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Items: 1 to 50 of 697

1.

Investigations of Cu/Zn Oxalates from Aqueous Solution: Single Phase Precursors and Beyond.

Zwiener L, Girgsdies F, Schlögl R, Frei E.

Chemistry. 2018 Aug 8. doi: 10.1002/chem.201803124. [Epub ahead of print]

PMID:
30088684
2.

Biotic and abiotic drivers of tree seedling recruitment across an alpine treeline ecotone.

Frei ER, Bianchi E, Bernareggi G, Bebi P, Dawes MA, Brown CD, Trant AJ, Mamet SD, Rixen C.

Sci Rep. 2018 Jul 18;8(1):10894. doi: 10.1038/s41598-018-28808-w.

3.

The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.

Cerna T, Hrabeta J, Eckschlager T, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Int J Mol Sci. 2018 Jan 5;19(1). pii: E164. doi: 10.3390/ijms19010164.

4.

Cytochrome b5 plays a dual role in the reaction cycle of cytochrome P450 3A4 during oxidation of the anticancer drug ellipticine.

Stiborová M, Indra R, Frei E, Kopečková K, Schmeiser HH, Eckschlager T, Adam V, Heger Z, Arlt VM, Martínek V.

Monatsh Chem. 2017;148(11):1983-1991. doi: 10.1007/s00706-017-1986-9. Epub 2017 Jul 4.

5.

Comparison of the oxidation of carcinogenic aristolochic acid I and II by microsomal cytochromes P450 in vitro: experimental and theoretical approaches.

Martínek V, Bárta F, Hodek P, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Monatsh Chem. 2017;148(11):1971-1981. doi: 10.1007/s00706-017-2014-9. Epub 2017 Jul 26.

6.

Comparison of human cytochrome P450 1A1-catalysed oxidation of benzo[a]pyrene in prokaryotic and eukaryotic expression systems.

Stiborová M, Indra R, Moserová M, Bořek-Dohalská L, Hodek P, Frei E, Kopka K, Schmeiser HH, Arlt VM.

Monatsh Chem. 2017;148(11):1959-1969. doi: 10.1007/s00706-017-2002-0. Epub 2017 Jul 10.

7.

The Electro-Deposition/Dissolution of CuSO4 Aqueous Electrolyte Investigated by In Situ Soft X-ray Absorption Spectroscopy.

Velasco-Vélez JJ, Skorupska K, Frei E, Huang YC, Dong CL, Su BJ, Hsu CJ, Chou HY, Chen JM, Strasser P, Schlögl R, Knop-Gericke A, Chuang CH.

J Phys Chem B. 2018 Jan 18;122(2):780-787. doi: 10.1021/acs.jpcb.7b06728. Epub 2017 Nov 2.

PMID:
29039938
8.

Der etwas andere Husten.

Tschallener M, Knechtle B, Bode-Lesniewska B, Braschler T, Frei E, Rothermundt C, Messerli M.

Praxis (Bern 1994). 2017 Sep;106(19):1065-1070. doi: 10.1024/1661-8157/a002778. German. No abstract available.

PMID:
28927367
9.

Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.

Sulc M, Mrizova I, Cerna T, Frei E, Eckschlager T, Adam V, Kopeckova K, Stiborova M.

Neuro Endocrinol Lett. 2016 Dec 18;37(Suppl1):95-102.

PMID:
28263536
10.

Amnioserosa cell constriction but not epidermal actin cable tension autonomously drives dorsal closure.

Pasakarnis L, Frei E, Caussinus E, Affolter M, Brunner D.

Nat Cell Biol. 2016 Nov;18(11):1161-1172. doi: 10.1038/ncb3420. Epub 2016 Oct 17.

PMID:
27749821
11.

Bridging the Time Gap: A Copper/Zinc Oxide/Aluminum Oxide Catalyst for Methanol Synthesis Studied under Industrially Relevant Conditions and Time Scales.

Lunkenbein T, Girgsdies F, Kandemir T, Thomas N, Behrens M, Schlögl R, Frei E.

Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12708-12. doi: 10.1002/anie.201603368. Epub 2016 Sep 8.

PMID:
27607344
12.

Correction to NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Sep 19;29(9):1571. doi: 10.1021/acs.chemrestox.6b00283. Epub 2016 Aug 30. No abstract available.

13.

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM.

Chem Res Toxicol. 2016 Aug 15;29(8):1325-34. doi: 10.1021/acs.chemrestox.6b00143. Epub 2016 Jul 20. Erratum in: Chem Res Toxicol. 2016 Sep 19;29(9):1571.

14.

Climate adaptation is not enough: warming does not facilitate success of southern tundra plant populations in the high Arctic.

Bjorkman AD, Vellend M, Frei ER, Henry GH.

Glob Chang Biol. 2017 Apr;23(4):1540-1551. doi: 10.1111/gcb.13417. Epub 2016 Aug 6.

PMID:
27391174
15.

Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM.

Monatsh Chem. 2016;147:897-904. Epub 2016 Jan 12.

16.

NADPH- and NADH-dependent metabolism of and DNA adduct formation by benzo[a]pyrene catalyzed with rat hepatic microsomes and cytochrome P450 1A1.

Stiborová M, Indra R, Moserová M, Šulc M, Hodek P, Frei E, Schmeiser HH, Arlt VM.

Monatsh Chem. 2016;147:847-855. Epub 2016 Mar 9.

17.

The impact of individual cytochrome P450 enzymes on oxidative metabolism of benzo[a]pyrene in human livers.

Šulc M, Indra R, Moserová M, Schmeiser HH, Frei E, Arlt VM, Stiborová M.

Environ Mol Mutagen. 2016 Apr;57(3):229-35. doi: 10.1002/em.22001. Epub 2016 Feb 26.

18.

Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.

Milichovský J, Bárta F, Schmeiser HH, Arlt VM, Frei E, Stiborová M, Martínek V.

Int J Mol Sci. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213.

19.

Induction of cytochromes P450 1A1 and 1A2 suppresses formation of DNA adducts by carcinogenic aristolochic acid I in rats in vivo.

Dračínská H, Bárta F, Levová K, Hudecová A, Moserová M, Schmeiser HH, Kopka K, Frei E, Arlt VM, Stiborová M.

Toxicology. 2016 Feb 17;344-346:7-18. doi: 10.1016/j.tox.2016.01.011. Epub 2016 Feb 1.

20.

Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.

Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Eckschlager T, Frei E.

Neuro Endocrinol Lett. 2015;36 Suppl 1:22-8.

PMID:
26757112
21.

Metal Containing Cytostatics and Their Interaction with Cellular Thiol Compounds Causing Chemoresistance.

Hrabeta J, Adam V, Eckschlager T, Frei E, Stiborova M, Kizek R.

Anticancer Agents Med Chem. 2016;16(6):686-98. Review.

PMID:
26584725
22.

Changes in urinary metabolic profiles of colorectal cancer patients enrolled in a prospective cohort study (ColoCare).

Liesenfeld DB, Habermann N, Toth R, Owen RW, Frei E, Staffa J, Schrotz-King P, Klika KD, Ulrich CM.

Metabolomics. 2015 Aug;11(4):998-1012. doi: 10.1007/s11306-014-0758-3. Epub 2014 Dec 20.

23.

Vacuolar-ATPase-mediated intracellular sequestration of ellipticine contributes to drug resistance in neuroblastoma cells.

Hrabeta J, Groh T, Khalil MA, Poljakova J, Adam V, Kizek R, Uhlik J, Doktorova H, Cerna T, Frei E, Stiborova M, Eckschlager T.

Int J Oncol. 2015 Sep;47(3):971-80. doi: 10.3892/ijo.2015.3066. Epub 2015 Jun 29.

PMID:
26134421
24.

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene.

Arlt VM, Krais AM, Godschalk RW, Riffo-Vasquez Y, Mrizova I, Roufosse CA, Corbin C, Shi Q, Frei E, Stiborova M, van Schooten FJ, Phillips DH, Spina D.

Toxicol Sci. 2015 Aug;146(2):213-25. doi: 10.1093/toxsci/kfv086. Epub 2015 Apr 23.

25.

Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.

Beyerle J, Frei E, Stiborova M, Habermann N, Ulrich CM.

Drug Metab Rev. 2015 May;47(2):199-221. doi: 10.3109/03602532.2014.996649. Epub 2015 Feb 17. Review.

PMID:
25686853
26.

Enzymes oxidizing the azo dye 1-phenylazo-2-naphthol (Sudan I) and their contribution to its genotoxicity and carcinogenicity.

Stiborova M, Schmeiser HH, Frei E, Hodek P, Martinek V.

Curr Drug Metab. 2014;15(8):829-40. Review.

PMID:
25658126
27.

Effect of dihydromyricetin on benzo[a]pyrene activation in rats.

Hodek P, Fousova P, Brabencova E, Moserova M, Pavek P, Anzenbacherova E, Brotanek J, Hudecek J, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2014;35 Suppl 2:158-68.

PMID:
25638381
28.

Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo.

Stiborova M, Levova K, Barta F, Dracinska H, Sulc M, Hodek P, Frei E, Arlt VM, Schmeiser HH.

Neuro Endocrinol Lett. 2014;35 Suppl 2:123-32.

PMID:
25638376
29.
30.

Formation of DNA adducts by ellipticine and its micellar form in rats - a comparative study.

Stiborova M, Manhartova Z, Hodek P, Adam V, Kizek R, Frei E.

Sensors (Basel). 2014 Dec 3;14(12):22982-97. doi: 10.3390/s141222982.

31.

The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.

Stiborová M, Bárta F, Levová K, Hodek P, Frei E, Arlt VM, Schmeiser HH.

Arch Toxicol. 2015 Nov;89(11):2141-58. doi: 10.1007/s00204-014-1360-1. Epub 2014 Sep 11.

PMID:
25209566
32.

Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.

Stiborová M, Frei E, Schmeiser HH, Arlt VM, Martínek V.

Int J Mol Sci. 2014 Jun 10;15(6):10271-95. doi: 10.3390/ijms150610271. Review.

33.

Plastic responses to elevated temperature in low and high elevation populations of three grassland species.

Frei ER, Ghazoul J, Pluess AR.

PLoS One. 2014 Jun 5;9(6):e98677. doi: 10.1371/journal.pone.0098677. eCollection 2014.

34.

The effect of aristolochic acid I on expression of NAD(P)H:quinone oxidoreductase in mice and rats--a comparative study.

Bárta F, Levová K, Frei E, Schmeiser HH, Arlt VM, Stiborová M.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Jul 1;768:1-7. doi: 10.1016/j.mrgentox.2014.01.012. Epub 2014 Apr 24.

PMID:
24769487
35.

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.

Minten C, Alt C, Gentner M, Frei E, Deutsch U, Lyck R, Schaeren-Wiemers N, Rot A, Engelhardt B.

Brain. 2014 May;137(Pt 5):1454-69. doi: 10.1093/brain/awu045. Epub 2014 Mar 12.

36.

The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.

Stiborová M, Levová K, Bárta F, Šulc M, Frei E, Arlt VM, Schmeiser HH.

Mutagenesis. 2014 May;29(3):189-200. doi: 10.1093/mutage/geu004. Epub 2014 Mar 5.

PMID:
24598128
37.

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

Stiborová M, Moserová M, Černá V, Indra R, Dračínský M, Šulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM.

Toxicology. 2014 Apr 6;318:1-12. doi: 10.1016/j.tox.2014.02.002. Epub 2014 Feb 14.

PMID:
24530354
38.

Engineered high aspect ratio vertical nanotubes as a model system for the investigation of catalytic methanol synthesis over Cu/ZnO.

Güder F, Frei E, Kücükbayrak UM, Menzel A, Thomann R, Luptak R, Hollaender B, Krossing I, Zacharias M.

ACS Appl Mater Interfaces. 2014 Feb 12;6(3):1576-82. doi: 10.1021/am4042959. Epub 2014 Jan 14.

PMID:
24392784
39.

Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.

Indra R, Moserova M, Sulc M, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2013;34 Suppl 2:55-63.

PMID:
24362093
40.

The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.

Stiborova M, Cerna V, Moserova M, Arlt VM, Frei E.

Neuro Endocrinol Lett. 2013;34 Suppl 2:43-54.

PMID:
24362092
41.

Challenges of asthma management for school nurses in districts with high asthma hospitalization rates.

Liberatos P, Leone J, Craig AM, Frei EM, Fuentes N, Harris IM.

J Sch Health. 2013 Dec;83(12):867-75. doi: 10.1111/josh.12105.

PMID:
24261521
42.

Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.

Stiborová M, Frei E, Arlt VM, Schmeiser HH.

Xenobiotica. 2014 Jan;44(2):135-45. doi: 10.3109/00498254.2013.848310. Epub 2013 Oct 23. Review.

PMID:
24152141
43.

Glacial history affected phenotypic differentiation in the alpine plant, Campanula thyrsoides.

Scheepens JF, Frei ES, Stöcklin J.

PLoS One. 2013 Oct 16;8(10):e73854. doi: 10.1371/journal.pone.0073854. eCollection 2013.

44.

Plant population differentiation and climate change: responses of grassland species along an elevational gradient.

Frei ER, Ghazoul J, Matter P, Heggli M, Pluess AR.

Glob Chang Biol. 2014 Feb;20(2):441-55. doi: 10.1111/gcb.12403. Epub 2013 Dec 26.

PMID:
24115364
45.

The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat.

Hodek P, Koblihová J, Kizek R, Frei E, Arlt VM, Stiborová M.

Environ Toxicol Pharmacol. 2013 Nov;36(3):989-96. doi: 10.1016/j.etap.2013.09.004. Epub 2013 Sep 17.

PMID:
24095716
46.

Ellipticines as DNA-targeted chemotherapeutics.

Stiborová M, Frei E.

Curr Med Chem. 2014;21(5):575-91. Review.

PMID:
24059226
47.

Addition of rituximab to chemotherapy overcomes the negative prognostic impact of cyclin E expression in diffuse large B-cell lymphoma.

Frei E, Visco C, Xu-Monette ZY, Dirnhofer S, Dybkær K, Orazi A, Bhagat G, Hsi ED, van Krieken JH, Ponzoni M, Go RS, Piris MA, Møller MB, Young KH, Tzankov A.

J Clin Pathol. 2013 Nov;66(11):956-61. doi: 10.1136/jclinpath-2013-201619. Epub 2013 Jun 17.

PMID:
23775435
48.

Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and urothelial cancer.

Stiborová M, Martínek V, Frei E, Arlt VM, Schmeiser HH.

Curr Drug Metab. 2013 Jul;14(6):695-705. Review.

PMID:
23701164
49.

Activation and detoxification metabolism of urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone by rat and mouse hepatic microsomes.

Stiborova M, Cechova T, Borek-Dohalska L, Moserova M, Frei E, Schmeiser HH, Paca J, Arlt VM.

Neuro Endocrinol Lett. 2012;33 Suppl 3:8-15.

PMID:
23353838
50.

Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).

Stiborová M, Dračínská H, Martínek V, Svášková D, Hodek P, Milichovský J, Hejduková Ž, Brotánek J, Schmeiser HH, Frei E.

Chem Res Toxicol. 2013 Feb 18;26(2):290-9. doi: 10.1021/tx3004533. Epub 2013 Jan 15.

PMID:
23289503

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