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Interpretation of results of pooled analysis of individual patient data.

Freemantle N, Pagano D.

Lancet. 2018 Sep 8;392(10150):817. doi: 10.1016/S0140-6736(18)31786-0. No abstract available.


Recruitment and retention strategies in mental health trials - A systematic review.

Liu Y, Pencheon E, Hunter RM, Moncrieff J, Freemantle N.

PLoS One. 2018 Aug 29;13(8):e0203127. doi: 10.1371/journal.pone.0203127. eCollection 2018.


Statistical Primer: heterogeneity, random- or fixed-effects model analyses?

Barili F, Parolari A, Kappetein PA, Freemantle N.

Interact Cardiovasc Thorac Surg. 2018 Sep 1;27(3):317-321. doi: 10.1093/icvts/ivy163.


Predicting health-related quality of life (EQ-5D-5 L) and capability wellbeing (ICECAP-A) in the context of opiate dependence using routine clinical outcome measures: CORE-OM, LDQ and TOP.

Peak J, Goranitis I, Day E, Copello A, Freemantle N, Frew E.

Health Qual Life Outcomes. 2018 May 30;16(1):106. doi: 10.1186/s12955-018-0926-7.


Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results?

Freemantle N, Pagano D.

Eur J Cardiothorac Surg. 2018 Jun 1;53(6):1108-1111. doi: 10.1093/ejcts/ezy120. No abstract available.


Self-sampling kits to increase HIV testing among black Africans in the UK: the HAUS mixed-methods study.

Seguin M, Dodds C, Mugweni E, McDaid L, Flowers P, Wayal S, Zomer E, Weatherburn P, Fakoya I, Hartney T, McDonagh L, Hunter R, Young I, Khan S, Freemantle N, Chwaula J, Sachikonye M, Anderson J, Singh S, Nastouli E, Rait G, Burns F.

Health Technol Assess. 2018 Apr;22(22):1-158. doi: 10.3310/hta22220.


On the pooling and subgrouping of data from percutaneous coronary intervention versus coronary artery bypass grafting trials: a call to circumspection.

Freemantle N, Ruel M, Gaudino MFL, Pagano D.

Eur J Cardiothorac Surg. 2018 May 1;53(5):915-918. doi: 10.1093/ejcts/ezy140. No abstract available.


Lived experiences of negative symptoms in first-episode psychosis: A qualitative secondary analysis.

Gee B, Hodgekins J, Lavis A, Notley C, Birchwood M, Everard L, Freemantle N, Jones PB, Singh SP, Amos T, Marshall M, Sharma V, Smith J, Fowler D.

Early Interv Psychiatry. 2018 Mar 24. doi: 10.1111/eip.12558. [Epub ahead of print]


A double-blind, randomised, placebo-controlled, cross-over study assessing the use of XEN-D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-beat monitoring of drug efficacy.

Shunmugam SR, Sugihara C, Freemantle N, Round P, Furniss S, Sulke N.

J Interv Card Electrophysiol. 2018 Apr;51(3):191-197. doi: 10.1007/s10840-018-0318-2. Epub 2018 Feb 19.


A pilot feasibility randomised controlled trial of an adjunct brief social network intervention in opiate substitution treatment services.

Day E, Copello A, Seddon JL, Christie M, Bamber D, Powell C, Bennett C, Akhtar S, George S, Ball A, Frew E, Goranitis I, Freemantle N.

BMC Psychiatry. 2018 Jan 15;18(1):8. doi: 10.1186/s12888-018-1600-7.


Social recovery therapy in combination with early intervention services for enhancement of social recovery in patients with first-episode psychosis (SUPEREDEN3): a single-blind, randomised controlled trial.

Fowler D, Hodgekins J, French P, Marshall M, Freemantle N, McCrone P, Everard L, Lavis A, Jones PB, Amos T, Singh S, Sharma V, Birchwood M.

Lancet Psychiatry. 2018 Jan;5(1):41-50. doi: 10.1016/S2215-0366(17)30476-5. Epub 2017 Dec 11.


Clinical correlates of hypoglycaemia over 4 years in people with type 2 diabetes starting insulin: An analysis from the CREDIT study.

Home P, Calvi-Gries F, Blonde L, Pilorget V, Berlingieri J, Freemantle N.

Diabetes Obes Metab. 2018 Apr;20(4):921-929. doi: 10.1111/dom.13179. Epub 2018 Jan 7.


Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website: cost-effectiveness analysis.

Hunter R, Wallace P, Struzzo P, Vedova RD, Scafuri F, Tersar C, Lygidakis C, McGregor R, Scafato E, Freemantle N.

BMJ Open. 2017 Nov 3;7(11):e014577. doi: 10.1136/bmjopen-2016-014577.


Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website.

Wallace P, Struzzo P, Della Vedova R, Scafuri F, Tersar C, Lygidakis C, McGregor R, Scafato E, Hunter R, Freemantle N.

BMJ Open. 2017 Nov 3;7(11):e014576. doi: 10.1136/bmjopen-2016-014576.


Reply to Kalra et al.

Barili F, Freemantle N, Folliguet T, Parolari A.

Eur J Cardiothorac Surg. 2017 Sep 14. doi: 10.1093/ejcts/ezx323. [Epub ahead of print] No abstract available.


Cost-effectiveness of early intervention services for psychosis and fidelity to national policy implementation guidance.

Radhakrishnan M, McCrone P, Lafortune L, Everard L, Fowler D, Amos T, Freemantle N, Singh SP, Marshall M, Sharma V, Lavis A, Jones PB, Birchwood M.

Early Interv Psychiatry. 2018 Aug;12(4):747-756. doi: 10.1111/eip.12481. Epub 2017 Aug 31.


Ophthalmic statistics note 12: multivariable or multivariate: what's in a name?

Bunce C, Czanner G, Grzeda MT, Doré CJ, Freemantle N.

Br J Ophthalmol. 2017 Oct;101(10):1303-1305. doi: 10.1136/bjophthalmol-2017-310846. Epub 2017 Aug 16. No abstract available.


Beliefs about hypertension among Nigerian immigrants to the United Kingdom: A qualitative study.

Akinlua JT, Meakin R, Freemantle N.

PLoS One. 2017 Jul 27;12(7):e0181909. doi: 10.1371/journal.pone.0181909. eCollection 2017.


The flaws in the detail of an observational study on transcatheter aortic valve implantation versus surgical aortic valve replacement in intermediate-risks patients.

Barili F, Freemantle N, Folliguet T, Muneretto C, De Bonis M, Czerny M, Obadia JF, Al-Attar N, Bonaros N, Kluin J, Lorusso R, Punjabi P, Sadaba R, Suwalski P, Benedetto U, Böning A, Falk V, Sousa-Uva M, Kappetein PA, Menicanti L.

Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1031-1035. doi: 10.1093/ejcts/ezx058.


Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial.

Titre-Johnson S, Schoeler N, Eltze C, Williams R, Vezyroglou K, McCullagh H, Freemantle N, Heales S, Kneen R, Marston L, Martland T, Nazareth I, Neal E, Lux A, Parker A, Agrawal S, Fallon P, Cross JH.

Trials. 2017 Apr 26;18(1):195. doi: 10.1186/s13063-017-1918-3.


The Men's Safer Sex Trial: A feasibility randomised controlled trial of an interactive digital intervention to increase condom use in men.

Bailey JV, Webster R, Griffin M, Freemantle N, Hunter R, Rait G, Estcourt C, Anderson J, Gerressu M, Stephenson J, Michie S, Murray E.

Digit Health. 2016 Nov 22;2:2055207616679002. doi: 10.1177/2055207616679002. eCollection 2016 Jan-Dec.


Maximizing Health or Sufficient Capability in Economic Evaluation? A Methodological Experiment of Treatment for Drug Addiction.

Goranitis I, Coast J, Day E, Copello A, Freemantle N, Frew E.

Med Decis Making. 2017 Jul;37(5):498-511. doi: 10.1177/0272989X16678844. Epub 2016 Nov 19.


Ophthalmic statistics note 11: logistic regression.

Stephenson J, Bunce C, Doré CJ, Freemantle N; Ophthalmic Statistics Group.

Br J Ophthalmol. 2016 Dec;100(12):1594-1595. doi: 10.1136/bjophthalmol-2016-309223. Epub 2016 Nov 3. No abstract available.


Economic Evaluations of Pharmaceuticals Granted a Marketing Authorisation Without the Results of Randomised Trials: A Systematic Review and Taxonomy.

Hatswell AJ, Freemantle N, Baio G.

Pharmacoeconomics. 2017 Feb;35(2):163-176. doi: 10.1007/s40273-016-0460-6. Review.


Measuring Health and Broader Well-Being Benefits in the Context of Opiate Dependence: The Psychometric Performance of the ICECAP-A and the EQ-5D-5L.

Goranitis I, Coast J, Day E, Copello A, Freemantle N, Seddon J, Bennett C, Frew E.

Value Health. 2016 Sep - Oct;19(6):820-828. doi: 10.1016/j.jval.2016.04.010. Epub 2016 Jun 9.


Vaccination planning in Italy: increasing vaccines while reducing coverage?

Garattini L, Curto A, Freemantle N.

Expert Rev Pharmacoecon Outcomes Res. 2016 Oct;16(5):547-548. Epub 2016 Jul 29. No abstract available.


Ophthalmic statistics note 10: data transformations.

Bunce C, Stephenson J, Doré CJ, Freemantle N; Ophthalmic Statistics Group.

Br J Ophthalmol. 2016 Dec;100(12):1591-1593. doi: 10.1136/bjophthalmol-2016-308824. Epub 2016 Jul 18. No abstract available.


Regulatory approval of pharmaceuticals without a randomised controlled study: analysis of EMA and FDA approvals 1999-2014.

Hatswell AJ, Baio G, Berlin JA, Irs A, Freemantle N.

BMJ Open. 2016 Jun 30;6(6):e011666. doi: 10.1136/bmjopen-2016-011666.


Challenges, solutions and future directions in the evaluation of service innovations in health care and public health.

Raine R, Fitzpatrick R, Barratt H, Bevan G, Black N, Boaden R, Bower P, Campbell M, Denis JL, Devers K, Dixon-Woods M, Fallowfield L, Forder J, Foy R, Freemantle N, Fulop NJ, Gibbons E, Gillies C, Goulding L, Grieve R, Grimshaw J, Howarth E, Lilford RJ, McDonald R, Moore G, Moore L, Newhouse R, O’Cathain A, Or Z, Papoutsi C, Prady S, Rycroft-Malone J, Sekhon J, Turner S, Watson SI, Zwarenstein M.

Southampton (UK): NIHR Journals Library; 2016 May.


Pursuit of truly independent data monitoring committees in research.

Marston L, McKenzie DR, Freemantle N.

BMJ. 2016 May 12;353:i2309. doi: 10.1136/bmj.i2309. No abstract available.


Beliefs of Health Care Providers, Lay Health Care Providers and Lay Persons in Nigeria Regarding Hypertension. A Systematic Mixed Studies Review.

Akinlua JT, Meakin R, Fadahunsi P, Freemantle N.

PLoS One. 2016 May 5;11(5):e0154287. doi: 10.1371/journal.pone.0154287. eCollection 2016. Review.


Don't turn your back on the symptoms of psychosis: the results of a proof-of-principle, quasi-experimental intervention to reduce duration of untreated psychosis.

Connor C, Birchwood M, Freemantle N, Palmer C, Channa S, Barker C, Patterson P, Singh S.

BMC Psychiatry. 2016 May 4;16:127. doi: 10.1186/s12888-016-0816-7.


The course of negative symptom in first episode psychosis and the relationship with social recovery.

Gee B, Hodgekins J, Fowler D, Marshall M, Everard L, Lester H, Jones PB, Amos T, P Singh S, Sharma V, Freemantle N, Birchwood M.

Schizophr Res. 2016 Jul;174(1-3):165-171. doi: 10.1016/j.schres.2016.04.017. Epub 2016 Apr 28.


Ophthalmic statistics note 9: parametric versus non-parametric methods for data analysis.

Skene SS, Bunce C, Freemantle N, Doré CJ; Ophthalmic Statistics Group.

Br J Ophthalmol. 2016 Jul;100(7):877-878. doi: 10.1136/bjophthalmol-2015-308252. Epub 2016 Apr 27. No abstract available.


BMI upon discharge from hospital and its relationship with survival: an observational study utilising linked patient records.

Freemantle N, Ray D, Falcaro M, McNulty D, Shallcross L, Wood J, Pagano D.

J R Soc Med. 2016 Apr 6. pii: 0141076816639047. [Epub ahead of print]


Risks and benefits of psychotropic medication in pregnancy: cohort studies based on UK electronic primary care health records.

Petersen I, McCrea RL, Sammon CJ, Osborn DP, Evans SJ, Cowen PJ, Freemantle N, Nazareth I.

Health Technol Assess. 2016 Mar;20(23):1-176. doi: 10.3310/hta20230. Review.


Results and lessons from the Spironolactone To Prevent Cardiovascular Events in Early Stage Chronic Kidney Disease (STOP-CKD) randomised controlled trial.

Ng KP, Jain P, Gill PS, Heer G, Townend JN, Freemantle N, Greenfield S, McManus RJ, Ferro CJ.

BMJ Open. 2016 Feb 25;6(2):e010519. doi: 10.1136/bmjopen-2015-010519.


Comparative assessment of onabotulinumtoxinA and mirabegron for overactive bladder: an indirect treatment comparison.

Freemantle N, Ginsberg DA, McCool R, Fleetwood K, Arber M, Khalaf K, Loveman C, Ni Q, Glanville J.

BMJ Open. 2016 Feb 23;6(2):e009122. doi: 10.1136/bmjopen-2015-009122.


Author's reply to Goldacre.

Freemantle N.

BMJ. 2016 Feb 17;352:i889. doi: 10.1136/bmj.i889. No abstract available.


Safety and efficacy of insulin glargine 300 u/mL compared with other basal insulin therapies in patients with type 2 diabetes mellitus: a network meta-analysis.

Freemantle N, Chou E, Frois C, Zhuo D, Lehmacher W, Vlajnic A, Wang H, Chung HW, Zhang Q, Wu E, Gerrits C.

BMJ Open. 2016 Feb 15;6(2):e009421. doi: 10.1136/bmjopen-2015-009421. Review.


Pharmaceutical Price Schemes in Europe: Time for a 'Continental' One?

Garattini L, Curto A, Freemantle N.

Pharmacoeconomics. 2016 May;34(5):423-6. doi: 10.1007/s40273-015-0377-5. No abstract available.


Ophthalmic statistics note 8: missing data--exploring the unknown.

Bunce C, Quartilho A, Freemantle N, Doré CJ; Ophthalmic Statistics Group.

Br J Ophthalmol. 2016 Mar;100(3):291-4. doi: 10.1136/bjophthalmol-2015-307821. Epub 2015 Dec 30. No abstract available.


IDegLira Versus Alternative Intensification Strategies in Patients with Type 2 Diabetes Inadequately Controlled on Basal Insulin Therapy.

Freemantle N, Mamdani M, Vilsbøll T, Kongsø JH, Kvist K, Bain SC.

Diabetes Ther. 2015 Dec;6(4):573-591. Epub 2015 Nov 18.


Ranolazine for the treatment of chronic stable angina: a cost-effectiveness analysis from the UK perspective.

Coleman CI, Freemantle N, Kohn CG.

BMJ Open. 2015 Nov 6;5(11):e008861. doi: 10.1136/bmjopen-2015-008861.


Cannabis Use Is Associated With Increased Psychotic Symptoms and Poorer Psychosocial Functioning in First-Episode Psychosis: A Report From the UK National EDEN Study.

Seddon JL, Birchwood M, Copello A, Everard L, Jones PB, Fowler D, Amos T, Freemantle N, Sharma V, Marshall M, Singh SP.

Schizophr Bull. 2016 May;42(3):619-25. doi: 10.1093/schbul/sbv154. Epub 2015 Nov 4.


National administrative data produces an accurate and stable risk prediction model for short-term and 1-year mortality following cardiac surgery.

Aktuerk D, McNulty D, Ray D, Begaj I, Howell N, Freemantle N, Pagano D.

Int J Cardiol. 2016 Jan 15;203:196-203. doi: 10.1016/j.ijcard.2015.10.086. Epub 2015 Oct 23.


OnabotulinumtoxinA in the treatment of overactive bladder: a cost-effectiveness analysis versus best supportive care in England and Wales.

Freemantle N, Khalaf K, Loveman C, Stanisic S, Gultyaev D, Lister J, Drake M.

Eur J Health Econ. 2016 Sep;17(7):911-21. doi: 10.1007/s10198-015-0737-2. Epub 2015 Oct 19.


The benefit of a remotely monitored implantable loop recorder as a first line investigation in unexplained syncope: the EaSyAS II trial.

Sulke N, Sugihara C, Hong P, Patel N, Freemantle N.

Europace. 2016 Jun;18(6):912-8. doi: 10.1093/europace/euv228. Epub 2015 Oct 12.


Current Prevalence Pattern of Hypertension in Nigeria: A Systematic Review.

Akinlua JT, Meakin R, Umar AM, Freemantle N.

PLoS One. 2015 Oct 13;10(10):e0140021. doi: 10.1371/journal.pone.0140021. eCollection 2015. Review.

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