Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 106

1.

Assessment of PEEP-Ventilation and the Time Point of Parallel-Conductance Determination for Pressure-Volume Analysis Under β-Adrenergic Stimulation in Mice.

Bacmeister L, Segin S, Medert R, Lindner D, Freichel M, Camacho Londoño JE.

Front Cardiovasc Med. 2019 Apr 10;6:36. doi: 10.3389/fcvm.2019.00036. eCollection 2019.

2.

TRPC channels are not required for graded persistent activity in entorhinal cortex neurons.

Egorov AV, Schumacher D, Medert R, Birnbaumer L, Freichel M, Draguhn A.

Hippocampus. 2019 Apr 19. doi: 10.1002/hipo.23094. [Epub ahead of print]

PMID:
31002217
3.

Lipid-independent control of endothelial and neuronal TRPC3 channels by light.

Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov T, Groschner K.

Chem Sci. 2019 Jan 15;10(9):2837-2842. doi: 10.1039/c8sc05536j. eCollection 2019 Mar 7.

4.

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

Fecher-Trost C, Lux F, Busch KM, Raza A, Winter M, Hielscher F, Belkacemi T, van der Eerden B, Boehm U, Freichel M, Weissgerber P.

J Bone Miner Res. 2019 Apr;34(4):699-710. doi: 10.1002/jbmr.3646. Epub 2019 Feb 20.

PMID:
30786075
5.

Regulation of the pleiotropic effects of tissue-resident mast cells.

Huber M, Cato ACB, Ainooson GK, Freichel M, Tsvilovskyy V, Jessberger R, Riedlinger E, Sommerhoff CP, Bischoff SC.

J Allergy Clin Immunol. 2019 Feb 15. pii: S0091-6749(19)30207-6. doi: 10.1016/j.jaci.2019.02.004. [Epub ahead of print]

6.

Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels.

Sachdeva R, Fleming T, Schumacher D, Homberg S, Stilz K, Mohr F, Wagner AH, Tsvilovskyy V, Mathar I, Freichel M.

Cell Calcium. 2019 Mar;78:66-75. doi: 10.1016/j.ceca.2019.01.002. Epub 2019 Jan 9.

PMID:
30658323
7.

Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes.

Schumacher D, Morgenstern J, Oguchi Y, Volk N, Kopf S, Groener JB, Nawroth PP, Fleming T, Freichel M.

Mol Metab. 2018 Dec;18:143-152. doi: 10.1016/j.molmet.2018.09.005. Epub 2018 Sep 19.

8.

TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.

Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS.

Oncotarget. 2018 Jul 3;9(51):29634-29643. doi: 10.18632/oncotarget.25659. eCollection 2018 Jul 3.

9.

Isolation of Peritoneum-derived Mast Cells and Their Functional Characterization with Ca2+-imaging and Degranulation Assays.

Tsvilovskyy V, Solis-Lopez A, Öhlenschläger K, Freichel M.

J Vis Exp. 2018 Jul 4;(137). doi: 10.3791/57222.

PMID:
30035759
10.

Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis.

Tsvilovskyy V, Solís-López A, Schumacher D, Medert R, Roers A, Kriebs U, Freichel M.

Cell Calcium. 2018 May;71:24-33. doi: 10.1016/j.ceca.2017.11.004. Epub 2017 Nov 27.

PMID:
29604961
11.

TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.

Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P, Birnbaumer L, Fleming T, Hammes HP, Freichel M.

Mol Metab. 2018 Mar;9:156-167. doi: 10.1016/j.molmet.2018.01.003. Epub 2018 Jan 5.

12.

TRP Channels in the Heart.

Freichel M, Berlin M, Schürger A, Mathar I, Bacmeister L, Medert R, Frede W, Marx A, Segin S, Londoño JEC.

In: Emir TLR, editor. Neurobiology of TRP Channels. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2017. Chapter 9.

13.

TRPM4 and TRPM5 are both required for normal signaling in taste receptor cells.

Dutta Banik D, Martin LE, Freichel M, Torregrossa AM, Medler KF.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E772-E781. doi: 10.1073/pnas.1718802115. Epub 2018 Jan 8.

14.

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway.

Lehmann LH, Jebessa ZH, Kreusser MM, Horsch A, He T, Kronlage M, Dewenter M, Sramek V, Oehl U, Krebs-Haupenthal J, von der Lieth AH, Schmidt A, Sun Q, Ritterhoff J, Finke D, Völkers M, Jungmann A, Sauer SW, Thiel C, Nickel A, Kohlhaas M, Schäfer M, Sticht C, Maack C, Gretz N, Wagner M, El-Armouche A, Maier LS, Londoño JEC, Meder B, Freichel M, Gröne HJ, Most P, Müller OJ, Herzig S, Furlong EEM, Katus HA, Backs J.

Nat Med. 2018 Jan;24(1):62-72. doi: 10.1038/nm.4452. Epub 2017 Dec 11.

PMID:
29227474
15.

9-Phenanthrol enhances the generation of an CD8+ T cell response following transcutaneous immunization with imiquimod in mice.

Hartmann AK, Aranda Lopez P, Zajac M, Freichel M, Schild H, Radsak MP, Stassen M.

J Dermatol Sci. 2017 Sep;87(3):260-267. doi: 10.1016/j.jdermsci.2017.07.018. Epub 2017 Aug 12.

PMID:
28823644
16.

Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.

Bröker-Lai J, Kollewe A, Schindeldecker B, Pohle J, Nguyen Chi V, Mathar I, Guzman R, Schwarz Y, Lai A, Weißgerber P, Schwegler H, Dietrich A, Both M, Sprengel R, Draguhn A, Köhr G, Fakler B, Flockerzi V, Bruns D, Freichel M.

EMBO J. 2017 Sep 15;36(18):2770-2789. doi: 10.15252/embj.201696369. Epub 2017 Aug 8.

17.

Dicarbonyls and Advanced Glycation End-Products in the Development of Diabetic Complications and Targets for Intervention.

Brings S, Fleming T, Freichel M, Muckenthaler MU, Herzig S, Nawroth PP.

Int J Mol Sci. 2017 May 5;18(5). pii: E984. doi: 10.3390/ijms18050984. Review.

18.

Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes.

Beck A, Götz V, Qiao S, Weissgerber P, Flockerzi V, Freichel M, Boehm U.

Endocrinology. 2017 Apr 1;158(4):887-902. doi: 10.1210/en.2016-1810.

PMID:
28324107
19.

Does Erythropoietin Regulate TRPC Channels in Red Blood Cells?

Danielczok J, Hertz L, Ruppenthal S, Kaiser E, Petkova-Kirova P, Bogdanova A, Krause E, Lipp P, Freichel M, Kaestner L, Birnbaumer L.

Cell Physiol Biochem. 2017;41(3):1219-1228. doi: 10.1159/000464384. Epub 2017 Mar 6.

20.

Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells.

Solís-López A, Kriebs U, Marx A, Mannebach S, Liedtke WB, Caterina MJ, Freichel M, Tsvilovskyy VV.

PLoS One. 2017 Feb 3;12(2):e0171366. doi: 10.1371/journal.pone.0171366. eCollection 2017.

21.

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells.

Morgenstern J, Fleming T, Schumacher D, Eckstein V, Freichel M, Herzig S, Nawroth P.

J Biol Chem. 2017 Feb 24;292(8):3224-3238. doi: 10.1074/jbc.M116.760132. Epub 2016 Dec 12.

22.

TRPM4-mediated control of FcεRI-evoked Ca(2+) elevation comprises enhanced plasmalemmal trafficking of TRPM4 channels in connective tissue type mast cells.

Rixecker T, Mathar I, Medert R, Mannebach S, Pfeifer A, Lipp P, Tsvilovskyy V, Freichel M.

Sci Rep. 2016 Sep 14;6:32981. doi: 10.1038/srep32981.

23.

The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.

Kurland DB, Gerzanich V, Karimy JK, Woo SK, Vennekens R, Freichel M, Nilius B, Bryan J, Simard JM.

J Neuroinflammation. 2016 Jun 1;13(1):130. doi: 10.1186/s12974-016-0599-2.

24.

The Gq signalling pathway inhibits brown and beige adipose tissue.

Klepac K, Kilić A, Gnad T, Brown LM, Herrmann B, Wilderman A, Balkow A, Glöde A, Simon K, Lidell ME, Betz MJ, Enerbäck S, Wess J, Freichel M, Blüher M, König G, Kostenis E, Insel PA, Pfeifer A.

Nat Commun. 2016 Mar 9;7:10895. doi: 10.1038/ncomms10895.

25.

Novel Endothelial Cell-Specific AQP1 Knockout Mice Confirm the Crucial Role of Endothelial AQP1 in Ultrafiltration during Peritoneal Dialysis.

Zhang W, Freichel M, van der Hoeven F, Nawroth PP, Katus H, Kälble F, Zitron E, Schwenger V.

PLoS One. 2016 Jan 13;11(1):e0145513. doi: 10.1371/journal.pone.0145513. eCollection 2016.

26.

TRPM4-dependent post-synaptic depolarization is essential for the induction of NMDA receptor-dependent LTP in CA1 hippocampal neurons.

Menigoz A, Ahmed T, Sabanov V, Philippaert K, Pinto S, Kerselaers S, Segal A, Freichel M, Voets T, Nilius B, Vennekens R, Balschun D.

Pflugers Arch. 2016 Apr;468(4):593-607. doi: 10.1007/s00424-015-1764-7. Epub 2015 Dec 3.

27.

Essential roles for Cavβ2 and Cav1 channels in thymocyte development and T cell homeostasis.

Jha A, Singh AK, Weissgerber P, Freichel M, Flockerzi V, Flavell RA, Jha MK.

Sci Signal. 2015 Oct 20;8(399):ra103. doi: 10.1126/scisignal.aac7538.

PMID:
26486172
28.

Contractility Measurements on Isolated Papillary Muscles for the Investigation of Cardiac Inotropy in Mice.

Uhl S, Freichel M, Mathar I.

J Vis Exp. 2015 Sep 17;(103). doi: 10.3791/53076.

29.

A background Ca2+ entry pathway mediated by TRPC1/TRPC4 is critical for development of pathological cardiac remodelling.

Camacho Londoño JE, Tian Q, Hammer K, Schröder L, Camacho Londoño J, Reil JC, He T, Oberhofer M, Mannebach S, Mathar I, Philipp SE, Tabellion W, Schweda F, Dietrich A, Kaestner L, Laufs U, Birnbaumer L, Flockerzi V, Freichel M, Lipp P.

Eur Heart J. 2015 Sep 1;36(33):2257-66. doi: 10.1093/eurheartj/ehv250. Epub 2015 Jun 11.

30.

The Ca(2+)-activated cation channel TRPM4 is a negative regulator of angiotensin II-induced cardiac hypertrophy.

Kecskés M, Jacobs G, Kerselaers S, Syam N, Menigoz A, Vangheluwe P, Freichel M, Flockerzi V, Voets T, Vennekens R.

Basic Res Cardiol. 2015;110(4):43. doi: 10.1007/s00395-015-0501-x. Epub 2015 Jun 5.

31.

Adenylyl cyclase-mediated effects contribute to increased Isoprenaline-induced cardiac contractility in TRPM4-deficient mice.

Uhl S, Mathar I, Vennekens R, Freichel M.

J Mol Cell Cardiol. 2014 Sep;74:307-17. doi: 10.1016/j.yjmcc.2014.06.007. Epub 2014 Jun 24.

PMID:
24972051
32.

TRPC4- and TRPC4-containing channels.

Freichel M, Tsvilovskyy V, Camacho-Londoño JE.

Handb Exp Pharmacol. 2014;222:85-128. doi: 10.1007/978-3-642-54215-2_5. Review.

PMID:
24756704
33.

Increase in cytosolic Ca2+ produced by hypoxia and other depolarizing stimuli activates a non-selective cation channel in chemoreceptor cells of rat carotid body.

Kang D, Wang J, Hogan JO, Vennekens R, Freichel M, White C, Kim D.

J Physiol. 2014 May 1;592(9):1975-92. doi: 10.1113/jphysiol.2013.266957. Epub 2014 Mar 3.

34.

Increased β-adrenergic inotropy in ventricular myocardium from Trpm4-/- mice.

Mathar I, Kecskes M, Van der Mieren G, Jacobs G, Camacho Londoño JE, Uhl S, Flockerzi V, Voets T, Freichel M, Nilius B, Herijgers P, Vennekens R.

Circ Res. 2014 Jan 17;114(2):283-94. doi: 10.1161/CIRCRESAHA.114.302835. Epub 2013 Nov 13.

PMID:
24226423
35.

Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels.

Tian J, Thakur DP, Lu Y, Zhu Y, Freichel M, Flockerzi V, Zhu MX.

Pflugers Arch. 2014 Jul;466(7):1301-16.

36.

Crucial role of TRPC1 and TRPC4 in cystitis-induced neuronal sprouting and bladder overactivity.

Boudes M, Uvin P, Pinto S, Freichel M, Birnbaumer L, Voets T, De Ridder D, Vennekens R.

PLoS One. 2013 Jul 29;8(7):e69550. doi: 10.1371/journal.pone.0069550. Print 2013.

37.

The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone.

Loga F, Domes K, Freichel M, Flockerzi V, Dietrich A, Birnbaumer L, Hofmann F, Wegener JW.

Cardiovasc Res. 2013 Nov 1;100(2):280-7. doi: 10.1093/cvr/cvt176. Epub 2013 Jul 4.

38.

Transient receptor potential channels function as a coincidence signal detector mediating phosphatidylserine exposure.

Harper MT, Londoño JE, Quick K, Londoño JC, Flockerzi V, Philipp SE, Birnbaumer L, Freichel M, Poole AW.

Sci Signal. 2013 Jun 25;6(281):ra50. doi: 10.1126/scisignal.2003701.

PMID:
23800468
39.

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion.

Matti U, Pattu V, Halimani M, Schirra C, Krause E, Liu Y, Weins L, Chang HF, Guzman R, Olausson J, Freichel M, Schmitz F, Pasche M, Becherer U, Bruns D, Rettig J.

Nat Commun. 2013;4:1439. doi: 10.1038/ncomms2467.

PMID:
23385584
40.

Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells.

Suresh Babu S, Wojtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M.

Sci Signal. 2012 Dec 11;5(254):ra91. doi: 10.1126/scisignal.2003173.

PMID:
23233529
41.

Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.

Phelan KD, Shwe UT, Abramowitz J, Wu H, Rhee SW, Howell MD, Gottschall PE, Freichel M, Flockerzi V, Birnbaumer L, Zheng F.

Mol Pharmacol. 2013 Feb;83(2):429-38. doi: 10.1124/mol.112.082271. Epub 2012 Nov 27.

42.

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.

Nat Med. 2012 Dec;18(12):1805-11. doi: 10.1038/nm.3015. Epub 2012 Nov 18.

PMID:
23160238
43.

Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption.

Woudenberg-Vrenken TE, Lameris AL, Weißgerber P, Olausson J, Flockerzi V, Bindels RJ, Freichel M, Hoenderop JG.

Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G879-85. doi: 10.1152/ajpgi.00089.2012. Epub 2012 Aug 9.

44.

TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.

Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN.

Open Biol. 2012 May;2(5):120068. doi: 10.1098/rsob.120068.

45.

The Role of TRP Proteins in Mast Cells.

Freichel M, Almering J, Tsvilovskyy V.

Front Immunol. 2012 Jun 12;3:150. doi: 10.3389/fimmu.2012.00150. eCollection 2012.

46.

Strategies and Protocols to Generate Mouse Models with Targeted Mutations to Analyze TRP Channel Functions.

Freichel M, Kriebs U, Vogt D, Mannebach S, Weißgerber P.

In: Zhu MX, editor. TRP Channels. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 8.

47.

NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.

Stroh O, Freichel M, Kretz O, Birnbaumer L, Hartmann J, Egger V.

J Neurosci. 2012 Apr 25;32(17):5737-46. doi: 10.1523/JNEUROSCI.3753-11.2012.

48.

Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.

Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M.

J Biol Chem. 2012 May 25;287(22):17930-41. doi: 10.1074/jbc.M111.328286. Epub 2012 Mar 15.

49.

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

Weissmann N, Sydykov A, Kalwa H, Storch U, Fuchs B, Mederos y Schnitzler M, Brandes RP, Grimminger F, Meissner M, Freichel M, Offermanns S, Veit F, Pak O, Krause KH, Schermuly RT, Brewer AC, Schmidt HH, Seeger W, Shah AM, Gudermann T, Ghofrani HA, Dietrich A.

Nat Commun. 2012 Jan 31;3:649. doi: 10.1038/ncomms1660.

50.

Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6.

Samapati R, Yang Y, Yin J, Stoerger C, Arenz C, Dietrich A, Gudermann T, Adam D, Wu S, Freichel M, Flockerzi V, Uhlig S, Kuebler WM.

Am J Respir Crit Care Med. 2012 Jan 15;185(2):160-70. doi: 10.1164/rccm.201104-0717OC.

PMID:
22246702

Supplemental Content

Loading ...
Support Center