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Items: 1 to 50 of 216

1.

Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems.

Kasture AS, Hummel T, Sucic S, Freissmuth M.

Int J Mol Sci. 2018 Jun 16;19(6). pii: E1788. doi: 10.3390/ijms19061788. Review.

2.

Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter.

Hamali B, Pichler S, Wischnitzki E, Schicker K, Burger M, Holy M, Jaentsch K, Molin M, Sehr EM, Kudlacek O, Freissmuth M.

PLoS Negl Trop Dis. 2018 Apr 27;12(4):e0006428. doi: 10.1371/journal.pntd.0006428. eCollection 2018 Apr.

3.

A label-free approach to detect ligand binding to cell surface proteins in real time.

Burtscher V, Hotka M, Li Y, Freissmuth M, Sandtner W.

Elife. 2018 Apr 26;7. pii: e34944. doi: 10.7554/eLife.34944.

4.

A kinetic account for amphetamine-induced monoamine release.

Hasenhuetl PS, Bhat S, Mayer FP, Sitte HH, Freissmuth M, Sandtner W.

J Gen Physiol. 2018 Feb 9. pii: jgp.201711915. doi: 10.1085/jgp.201711915. [Epub ahead of print]

PMID:
29439119
5.

Clinoptilolite in Dextran Sulphate Sodium-Induced Murine Colitis: Efficacy and Safety of a Microparticulate Preparation.

Nizet S, Muñoz E, Fiebich BL, Abuja PM, Kashofer K, Zatloukal K, Tangermann S, Kenner L, Tschegg C, Nagl D, Scheichl L, Meisslitzer-Ruppitsch C, Freissmuth M, Berger T.

Inflamm Bowel Dis. 2017 Dec 19;24(1):54-66. doi: 10.1093/ibd/izx042.

PMID:
29272495
6.

Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.

Asjad HMM, Nasrollahi-Shirazi S, Sucic S, Freissmuth M, Nanoff C.

Int J Mol Sci. 2017 Nov 14;18(11). pii: E2416. doi: 10.3390/ijms18112416. Review.

7.

SLC6 Transporter Folding Diseases and Pharmacochaperoning.

Freissmuth M, Stockner T, Sucic S.

Handb Exp Pharmacol. 2018;245:249-270. doi: 10.1007/164_2017_71.

PMID:
29086036
8.

Pharmacochaperoning in a Drosophila model system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism.

Asjad HMM, Kasture A, El-Kasaby A, Sackel M, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2017 Nov 24;292(47):19250-19265. doi: 10.1074/jbc.M117.797092. Epub 2017 Sep 29.

9.

An unfolding story: Small molecules remedy misfolded monoamine transporters.

Kasture A, Stockner T, Freissmuth M, Sucic S.

Int J Biochem Cell Biol. 2017 Nov;92:1-5. doi: 10.1016/j.biocel.2017.09.004. Epub 2017 Sep 7. Review.

10.

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates.

Bhat S, Hasenhuetl PS, Kasture A, El-Kasaby A, Baumann MH, Blough BE, Sucic S, Sandtner W, Freissmuth M.

J Biol Chem. 2017 Oct 6;292(40):16773-16786. doi: 10.1074/jbc.M117.794081. Epub 2017 Aug 23.

11.

Hyponatremia and V2 vasopressin receptor upregulation: a result of HSP90 inhibition.

Yang Q, Puhm F, Freissmuth M, Nanoff C.

Cancer Chemother Pharmacol. 2017 Oct;80(4):673-684. doi: 10.1007/s00280-017-3390-x. Epub 2017 Aug 4.

12.

Cocaine adulteration.

Kudlacek O, Hofmaier T, Luf A, Mayer FP, Stockner T, Nagy C, Holy M, Freissmuth M, Schmid R, Sitte HH.

J Chem Neuroanat. 2017 Oct;83-84:75-81. doi: 10.1016/j.jchemneu.2017.06.001. Epub 2017 Jun 12. Review.

PMID:
28619473
13.

Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept.

Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T.

Pharmacol Res Perspect. 2017 May 26;5(3):e00325. doi: 10.1002/prp2.325. eCollection 2017 Jun.

14.

Occupancy of the zinc-binding site by transition metals decreases the substrate affinity of the human dopamine transporter by an allosteric mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Apr 28;292(17):7161. doi: 10.1074/jbc.A116.760140. No abstract available.

15.

When transporters fail to be transported: how to rescue folding-deficient SLC6 transporters.

Sucic S, Kasture A, Mazhar Asjad HM, Kern C, El-Kasaby A, Freissmuth M.

J Neurol Neuromedicine. 2016 Dec 30;1(9):34-40.

16.

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter.

Kern C, Erdem FA, El-Kasaby A, Sandtner W, Freissmuth M, Sucic S.

J Biol Chem. 2017 Mar 3;292(9):3603-3613. doi: 10.1074/jbc.M116.771360. Epub 2017 Jan 19.

17.

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism.

Li Y, Mayer FP, Hasenhuetl PS, Burtscher V, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2017 Mar 10;292(10):4235-4243. doi: 10.1074/jbc.M116.760140. Epub 2017 Jan 17. Erratum in: J Biol Chem. 2017 Apr 28;292(17 ):7161.

18.

Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters.

Mayer FP, Luf A, Nagy C, Holy M, Schmid R, Freissmuth M, Sitte HH.

Curr Top Behav Neurosci. 2017;32:333-350. doi: 10.1007/7854_2016_63. Review.

PMID:
28025810
19.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

20.

Several adaptor proteins promote intracellular localisation of the transporter MRP4/ABCC4 in platelets and haematopoietic cells.

Schaletzki Y, Kromrey ML, Bröderdorf S, Hammer E, Grube M, Hagen P, Sucic S, Freissmuth M, Völker U, Greinacher A, Rauch BH, Kroemer HK, Jedlitschky G.

Thromb Haemost. 2017 Jan 5;117(1):105-115. doi: 10.1160/TH16-01-0045. Epub 2016 Oct 20.

PMID:
27761583
21.

Electrogenic Binding of Intracellular Cations Defines a Kinetic Decision Point in the Transport Cycle of the Human Serotonin Transporter.

Hasenhuetl PS, Freissmuth M, Sandtner W.

J Biol Chem. 2016 Dec 9;291(50):25864-25876. Epub 2016 Oct 18.

22.

Oxidized macrophage migration inhibitory factor is a potential new tissue marker and drug target in cancer.

Schinagl A, Thiele M, Douillard P, Völkel D, Kenner L, Kazemi Z, Freissmuth M, Scheiflinger F, Kerschbaumer RJ.

Oncotarget. 2016 Nov 8;7(45):73486-73496. doi: 10.18632/oncotarget.11970.

23.

A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis.

Kollmann K, Heller G, Schneckenleithner C, Warsch W, Scheicher R, Ott RG, Schäfer M, Fajmann S, Schlederer M, Schiefer AI, Reichart U, Mayerhofer M, Hoeller C, Zöchbauer-Müller S, Kerjaschki D, Bock C, Kenner L, Hoefler G, Freissmuth M, Green AR, Moriggl R, Busslinger M, Malumbres M, Sexl V.

Cancer Cell. 2016 Aug 8;30(2):359-360. doi: 10.1016/j.ccell.2016.07.003. Epub 2016 Aug 8. No abstract available.

24.

Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.

Kasture A, El-Kasaby A, Szöllősi D, Asjad HMM, Grimm A, Stockner T, Hummel T, Freissmuth M, Sucic S.

J Biol Chem. 2016 Sep 30;291(40):20876-20890. doi: 10.1074/jbc.M116.737551. Epub 2016 Aug 1.

25.

Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.

Nasrollahi-Shirazi S, Sucic S, Yang Q, Freissmuth M, Nanoff C.

J Pharmacol Exp Ther. 2016 Oct;359(1):73-81. doi: 10.1124/jpet.116.232884. Epub 2016 Jul 22.

26.

Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.

Kazemi Z, Bergmayr C, Prchal-Murphy M, Javaheri T, Themanns M, Pham HT, Strohmaier W, Sexl V, Freissmuth M, Zebedin-Brandl E.

Mol Pharmacol. 2016 Jun;89(6):630-44. doi: 10.1124/mol.116.103267. Epub 2016 Mar 17.

27.

Nanopharmacological Force Sensing to Reveal Allosteric Coupling in Transporter Binding Sites.

Zhu R, Sinwel D, Hasenhuetl PS, Saha K, Kumar V, Zhang P, Rankl C, Holy M, Sucic S, Kudlacek O, Karner A, Sandtner W, Stockner T, Gruber HJ, Freissmuth M, Newman AH, Sitte HH, Hinterdorfer P.

Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1719-22. doi: 10.1002/anie.201508755. Epub 2015 Dec 22.

28.

Dual Action of Zn2+ on the Transport Cycle of the Dopamine Transporter.

Li Y, Hasenhuetl PS, Schicker K, Sitte HH, Freissmuth M, Sandtner W.

J Biol Chem. 2015 Dec 25;290(52):31069-76. doi: 10.1074/jbc.M115.688275. Epub 2015 Oct 26.

29.

Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site.

Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T.

PLoS Comput Biol. 2015 Oct 20;11(10):e1004551. doi: 10.1371/journal.pcbi.1004551. eCollection 2015 Oct.

30.

Corrigendum: STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behaviour.

Kong E, Sucic S, Monje FJ, Reisinger SN, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Jul 15;5:11965. doi: 10.1038/srep11965. No abstract available.

31.

Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII.

Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH.

J Neurosci. 2015 May 27;35(21):8258-71. doi: 10.1523/JNEUROSCI.4034-14.2015. Erratum in: J Neurosci. 2015 Aug 19;35(33):11762.

32.

Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Hasenhuetl PS, Schicker K, Koenig X, Li Y, Sarker S, Stockner T, Sucic S, Sitte HH, Freissmuth M, Sandtner W.

Mol Pharmacol. 2015 Jul;88(1):12-8. doi: 10.1124/mol.115.099036. Epub 2015 Apr 14.

33.

A salt bridge linking the first intracellular loop with the C terminus facilitates the folding of the serotonin transporter.

Koban F, El-Kasaby A, Häusler C, Stockner T, Simbrunner BM, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2015 May 22;290(21):13263-78. doi: 10.1074/jbc.M115.641357. Epub 2015 Apr 13.

34.

Cooperativity between individual transporter protomers: new data fuelling old complexes.

Sitte HH, Schütz GJ, Freissmuth M.

J Neurochem. 2015 Apr;133(2):163-6. doi: 10.1111/jnc.13086. Epub 2015 Mar 15.

35.

STAT3 controls IL6-dependent regulation of serotonin transporter function and depression-like behavior.

Kong E, Sucic S, Monje FJ, Savalli G, Diao W, Khan D, Ronovsky M, Cabatic M, Koban F, Freissmuth M, Pollak DD.

Sci Rep. 2015 Mar 11;5:9009. doi: 10.1038/srep09009. Erratum in: Sci Rep. 2015;5:11965.

36.

Amphetamines, new psychoactive drugs and the monoamine transporter cycle.

Sitte HH, Freissmuth M.

Trends Pharmacol Sci. 2015 Jan;36(1):41-50. doi: 10.1016/j.tips.2014.11.006. Epub 2014 Dec 23. Review.

37.

Chaperoning of the A1-adenosine receptor by endogenous adenosine - an extension of the retaliatory metabolite concept.

Kusek J, Yang Q, Witek M, Gruber CW, Nanoff C, Freissmuth M.

Mol Pharmacol. 2015 Jan;87(1):39-51. doi: 10.1124/mol.114.094045. Epub 2014 Oct 29.

38.

Late-onset palsy of the recurrent laryngeal nerve after thyroid surgery.

Bures C, Bobak-Wieser R, Koppitsch C, Klatte T, Zielinski V, Freissmuth M, Friedrich G, Repasi R, Hermann M.

Br J Surg. 2014 Nov;101(12):1556-9. doi: 10.1002/bjs.9648. Epub 2014 Sep 16.

PMID:
25223396
39.

A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter.

El-Kasaby A, Koban F, Sitte HH, Freissmuth M, Sucic S.

J Biol Chem. 2014 Oct 17;289(42):28987-9000. doi: 10.1074/jbc.M114.595090. Epub 2014 Sep 8.

40.

A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities.

Michl J, Scharinger C, Zauner M, Kasper S, Freissmuth M, Sitte HH, Ecker GF, Pezawas L.

Eur Neuropsychopharmacol. 2014 Sep;24(9):1463-74. doi: 10.1016/j.euroneuro.2014.06.013. Epub 2014 Jul 3.

41.

Pharmacological correction of misfolding of ABC proteins.

Rudashevskaya EL, Stockner T, Trauner M, Freissmuth M, Chiba P.

Drug Discov Today Technol. 2014 Jun;12:e87-94. doi: 10.1016/j.ddtec.2014.03.009. Review.

42.

In vivo amphetamine action is contingent on αCaMKII.

Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, Pollak DD, Gainetdinov RR, Sitte HH.

Neuropsychopharmacology. 2014 Oct;39(11):2681-93. doi: 10.1038/npp.2014.124. Epub 2014 May 29.

43.

Perioperative kinetics of parathyroid hormone in unilateral, primary thyroid surgery.

Promberger R, Ott J, Bures C, Freissmuth M, Seemann R, Hermann M.

Endocrine. 2015 Feb;48(1):293-8. doi: 10.1007/s12020-014-0300-4. Epub 2014 May 25.

PMID:
24858628
44.

The conservative view: is it necessary to implant a stent into the dopamine transporter?

Schmid D, Koenig X, Bulusu S, Schicker K, Freissmuth M, Sitte HH, Sandtner W.

Br J Pharmacol. 2015 Oct;172(19):4775-8. doi: 10.1111/bph.12766. No abstract available.

45.

Tracking single serotonin transporter molecules at the endoplasmic reticulum and plasma membrane.

Anderluh A, Klotzsch E, Ries J, Reismann AW, Weber S, Fölser M, Koban F, Freissmuth M, Sitte HH, Schütz GJ.

Biophys J. 2014 May 6;106(9):L33-5. doi: 10.1016/j.bpj.2014.03.019.

46.

Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.

Burtscher V, Schicker K, Novikova E, Pöhn B, Stockner T, Kugler C, Singh A, Zeitz C, Lancelot ME, Audo I, Leroy BP, Freissmuth M, Herzig S, Matthes J, Koschak A.

Biochim Biophys Acta. 2014 Aug;1838(8):2053-65. doi: 10.1016/j.bbamem.2014.04.023. Epub 2014 May 4.

47.

Axonal targeting of the serotonin transporter in cultured rat dorsal raphe neurons is specified by SEC24C-dependent export from the endoplasmic reticulum.

Montgomery TR, Steinkellner T, Sucic S, Koban F, Schüchner S, Ogris E, Sitte HH, Freissmuth M.

J Neurosci. 2014 Apr 30;34(18):6344-6351. doi: 10.1523/JNEUROSCI.2991-13.2014.

48.

Can a surgeon predict the risk of postoperative hypoparathyroidism during thyroid surgery? A prospective study on self-assessment by experts.

Promberger R, Ott J, Bures C, Kober F, Freissmuth M, Seemann R, Hermann M.

Am J Surg. 2014 Jul;208(1):13-20. doi: 10.1016/j.amjsurg.2013.11.007. Epub 2014 Mar 26.

PMID:
24746378
49.

Platelet serotonin transporter function predicts default-mode network activity.

Scharinger C, Rabl U, Kasess CH, Meyer BM, Hofmaier T, Diers K, Bartova L, Pail G, Huf W, Uzelac Z, Hartinger B, Kalcher K, Perkmann T, Haslacher H, Meyer-Lindenberg A, Kasper S, Freissmuth M, Windischberger C, Willeit M, Lanzenberger R, Esterbauer H, Brocke B, Moser E, Sitte HH, Pezawas L.

PLoS One. 2014 Mar 25;9(3):e92543. doi: 10.1371/journal.pone.0092543. eCollection 2014.

50.

A two-state model for the diffusion of the A2A adenosine receptor in hippocampal neurons: agonist-induced switch to slow mobility is modified by synapse-associated protein 102 (SAP102).

Thurner P, Gsandtner I, Kudlacek O, Choquet D, Nanoff C, Freissmuth M, Zezula J.

J Biol Chem. 2014 Mar 28;289(13):9263-74. doi: 10.1074/jbc.M113.505685. Epub 2014 Feb 7.

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