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Items: 1 to 50 of 87

1.

Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice.

Bárcena C, Valdés-Mas R, Mayoral P, Garabaya C, Durand S, Rodríguez F, Fernández-García MT, Salazar N, Nogacka AM, Garatachea N, Bossut N, Aprahamian F, Lucia A, Kroemer G, Freije JMP, Quirós PM, López-Otín C.

Nat Med. 2019 Aug;25(8):1234-1242. doi: 10.1038/s41591-019-0504-5. Epub 2019 Jul 22.

PMID:
31332389
2.

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome.

Santiago-Fernández O, Osorio FG, Quesada V, Rodríguez F, Basso S, Maeso D, Rolas L, Barkaway A, Nourshargh S, Folgueras AR, Freije JMP, López-Otín C.

Nat Med. 2019 Mar;25(3):423-426. doi: 10.1038/s41591-018-0338-6. Epub 2019 Feb 18.

3.

Retraction Note: NF-κB activation impairs somatic cell reprogramming in ageing.

Soria-Valles C, Osorio FG, Gutiérrez-Fernández A, De Los Angeles A, Bueno C, Menéndez P, Martín-Subero JI, Daley GQ, Freije JMP, López-Otín C.

Nat Cell Biol. 2019 Mar;21(3):410. doi: 10.1038/s41556-018-0259-0.

PMID:
30559458
4.

The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function.

Caravia XM, Fanjul V, Oliver E, Roiz-Valle D, Morán-Álvarez A, Desdín-Micó G, Mittelbrunn M, Cabo R, Vega JA, Rodríguez F, Fueyo A, Gómez M, Lobo-González M, Bueno H, Velasco G, Freije JMP, Andrés V, Ibáñez B, Ugalde AP, López-Otín C.

PLoS Biol. 2018 Oct 22;16(10):e2006247. doi: 10.1371/journal.pbio.2006247. eCollection 2018 Oct.

5.

Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.

Bárcena C, Quirós PM, Durand S, Mayoral P, Rodríguez F, Caravia XM, Mariño G, Garabaya C, Fernández-García MT, Kroemer G, Freije JMP, López-Otín C.

Cell Rep. 2018 Aug 28;24(9):2392-2403. doi: 10.1016/j.celrep.2018.07.089.

6.

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.

Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JMP, López-Otín C.

J Biol Chem. 2018 Jul 27;293(30):11970. doi: 10.1074/jbc.AAC118.004704. No abstract available.

7.

Protease Silencing to Explore the Molecular Mechanisms of Cancer and Aging.

Fraile JM, Campos-Iglesias D, Freije JMP.

Methods Mol Biol. 2018;1731:261-269. doi: 10.1007/978-1-4939-7595-2_23.

PMID:
29318560
8.

Loss of the deubiquitinase USP36 destabilizes the RNA helicase DHX33 and causes preimplantation lethality in mice.

Fraile JM, Campos-Iglesias D, Rodríguez F, Astudillo A, Vilarrasa-Blasi R, Verdaguer-Dot N, Prado MA, Paulo JA, Gygi SP, Martín-Subero JI, Freije JMP, López-Otín C.

J Biol Chem. 2018 Feb 9;293(6):2183-2194. doi: 10.1074/jbc.M117.788430. Epub 2017 Dec 22.

9.

Deubiquitination in cancer stem cells.

Fraile JM, Campos-Iglesias D, Freije JM.

Aging (Albany NY). 2017 Feb 12;9(2):297-298. doi: 10.18632/aging.101182. No abstract available.

10.

USP39 Deubiquitinase Is Essential for KRAS Oncogene-driven Cancer.

Fraile JM, Manchado E, Lujambio A, Quesada V, Campos-Iglesias D, Webb TR, Lowe SW, López-Otín C, Freije JM.

J Biol Chem. 2017 Mar 10;292(10):4164-4175. doi: 10.1074/jbc.M116.762757. Epub 2017 Feb 1.

11.

The deubiquitinase USP54 is overexpressed in colorectal cancer stem cells and promotes intestinal tumorigenesis.

Fraile JM, Campos-Iglesias D, Rodríguez F, Español Y, Freije JM.

Oncotarget. 2016 Nov 15;7(46):74427-74434. doi: 10.18632/oncotarget.12769.

12.

Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype.

Lee SJ, Jung YS, Yoon MH, Kang SM, Oh AY, Lee JH, Jun SY, Woo TG, Chun HY, Kim SK, Chung KJ, Lee HY, Lee K, Jin G, Na MK, Ha NC, Bárcena C, Freije JM, López-Otín C, Song GY, Park BJ.

J Clin Invest. 2016 Oct 3;126(10):3879-3893. doi: 10.1172/JCI84164. Epub 2016 Sep 12.

13.

NF-κB signaling as a driver of ageing.

Osorio FG, Soria-Valles C, Santiago-Fernández O, Freije JM, López-Otín C.

Int Rev Cell Mol Biol. 2016;326:133-74. doi: 10.1016/bs.ircmb.2016.04.003. Epub 2016 May 30. Review.

PMID:
27572128
14.

Metabolic Control of Longevity.

López-Otín C, Galluzzi L, Freije JMP, Madeo F, Kroemer G.

Cell. 2016 Aug 11;166(4):802-821. doi: 10.1016/j.cell.2016.07.031. Review.

15.

The novel tumor suppressor AIRAPL regulates IGF1R proteostasis.

Osorio FG, Freije JM, López-Otín C.

Cell Cycle. 2016;15(7):873-4. doi: 10.1080/15384101.2016.1151725. Epub 2016 Feb 22. No abstract available.

16.

Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling.

Osorio FG, Soria-Valles C, Santiago-Fernández O, Bernal T, Mittelbrunn M, Colado E, Rodríguez F, Bonzon-Kulichenko E, Vázquez J, Porta-de-la-Riva M, Cerón J, Fueyo A, Li J, Green AR, Freije JM, López-Otín C.

Nat Med. 2016 Jan;22(1):91-6. doi: 10.1038/nm.4013. Epub 2015 Dec 21.

PMID:
26692333
17.

NF-κB activation impairs somatic cell reprogramming in ageing.

Soria-Valles C, Osorio FG, Gutiérrez-Fernández A, De Los Angeles A, Bueno C, Menéndez P, Martín-Subero JI, Daley GQ, Freije JM, López-Otín C.

Nat Cell Biol. 2015 Aug;17(8):1004-13. doi: 10.1038/ncb3207. Epub 2015 Jul 27. Retraction in: Nat Cell Biol. 2019 Mar;21(3):410.

PMID:
26214134
18.

Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.

Aguilera Ó, González-Sancho JM, Zazo S, Rincón R, Fernández AF, Tapia O, Canals F, Morte B, Calvanese V, Orgaz JL, Niell N, Aguilar S, Freije JM, Graña O, Pisano DG, Borrero A, Martínez-Useros J, Jiménez B, Fraga MF, García-Foncillas J, López-Otín C, Lafarga M, Rojo F, Muñoz A.

Oncotarget. 2015 Mar 20;6(8):5903-17.

19.

Loss of GLUT4 induces metabolic reprogramming and impairs viability of breast cancer cells.

Garrido P, Osorio FG, Morán J, Cabello E, Alonso A, Freije JM, González C.

J Cell Physiol. 2015 Jan;230(1):191-8. doi: 10.1002/jcp.24698.

PMID:
24931902
20.

Nuclear envelope lamin-A couples actin dynamics with immunological synapse architecture and T cell activation.

González-Granado JM, Silvestre-Roig C, Rocha-Perugini V, Trigueros-Motos L, Cibrián D, Morlino G, Blanco-Berrocal M, Osorio FG, Freije JMP, López-Otín C, Sánchez-Madrid F, Andrés V.

Sci Signal. 2014 Apr 22;7(322):ra37. doi: 10.1126/scisignal.2004872.

21.

Identification of novel tumor suppressor proteases by degradome profiling of colorectal carcinomas.

Fraile JM, Ordóñez GR, Quirós PM, Astudillo A, Galván JA, Colomer D, López-Otín C, Freije JM, Puente XS.

Oncotarget. 2013 Nov;4(11):1931-2.

22.

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion.

de la Rosa J, Freije JM, Cabanillas R, Osorio FG, Fraga MF, Fernández-García MS, Rad R, Fanjul V, Ugalde AP, Liang Q, Prosser HM, Bradley A, Cadiñanos J, López-Otín C.

Nat Commun. 2013;4:2268. doi: 10.1038/ncomms3268.

23.

ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis.

Cabrera S, Fernández AF, Mariño G, Aguirre A, Suárez MF, Español Y, Vega JA, Laurà R, Fueyo A, Fernández-García MS, Freije JM, Kroemer G, López-Otín C.

Autophagy. 2013 Aug;9(8):1188-200. doi: 10.4161/auto.24797. Epub 2013 May 8.

24.

Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain).

Blay P, Santamaría I, Pitiot AS, Luque M, Alvarado MG, Lastra A, Fernández Y, Paredes A, Freije JM, Balbín M.

BMC Cancer. 2013 May 17;13:243. doi: 10.1186/1471-2407-13-243.

25.

Matrix metalloproteinase Mmp-1a is dispensable for normal growth and fertility in mice and promotes lung cancer progression by modulating inflammatory responses.

Fanjul-Fernández M, Folgueras AR, Fueyo A, Balbín M, Suárez MF, Fernández-García MS, Shapiro SD, Freije JM, López-Otín C.

J Biol Chem. 2013 May 17;288(20):14647-56. doi: 10.1074/jbc.M112.439893. Epub 2013 Apr 2. Erratum in: J Biol Chem. 2018 Jul 27;293(30):11970.

26.

Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach.

Osorio FG, de la Rosa J, Freije JM.

Cell Commun Signal. 2013 Mar 21;11(1):19. doi: 10.1186/1478-811X-11-19.

27.

Functional analysis of sucrase-isomaltase mutations from chronic lymphocytic leukemia patients.

Rodríguez D, Ramsay AJ, Quesada V, Garabaya C, Campo E, Freije JM, López-Otín C.

Hum Mol Genet. 2013 Jun 1;22(11):2273-82. doi: 10.1093/hmg/ddt078. Epub 2013 Feb 14.

PMID:
23418305
28.

Detection of nuclear envelope alterations in senescence.

Bárcena C, Osorio FG, Freije JM.

Methods Mol Biol. 2013;965:243-51. doi: 10.1007/978-1-62703-239-1_16.

PMID:
23296663
29.

NF-kB in premature aging.

Osorio FG, López-Otín C, Freije JM.

Aging (Albany NY). 2012 Nov;4(11):726-7. Review. No abstract available.

30.

Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.

Osorio FG, Bárcena C, Soria-Valles C, Ramsay AJ, de Carlos F, Cobo J, Fueyo A, Freije JM, López-Otín C.

Genes Dev. 2012 Oct 15;26(20):2311-24. doi: 10.1101/gad.197954.112. Epub 2012 Sep 26.

31.

Reprogramming aging and progeria.

Freije JM, López-Otín C.

Curr Opin Cell Biol. 2012 Dec;24(6):757-64. doi: 10.1016/j.ceb.2012.08.009. Epub 2012 Sep 6. Review.

PMID:
22959961
32.

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia.

Quesada V, Conde L, Villamor N, Ordóñez GR, Jares P, Bassaganyas L, Ramsay AJ, Beà S, Pinyol M, Martínez-Trillos A, López-Guerra M, Colomer D, Navarro A, Baumann T, Aymerich M, Rozman M, Delgado J, Giné E, Hernández JM, González-Díaz M, Puente DA, Velasco G, Freije JM, Tubío JM, Royo R, Gelpí JL, Orozco M, Pisano DG, Zamora J, Vázquez M, Valencia A, Himmelbauer H, Bayés M, Heath S, Gut M, Gut I, Estivill X, López-Guillermo A, Puente XS, Campo E, López-Otín C.

Nat Genet. 2011 Dec 11;44(1):47-52. doi: 10.1038/ng.1032.

PMID:
22158541
33.

Cell autonomous and systemic factors in progeria development.

Osorio FG, Ugalde AP, Mariño G, Puente XS, Freije JM, López-Otín C.

Biochem Soc Trans. 2011 Dec;39(6):1710-4. doi: 10.1042/BST20110677. Review.

PMID:
22103512
34.

Splicing-directed therapy in a new mouse model of human accelerated aging.

Osorio FG, Navarro CL, Cadiñanos J, López-Mejía IC, Quirós PM, Bartoli C, Rivera J, Tazi J, Guzmán G, Varela I, Depetris D, de Carlos F, Cobo J, Andrés V, De Sandre-Giovannoli A, Freije JM, Lévy N, López-Otín C.

Sci Transl Med. 2011 Oct 26;3(106):106ra107. doi: 10.1126/scitranslmed.3002847.

35.

Deubiquitinases in cancer: new functions and therapeutic options.

Fraile JM, Quesada V, Rodríguez D, Freije JM, López-Otín C.

Oncogene. 2012 May 10;31(19):2373-88. doi: 10.1038/onc.2011.443. Epub 2011 Sep 26. Review.

PMID:
21996736
36.

Lamins, guardians of the soma and the genome.

Freije JM, Pendás AM.

Cell Cycle. 2011 Oct 1;10(19):3236. doi: 10.4161/cc.10.19.17129. Epub 2011 Oct 1. No abstract available.

37.

A conserved splicing mechanism of the LMNA gene controls premature aging.

Lopez-Mejia IC, Vautrot V, De Toledo M, Behm-Ansmant I, Bourgeois CF, Navarro CL, Osorio FG, Freije JM, Stévenin J, De Sandre-Giovannoli A, Lopez-Otin C, Lévy N, Branlant C, Tazi J.

Hum Mol Genet. 2011 Dec 1;20(23):4540-55. doi: 10.1093/hmg/ddr385. Epub 2011 Aug 29.

PMID:
21875900
38.

Proteomic profiling of adipose tissue from Zmpste24-/- mice, a model of lipodystrophy and premature aging, reveals major changes in mitochondrial function and vimentin processing.

Peinado JR, Quirós PM, Pulido MR, Mariño G, Martínez-Chantar ML, Vázquez-Martínez R, Freije JM, López-Otín C, Malagón MM.

Mol Cell Proteomics. 2011 Nov;10(11):M111.008094. doi: 10.1074/mcp.M111.008094. Epub 2011 Aug 9.

39.

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia.

Puente XS, Pinyol M, Quesada V, Conde L, Ordóñez GR, Villamor N, Escaramis G, Jares P, Beà S, González-Díaz M, Bassaganyas L, Baumann T, Juan M, López-Guerra M, Colomer D, Tubío JM, López C, Navarro A, Tornador C, Aymerich M, Rozman M, Hernández JM, Puente DA, Freije JM, Velasco G, Gutiérrez-Fernández A, Costa D, Carrió A, Guijarro S, Enjuanes A, Hernández L, Yagüe J, Nicolás P, Romeo-Casabona CM, Himmelbauer H, Castillo E, Dohm JC, de Sanjosé S, Piris MA, de Alava E, San Miguel J, Royo R, Gelpí JL, Torrents D, Orozco M, Pisano DG, Valencia A, Guigó R, Bayés M, Heath S, Gut M, Klatt P, Marshall J, Raine K, Stebbings LA, Futreal PA, Stratton MR, Campbell PJ, Gut I, López-Guillermo A, Estivill X, Montserrat E, López-Otín C, Campo E.

Nature. 2011 Jun 5;475(7354):101-5. doi: 10.1038/nature10113.

40.

Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma.

Centeno I, Blay P, Santamaría I, Astudillo A, Pitiot AS, Osorio FG, González-Arriaga P, Iglesias F, Menéndez P, Tardón A, Freije JM, Balbín M.

BMC Cancer. 2011 May 16;11:172. doi: 10.1186/1471-2407-11-172.

41.

Exome sequencing and functional analysis identifies BANF1 mutation as the cause of a hereditary progeroid syndrome.

Puente XS, Quesada V, Osorio FG, Cabanillas R, Cadiñanos J, Fraile JM, Ordóñez GR, Puente DA, Gutiérrez-Fernández A, Fanjul-Fernández M, Lévy N, Freije JM, López-Otín C.

Am J Hum Genet. 2011 May 13;88(5):650-6. doi: 10.1016/j.ajhg.2011.04.010. Epub 2011 May 5.

42.

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

Ugalde AP, Ramsay AJ, de la Rosa J, Varela I, Mariño G, Cadiñanos J, Lu J, Freije JM, López-Otín C.

EMBO J. 2011 Jun 1;30(11):2219-32. doi: 10.1038/emboj.2011.124. Epub 2011 Apr 26.

43.

Protease addiction and synthetic lethality in cancer.

Freije JM, Fraile JM, López-Otín C.

Front Oncol. 2011 Sep 5;1:25. doi: 10.3389/fonc.2011.00025. eCollection 2011.

44.

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.

Osorio FG, Varela I, Lara E, Puente XS, Espada J, Santoro R, Freije JM, Fraga MF, López-Otín C.

Aging Cell. 2010 Dec;9(6):947-57. doi: 10.1111/j.1474-9726.2010.00621.x. Epub 2010 Oct 21.

45.

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function.

Mariño G, Ugalde AP, Fernández AF, Osorio FG, Fueyo A, Freije JM, López-Otín C.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16268-73. doi: 10.1073/pnas.1002696107. Epub 2010 Aug 30.

46.

Autophagy is essential for mouse sense of balance.

Mariño G, Fernández AF, Cabrera S, Lundberg YW, Cabanillas R, Rodríguez F, Salvador-Montoliu N, Vega JA, Germanà A, Fueyo A, Freije JM, López-Otín C.

J Clin Invest. 2010 Jul;120(7):2331-44. doi: 10.1172/JCI42601. Epub 2010 Jun 23.

47.

Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.

Alvarez-Díaz S, Valle N, García JM, Peña C, Freije JM, Quesada V, Astudillo A, Bonilla F, López-Otín C, Muñoz A.

J Clin Invest. 2009 Aug;119(8):2343-58.

48.

Accelerated ageing: from mechanism to therapy through animal models.

Osorio FG, Obaya AJ, López-Otín C, Freije JM.

Transgenic Res. 2009 Feb;18(1):7-15. doi: 10.1007/s11248-008-9226-z. Epub 2008 Nov 18. Review.

PMID:
19015945
49.

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

de Carlos F, Varela I, Germanà A, Montalbano G, Freije JM, Vega JA, López-Otin C, Cobo JM.

J Anat. 2008 Nov;213(5):509-19. doi: 10.1111/j.1469-7580.2008.00970.x.

50.

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

Varela I, Pereira S, Ugalde AP, Navarro CL, Suárez MF, Cau P, Cadiñanos J, Osorio FG, Foray N, Cobo J, de Carlos F, Lévy N, Freije JM, López-Otín C.

Nat Med. 2008 Jul;14(7):767-72. doi: 10.1038/nm1786. Epub 2008 Jun 29.

PMID:
18587406

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