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Regimen-dependent synergism and antagonism of treprostinil and vildagliptin in hematopoietic cell transplantation.

Zebedin-Brandl E, Themanns M, Kazemi Z, Nasrollahi-Shirazi S, Mussbacher M, Heyes E, Meissl K, Prchal-Murphy M, Strohmaier W, Krumpl G, Freissmuth M.

J Mol Med (Berl). 2020 Feb;98(2):233-243. doi: 10.1007/s00109-019-01869-8. Epub 2019 Dec 24.


Effect of rain on absorption after transdermal application of flunixin in calves.

Altenbrunner-Martinek B, Witek M, Koppatz K, Freissmuth M, Kraft A, Sutter C, Torres S, Gelfert C, Wittek T.

J Vet Pharmacol Ther. 2020 Jan;43(1):87-90. doi: 10.1111/jvp.12829. Epub 2019 Dec 13.


Kinetic Models of Secondary Active Transporters.

Burtscher V, Schicker K, Freissmuth M, Sandtner W.

Int J Mol Sci. 2019 Oct 28;20(21). pii: E5365. doi: 10.3390/ijms20215365.


Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics.

Douillard P, Freissmuth M, Antoine G, Thiele M, Fleischanderl D, Matthiessen P, Voelkel D, Kerschbaumer RJ, Scheiflinger F, Sabarth N.

Antibodies (Basel). 2019 Sep 6;8(3). pii: E46. doi: 10.3390/antib8030046.


An Electrophysiological Approach to Measure Changes in the Membrane Surface Potential in Real Time.

Burtscher V, Hotka M, Freissmuth M, Sandtner W.

Biophys J. 2019 Jul 5. pii: S0006-3495(19)30542-9. doi: 10.1016/j.bpj.2019.06.033. [Epub ahead of print]


A comparison of the transport kinetics of glycine transporter 1 and glycine transporter 2.

Erdem FA, Ilic M, Koppensteiner P, Gołacki J, Lubec G, Freissmuth M, Sandtner W.

J Gen Physiol. 2019 Aug 5;151(8):1035-1050. doi: 10.1085/jgp.201912318. Epub 2019 Jul 3.


How to rescue misfolded SERT, DAT and NET: targeting conformational intermediates with atypical inhibitors and partial releasers.

Bhat S, Newman AH, Freissmuth M.

Biochem Soc Trans. 2019 Jun 28;47(3):861-874. doi: 10.1042/BST20180512. Epub 2019 May 7. Review.


para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter.

Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH.

Neuropharmacology. 2019 Dec 15;161:107615. doi: 10.1016/j.neuropharm.2019.04.021. Epub 2019 Apr 24.


Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery.

Muratspahić E, Freissmuth M, Gruber CW.

Trends Pharmacol Sci. 2019 May;40(5):309-326. doi: 10.1016/ Epub 2019 Apr 5. Review.


Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.

El-Kasaby A, Kasture A, Koban F, Hotka M, Asjad HMM, Kubista H, Freissmuth M, Sucic S.

Neuropharmacology. 2019 Dec 15;161:107572. doi: 10.1016/j.neuropharm.2019.03.015. Epub 2019 Mar 15.


Distinct contribution of axonal and somatodendritic serotonin transporters in drosophila olfaction.

Kasture AS, Bartel D, Steinkellner T, Sucic S, Hummel T, Freissmuth M.

Neuropharmacology. 2019 Dec 15;161:107564. doi: 10.1016/j.neuropharm.2019.03.007. Epub 2019 Mar 6.


Functional Selectivity and Partial Efficacy at the Monoamine Transporters: A Unified Model of Allosteric Modulation and Amphetamine-Induced Substrate Release.

Hasenhuetl PS, Bhat S, Freissmuth M, Sandtner W.

Mol Pharmacol. 2019 Mar;95(3):303-312. doi: 10.1124/mol.118.114793. Epub 2018 Dec 19. Review.


Treprostinil reduces endothelial damage in murine sinusoidal obstruction syndrome.

Themanns M, Koban F, Bergmayr C, Chrzan A, Strohmaier W, Haybaeck J, Freissmuth M, Zebedin-Brandl E.

J Mol Med (Berl). 2019 Feb;97(2):201-213. doi: 10.1007/s00109-018-1726-6. Epub 2018 Dec 7.


Trafficking of the amino acid transporter B0,+ (SLC6A14) to the plasma membrane involves an exclusive interaction with SEC24C for its exit from the endoplasmic reticulum.

Kovalchuk V, Samluk Ł, Juraszek B, Jurkiewicz-Trząska D, Sucic S, Freissmuth M, Nałęcz KA.

Biochim Biophys Acta Mol Cell Res. 2019 Feb;1866(2):252-263. doi: 10.1016/j.bbamcr.2018.11.005. Epub 2018 Nov 14.


Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.


Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.

Hamali B, Pichler S, Wischnitzki E, Schicker K, Burger M, Holy M, Jaentsch K, Molin M, Sehr EM, Kudlacek O, Freissmuth M.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006428. doi: 10.1371/journal.pntd.0006428. eCollection 2018 Apr.


A label-free approach to detect ligand binding to cell surface proteins in real time.

Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W.

Elife. 2018 Apr 26;7. pii: e34944. doi: 10.7554/eLife.34944.


A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Mar 5;150(3):431-451. doi: 10.1085/jgp.201711915. Epub 2018 Feb 9.


Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.

Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T.

Inflamm Bowel Dis. 2017 Dec 19;24(1):54-66. doi: 10.1093/ibd/izx042. Erratum in: Inflamm Bowel Dis. 2018 Oct 12;24(11):2478.


Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.


SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71. Review.


Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.


An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.


Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.


Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.

Yang Q, Puhm F, Freissmuth M, Nanoff C.

Cancer Chemother Pharmacol. 2017 Oct;80(4):673-684. doi: 10.1007/s00280-017-3390-x. Epub 2017 Aug 4.


Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.


Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.

Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T.

Pharmacol Res Perspect. 2017 May 26;5(3):e00325. doi: 10.1002/prp2.325. eCollection 2017 Jun.


Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Apr 28;292(17):7161. doi: 10.1074/jbc.A116.760140. No abstract available.


When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M.

J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40.


The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.


Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Mar 10;292(10):4235-4243. doi: 10.1074/jbc.M116.760140. Epub 2017 Jan 17. Erratum in: J Biol Chem. 2017 Apr 28;292(17 ):7161.


Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.

Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH.

Curr Top Behav Neurosci. 2017;32:333-350. doi: 10.1007/7854_2016_63. Review.


The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.


Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G.

Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20.


Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter.

Hasenhuetl PS, Freissmuth M, Sandtner W.

J Biol Chem. 2016 Dec 9;291(50):25864-25876. Epub 2016 Oct 18.


Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer.

Schinagl A, Thiele M, Douillard P, Völkel D, Kenner L, Kazemi Z, Freissmuth M, Scheiflinger F, Kerschbaumer RJ.

Oncotarget. 2016 Nov 8;7(45):73486-73496. doi: 10.18632/oncotarget.11970.


A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.

Cancer Cell. 2016 Aug 8;30(2):359-360. doi: 10.1016/j.ccell.2016.07.003. Epub 2016 Aug 8. No abstract available.


Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1.


Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.

Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C.

J Pharmacol Exp Ther. 2016 Oct;359(1):73-81. doi: 10.1124/jpet.116.232884. Epub 2016 Jul 22.


Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.

Kazemi Z, Bergmayr C, Prchal-Murphy M, Javaheri T, Themanns M, Pham HT, Strohmaier W, Sexl V, Freissmuth M, Zebedin-Brandl E.

Mol Pharmacol. 2016 Jun;89(6):630-44. doi: 10.1124/mol.116.103267. Epub 2016 Mar 17.


Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.


Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2015 Dec 25;290(52):31069-76. doi: 10.1074/jbc.M115.688275. Epub 2015 Oct 26.


Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.


Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour.

Kong E, Sucic S, Monje FJ, Reisinger SN, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Jul 15;5:11965. doi: 10.1038/srep11965. No abstract available.


Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH.

J Neurosci. 2015 May 27;35(21):8258-71. doi: 10.1523/JNEUROSCI.4034-14.2015. Erratum in: J Neurosci. 2015 Aug 19;35(33):11762.


Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.


A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.


Cooperativity between individual transporter protomers: new data fuelling old complexes.

Sitte HH, Schütz GJ, Freissmuth M.

J Neurochem. 2015 Apr;133(2):163-6. doi: 10.1111/jnc.13086. Epub 2015 Mar 15.


STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.

Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Mar 11;5:9009. doi: 10.1038/srep09009. Erratum in: Sci Rep. 2015;5:11965.

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