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The Use of Multivitamin/Multimineral Supplements: A Modified Delphi Consensus Panel Report.

Blumberg JB, Cena H, Barr SI, Biesalski HK, Dagach RU, Delaney B, Frei B, Moreno González MI, Hwalla N, Lategan-Potgieter R, McNulty H, van der Pols JC, Winichagoon P, Li D.

Clin Ther. 2018 Apr;40(4):640-657. doi: 10.1016/j.clinthera.2018.02.014. Epub 2018 Mar 21. Review.


Purification and functional characterization of the vacuolar malate transporter tDT from Arabidopsis.

Frei B, Eisenach C, Martinoia E, Hussein S, Chen XZ, Arrivault S, Neuhaus HE.

J Biol Chem. 2018 Mar 16;293(11):4180-4190. doi: 10.1074/jbc.RA117.000851. Epub 2018 Jan 24.


Contribution of Dietary Supplements to Nutritional Adequacy by Socioeconomic Subgroups in Adults of the United States.

Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Dec 22;10(1). pii: E4. doi: 10.3390/nu10010004.


Contribution of Dietary Supplements to Nutritional Adequacy in Various Adult Age Groups.

Blumberg JB, Frei B, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Dec 6;9(12). pii: E1325. doi: 10.3390/nu9121325.


Contribution of Dietary Supplements to Nutritional Adequacy in Race/Ethnic Population Subgroups in the United States.

Blumberg JB, Frei B, Fulgoni VL III, Weaver CM, Zeisel SH.

Nutrients. 2017 Nov 28;9(12). pii: E1295. doi: 10.3390/nu9121295.


Impact of Frequency of Multi-Vitamin/Multi-Mineral Supplement Intake on Nutritional Adequacy and Nutrient Deficiencies in U.S. Adults.

Blumberg JB, Frei BB, Fulgoni VL, Weaver CM, Zeisel SH.

Nutrients. 2017 Aug 9;9(8). pii: E849. doi: 10.3390/nu9080849.


Vitamin and Mineral Intake Is Inadequate for Most Americans: What Should We Advise Patients About Supplements?

Blumberg JB, Frei B, Fulgoni VL 3rd, Weaver CM, Zeisel SH.

J Fam Pract. 2016 Sep;65(9 Suppl):S1-S8.


Improved estimation of reflectance spectra by utilizing prior knowledge.

Dierl M, Eckhard T, Frei B, Klammer M, Eichstädt S, Elster C.

J Opt Soc Am A Opt Image Sci Vis. 2016 Jul 1;33(7):1370-6. doi: 10.1364/JOSAA.33.001370.


Astragaloside IV inhibits NF- κ B activation and inflammatory gene expression in LPS-treated mice.

Zhang WJ, Frei B.

Mediators Inflamm. 2015;2015:274314. doi: 10.1155/2015/274314. Epub 2015 Apr 16.


Initiation of rivaroxaban in patients with nonvalvular atrial fibrillation at the primary care level: the Swiss Therapy in Atrial Fibrillation for the Regulation of Coagulation (STAR) Study.

Engelberger RP, Noll G, Schmidt D, Alatri A, Frei B, Kaiser WE, Kucher N.

Eur J Intern Med. 2015 Sep;26(7):508-14. doi: 10.1016/j.ejim.2015.04.014. Epub 2015 Apr 30.


Associations between vitamin D levels and depressive symptoms in healthy young adult women.

Kerr DC, Zava DT, Piper WT, Saturn SR, Frei B, Gombart AF.

Psychiatry Res. 2015 May 30;227(1):46-51. doi: 10.1016/j.psychres.2015.02.016. Epub 2015 Mar 5.


Effects of different organic weed management strategies on the physicochemical, sensory, and antioxidant properties of machine-harvested blackberry fruits.

Cavender G, Liu M, Hobbs D, Frei B, Strik B, Zhao Y.

J Food Sci. 2014 Oct;79(10):S2107-16. doi: 10.1111/1750-3841.12639. Epub 2014 Sep 17.


Efficacy of Multivitamin/mineral Supplementation to Reduce Chronic Disease Risk: A Critical Review of the Evidence from Observational Studies and Randomized Controlled Trials.

Angelo G, Drake VJ, Frei B.

Crit Rev Food Sci Nutr. 2015;55(14):1968-91. doi: 10.1080/10408398.2014.912199. Review.


The PH gene determines fruit acidity and contributes to the evolution of sweet melons.

Cohen S, Itkin M, Yeselson Y, Tzuri G, Portnoy V, Harel-Baja R, Lev S, Sa'ar U, Davidovitz-Rikanati R, Baranes N, Bar E, Wolf D, Petreikov M, Shen S, Ben-Dor S, Rogachev I, Aharoni A, Ast T, Schuldiner M, Belausov E, Eshed R, Ophir R, Sherman A, Frei B, Neuhaus HE, Xu Y, Fei Z, Giovannoni J, Lewinsohn E, Tadmor Y, Paris HS, Katzir N, Burger Y, Schaffer AA.

Nat Commun. 2014 Jun 5;5:4026. doi: 10.1038/ncomms5026.


Enough is enough.

Frei B, Ames BN, Blumberg JB, Willett WC.

Ann Intern Med. 2014 Jun 3;160(11):807. doi: 10.7326/L14-5011. No abstract available.


Vitamin C supplementation for pregnant smoking women and pulmonary function in their newborn infants: a randomized clinical trial.

McEvoy CT, Schilling D, Clay N, Jackson K, Go MD, Spitale P, Bunten C, Leiva M, Gonzales D, Hollister-Smith J, Durand M, Frei B, Buist AS, Peters D, Morris CD, Spindel ER.

JAMA. 2014 May;311(20):2074-82. doi: 10.1001/jama.2014.5217.


Vitamin C.

Lykkesfeldt J, Michels AJ, Frei B.

Adv Nutr. 2014 Jan 1;5(1):16-8. doi: 10.3945/an.113.005157. No abstract available.


Myths, artifacts, and fatal flaws: identifying limitations and opportunities in vitamin C research.

Michels AJ, Frei B.

Nutrients. 2013 Dec 16;5(12):5161-92. doi: 10.3390/nu5125161. Review.


Copper induces--and copper chelation by tetrathiomolybdate inhibits--endothelial activation in vitro.

Wei H, Zhang WJ, Leboeuf R, Frei B.

Redox Rep. 2014 Jan;19(1):40-8. doi: 10.1179/1351000213Y.0000000070. Epub 2013 Nov 12.


A purified feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway.

Rodriguez KJ, Wong HK, Oddos T, Southall M, Frei B, Kaur S.

J Dermatol Sci. 2013 Dec;72(3):304-10. doi: 10.1016/j.jdermsci.2013.08.004. Epub 2013 Aug 16.


Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.

Michels AJ, Hagen TM, Frei B.

Annu Rev Nutr. 2013;33:45-70. doi: 10.1146/annurev-nutr-071812-161246. Epub 2013 Apr 29. Review.


Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.

Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard N, Gombart AF.

BMC Res Notes. 2012 Oct 24;5:575. doi: 10.1186/1756-0500-5-575.


Copper chelation by tetrathiomolybdate inhibits vascular inflammation and atherosclerotic lesion development in apolipoprotein E-deficient mice.

Wei H, Zhang WJ, McMillen TS, Leboeuf RC, Frei B.

Atherosclerosis. 2012 Aug;223(2):306-13. doi: 10.1016/j.atherosclerosis.2012.06.013. Epub 2012 Jun 16.


Authors' perspective: What is the optimum intake of vitamin C in humans?

Frei B, Birlouez-Aragon I, Lykkesfeldt J.

Crit Rev Food Sci Nutr. 2012;52(9):815-29. doi: 10.1080/10408398.2011.649149. Review.


Grape seed and tea extracts and catechin 3-gallates are potent inhibitors of α-amylase and α-glucosidase activity.

Yilmazer-Musa M, Griffith AM, Michels AJ, Schneider E, Frei B.

J Agric Food Chem. 2012 Sep 12;60(36):8924-9. doi: 10.1021/jf301147n. Epub 2012 Jun 29.


Use of high-fidelity simulation to teach end-of-life care to pharmacy students in an interdisciplinary course.

Gilliland I, Frei BL, McNeill J, Stovall J.

Am J Pharm Educ. 2012 May 10;76(4):66. doi: 10.5688/ajpe76466.


Vibration detection and discrimination in the masked birch caterpillar (Drepana arcuata).

Guedes RN, Matheson SM, Frei B, Smith ML, Yack JE.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2012 May;198(5):325-35. doi: 10.1007/s00359-012-0711-8.


Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging.

Bowman GL, Silbert LC, Howieson D, Dodge HH, Traber MG, Frei B, Kaye JA, Shannon J, Quinn JF.

Neurology. 2012 Jan 24;78(4):241-9. doi: 10.1212/WNL.0b013e3182436598. Epub 2011 Dec 28.


R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM.

Am J Physiol Regul Integr Comp Physiol. 2012 Mar 1;302(5):R587-97. doi: 10.1152/ajpregu.00393.2011. Epub 2011 Nov 2.


Copper chelation by tetrathiomolybdate inhibits lipopolysaccharide-induced inflammatory responses in vivo.

Wei H, Frei B, Beckman JS, Zhang WJ.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H712-20. doi: 10.1152/ajpheart.01299.2010. Epub 2011 Jul 1.


Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant properties.

Lotito SB, Zhang WJ, Yang CS, Crozier A, Frei B.

Free Radic Biol Med. 2011 Jul 15;51(2):454-63. doi: 10.1016/j.freeradbiomed.2011.04.032. Epub 2011 Apr 22.


Genetic ablation of phagocytic NADPH oxidase in mice limits TNFα-induced inflammation in the lungs but not other tissues.

Zhang WJ, Wei H, Tien YT, Frei B.

Free Radic Biol Med. 2011 Jun 1;50(11):1517-25. doi: 10.1016/j.freeradbiomed.2011.02.027. Epub 2011 Mar 2.


Impact of clinical pharmacy services on patients in an outpatient chemotherapy academic clinic.

McKee M, Frei BL, Garcia A, Fike D, Soefje SA.

J Oncol Pharm Pract. 2011 Dec;17(4):387-94. doi: 10.1177/1078155210389217. Epub 2011 Jan 14.


Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex.

Zhu BZ, Mao L, Fan RM, Zhu JG, Zhang YN, Wang J, Kalyanaraman B, Frei B.

Chem Res Toxicol. 2011 Jan 14;24(1):30-4. doi: 10.1021/tx100214t. Epub 2010 Nov 3.


Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment.

Bowman GL, Shannon J, Ho E, Traber MG, Frei B, Oken BS, Kaye JA, Quinn JF.

Alzheimer Dis Assoc Disord. 2011 Jan-Mar;25(1):49-57. doi: 10.1097/WAD.0b013e3181f333d6.


Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.

Li L, Smith A, Hagen TM, Frei B.

Ann N Y Acad Sci. 2010 Aug;1203:151-9. doi: 10.1111/j.1749-6632.2010.05555.x.


A new twist on an old vitamin: human polymorphisms in the gene encoding the sodium-dependent vitamin C transporter 1.

Michels AJ, Hagen TM, Frei B.

Am J Clin Nutr. 2010 Aug;92(2):271-2. doi: 10.3945/ajcn.2010.29979. Epub 2010 Jun 30. No abstract available.


The iron chelator, desferrioxamine, reduces inflammation and atherosclerotic lesion development in experimental mice.

Zhang WJ, Wei H, Frei B.

Exp Biol Med (Maywood). 2010 May;235(5):633-41. doi: 10.1258/ebm.2009.009229.


Micronutrient concentrations and subclinical atherosclerosis in adults with HIV.

Traber MG, Frei B.

Am J Clin Nutr. 2010 Jul;92(1):266-7; author reply 267. doi: 10.3945/ajcn.2010.29608. Epub 2010 May 12. No abstract available.


Uric acid as a CNS antioxidant.

Bowman GL, Shannon J, Frei B, Kaye JA, Quinn JF.

J Alzheimers Dis. 2010;19(4):1331-6. doi: 10.3233/JAD-2010-1330.


Vitamins E and C in the prevention of cardiovascular disease and cancer in men.

Roberts LJ 2nd, Traber MG, Frei B.

Free Radic Biol Med. 2009 Jun 1;46(11):1558. doi: 10.1016/j.freeradbiomed.2009.03.002. Epub 2009 Mar 11. No abstract available.


Prolonged exposure to LPS increases iron, heme, and p22phox levels and NADPH oxidase activity in human aortic endothelial cells: inhibition by desferrioxamine.

Li L, Frei B.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):732-8. doi: 10.1161/ATVBAHA.108.183210. Epub 2009 Feb 26.


Ascorbic acid and rates of cognitive decline in Alzheimer's disease.

Bowman GL, Dodge H, Frei B, Calabrese C, Oken BS, Kaye JA, Quinn JF.

J Alzheimers Dis. 2009;16(1):93-8. doi: 10.3233/JAD-2009-0923.


Genetic deficiency of NADPH oxidase does not diminish, but rather enhances, LPS-induced acute inflammatory responses in vivo.

Zhang WJ, Wei H, Frei B.

Free Radic Biol Med. 2009 Mar 15;46(6):791-8. doi: 10.1016/j.freeradbiomed.2008.12.003. Epub 2008 Dec 24.


Vitamin C and cancer revisited.

Frei B, Lawson S.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11037-8. doi: 10.1073/pnas.0806433105. Epub 2008 Aug 5. No abstract available.


An error in the US Department of Agriculture nutrient database results in vitamin A values that are 6 times too high.

Drake VJ, Frei B, Bouley LM.

Am J Clin Nutr. 2008 Apr;87(4):1067-8; author reply 1068-9. No abstract available.


Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.

Smith AR, Visioli F, Frei B, Hagen TM.

Br J Pharmacol. 2008 Apr;153(8):1615-22. doi: 10.1038/bjp.2008.28. Epub 2008 Feb 25.


Additive-Subtractive Two-Wavelength ESPI Contouring by Using a Synthetic Wavelength Phase Shift.

Hack E, Frei B, Kästle R, Sennhauser U.

Appl Opt. 1998 May 1;37(13):2591-7.


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