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Characterisation of the natural attenuation of chromium contamination in the presence of nitrate using isotopic methods. A case study from the Matanza-Riachuelo River basin, Argentina.

Ceballos E, Margalef-Martí R, Carrey R, Frei R, Otero N, Soler A, Ayora C.

Sci Total Environ. 2019 Sep 9;699:134331. doi: 10.1016/j.scitotenv.2019.134331. [Epub ahead of print]


Subtle Cr isotope signals track the variably anoxic Cryogenian interglacial period with voluminous manganese accumulation and decrease in biodiversity.

Xu L, Frank AB, Lehmann B, Zhu J, Mao J, Ju Y, Frei R.

Sci Rep. 2019 Oct 21;9(1):15056. doi: 10.1038/s41598-019-51495-0.


East Greenland ice core dust record reveals timing of Greenland ice sheet advance and retreat.

Simonsen MF, Baccolo G, Blunier T, Borunda A, Delmonte B, Frei R, Goldstein S, Grinsted A, Kjær HA, Sowers T, Svensson A, Vinther B, Vladimirova D, Winckler G, Winstrup M, Vallelonga P.

Nat Commun. 2019 Oct 3;10(1):4494. doi: 10.1038/s41467-019-12546-2.


EAACI position paper on diet diversity in pregnancy, infancy and childhood: Novel concepts and implications for studies in allergy and asthma.

Venter C, Greenhawt M, Meyer RW, Agostoni C, Reese I, du Toit G, Feeney M, Maslin K, Nwaru BI, Roduit C, Untersmayr E, Vlieg-Boerstra B, Pali-Schöll I, Roberts GC, Smith P, Akdis CA, Agache I, Ben-Adallah M, Bischoff S, Frei R, Garn H, Grimshaw K, Hoffmann-Sommergruber K, Lunjani N, Muraro A, Poulsen LK, Renz H, Sokolowska M, Stanton C, O'Mahony L.

Allergy. 2019 Sep 14. doi: 10.1111/all.14051. [Epub ahead of print]


Revealing biogeochemical signatures of Arctic landscapes with river chemistry.

Shogren AJ, Zarnetske JP, Abbott BW, Iannucci F, Frei RJ, Griffin NA, Bowden WB.

Sci Rep. 2019 Sep 9;9(1):12894. doi: 10.1038/s41598-019-49296-6.


Impact of alcohol-based hand-gel sanitizer and hand hygiene advice on travellers' diarrhoea and colonization with extended-spectrum beta-lactamase-producing Enterobacteriaceae: A randomised, controlled trial.

Kuenzli E, Jaeger VK, DeCrom S, Sydow V, Muigg V, Frei R, Egli A, Fehr J, Hatz C.

Travel Med Infect Dis. 2019 Sep 6:101475. doi: 10.1016/j.tmaid.2019.101475. [Epub ahead of print]


Vaginal-perineal cultures for detecting group B streptococci and extended spectrum β-lactamase producing bacteria in pregnancy.

Huang DJ, Hösli I, Tschudin-Sutter S, Pfister T, Granado C, Müller-Borer D, Schötzau A, Frei R, Dangel M, Huhn EA, Widmer A, Vuichard-Gysin D.

Eur J Obstet Gynecol Reprod Biol. 2019 Oct;241:24-29. doi: 10.1016/j.ejogrb.2019.07.024. Epub 2019 Jul 19.


Mapping human mobility during the third and second millennia BC in present-day Denmark.

Frei KM, Bergerbrant S, Sjögren KG, Jørkov ML, Lynnerup N, Harvig L, Allentoft ME, Sikora M, Price TD, Frei R, Kristiansen K.

PLoS One. 2019 Aug 21;14(8):e0219850. doi: 10.1371/journal.pone.0219850. eCollection 2019.


Exposure of Children to Rural Lifestyle Factors Associated With Protection Against Allergies Induces an Anti-Neu5Gc Antibody Response.

Frei R, Roduit C, Ferstl R, O'Mahony L, Lauener RP.

Front Immunol. 2019 Jul 16;10:1628. doi: 10.3389/fimmu.2019.01628. eCollection 2019.


Revisiting the dermatomal recruitment of, and pressure-dependent influences on, human eccrine sweating.

Frei R, Notley SR, Taylor EA, Burdon CA, Ohnishi N, Taylor NAS.

J Therm Biol. 2019 May;82:52-62. doi: 10.1016/j.jtherbio.2019.03.008. Epub 2019 Mar 22.


EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis.

Venter C, Meyer RW, Nwaru BI, Roduit C, Untersmayr E, Adel-Patient K, Agache I, Agostoni C, Akdis CA, Bischoff SC, du Toit G, Feeney M, Frei R, Garn H, Greenhawt M, Hoffmann-Sommergruber K, Lunjani N, Maslin K, Mills C, Muraro A, Pali-Schöll I, Poulson LK, Reese I, Renz H, Roberts GC, Smith P, Smolinska S, Sokolowska M, Stanton C, Vlieg-Boerstra B, O'Mahony L.

Allergy. 2019 Aug;74(8):1429-1444. doi: 10.1111/all.13764. Epub 2019 May 3.


Bioavailable 87Sr/86Sr in European soils: A baseline for provenancing studies.

Hoogewerff JA, Reimann C, Ueckermann H, Frei R, Frei KM, van Aswegen T, Stirling C, Reid M, Clayton A, Ladenberger A; GEMAS Project Team.

Sci Total Environ. 2019 Jul 1;672:1033-1044. doi: 10.1016/j.scitotenv.2019.03.387. Epub 2019 Mar 31.


Early Initiation of Anti-TNF is Associated with Favourable Long-term Outcome in Crohn's Disease: 10-Year-Follow-up Data from the Swiss IBD Cohort Study.

Frei R, Fournier N, Zeitz J, Scharl M, Morell B, Greuter T, Schreiner P, Misselwitz B, Safroneeva E, Schoepfer AM, Vavricka SR, Rogler G, Biedermann L.

J Crohns Colitis. 2019 Sep 27;13(10):1292-1301. doi: 10.1093/ecco-jcc/jjz057.


ESBL-colonization at ICU admission: impact on subsequent infection, carbapenem-consumption, and outcome.

Emmanuel Martinez A, Widmer A, Frei R, Pargger H, Tuchscherer D, Marsch S, Egli A, Tschudin-Sutter S.

Infect Control Hosp Epidemiol. 2019 Apr;40(4):408-413. doi: 10.1017/ice.2019.5. Epub 2019 Feb 21.


Association between antibiotic treatment during pregnancy and infancy and the development of allergic diseases.

Metzler S, Frei R, Schmaußer-Hechfellner E, von Mutius E, Pekkanen J, Karvonen AM, Kirjavainen PV, Dalphin JC, Divaret-Chauveau A, Riedler J, Lauener R, Roduit C; PASTURE/EFRAIM study group.

Pediatr Allergy Immunol. 2019 Jun;30(4):423-433. doi: 10.1111/pai.13039. Epub 2019 Mar 5.


Bacterial secretion of histamine within the gut influences immune responses within the lung.

Barcik W, Pugin B, Brescó MS, Westermann P, Rinaldi A, Groeger D, Van Elst D, Sokolowska M, Krawczyk K, Frei R, Ferstl R, Wawrzyniak M, Altunbulakli C, Akdis CA, O'Mahony L.

Allergy. 2019 May;74(5):899-909. doi: 10.1111/all.13709. Epub 2019 Feb 7.


Overall bioburden by total colony count does not predict the presence of pathogens with high clinical relevance in hospital and community environments.

Widmer FC, Frei R, Romanyuk A, Tschudin Sutter S, Widmer AF.

J Hosp Infect. 2019 Feb;101(2):240-244. doi: 10.1016/j.jhin.2018.11.014. Epub 2018 Nov 27.


Basic patient characteristics predict antimicrobial resistance in E. coli from urinary tract specimens: a retrospective cohort analysis of 5246 urine samples.

Erb S, Frei R, Tschudin Sutter S, Egli A, Dangel M, Bonkat G, Widmer AF.

Swiss Med Wkly. 2018 Nov 15;148:w14660. doi: 10.4414/smw.2018.14660. eCollection 2018 Nov 5.


Simplifying the WHO protocol: Three steps versus six steps for performance of hand hygiene - a cluster-randomized trial.

Tschudin-Sutter S, Sepulcri D, Dangel M, Ulrich A, Frei R, Widmer AF.

Clin Infect Dis. 2018 Nov 3. doi: 10.1093/cid/ciy948. [Epub ahead of print]


High levels of butyrate and propionate in early life are associated with protection against atopy.

Roduit C, Frei R, Ferstl R, Loeliger S, Westermann P, Rhyner C, Schiavi E, Barcik W, Rodriguez-Perez N, Wawrzyniak M, Chassard C, Lacroix C, Schmausser-Hechfellner E, Depner M, von Mutius E, Braun-Fahrländer C, Karvonen AM, Kirjavainen PV, Pekkanen J, Dalphin JC, Riedler J, Akdis C, Lauener R, O'Mahony L; PASTURE/EFRAIM study group.

Allergy. 2019 Apr;74(4):799-809. doi: 10.1111/all.13660. Epub 2018 Nov 25.


Combination therapy for treatment of Pseudomonas aeruginosa bloodstream infections.

Tschudin-Sutter S, Fosse N, Frei R, Widmer AF.

PLoS One. 2018 Sep 20;13(9):e0203295. doi: 10.1371/journal.pone.0203295. eCollection 2018.


Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients.

Affolter K, Schumann DM, Tamm M, Jahn K, Siebeneichler A, Junker L, Wagner K, Keller PM, Frei R, Stolz D.

Chest. 2018 Sep;154(3):722-725. doi: 10.1016/j.chest.2018.06.018. No abstract available.


Culture of Bone Biopsy Specimens Overestimates Rate of Residual Osteomyelitis After Toe or Forefoot Amputation.

Mijuskovic B, Kuehl R, Widmer AF, Jundt G, Frei R, Gürke L, Wolff T.

J Bone Joint Surg Am. 2018 Sep 5;100(17):1448-1454. doi: 10.2106/JBJS.17.01152.


Endoscopic Treatment of Early Barrett's Adenocarcinoma and Dysplasia: Focus on Submucosal Cancer.

Frei N, Frei R, Semadeni GM, Jochum W, Brand S, Borovicka J.

Digestion. 2019;99(4):293-300. doi: 10.1159/000492217. Epub 2018 Sep 3.


Highly fractionated chromium isotopes in Mesoproterozoic-aged shales and atmospheric oxygen.

Canfield DE, Zhang S, Frank AB, Wang X, Wang H, Su J, Ye Y, Frei R.

Nat Commun. 2018 Jul 20;9(1):2871. doi: 10.1038/s41467-018-05263-9.


Different Types of Heater-Cooler Units and Their Risk of Transmission of Mycobacterium chimaera During Open-Heart Surgery: Clues From Device Design.

Kuehl R, Banderet F, Egli A, Keller PM, Frei R, Döbele T, Eckstein F, Widmer AF.

Infect Control Hosp Epidemiol. 2018 Jul;39(7):834-840. doi: 10.1017/ice.2018.102. Epub 2018 May 28.


Endoscopic full thickness resection (EFTR) of colorectal neoplasms with the Full Thickness Resection Device (FTRD): Clinical experience from two tertiary referral centers in Switzerland.

Aepli P, Criblez D, Baumeler S, Borovicka J, Frei R.

United European Gastroenterol J. 2018 Apr;6(3):463-470. doi: 10.1177/2050640617728001. Epub 2017 Aug 23.


Exopolysaccharide from Bifidobacterium longum subsp. longum 35624™ modulates murine allergic airway responses.

Schiavi E, Plattner S, Rodriguez-Perez N, Barcik W, Frei R, Ferstl R, Kurnik-Lucka M, Groeger D, Grant R, Roper J, Altmann F, van Sinderen D, Akdis CA, O'Mahony L.

Benef Microbes. 2018 Sep 18;9(5):761-773. doi: 10.3920/BM2017.0180. Epub 2018 May 4.


Correction to: Catheter retention as a consequence rather than a cause of unfavorable outcome in candidemia.

Damonti L, Erard V, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Imhof A, Zbinden R, Fehr J, Boggian K, Bruderer T, Flückiger U, Frei R, Orasch C, Conen A, Khanna N, Bregenzer T, Bille J, Lamoth F, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS).

Intensive Care Med. 2018 Mar;44(3):405-407. doi: 10.1007/s00134-018-5081-4.


Fluconazole non-susceptible breakthrough candidemia after prolonged low-dose prophylaxis: a prospective FUNGINOS study.

Orasch C, Mertz D, Garbino J, van Delden C, Emonet S, Schrenzel J, Zimmerli S, Damonti L, Mühlethaler K, Imhof A, Ruef C, Fehr J, Zbinden R, Boggian K, Bruderer T, Flückiger U, Conen A, Khanna N, Frei R, Bregenzer T, Lamoth F, Erard V, Bochud PY, Calandra T, Bille J, Marchetti O; Fungal Infection Network of Switzerland (FUNGINOS).

J Infect. 2018 May;76(5):489-495. doi: 10.1016/j.jinf.2017.12.018. Epub 2018 Jan 31.


Funding characteristics of randomised clinical trials supported by the Swiss National Science Foundation: a retrospective cohort study.

Amstutz A, Schandelmaier S, Frei R, Surina J, Agarwal A, Alturki R, von Niederhäusern B, von Elm E, Briel M, On Behalf Of The MAking Randomized Trials Affordable Marta Group.

Swiss Med Wkly. 2018 Jan 26;148:w14587. doi: 10.4414/smw.2018.14587. eCollection 2018.


Environmentally available hexavalent chromium in soils and sediments impacted by dispersed fly ash in Sarigkiol basin (Northern Greece).

Kazakis N, Kantiranis N, Kalaitzidou K, Kaprara E, Mitrakas M, Frei R, Vargemezis G, Vogiatzis D, Zouboulis A, Filippidis A.

Environ Pollut. 2018 Apr;235:632-641. doi: 10.1016/j.envpol.2017.12.117. Epub 2018 Jan 11.


Microbiome and asthma.

Sokolowska M, Frei R, Lunjani N, Akdis CA, O'Mahony L.

Asthma Res Pract. 2018 Jan 5;4:1. doi: 10.1186/s40733-017-0037-y. eCollection 2018. Review.


High prevalence of ESBL-Producing E. coli in private and shared latrines in an informal urban settlement in Dar es Salaam, Tanzania.

Erb S, D'Mello-Guyett L, Malebo HM, Njee RM, Matwewe F, Ensink J, Hinic V, Widmer A, Frei R.

Antimicrob Resist Infect Control. 2018 Jan 6;7:3. doi: 10.1186/s13756-017-0292-y. eCollection 2018.


Respiratory Syncytial Virus Infection Control Challenges with a Novel Polymerase Chain Reaction Assay in a Tertiary Medical Center.

Sendi P, Egli A, Dangel M, Frei R, Tschudin-Sutter S, Widmer AF.

Infect Control Hosp Epidemiol. 2017 Nov;38(11):1291-1297. doi: 10.1017/ice.2017.213. Epub 2017 Oct 23.


Survival from methicillin-sensitive Staphylococcus aureus bloodstream infections over 20 years: a cohort of 1328 patients.

Wiggli BJ, Frei R, Laffer R, Tschudin Sutter S, Widmer AF.

Swiss Med Wkly. 2017 Sep 30;147:w14508. doi: 10.4414/smw.2017.14508. eCollection 2017.


Specificity of two HIV screening tests detecting simultaneously HIV-1 p24 antigen and antibodies to HIV-1 and -2.

Blaich A, Buser A, Stöckle M, Gehringer C, Hirsch HH, Battegay M, Klimkait T, Frei R.

J Virol Methods. 2017 Nov;249:143-146. doi: 10.1016/j.jviromet.2017.09.005. Epub 2017 Sep 8.


Value of the Pitt Bacteraemia Score to predict short-term mortality in Staphylococcus aureus bloodstream infection: a validation study.

Roth JA, Tschudin-Sutter S, Dangel M, Frei R, Battegay M, Widmer AF.

Swiss Med Wkly. 2017 Aug 10;147:w14482. doi: 10.4414/smw.2017.14482. eCollection 2017.


Discontinuation and non-publication of randomised clinical trials supported by the main public funding body in Switzerland: a retrospective cohort study.

Amstutz A, Schandelmaier S, Frei R, Surina J, Agarwal A, Olu KK, Alturki R, Von Niederhäusern B, Von Elm E, Briel M.

BMJ Open. 2017 Aug 1;7(7):e016216. doi: 10.1136/bmjopen-2017-016216.


Exposure to nonmicrobial N-glycolylneuraminic acid protects farmers' children against airway inflammation and colitis.

Frei R, Ferstl R, Roduit C, Ziegler M, Schiavi E, Barcik W, Rodriguez-Perez N, Wirz OF, Wawrzyniak M, Pugin B, Nehrbass D, Jutel M, Smolinska S, Konieczna P, Bieli C, Loeliger S, Waser M, Pershagen G, Riedler J, Depner M, Schaub B, Genuneit J, Renz H, Pekkanen J, Karvonen AM, Dalphin JC, van Hage M, Doekes G, Akdis M, Braun-Fahrländer C, Akdis CA, von Mutius E, O'Mahony L, Lauener RP; Prevention of Allergy Risk factors for Sensitization in Children Related to Farming and Anthroposophic Lifestyle (PARSIFAL) study group; Protection Against Allergy Study in Rural Environments (PASTURE)/Mechanisms of Early Protective Exposures on Allergy Development (EFRAIM) study group.

J Allergy Clin Immunol. 2018 Jan;141(1):382-390.e7. doi: 10.1016/j.jaci.2017.04.051. Epub 2017 Jun 17.


Histamine receptor 2 modifies iNKT cell activity within the inflamed lung.

Ferstl R, Frei R, Barcik W, Schiavi E, Wanke K, Ziegler M, Rodriguez-Perez N, Groeger D, Konieczna P, Zeiter S, Nehrbass D, Lauener R, Akdis CA, O'Mahony L.

Allergy. 2017 Dec;72(12):1925-1935. doi: 10.1111/all.13227. Epub 2017 Jun 30.


Distinguishing Clostridium difficile Recurrence From Reinfection: Independent Validation of Current Recommendations.

Durovic A, Widmer AF, Frei R, Tschudin-Sutter S.

Infect Control Hosp Epidemiol. 2017 Aug;38(8):891-896. doi: 10.1017/ice.2017.119. Epub 2017 Jun 8.


A matter of months: High precision migration chronology of a Bronze Age female.

Frei KM, Villa C, Jørkov ML, Allentoft ME, Kaul F, Ethelberg P, Reiter SS, Wilson AS, Taube M, Olsen J, Lynnerup N, Willerslev E, Kristiansen K, Frei R.

PLoS One. 2017 Jun 5;12(6):e0178834. doi: 10.1371/journal.pone.0178834. eCollection 2017.


Phenotypes of Atopic Dermatitis Depending on the Timing of Onset and Progression in Childhood.

Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, Schmausser-Hechfellner E, Pekkanen J, Riedler J, Dalphin JC, von Mutius E, Lauener RP; the PASTURE study group, Hyvärinen A, Kirjavainen P, Remes S, Roponen M, Dalphin ML, Kaulek V, Ege M, Genuneit J, Illi S, Kabesch M, Schaub B, Pfefferle PI, Doekes G.

JAMA Pediatr. 2017 Jul 1;171(7):655-662. doi: 10.1001/jamapediatrics.2017.0556.


Clinical evaluation of the Abbott RealTime MTB Assay for direct detection of Mycobacterium tuberculosis-complex from respiratory and non-respiratory samples.

Hinić V, Feuz K, Turan S, Berini A, Frei R, Pfeifer K, Goldenberger D.

Tuberculosis (Edinb). 2017 May;104:65-69. doi: 10.1016/ Epub 2017 Mar 3.


The Model for End-stage Liver Disease (MELD) as a predictor of short-term mortality in Staphylococcus aureus bloodstream infection: A single-centre observational study.

Roth JA, Widmer AF, Tschudin-Sutter S, Dangel M, Frei R, Battegay M, Hug BL.

PLoS One. 2017 Apr 17;12(4):e0175669. doi: 10.1371/journal.pone.0175669. eCollection 2017.


Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma.

Rodriguez-Perez N, Schiavi E, Frei R, Ferstl R, Wawrzyniak P, Smolinska S, Sokolowska M, Sievi NA, Kohler M, Schmid-Grendelmeier P, Michalovich D, Simpson KD, Hessel EM, Jutel M, Martin-Fontecha M, Palomares O, Akdis CA, O'Mahony L.

Allergy. 2017 Nov;72(11):1744-1752. doi: 10.1111/all.13180. Epub 2017 May 10.


Origin of hexavalent chromium in groundwater: The example of Sarigkiol Basin, Northern Greece.

Kazakis N, Kantiranis N, Kalaitzidou K, Kaprara E, Mitrakas M, Frei R, Vargemezis G, Tsourlos P, Zouboulis A, Filippidis A.

Sci Total Environ. 2017 Sep 1;593-594:552-566. doi: 10.1016/j.scitotenv.2017.03.128. Epub 2017 Mar 28.


Catheter retention as a consequence rather than a cause of unfavorable outcome in candidemia.

Damonti L, Erard V, Garbino J, Schrenzel J, Zimmerli S, Mühlethaler K, Imhof A, Zbinden R, Fehr J, Boggian K, Bruderer T, Flückiger U, Frei R, Orasch C, Conen A, Khanna N, Bregenzer T, Bille J, Lamoth F, Marchetti O, Bochud PY; Fungal Infection Network of Switzerland (FUNGINOS).

Intensive Care Med. 2017 Jun;43(6):935-939. doi: 10.1007/s00134-017-4737-9. Epub 2017 Mar 7. No abstract available. Erratum in: Intensive Care Med. 2018 Feb 20;:.


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