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Items: 49


SosA inhibits cell division in Staphylococcus aureus in response to DNA damage.

Bojer MS, Wacnik K, Kjelgaard P, Gallay C, Bottomley AL, Cohn MT, Lindahl G, Frees D, Veening JW, Foster SJ, Ingmer H.

Mol Microbiol. 2019 Jul 10. doi: 10.1111/mmi.14350. [Epub ahead of print]


Antibiotic Resistance and the MRSA Problem.

Vestergaard M, Frees D, Ingmer H.

Microbiol Spectr. 2019 Mar;7(2). doi: 10.1128/microbiolspec.GPP3-0057-2018. Review.


Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease.

Baldry M, Nakamura Y, Nakagawa S, Frees D, Matsue H, Núñez G, Ingmer H.

J Infect Dis. 2018 Aug 14;218(6):1009-1013. doi: 10.1093/infdis/jiy259.


The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus.

Stahlhut SG, Alqarzaee AA, Jensen C, Fisker NS, Pereira AR, Pinho MG, Thomas VC, Frees D.

Sci Rep. 2017 Sep 18;7(1):11739. doi: 10.1038/s41598-017-12122-y.


Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus.

Baldry M, Nielsen A, Bojer MS, Zhao Y, Friberg C, Ifrah D, Glasser Heede N, Larsen TO, Frøkiær H, Frees D, Zhang L, Dai H, Ingmer H.

PLoS One. 2016 Dec 22;11(12):e0168305. doi: 10.1371/journal.pone.0168305. eCollection 2016.


Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis.

Breüner A, Frees D, Varmanen P, Boguta AM, Hammer K, Martinussen J, Kilstrup M.

Microbiology. 2016 Oct;162(10):1829-1839. doi: 10.1099/mic.0.000362. Epub 2016 Aug 23.


The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone.

Bæk KT, Bowman L, Millership C, Dupont Søgaard M, Kaever V, Siljamäki P, Savijoki K, Varmanen P, Nyman TA, Gründling A, Frees D.

MBio. 2016 Aug 9;7(4). pii: e01228-16. doi: 10.1128/mBio.01228-16.


Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus.

Villanueva M, Jousselin A, Baek KT, Prados J, Andrey DO, Renzoni A, Ingmer H, Frees D, Kelley WL.

J Bacteriol. 2016 Sep 9;198(19):2719-31. doi: 10.1128/JB.00261-16. Print 2016 Oct 1.


Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri.

Korbut R, Mehrdana F, Kania PW, Larsen MH, Frees D, Dalsgaard I, Jørgensen Lv.

PLoS One. 2016 Jul 12;11(7):e0158968. doi: 10.1371/journal.pone.0158968. eCollection 2016.


Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline.

Larsen J, Clasen J, Hansen JE, Paulander W, Petersen A, Larsen AR, Frees D.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4401-3. doi: 10.1128/AAC.00426-16. Print 2016 Jul.


Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene.

Bæk KT, Thøgersen L, Mogenssen RG, Mellergaard M, Thomsen LE, Petersen A, Skov S, Cameron DR, Peleg AY, Frees D.

Antimicrob Agents Chemother. 2015 Nov;59(11):6983-91. doi: 10.1128/AAC.01303-15. Epub 2015 Aug 31.


Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus.

Farrand AJ, Friedman DB, Reniere ML, Ingmer H, Frees D, Skaar EP.

Pathog Dis. 2015 Apr;73(3). pii: ftv004. doi: 10.1093/femspd/ftv004. Epub 2015 Jan 20.


β-Lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease.

Bæk KT, Gründling A, Mogensen RG, Thøgersen L, Petersen A, Paulander W, Frees D.

Antimicrob Agents Chemother. 2014 Aug;58(8):4593-603. doi: 10.1128/AAC.02802-14. Epub 2014 May 27.


Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus.

Frees D, Gerth U, Ingmer H.

Int J Med Microbiol. 2014 Mar;304(2):142-9. doi: 10.1016/j.ijmm.2013.11.009. Epub 2013 Dec 1. Review.


Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils.

Nielsen A, Månsson M, Bojer MS, Gram L, Larsen TO, Novick RP, Frees D, Frøkiær H, Ingmer H.

PLoS One. 2014 Jan 8;9(1):e84992. doi: 10.1371/journal.pone.0084992. eCollection 2014.


Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing.

Bæk KT, Frees D, Renzoni A, Barras C, Rodriguez N, Manzano C, Kelley WL.

PLoS One. 2013 Sep 30;8(9):e77122. doi: 10.1371/journal.pone.0077122. eCollection 2013.


Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system.

Farrand AJ, Reniere ML, Ingmer H, Frees D, Skaar EP.

J Bacteriol. 2013 Nov;195(22):5041-50. doi: 10.1128/JB.00505-13. Epub 2013 Aug 30.


The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice.

Harslund J, Frees D, Leifsson PS, Offenberg H, Rømer MU, Brünner N, Olsen JE.

Pathog Dis. 2013 Aug;68(3):96-104. doi: 10.1111/2049-632X.12055. Epub 2013 Jul 8.


Therapy of haematogenous osteomyelitis--a comparative study in a porcine model and Angolan children.

Johansen LK, Koch J, Kirketerp-Møller K, Wamsler OJ, Nielsen OL, Leifsson PS, Frees D, Aalbæk B, Jensen HE.

In Vivo. 2013 May-Jun;27(3):305-12.


Bacterial proteases and virulence.

Frees D, Brøndsted L, Ingmer H.

Subcell Biochem. 2013;66:161-92. doi: 10.1007/978-94-007-5940-4_7. Review.


A new technique for modeling of hematogenous osteomyelitis in pigs: inoculation into femoral artery.

Johansen LK, Svalastoga EL, Frees D, Aalbæk B, Koch J, Iburg TM, Nielsen OL, Leifsson PS, Jensen HE.

J Invest Surg. 2013 Jun;26(3):149-53. doi: 10.3109/08941939.2012.718043. Epub 2012 Dec 28.


Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus.

Feng J, Michalik S, Varming AN, Andersen JH, Albrecht D, Jelsbak L, Krieger S, Ohlsen K, Hecker M, Gerth U, Ingmer H, Frees D.

J Proteome Res. 2013 Feb 1;12(2):547-58. doi: 10.1021/pr300394r. Epub 2013 Jan 8.


Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus.

Paulander W, Nissen Varming A, Bæk KT, Haaber J, Frees D, Ingmer H.

MBio. 2013 Jan 2;3(6):e00459-12. doi: 10.1128/mBio.00459-12.


Planktonic aggregates of Staphylococcus aureus protect against common antibiotics.

Haaber J, Cohn MT, Frees D, Andersen TJ, Ingmer H.

PLoS One. 2012;7(7):e41075. doi: 10.1371/journal.pone.0041075. Epub 2012 Jul 18. Erratum in: PLoS One. 2012;7(10). doi:10.1371/annotation/08d0f2a8-0c40-4a0c-b546-0025648e73f0.


Pathology and biofilm formation in a porcine model of staphylococcal osteomyelitis.

Johansen LK, Koch J, Frees D, Aalbæk B, Nielsen OL, Leifsson PS, Iburg TM, Svalastoga E, Buelund LE, Bjarnsholt T, Høiby N, Jensen HE.

J Comp Pathol. 2012 Aug-Oct;147(2-3):343-53. doi: 10.1016/j.jcpa.2012.01.018. Epub 2012 Apr 24.


Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis.

Johansen LK, Iburg TM, Nielsen OL, Leifsson PS, Dahl-Petersen K, Koch J, Frees D, Aalbæk B, Heegaard PM, Jensen HE.

Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):103-8. doi: 10.1016/j.prostaglandins.2012.01.002. Epub 2012 Jan 14.


The YjbH adaptor protein enhances proteolysis of the transcriptional regulator Spx in Staphylococcus aureus.

Engman J, Rogstam A, Frees D, Ingmer H, von Wachenfeldt C.

J Bacteriol. 2012 Mar;194(5):1186-94. doi: 10.1128/JB.06414-11. Epub 2011 Dec 22.


New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564.

Frees D, Andersen JH, Hemmingsen L, Koskenniemi K, Bæk KT, Muhammed MK, Gudeta DD, Nyman TA, Sukura A, Varmanen P, Savijoki K.

J Proteome Res. 2012 Jan 1;11(1):95-108. doi: 10.1021/pr200956s. Epub 2011 Dec 12.


Expression and secretion of the RTX-toxin GtxA among members of the genus Gallibacterium.

Kristensen BM, Frees D, Bojesen AM.

Vet Microbiol. 2011 Nov 21;153(1-2):116-23. doi: 10.1016/j.vetmic.2011.05.019. Epub 2011 May 19.


A porcine model of acute, haematogenous, localized osteomyelitis due to Staphylococcus aureus: a pathomorphological study.

Johansen LK, Frees D, Aalbaek B, Koch J, Iburg T, Nielsen OL, Leifsson PS, Jensen HE.

APMIS. 2011 Feb;119(2):111-8. doi: 10.1111/j.1600-0463.2010.02700.x. Epub 2010 Dec 1.


Clp-dependent proteolysis of the LexA N-terminal domain in Staphylococcus aureus.

Cohn MT, Kjelgaard P, Frees D, Penadés JR, Ingmer H.

Microbiology. 2011 Mar;157(Pt 3):677-84. doi: 10.1099/mic.0.043794-0. Epub 2010 Dec 23.


Searching for small σB-regulated genes in Staphylococcus aureus.

Nielsen JS, Christiansen MH, Bonde M, Gottschalk S, Frees D, Thomsen LE, Kallipolitis BH.

Arch Microbiol. 2011 Jan;193(1):23-34. doi: 10.1007/s00203-010-0641-1. Epub 2010 Oct 27.


The chaperone ClpX stimulates expression of Staphylococcus aureus protein A by Rot dependent and independent pathways.

Jelsbak L, Ingmer H, Valihrach L, Cohn MT, Christiansen MH, Kallipolitis BH, Frees D.

PLoS One. 2010 Sep 14;5(9):e12752. doi: 10.1371/journal.pone.0012752.


GtxA from Gallibacterium anatis, a cytolytic RTX-toxin with a novel domain organisation.

Kristensen BM, Frees D, Bojesen AM.

Vet Res. 2010 May-Jun;41(3):25. doi: 10.1051/vetres/2009073. Epub 2009 Dec 4.


Method for screening compounds that influence virulence gene expression in Staphylococcus aureus.

Nielsen A, Nielsen KF, Frees D, Larsen TO, Ingmer H.

Antimicrob Agents Chemother. 2010 Jan;54(1):509-12. doi: 10.1128/AAC.00940-09. Epub 2009 Nov 16.


Growth phase-dependent regulation of the global virulence regulator Rot in clinical isolates of Staphylococcus aureus.

Jelsbak L, Hemmingsen L, Donat S, Ohlsen K, Boye K, Westh H, Ingmer H, Frees D.

Int J Med Microbiol. 2010 Apr;300(4):229-36. doi: 10.1016/j.ijmm.2009.07.003. Epub 2009 Aug 8.


SpxB regulates O-acetylation-dependent resistance of Lactococcus lactis peptidoglycan to hydrolysis.

Veiga P, Bulbarela-Sampieri C, Furlan S, Maisons A, Chapot-Chartier MP, Erkelenz M, Mervelet P, Noirot P, Frees D, Kuipers OP, Kok J, Gruss A, Buist G, Kulakauskas S.

J Biol Chem. 2007 Jul 6;282(27):19342-54. Epub 2007 May 7.


Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria.

Frees D, Savijoki K, Varmanen P, Ingmer H.

Mol Microbiol. 2007 Mar;63(5):1285-95. Review.


Spx is a global effector impacting stress tolerance and biofilm formation in Staphylococcus aureus.

Pamp SJ, Frees D, Engelmann S, Hecker M, Ingmer H.

J Bacteriol. 2006 Jul;188(13):4861-70.


Staphylococcus aureus ClpYQ plays a minor role in stress survival.

Frees D, Thomsen LE, Ingmer H.

Arch Microbiol. 2005 May;183(4):286-91. Epub 2005 Apr 21.


Clp ATPases are required for stress tolerance, intracellular replication and biofilm formation in Staphylococcus aureus.

Frees D, Chastanet A, Qazi S, Sørensen K, Hill P, Msadek T, Ingmer H.

Mol Microbiol. 2004 Dec;54(5):1445-62.


Heat and DNA damage induction of the LexA-like regulator HdiR from Lactococcus lactis is mediated by RecA and ClpP.

Savijoki K, Ingmer H, Frees D, Vogensen FK, Palva A, Varmanen P.

Mol Microbiol. 2003 Oct;50(2):609-21.


Identification of proteins induced at low pH in Lactococcus lactis.

Frees D, Vogensen FK, Ingmer H.

Int J Food Microbiol. 2003 Nov 1;87(3):293-300.


Alternative roles of ClpX and ClpP in Staphylococcus aureus stress tolerance and virulence.

Frees D, Qazi SN, Hill PJ, Ingmer H.

Mol Microbiol. 2003 Jun;48(6):1565-78.


Uracil uptake in Escherichia coli K-12: isolation of uraA mutants and cloning of the gene.

Andersen PS, Frees D, Fast R, Mygind B.

J Bacteriol. 1995 Apr;177(8):2008-13.


Theoretical infrared spectra of some model polycyclic aromatic hydrocarbons: effect of ionization.

De Frees DJ, Miller MD, Talbi D, Pauzat F, Ellinger Y.

Astrophys J. 1993 May 10;408(2):530-8.


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