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Items: 37


Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1.

Freemerman AJ, Zhao L, Pingili AK, Teng B, Cozzo AJ, Fuller AM, Johnson AR, Milner JJ, Lim MF, Galanko JA, Beck MA, Bear JE, Rotty JD, Bezavada L, Smallwood HS, Puchowicz MA, Liu J, Locasale JW, Lee DP, Bennett BJ, Abel ED, Rathmell JC, Makowski L.

J Immunol. 2019 Feb 15;202(4):1265-1286. doi: 10.4049/jimmunol.1800002. Epub 2019 Jan 18.


Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr-/- mice.

Zhao L, Cozzo AJ, Johnson AR, Christensen T, Freemerman AJ, Bear JE, Rotty JD, Bennett BJ, Makowski L.

Atherosclerosis. 2017 Nov;266:182-189. doi: 10.1016/j.atherosclerosis.2017.10.009. Epub 2017 Oct 7.


Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L.

Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul.


cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer.

Cozzo AJ, Sundaram S, Zattra O, Qin Y, Freemerman AJ, Essaid L, Darr DB, Montgomery SA, McNaughton KK, Ezzell JA, Galanko JA, Troester MA, Makowski L.

Springerplus. 2016 Mar 19;5:348. doi: 10.1186/s40064-016-1920-3. eCollection 2016.


Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice.

Sundaram S, Freemerman AJ, Galanko JA, McNaughton KK, Bendt KM, Darr DB, Troester MA, Makowski L.

PLoS One. 2014 Oct 29;9(10):e111394. doi: 10.1371/journal.pone.0111394. eCollection 2014.


Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression.

Sundaram S, Le TL, Essaid L, Freemerman AJ, Huang MJ, Galanko JA, McNaughton KK, Bendt KM, Darr DB, Troester MA, Makowski L.

Front Oncol. 2014 Jul 8;4:175. doi: 10.3389/fonc.2014.00175. eCollection 2014.


Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype.

Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, Macintyre AN, Goraksha-Hicks P, Rathmell JC, Makowski L.

J Biol Chem. 2014 Mar 14;289(11):7884-96. doi: 10.1074/jbc.M113.522037. Epub 2014 Feb 3.


Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer.

Sundaram S, Freemerman AJ, Johnson AR, Milner JJ, McNaughton KK, Galanko JA, Bendt KM, Darr DB, Perou CM, Troester MA, Makowski L.

Breast Cancer Res Treat. 2013 Dec;142(3):489-503. doi: 10.1007/s10549-013-2741-5. Epub 2013 Nov 12.


Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer.

Brauer HA, Makowski L, Hoadley KA, Casbas-Hernandez P, Lang LJ, Romàn-Pèrez E, D'Arcy M, Freemerman AJ, Perou CM, Troester MA.

Clin Cancer Res. 2013 Feb 1;19(3):571-85. doi: 10.1158/1078-0432.CCR-12-2123. Epub 2012 Dec 12.


Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.

Bhatt AP, Jacobs SR, Freemerman AJ, Makowski L, Rathmell JC, Dittmer DP, Damania B.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11818-23. doi: 10.1073/pnas.1205995109. Epub 2012 Jun 29.


Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation.

Sampey BP, Freemerman AJ, Zhang J, Kuan PF, Galanko JA, O'Connell TM, Ilkayeva OR, Muehlbauer MJ, Stevens RD, Newgard CB, Brauer HA, Troester MA, Makowski L.

PLoS One. 2012;7(6):e38812. doi: 10.1371/journal.pone.0038812. Epub 2012 Jun 12.


High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma.

Ang MK, Patel MR, Yin XY, Sundaram S, Fritchie K, Zhao N, Liu Y, Freemerman AJ, Wilkerson MD, Walter V, Weissler MC, Shockley WW, Couch ME, Zanation AM, Hackman T, Chera BS, Harris SL, Miller CR, Thorne LB, Hayward MC, Funkhouser WK, Olshan AF, Shores CG, Makowski L, Hayes DN.

Clin Cancer Res. 2011 Oct 15;17(20):6542-52. doi: 10.1158/1078-0432.CCR-10-1604. Epub 2011 Sep 9.


Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet.

Sampey BP, Vanhoose AM, Winfield HM, Freemerman AJ, Muehlbauer MJ, Fueger PT, Newgard CB, Makowski L.

Obesity (Silver Spring). 2011 Jun;19(6):1109-17. doi: 10.1038/oby.2011.18. Epub 2011 Feb 17.


RET activation inhibits doxorubicin-induced apoptosis in SK-N-MC cells.

Skinner MA, Lackey KE, Freemerman AJ.

Anticancer Res. 2008 Jul-Aug;28(4B):2019-25.


Renal aplasia in humans is associated with RET mutations.

Skinner MA, Safford SD, Reeves JG, Jackson ME, Freemerman AJ.

Am J Hum Genet. 2008 Feb;82(2):344-51. doi: 10.1016/j.ajhg.2007.10.008. Epub 2008 Jan 31.


The discovery of substituted 4-(3-hydroxyanilino)-quinolines as potent RET kinase inhibitors.

Graham Robinett R, Freemerman AJ, Skinner MA, Shewchuk L, Lackey K.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5886-93. Epub 2007 Aug 25.


Superparamagnetic iron oxide labeling and transplantation of adipose-derived stem cells in middle cerebral artery occlusion-injured mice.

Rice HE, Hsu EW, Sheng H, Evenson DA, Freemerman AJ, Safford KM, Provenzale JM, Warner DS, Johnson GA.

AJR Am J Roentgenol. 2007 Apr;188(4):1101-8.


Longitudinal mechanical tension induces growth in the small bowel of juvenile rats.

Safford SD, Freemerman AJ, Safford KM, Bentley R, Skinner MA.

Gut. 2005 Aug;54(8):1085-90. Epub 2005 Apr 19.


Decreased E-cadherin expression correlates with higher stage of Wilms' tumors.

Safford SD, Freemerman AJ, Langdon S, Bentley R, Goyeau D, Grundy PE, Skinner MA.

J Pediatr Surg. 2005 Feb;40(2):341-8.


RET tyrosine kinase and medullary thyroid cells are unaffected by clinical doses of STI571.

Skinner MA, Safford SD, Freemerman AJ.

Anticancer Res. 2003 Sep-Oct;23(5A):3601-6.


Fine mapping of Wilms' tumors with 16q loss of heterozygosity localizes the putative tumor suppressor gene to a region of 6.7 megabases.

Safford SD, Goyeau D, Freemerman AJ, Bentley R, Everett ML, Grundy PE, Skinner MA.

Ann Surg Oncol. 2003 Mar;10(2):136-43.


A redox-inactive thioredoxin reduces growth and enhances apoptosis in WEHI7.2 cells.

Freemerman AJ, Powis G.

Biochem Biophys Res Commun. 2000 Jul 21;274(1):136-41.


Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine.

Jarvis WD, Fornari FA Jr, Auer KL, Freemerman AJ, Szabo E, Birrer MJ, Johnson CR, Barbour SE, Dent P, Grant S.

Mol Pharmacol. 1997 Dec;52(6):935-47.


Agents that down-regulate or inhibit protein kinase C circumvent resistance to 1-beta-D-arabinofuranosylcytosine-induced apoptosis in human leukemia cells that overexpress Bcl-2.

Wang S, Vrana JA, Bartimole TM, Freemerman AJ, Jarvis WD, Kramer LB, Krystal G, Dent P, Grant S.

Mol Pharmacol. 1997 Dec;52(6):1000-9.


Effects of antisense p21 (WAF1/CIP1/MDA6) expression on the induction of differentiation and drug-mediated apoptosis in human myeloid leukemia cells (HL-60).

Freemerman AJ, Vrana JA, Tombes RM, Jiang H, Chellappan SP, Fisher PB, Grant S.

Leukemia. 1997 Apr;11(4):504-13.


Effect of AS101 on bryostatin 1-mediated differentiation induction, cell cycle arrest, and modulation of drug-induced apoptosis in human myeloid leukemia cells.

Rao AS, Freemerman AJ, Jarvis WD, Chelliah J, Bear HD, Mikkelsen R, Grant S.

Leukemia. 1996 Jul;10(7):1150-8.


Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and differentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67).

Grant S, Freemerman AJ, Birrer MJ, Martin HA, Turner AJ, Szabo E, Chelliah J, Jarvis WD.

Cell Growth Differ. 1996 May;7(5):603-13.


Role of c-jun in human myeloid leukemia cell apoptosis induced by pharmacological inhibitors of protein kinase C.

Freemerman AJ, Turner AJ, Birrer MJ, Szabo E, Valerie K, Grant S.

Mol Pharmacol. 1996 May;49(5):788-95.


Characterization of alternatively spliced human SP-10 mRNAs.

Freemerman AJ, Flickinger CJ, Herr JC.

Mol Reprod Dev. 1995 May;41(1):100-8.


Induction of apoptotic DNA fragmentation and c-jun downregulation in human myeloid leukemia cells by the permeant Ca2+ chelator BAPTA/AM.

Grant S, Freemerman AJ, Gregory PC, Martin HA, Turner AJ, Mikkelsen R, Chelliah J, Yanovich S, Jarvis WD.

Oncol Res. 1995;7(7-8):381-92.


Vitronectin is an intrinsic protein of human spermatozoa released during the acrosome reaction.

Fusi FM, Lorenzetti I, Mangili F, Herr JC, Freemerman AJ, Gailit J, Bronson RA.

Mol Reprod Dev. 1994 Nov;39(3):337-43.


Tissue specificity of the acrosomal protein SP-10: a contraceptive vaccine candidate molecule.

Freemerman AJ, Wright RM, Flickinger CJ, Herr JC.

Biol Reprod. 1994 Mar;50(3):615-21.


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