2010 Nov;76(21):7302-5. doi: 10.1128/AEM.01338-10. Epub 2010 Sep 3.


The virulence regulator PrfA promotes biofilm formation by Listeria monocytogenes.

Lemon KP, Freitag NE, Kolter R.

J Bacteriol. 2010 Aug;192(15):3969-76. doi: 10.1128/JB.00179-10. Epub 2010 May 28.


A bacterial pathogen flips the riboswitch.

Xayarath B, Freitag NE.

Cell Host Microbe. 2009 Nov 19;6(5):400-2. doi: 10.1016/j.chom.2009.10.009.


Listeria monocytogenes CtaP is a multifunctional cysteine transport-associated protein required for bacterial pathogenesis.

Xayarath B, Marquis H, Port GC, Freitag NE.

Mol Microbiol. 2009 Nov;74(4):956-73. doi: 10.1111/j.1365-2958.2009.06910.x. Epub 2009 Oct 8.


Complete transcriptional profile of an environmental pathogen.

Freitag NE.

Future Microbiol. 2009 Sep;4(7):779-82. doi: 10.2217/fmb.09.56.


Listeria monocytogenes - from saprophyte to intracellular pathogen.

Freitag NE, Port GC, Miner MD.

Nat Rev Microbiol. 2009 Sep;7(9):623-8. doi: 10.1038/nrmicro2171. Epub 2009 Aug 3. Review.


The posttranslocation chaperone PrsA2 contributes to multiple facets of Listeria monocytogenes pathogenesis.

Alonzo F 3rd, Port GC, Cao M, Freitag NE.

Infect Immun. 2009 Jul;77(7):2612-23. doi: 10.1128/IAI.00280-09. Epub 2009 May 18.


Functional impact of mutational activation on the Listeria monocytogenes central virulence regulator PrfA.

Miner MD, Port GC, Freitag NE.

Microbiology. 2008 Nov;154(Pt 11):3579-3589. doi: 10.1099/mic.0.2008/021063-0.


A novel prfA mutation that promotes Listeria monocytogenes cytosol entry but reduces bacterial spread and cytotoxicity.

Miner MD, Port GC, Bouwer HG, Chang JC, Freitag NE.

Microb Pathog. 2008 Oct;45(4):273-81. doi: 10.1016/j.micpath.2008.06.006. Epub 2008 Jul 15.


Constitutive Activation of the PrfA regulon enhances the potency of vaccines based on live-attenuated and killed but metabolically active Listeria monocytogenes strains.

Lauer P, Hanson B, Lemmens EE, Liu W, Luckett WS, Leong ML, Allen HE, Skoble J, Bahjat KS, Freitag NE, Brockstedt DG, Dubensky TW Jr.

Infect Immun. 2008 Aug;76(8):3742-53. doi: 10.1128/IAI.00390-08. Epub 2008 Jun 9.


Selected prfA* mutations in recombinant attenuated Listeria monocytogenes strains augment expression of foreign immunogens and enhance vaccine-elicited humoral and cellular immune responses.

Yan L, Qiu J, Chen J, Ryan-Payseur B, Huang D, Wang Y, Rong L, Melton-Witt JA, Freitag NE, Chen ZW.

Infect Immun. 2008 Aug;76(8):3439-50. doi: 10.1128/IAI.00245-08. Epub 2008 May 12.

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