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Items: 36

1.

Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential.

Keller CW, Freigang S, Lünemann JD.

Front Immunol. 2017 May 24;8:570. doi: 10.3389/fimmu.2017.00570. eCollection 2017. Review.

2.

The autophagy machinery restrains iNKT cell activation through CD1D1 internalization.

Keller CW, Loi M, Ewert S, Quast I, Theiler R, Gannagé M, Münz C, De Libero G, Freigang S, Lünemann JD.

Autophagy. 2017 Jun 3;13(6):1025-1036. doi: 10.1080/15548627.2017.1297907. Epub 2017 Mar 15.

3.

TREM-1 links dyslipidemia to inflammation and lipid deposition in atherosclerosis.

Zysset D, Weber B, Rihs S, Brasseit J, Freigang S, Riether C, Banz Y, Cerwenka A, Simillion C, Marques-Vidal P, Ochsenbein AF, Saurer L, Mueller C.

Nat Commun. 2016 Oct 20;7:13151. doi: 10.1038/ncomms13151.

4.

Cyclopentenone-containing oxidized phospholipids and their isoprostanes as pro-resolving mediators of inflammation.

Friedli O, Freigang S.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Apr;1862(4):382-392. doi: 10.1016/j.bbalip.2016.07.006. Epub 2016 Jul 12. Review.

PMID:
27422370
5.

The regulation of inflammation by oxidized phospholipids.

Freigang S.

Eur J Immunol. 2016 Aug;46(8):1818-25. doi: 10.1002/eji.201545676. Epub 2016 Jul 14. Review.

6.

Total Synthesis of Prostaglandin 15d-PGJ(2) and Investigation of its Effect on the Secretion of IL-6 and IL-12.

Egger J, Fischer S, Bretscher P, Freigang S, Kopf M, Carreira EM.

Org Lett. 2015 Sep 4;17(17):4340-3. doi: 10.1021/acs.orglett.5b02181. Epub 2015 Aug 24.

PMID:
26301727
7.

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M.

J Exp Med. 2015 Apr 6;212(4):555-68. doi: 10.1084/jem.20140857. Epub 2015 Mar 30.

8.

Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2.

Bretscher P, Egger J, Shamshiev A, Trötzmüller M, Köfeler H, Carreira EM, Kopf M, Freigang S.

EMBO Mol Med. 2015 May;7(5):593-607. doi: 10.15252/emmm.201404702.

9.

Discovery of a highly potent anti-inflammatory epoxyisoprostane-derived lactone.

Egger J, Bretscher P, Freigang S, Kopf M, Carreira EM.

J Am Chem Soc. 2014 Dec 17;136(50):17382-5. doi: 10.1021/ja509892u. Epub 2014 Dec 4.

PMID:
25474746
10.

Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis.

Freigang S, Ampenberger F, Weiss A, Kanneganti TD, Iwakura Y, Hersberger M, Kopf M.

Nat Immunol. 2013 Oct;14(10):1045-53. doi: 10.1038/ni.2704. Epub 2013 Sep 1.

PMID:
23995233
11.

IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard WJ, Sparwasser T, Oxenius A, Freigang S, Kopf M.

PLoS Pathog. 2013;9(5):e1003362. doi: 10.1371/journal.ppat.1003362. Epub 2013 May 16.

12.

Synthesis of epoxyisoprostanes: effects in reducing secretion of pro-inflammatory cytokines IL-6 and IL-12.

Egger J, Bretscher P, Freigang S, Kopf M, Carreira EM.

Angew Chem Int Ed Engl. 2013 May 10;52(20):5382-5. doi: 10.1002/anie.201300739. Epub 2013 Apr 16. No abstract available.

PMID:
23592365
13.

Transport and uptake of immunogenic lipids.

Freigang S, Kain L, Teyton L.

Mol Immunol. 2013 Sep;55(2):179-81. doi: 10.1016/j.molimm.2012.10.016. Epub 2012 Nov 20. Review.

14.

Scavenger receptors target glycolipids for natural killer T cell activation.

Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L.

J Clin Invest. 2012 Nov;122(11):3943-54. doi: 10.1172/JCI62267. Epub 2012 Oct 15.

15.

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis.

Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF, Kopf M.

Eur J Immunol. 2011 Jul;41(7):2040-51. doi: 10.1002/eji.201041316. Epub 2011 Jun 8.

16.

Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.

Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L.

J Clin Invest. 2010 Jun;120(6):1873-84. doi: 10.1172/JCI40451. Epub 2010 May 17.

17.

Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen alphaGalCer.

Bai L, Sagiv Y, Liu Y, Freigang S, Yu KO, Teyton L, Porcelli SA, Savage PB, Bendelac A.

Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10254-9. doi: 10.1073/pnas.0901228106. Epub 2009 Jun 8.

18.

IL-21R on T cells is critical for sustained functionality and control of chronic viral infection.

Fröhlich A, Kisielow J, Schmitz I, Freigang S, Shamshiev AT, Weber J, Marsland BJ, Oxenius A, Kopf M.

Science. 2009 Jun 19;324(5934):1576-80. doi: 10.1126/science.1172815. Epub 2009 May 28.

19.

Developmental programming: maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis.

Palinski W, Yamashita T, Freigang S, Napoli C.

Nutr Rev. 2007 Dec;65(12 Pt 2):S182-7. Review.

PMID:
18240546
20.

Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties.

Liu Y, Deng S, Bai L, Freigang S, Mattner J, Teyton L, Bendelac A, Savage PB.

Bioorg Med Chem Lett. 2008 May 15;18(10):3052-5. doi: 10.1016/j.bmcl.2007.12.067. Epub 2008 Jan 1.

21.

Corrugoside, a new immunostimulatory alpha-galactoglycosphingolipid from the marine sponge Axinella corrugata.

Costantino V, Fattorusso E, Imperatore C, Mangoni A, Freigang S, Teyton L.

Bioorg Med Chem. 2008 Feb 15;16(4):2077-85. Epub 2007 Nov 4.

PMID:
18037298
22.

Extralymphatic virus sanctuaries as a consequence of potent T-cell activation.

Recher M, Lang KS, Navarini A, Hunziker L, Lang PA, Fink K, Freigang S, Georgiev P, Hangartner L, Zellweger R, Bergthaler A, Hegazy AN, Eschli B, Theocharides A, Jeker LT, Merkler D, Odermatt B, Hersberger M, Hengartner H, Zinkernagel RM.

Nat Med. 2007 Nov;13(11):1316-23. Epub 2007 Nov 4.

PMID:
17982463
23.

A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses.

Freigang S, Eschli B, Harris N, Geuking M, Quirin K, Schrempf S, Zellweger R, Weber J, Hengartner H, Zinkernagel RM.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13426-31. Epub 2007 Aug 8.

24.

Maternal immunization programs postnatal immune responses and reduces atherosclerosis in offspring.

Yamashita T, Freigang S, Eberle C, Pattison J, Gupta S, Napoli C, Palinski W.

Circ Res. 2006 Sep 29;99(7):e51-64. Epub 2006 Aug 31.

PMID:
16946133
25.

Osteopontin is not required for the development of Th1 responses and viral immunity.

Abel B, Freigang S, Bachmann MF, Boschert U, Kopf M.

J Immunol. 2005 Nov 1;175(9):6006-13.

26.

Requirement for neutralizing antibodies to control bone marrow transplantation-associated persistent viral infection and to reduce immunopathology.

Lang KS, Recher M, Navarini AA, Freigang S, Harris NL, van den Broek M, Odermatt B, Hengartner H, Zinkernagel RM.

J Immunol. 2005 Oct 15;175(8):5524-31.

27.

Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.

Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM.

Nat Med. 2005 Feb;11(2):138-45. Epub 2005 Jan 16. Erratum in: Nat Med. 2005 Nov;11(11):1256.

PMID:
15654326
28.

DC infection promotes antiviral CTL priming: the 'Winkelried' strategy.

Freigang S, Probst HC, van den Broek M.

Trends Immunol. 2005 Jan;26(1):13-8. Review.

PMID:
15629404
29.

Deliberate removal of T cell help improves virus-neutralizing antibody production.

Recher M, Lang KS, Hunziker L, Freigang S, Eschli B, Harris NL, Navarini A, Senn BM, Fink K, Lötscher M, Hangartner L, Zellweger R, Hersberger M, Theocharides A, Hengartner H, Zinkernagel RM.

Nat Immunol. 2004 Sep;5(9):934-42. Epub 2004 Aug 8.

PMID:
15300247
30.

Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.

Genoud N, Behrens A, Miele G, Robay D, Heppner FL, Freigang S, Aguzzi A.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4198-203. Epub 2004 Mar 8.

31.

Expansion of protective CD8+ T-cell responses driven by recombinant cytomegaloviruses.

Karrer U, Wagner M, Sierro S, Oxenius A, Hengel H, Dumrese T, Freigang S, Koszinowski UH, Phillips RE, Klenerman P.

J Virol. 2004 Mar;78(5):2255-64.

32.

Endogenous neosynthesis vs. cross-presentation of viral antigens for cytotoxic T cell priming.

Freigang S, Egger D, Bienz K, Hengartner H, Zinkernagel RM.

Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13477-82. Epub 2003 Oct 31.

33.

Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections.

Hunziker L, Recher M, Macpherson AJ, Ciurea A, Freigang S, Hengartner H, Zinkernagel RM.

Nat Immunol. 2003 Apr;4(4):343-9. Epub 2003 Mar 10.

PMID:
12627229
34.

Allogeneic beta-islet cells correct diabetes and resist immune rejection.

Pericin M, Althage A, Freigang S, Hengartner H, Rolland E, Dupraz P, Thorens B, Aebischer P, Zinkernagel RM.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8203-6.

35.

Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model.

Ludewig B, Freigang S, Jäggi M, Kurrer MO, Pei YC, Vlk L, Odermatt B, Zinkernagel RM, Hengartner H.

Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12752-7.

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