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Volume and Outcomes for Transcatheter Aortic-Valve Replacement.

Noble S, Frei A.

N Engl J Med. 2019 Oct 3;381(14):1393. doi: 10.1056/NEJMc1910012. No abstract available.


Two is better than one: difunctional high-affinity PSMA probes based on a [CpM(CO)3] (M = Re/99mTc) scaffold.

Frei A, Fischer E, Childs BC, Holland JP, Alberto R.

Dalton Trans. 2019 Oct 7;48(39):14600-14605. doi: 10.1039/c9dt02506e.


Economic Challenges in Nutritional Management.

Reber E, Norman K, Endrich O, Schuetz P, Frei A, Stanga Z.

J Clin Med. 2019 Jul 10;8(7). pii: E1005. doi: 10.3390/jcm8071005.


Determinants of hospital length of stay after transcatheter aortic valve implantation with self-expanding prostheses: a prospective, single centre observational study.

Frei A, Adamopoulos D, Müller H, Walder B, Perrin N, Reynaud T, Ho S, Roffi M, Mach F, Licker MJ, Noble S.

Swiss Med Wkly. 2019 Jun 30;149:w20095. doi: 10.4414/smw.2019.20095. eCollection 2019 Jun 17.


Chemistry at High Dilution: Dinuclear 99 m Tc Complexes.

Bolliger R, Frei A, Braband H, Meola G, Spingler B, Alberto R.

Chemistry. 2019 May 23;25(29):7101-7104. doi: 10.1002/chem.201901161. Epub 2019 Apr 30.


A novel approach to increase physical activity in older adults in the community using citizen science: a mixed-methods study.

Frei A, Dalla Lana K, Radtke T, Stone E, Knöpfli N, Puhan MA.

Int J Public Health. 2019 Jun;64(5):669-678. doi: 10.1007/s00038-019-01230-3. Epub 2019 Apr 1.


Synthetic Routes towards Multifunctional Cyclopentadienes.

Frei A.

Chemistry. 2019 May 23;25(29):7074-7090. doi: 10.1002/chem.201900276. Epub 2019 Apr 23. Review.


Reply to Roswitha Koch et al.

Chmiel C, Giewer I, Frei A, Rosemann T.

Swiss Med Wkly. 2019 Mar 10;149:w20009. doi: 10.4414/smw.2019.20009. eCollection 2019 Feb 25. No abstract available.


Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.

Schlaak RA, Frei A, Schottstaedt AM, Tsaih SW, Fish BL, Harmann L, Liu Q, Gasperetti T, Medhora M, North PE, Strande JL, Sun Y, Rui H, Flister MJ, Bergom C.

Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1267-H1280. doi: 10.1152/ajpheart.00482.2018. Epub 2019 Mar 8.


Efficacy of motivating short interventions for smokers in primary care (COSMOS trial): study protocol for a cluster-RCT.

Grischott T, Senn O, Rosemann T, Frei A, Cornuz J, Martin-Diener E, Neuner-Jehle S.

Trials. 2019 Jan 25;20(1):81. doi: 10.1186/s13063-018-3071-z.


High-dimensional single-cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis.

Fuchs S, Sawas N, Staedler N, Schubert DA, D'Andrea A, Zeiser R, Piali L, Hruz P, Frei AP.

Eur J Immunol. 2019 Mar;49(3):462-475. doi: 10.1002/eji.201847862. Epub 2019 Jan 9.


Smartphone-Based Physical Activity Telecoaching in Chronic Obstructive Pulmonary Disease: Mixed-Methods Study on Patient Experiences and Lessons for Implementation.

Loeckx M, Rabinovich RA, Demeyer H, Louvaris Z, Tanner R, Rubio N, Frei A, De Jong C, Gimeno-Santos E, Rodrigues FM, Buttery SC, Hopkinson NS, Büsching G, Strassmann A, Serra I, Vogiatzis I, Garcia-Aymerich J, Polkey MI, Troosters T.

JMIR Mhealth Uhealth. 2018 Dec 21;6(12):e200. doi: 10.2196/mhealth.9774.


Antibiotics for exacerbations of chronic obstructive pulmonary disease.

Vollenweider DJ, Frei A, Steurer-Stey CA, Garcia-Aymerich J, Puhan MA.

Cochrane Database Syst Rev. 2018 Oct 29;10:CD010257. doi: 10.1002/14651858.CD010257.pub2.


Transcatheter aortic valve implantation: Update in 2018.

Perrin N, Frei A, Noble S.

Eur J Intern Med. 2018 Sep;55:12-19. doi: 10.1016/j.ejim.2018.07.002. Epub 2018 Jul 4. Review.


The association between daily exacerbation symptoms and physical activity in patients with chronic obstructive pulmonary disease.

Crook S, Büsching G, Keusch S, Wieser S, Turk A, Frey M, Puhan MA, Frei A.

Int J Chron Obstruct Pulmon Dis. 2018 Jul 18;13:2199-2206. doi: 10.2147/COPD.S156986. eCollection 2018.


Minimum important difference of the Epworth Sleepiness Scale in obstructive sleep apnoea: estimation from three randomised controlled trials.

Crook S, Sievi NA, Bloch KE, Stradling JR, Frei A, Puhan MA, Kohler M.

Thorax. 2019 Apr;74(4):390-396. doi: 10.1136/thoraxjnl-2018-211959. Epub 2018 Aug 12.


Prognostic value of revascularising viable myocardium in elderly patients with stable coronary artery disease and left ventricular dysfunction: a PET/CT study.

Namdar M, Rager O, Priamo J, Frei A, Noble S, Amzalag G, Ratib O, Nkoulou R.

Int J Cardiovasc Imaging. 2018 Oct;34(10):1673-1678. doi: 10.1007/s10554-018-1380-7. Epub 2018 May 28.


Self-Assembled Multinuclear Complexes Incorporating 99m Tc.

Frei A, Mokolokolo PP, Bolliger R, Braband H, Tsosane MS, Brink A, Roodt A, Alberto R.

Chemistry. 2018 Jul 20;24(41):10397-10402. doi: 10.1002/chem.201800600. Epub 2018 Jun 19.


Multifunctional Cyclopentadienes as a Scaffold for Combinatorial Bioorganometallics in [(η5 -C5 H2 R1 R2 R3 )M(CO)3 ] (M=Re, 99m Tc) Piano-Stool Complexes.

Frei A, Spingler B, Alberto R.

Chemistry. 2018 Apr 19. doi: 10.1002/chem.201801271. [Epub ahead of print]


Conduction disorders using the Evolut R prosthesis compared with the CoreValve: has anything changed?

Perrin N, Perrin T, Hachulla AL, Frei A, Müller H, Roffi M, Cikirikcioglu M, Ellenberger C, Licker MJ, Burri H, Noble S.

Open Heart. 2018 Mar 25;5(1):e000770. doi: 10.1136/openhrt-2017-000770. eCollection 2018.


The German version of the Expanded Prostate Cancer Index Composite (EPIC): translation, validation and minimal important difference estimation.

Umbehr MH, Bachmann LM, Poyet C, Hammerer P, Steurer J, Puhan MA, Frei A.

Health Qual Life Outcomes. 2018 Feb 20;16(1):36. doi: 10.1186/s12955-018-0859-1.


FZD4 Marks Lateral Plate Mesoderm and Signals with NORRIN to Increase Cardiomyocyte Induction from Pluripotent Stem Cell-Derived Cardiac Progenitors.

Yoon C, Song H, Yin T, Bausch-Fluck D, Frei AP, Kattman S, Dubois N, Witty AD, Hewel JA, Guo H, Emili A, Wollscheid B, Keller G, Zandstra PW.

Stem Cell Reports. 2018 Jan 9;10(1):87-100. doi: 10.1016/j.stemcr.2017.11.008. Epub 2017 Dec 14.


Impact of Stressful Life Events on Patients with Chronic Obstructive Pulmonary Disease.

Yu T, Frei A, Ter Riet G, Puhan MA.

Respiration. 2018;95(2):73-79. doi: 10.1159/000481714. Epub 2017 Nov 1.


Four-year long-term follow-up of diabetes patients after implementation of the Chronic Care Model in primary care: a cross-sectional study.

Chmiel C, Giewer I, Frei A, Rosemann T.

Swiss Med Wkly. 2017 Oct 27;147:w14522. doi: 10.4414/smw.2017.14522. eCollection 2017.


The validation of the sit-to-stand test for COPD patients.

Crook S, Puhan MA, Frei A; STAND-UP and RIMTCORE study groups.

Eur Respir J. 2017 Sep 20;50(3). pii: 1701506. doi: 10.1183/13993003.01506-2017. Print 2017 Sep. No abstract available.


Commonly Used Patient-Reported Outcomes Do Not Improve Prediction of COPD Exacerbations: A Multicenter 4½ Year Prospective Cohort Study.

Strassmann A, Frei A, Haile SR, Ter Riet G, Puhan MA.

Chest. 2017 Dec;152(6):1179-1187. doi: 10.1016/j.chest.2017.09.003. Epub 2017 Sep 18.


Physical activity and risk of comorbidities in patients with chronic obstructive pulmonary disease: a cohort study.

Yu T, Ter Riet G, Puhan MA, Frei A.

NPJ Prim Care Respir Med. 2017 May 18;27(1):36. doi: 10.1038/s41533-017-0034-x.


Ultrafast Vibrational Energy Transfer in Catalytic Monolayers at Solid-Liquid Interfaces.

Kraack JP, Frei A, Alberto R, Hamm P.

J Phys Chem Lett. 2017 Jun 1;8(11):2489-2495. doi: 10.1021/acs.jpclett.7b01034. Epub 2017 May 22.


Local delivery of fingolimod from three-dimensional scaffolds impacts islet graft efficacy and microenvironment in a murine diabetic model.

Frei AW, Li Y, Jiang K, Buchwald P, Stabler CL.

J Tissue Eng Regen Med. 2018 Feb;12(2):393-404. doi: 10.1002/term.2464. Epub 2017 Aug 1.


Downstream indication to revascularization following hybrid cardiac PET/MRI: preliminary results.

Priamo J, Adamopoulos D, Rager O, Frei A, Noble S, Carballo D, Ratib O, Nkoulou R.

Nucl Med Commun. 2017 Jun;38(6):515-522. doi: 10.1097/MNM.0000000000000680.


A multicentre validation of the 1-min sit-to-stand test in patients with COPD.

Crook S, Büsching G, Schultz K, Lehbert N, Jelusic D, Keusch S, Wittmann M, Schuler M, Radtke T, Frey M, Turk A, Puhan MA, Frei A.

Eur Respir J. 2017 Mar 2;49(3). pii: 1601871. doi: 10.1183/13993003.01871-2016. Print 2017 Mar.


Physical activity is increased by a 12-week semiautomated telecoaching programme in patients with COPD: a multicentre randomised controlled trial.

Demeyer H, Louvaris Z, Frei A, Rabinovich RA, de Jong C, Gimeno-Santos E, Loeckx M, Buttery SC, Rubio N, Van der Molen T, Hopkinson NS, Vogiatzis I, Puhan MA, Garcia-Aymerich J, Polkey MI, Troosters T; Mr Papp PROactive study group and the PROactive consortium.

Thorax. 2017 May;72(5):415-423. doi: 10.1136/thoraxjnl-2016-209026. Epub 2017 Jan 30.


High-throughput precision measurement of subcellular localization in single cells.

Burns TJ, Frei AP, Gherardini PF, Bava FA, Batchelder JE, Yoshiyasu Y, Yu JM, Groziak AR, Kimmey SC, Gonzalez VD, Fantl WJ, Nolan GP.

Cytometry A. 2017 Feb;91(2):180-189. doi: 10.1002/cyto.a.23054. Epub 2017 Jan 17.


Thirty-day Outcome Following CoreValve Evolut R Transcatheter Aortic Valve Implantation: An All-comers Prospective Study.

Perrin N, Roffi M, Frei A, Hachulla AL, Ellenberger C, Müller H, Cikirikcioglu M, Licker M, Noble S.

Rev Esp Cardiol (Engl Ed). 2017 Sep;70(9):713-719. doi: 10.1016/j.rec.2016.11.024. Epub 2016 Dec 27. English, Spanish.


Laminin targeting of a peripheral nerve-highlighting peptide enables degenerated nerve visualization.

Glasgow HL, Whitney MA, Gross LA, Friedman B, Adams SR, Crisp JL, Hussain T, Frei AP, Novy K, Wollscheid B, Nguyen QT, Tsien RY.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):12774-12779. doi: 10.1073/pnas.1611642113. Epub 2016 Oct 20.


Kinetics and Mechanism of CO Exchange in fac-[MBr2(solvent)(CO)3](-) (M = Re, (99)Tc).

Frei A, Sidler D, Mokolokolo P, Braband H, Fox T, Spingler B, Roodt A, Alberto R.

Inorg Chem. 2016 Sep 19;55(18):9352-60. doi: 10.1021/acs.inorgchem.6b01503. Epub 2016 Sep 8.


Vasospastic angina: A forgotten acute coronary syndrome and the usefulness of twelve-lead electrocardiogram monitoring in diagnosis.

Rey F, Mock S, Frei A, Noble S.

Int J Cardiol. 2016 Nov 15;223:46-47. doi: 10.1016/j.ijcard.2016.08.049. Epub 2016 Aug 7. No abstract available.


Memo interacts with c-Src to control Estrogen Receptor alpha sub-cellular localization.

Frei A, MacDonald G, Lund I, Gustafsson JÅ, Hynes NE, Nalvarte I.

Oncotarget. 2016 Aug 30;7(35):56170-56182. doi: 10.18632/oncotarget.10856.


Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models.

Bottos A, Gotthardt D, Gill JW, Gattelli A, Frei A, Tzankov A, Sexl V, Wodnar-Filipowicz A, Hynes NE.

Nat Commun. 2016 Jul 13;7:12258. doi: 10.1038/ncomms12258.


Determinants of Physical Activity in Patients with Chronic Obstructive Pulmonary Disease: A 5-Year Prospective Follow-Up Study.

Yu T, Frei A, Ter Riet G, Puhan MA.

Respiration. 2016;92(2):72-9. doi: 10.1159/000447975. Epub 2016 Jul 13.


The Inaccuracy of Patient Recall for COPD Exacerbation Rate Estimation and Its Implications: Results from Central Adjudication.

Frei A, Siebeling L, Wolters C, Held L, Muggensturm P, Strassmann A, Zoller M, Ter Riet G, Puhan MA.

Chest. 2016 Oct;150(4):860-868. doi: 10.1016/j.chest.2016.06.031. Epub 2016 Aug 26.


Adult attention-deficit/hyperactivity disorder and nicotine withdrawal: a qualitative study of patient perceptions.

Liebrenz M, Fisher CE, Nellen R, Frei A, Biechl AC, Hiestand N, Huber A, Buadze A, Eich D.

BMC Psychiatry. 2016 Jul 4;16:208. doi: 10.1186/s12888-016-0911-9.


Extra-cardiac stimulators: what do cardiologists need to know?

Guinand A, Noble S, Frei A, Renard J, Tramer MR, Burri H.

Europace. 2016 Sep;18(9):1299-307. doi: 10.1093/europace/euv453. Epub 2016 May 26. Review.


The tumor-suppressive small GTPase DiRas1 binds the noncanonical guanine nucleotide exchange factor SmgGDS and antagonizes SmgGDS interactions with oncogenic small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC Jr, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 May 13;291(20):10948. doi: 10.1074/jbc.A115.696831. No abstract available.


The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases.

Bergom C, Hauser AD, Rymaszewski A, Gonyo P, Prokop JW, Jennings BC, Lawton AJ, Frei A, Lorimer EL, Aguilera-Barrantes I, Mackinnon AC, Noon K, Fierke CA, Williams CL.

J Biol Chem. 2016 Mar 18;291(12):6534-45. doi: 10.1074/jbc.M115.696831. Epub 2016 Jan 26. Erratum in: J Biol Chem. 2016 May 13;291(20):10948.


Highly multiplexed simultaneous detection of RNAs and proteins in single cells.

Frei AP, Bava FA, Zunder ER, Hsieh EW, Chen SY, Nolan GP, Gherardini PF.

Nat Methods. 2016 Mar;13(3):269-75. doi: 10.1038/nmeth.3742. Epub 2016 Jan 25.


The Chronic Care for Wet Age Related Macular Degeneration (CHARMED) Study: A Randomized Controlled Trial.

Markun S, Dishy A, Neuner-Jehle S, Rosemann T, Frei A.

PLoS One. 2015 Nov 16;10(11):e0143085. doi: 10.1371/journal.pone.0143085. eCollection 2015.


Bow tie or no tie: a rule to reduce healthcare-acquired infections.

Frei AS.

J Community Hosp Intern Med Perspect. 2015 Oct 19;5(5):28808. doi: 10.3402/jchimp.v5.28808. eCollection 2015. No abstract available.

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