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Comment on: 'Value-Based Pricing Alternatives for Personalised Drugs: Implications of Asymmetric Information and Competition'.

Garattini L, Freemantle N.

Appl Health Econ Health Policy. 2020 Feb 3. doi: 10.1007/s40258-020-00552-1. [Epub ahead of print] No abstract available.


Real-world outcomes of treatment with insulin glargine 300 U/mL versus standard-of-care in people with uncontrolled type 2 diabetes mellitus.

Freemantle N, Mauricio D, Giaccari A, Bailey T, Roussel R, Franco D, Berthou B, Pilorget V, Westerbacka J, Bosnyak Z, Bonnemaire M, Cali AMG, Nguyên-Pascal ML, Penfornis A, Perez-Maraver M, Seufert J, Sullivan SD, Wilding J, Wysham C, Davies M.

Curr Med Res Opin. 2020 Jan 19:1-11. doi: 10.1080/03007995.2019.1708287. [Epub ahead of print]


Comment on: 'NICE, in Confidence: An Assessment of Redaction to Obscure Confidential Information in Single Technology Appraisals by the National Institute for Health and Care Excellence'.

Garattini L, Freemantle N.

Pharmacoeconomics. 2020 Jan;38(1):121-122. doi: 10.1007/s40273-019-00875-5. No abstract available.


Randomised controlled trial of gradual antipsychotic reduction and discontinuation in people with schizophrenia and related disorders: the RADAR trial (Research into Antipsychotic Discontinuation and Reduction).

Moncrieff J, Lewis G, Freemantle N, Johnson S, Barnes TRE, Morant N, Pinfold V, Hunter R, Kent LJ, Smith R, Darton K, Horne R, Crellin NE, Cooper RE, Priebe S.

BMJ Open. 2019 Nov 27;9(11):e030912. doi: 10.1136/bmjopen-2019-030912.


Opportunities to reduce antibiotic prescribing for patients with COPD in primary care: a cohort study using electronic health records from the Clinical Practice Research Datalink (CPRD).

Rockenschaub P, Jhass A, Freemantle N, Aryee A, Rafiq M, Hayward A, Shallcross L.

J Antimicrob Chemother. 2020 Jan 1;75(1):243-251. doi: 10.1093/jac/dkz411.


Pharmacological treatments for generalised anxiety disorder - Authors' reply.

Freemantle N, Slee A, Nazareth I.

Lancet. 2019 Oct 5;394(10205):1230. doi: 10.1016/S0140-6736(19)31415-1. No abstract available.


A trial of three non-invasive blood pressure monitors compared with invasive blood pressure assessment in atrial fibrillation and sinus rhythm.

Eysenck W, Ammar A, Kanthasamy V, Freemantle N, Veasey RA, Patel NR, Furniss SS, Sulke N.

Int J Clin Pract. 2019 Aug 29:e13410. doi: 10.1111/ijcp.13410. [Epub ahead of print]


The hemodynamic effects of a central iliac arteriovenous anastomosis at 6 months in patients with resistant and uncontrolled hypertension.

Eysenck W, van Zalen J, Freemantle N, Lloyd G, Furniss S, Sulke N.

J Clin Hypertens (Greenwich). 2019 Sep;21(9):1399-1405. doi: 10.1111/jch.13646. Epub 2019 Jul 26.


Ophthalmic statistics note 13: method agreement studies in ophthalmology-please don't carry on correlating….

Bunce C, Stratton IM, Elders A, Czanner G, Doré C, Freemantle N; Ophthalmic Statistics Group.

Br J Ophthalmol. 2019 Sep;103(9):1201-1203. doi: 10.1136/bjophthalmol-2018-313759. Epub 2019 Jul 18. No abstract available.


A randomised controlled trial assessing the use of citalopram, sertraline, fluoxetine and mirtazapine in preventing relapse in primary care patients who are taking long-term maintenance antidepressants (ANTLER: ANTidepressants to prevent reLapse in dEpRession): study protocol for a randomised controlled trial.

Duffy L, Bacon F, Clarke CS, Donkor Y, Freemantle N, Gilbody S, Hunter R, Kendrick T, Kessler D, King M, Lanham P, Lewis G, Mangin D, Marston L, Moore M, Nazareth I, Wiles N, Lewis G.

Trials. 2019 Jun 3;20(1):319. doi: 10.1186/s13063-019-3390-8.


Transcatheter versus surgical aortic valve replacement: what does the latest evidence tell us?

Freemantle N, Irs A, De Paulis R, Pagano D, Falk V, Beyersdorf F.

Eur J Cardiothorac Surg. 2019 Jul 1;56(1):7-9. doi: 10.1093/ejcts/ezz163. No abstract available.


Interpreting Comparisons Between Clinical Trials.

Lim HS, Freemantle N.

ASAIO J. 2019 Sep/Oct;65(7):e80. doi: 10.1097/MAT.0000000000000978. No abstract available.


Identifying cardiac surgery operations in hospital episode statistics administrative database, with an OPCS-based classification of procedures, validated against clinical data.

Bortolussi G, McNulty D, Waheed H, Mawhinney JA, Freemantle N, Pagano D.

BMJ Open. 2019 Mar 23;9(3):e023316. doi: 10.1136/bmjopen-2018-023316.


Comment on "a comparative effectiveness study of degludec and insulin glargine 300 U/mL in insulin-naïve patients with type 2 diabetes".

Freemantle N, Jourdan S.

Diabetes Obes Metab. 2019 Jul;21(7):1758-1759. doi: 10.1111/dom.13711. Epub 2019 Apr 11. No abstract available.


Factors associated with discontinuation of antidepressant treatment after a single prescription among patients aged 55 or over: evidence from English primary care.

Falcaro M, Ben-Shlomo Y, King M, Freemantle N, Walters K.

Soc Psychiatry Psychiatr Epidemiol. 2019 Dec;54(12):1545-1553. doi: 10.1007/s00127-019-01678-x. Epub 2019 Mar 19.


Evaluation of the efficacy and safety of sarilumab combination therapy in patients with rheumatoid arthritis with inadequate response to conventional disease-modifying antirheumatic drugs or tumour necrosis factor α inhibitors: systematic literature review and network meta-analyses.

Choy E, Freemantle N, Proudfoot C, Chen CI, Pollissard L, Kuznik A, Van Hoogstraten H, Mangan E, Carita P, Huynh TM.

RMD Open. 2019 Feb 18;5(1):e000798. doi: 10.1136/rmdopen-2018-000798. eCollection 2019.


Indirect Treatment Comparison of the Efficacy and Safety of Sarilumab Monotherapy in Rheumatoid Arthritis Patients with Inadequate Response to Conventional Disease-Modifying Antirheumatic Drugs.

Choy E, Freemantle N, Proudfoot C, Chen CI, Pollissard L, Kuznik A, van Hoogstraten H, Mangan E, Carita P, Huynh TM.

Adv Ther. 2019 Apr;36(4):817-827. doi: 10.1007/s12325-019-00912-x. Epub 2019 Mar 12.


Characteristics of non-randomised studies using comparisons with external controls submitted for regulatory approval in the USA and Europe: a systematic review.

Goring S, Taylor A, Müller K, Li TJJ, Korol EE, Levy AR, Freemantle N.

BMJ Open. 2019 Feb 27;9(2):e024895. doi: 10.1136/bmjopen-2018-024895.


The effect of atrial fibrillation intervention on nocturnal respiratory events in elderly patients with persistent AF.

Eysenck W, Sulke N, Freemantle N, Patel NR, Furniss SS, Veasey RA.

Clin Respir J. 2019 May;13(5):280-288. doi: 10.1111/crj.13008. Epub 2019 Apr 1.


A randomized trial evaluating the accuracy of AF detection by four external ambulatory ECG monitors compared to permanent pacemaker AF detection.

Eysenck W, Freemantle N, Sulke N.

J Interv Card Electrophysiol. 2019 Feb 11. doi: 10.1007/s10840-019-00515-0. [Epub ahead of print]


Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis.

Slee A, Nazareth I, Bondaronek P, Liu Y, Cheng Z, Freemantle N.

Lancet. 2019 Feb 23;393(10173):768-777. doi: 10.1016/S0140-6736(18)31793-8. Epub 2019 Jan 31. Erratum in: Lancet. 2019 Apr 27;393(10182):1698.


Beliefs about hypertension among primary health care workers and clients in Nigeria: A qualitative study.

Akinlua JT, Meakin R, Bashir I, Freemantle N.

PLoS One. 2018 Dec 19;13(12):e0209334. doi: 10.1371/journal.pone.0209334. eCollection 2018.


Myocardial Revascularization Trials.

Ruel M, Falk V, Farkouh ME, Freemantle N, Gaudino MF, Glineur D, Cameron DE, Taggart DP.

Circulation. 2018 Dec 18;138(25):2943-2951. doi: 10.1161/CIRCULATIONAHA.118.035970. Review.


Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension and paroxysmal AF.

Eysenck W, van Zalen J, Freemantle N, Lloyd G, Furniss S, Sulke N.

Am Heart J. 2019 Jan;207:86-87. doi: 10.1016/j.ahj.2018.09.010. Epub 2018 Sep 29.


32nd EACTS Annual Meeting clinical trials update: ART, IMPAG, MITRA-FR and COAPT.

Freemantle N, Milojevic M, Lim S, Fremes S, Pagano D.

Eur J Cardiothorac Surg. 2019 Feb 1;55(2):186-190. doi: 10.1093/ejcts/ezy396. No abstract available.


Development and clinimetric assessment of a nurse-administered screening tool for movement disorders in psychosis.

Balint B, Killaspy H, Marston L, Barnes T, Latorre A, Joyce E, Clarke CS, De Micco R, Edwards MJ, Erro R, Foltynie T, Hunter RM, Nolan F, Schrag A, Freemantle N, Foreshaw Y, Green N, Bhatia KP, Martino D.

BJPsych Open. 2018 Sep 27;4(5):404-410. doi: 10.1192/bjo.2018.55. eCollection 2018 Sep.


Interpretation of results of pooled analysis of individual patient data.

Freemantle N, Pagano D.

Lancet. 2018 Sep 8;392(10150):817. doi: 10.1016/S0140-6736(18)31786-0. No abstract available.


Short-term outcome of first episode delusional disorder in an early intervention population.

Rowland T, Birchwood M, Singh S, Freemantle N, Everard L, Jones P, Fowler D, Amos T, Marshall M, Sharma V, Thompson A.

Schizophr Res. 2019 Feb;204:72-79. doi: 10.1016/j.schres.2018.08.036. Epub 2018 Sep 6.


Recruitment and retention strategies in mental health trials - A systematic review.

Liu Y, Pencheon E, Hunter RM, Moncrieff J, Freemantle N.

PLoS One. 2018 Aug 29;13(8):e0203127. doi: 10.1371/journal.pone.0203127. eCollection 2018.


Statistical Primer: heterogeneity, random- or fixed-effects model analyses?

Barili F, Parolari A, Kappetein PA, Freemantle N.

Interact Cardiovasc Thorac Surg. 2018 Sep 1;27(3):317-321. doi: 10.1093/icvts/ivy163.


Predicting health-related quality of life (EQ-5D-5 L) and capability wellbeing (ICECAP-A) in the context of opiate dependence using routine clinical outcome measures: CORE-OM, LDQ and TOP.

Peak J, Goranitis I, Day E, Copello A, Freemantle N, Frew E.

Health Qual Life Outcomes. 2018 May 30;16(1):106. doi: 10.1186/s12955-018-0926-7.


Randomized trials and propensity score analyses in transcatheter aortic valve replacement: how should we interpret the results?

Freemantle N, Pagano D.

Eur J Cardiothorac Surg. 2018 Jun 1;53(6):1108-1111. doi: 10.1093/ejcts/ezy120. No abstract available.


Self-sampling kits to increase HIV testing among black Africans in the UK: the HAUS mixed-methods study.

Seguin M, Dodds C, Mugweni E, McDaid L, Flowers P, Wayal S, Zomer E, Weatherburn P, Fakoya I, Hartney T, McDonagh L, Hunter R, Young I, Khan S, Freemantle N, Chwaula J, Sachikonye M, Anderson J, Singh S, Nastouli E, Rait G, Burns F.

Health Technol Assess. 2018 Apr;22(22):1-158. doi: 10.3310/hta22220.


On the pooling and subgrouping of data from percutaneous coronary intervention versus coronary artery bypass grafting trials: a call to circumspection.

Freemantle N, Ruel M, Gaudino MFL, Pagano D.

Eur J Cardiothorac Surg. 2018 May 1;53(5):915-918. doi: 10.1093/ejcts/ezy140. No abstract available.


Lived experiences of negative symptoms in first-episode psychosis: A qualitative secondary analysis.

Gee B, Hodgekins J, Lavis A, Notley C, Birchwood M, Everard L, Freemantle N, Jones PB, Singh SP, Amos T, Marshall M, Sharma V, Smith J, Fowler D.

Early Interv Psychiatry. 2019 Aug;13(4):773-779. doi: 10.1111/eip.12558. Epub 2018 Mar 24.


A double-blind, randomised, placebo-controlled, cross-over study assessing the use of XEN-D0103 in patients with paroxysmal atrial fibrillation and implanted pacemakers allowing continuous beat-to-beat monitoring of drug efficacy.

Shunmugam SR, Sugihara C, Freemantle N, Round P, Furniss S, Sulke N.

J Interv Card Electrophysiol. 2018 Apr;51(3):191-197. doi: 10.1007/s10840-018-0318-2. Epub 2018 Feb 19.


A pilot feasibility randomised controlled trial of an adjunct brief social network intervention in opiate substitution treatment services.

Day E, Copello A, Seddon JL, Christie M, Bamber D, Powell C, Bennett C, Akhtar S, George S, Ball A, Frew E, Goranitis I, Freemantle N.

BMC Psychiatry. 2018 Jan 15;18(1):8. doi: 10.1186/s12888-018-1600-7.


Social recovery therapy in combination with early intervention services for enhancement of social recovery in patients with first-episode psychosis (SUPEREDEN3): a single-blind, randomised controlled trial.

Fowler D, Hodgekins J, French P, Marshall M, Freemantle N, McCrone P, Everard L, Lavis A, Jones PB, Amos T, Singh S, Sharma V, Birchwood M.

Lancet Psychiatry. 2018 Jan;5(1):41-50. doi: 10.1016/S2215-0366(17)30476-5. Epub 2017 Dec 11.


Clinical correlates of hypoglycaemia over 4 years in people with type 2 diabetes starting insulin: An analysis from the CREDIT study.

Home P, Calvi-Gries F, Blonde L, Pilorget V, Berlingieri J, Freemantle N.

Diabetes Obes Metab. 2018 Apr;20(4):921-929. doi: 10.1111/dom.13179. Epub 2018 Jan 7.


Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website: cost-effectiveness analysis.

Hunter R, Wallace P, Struzzo P, Vedova RD, Scafuri F, Tersar C, Lygidakis C, McGregor R, Scafato E, Freemantle N.

BMJ Open. 2017 Nov 3;7(11):e014577. doi: 10.1136/bmjopen-2016-014577.


Randomised controlled non-inferiority trial of primary care-based facilitated access to an alcohol reduction website.

Wallace P, Struzzo P, Della Vedova R, Scafuri F, Tersar C, Lygidakis C, McGregor R, Scafato E, Hunter R, Freemantle N.

BMJ Open. 2017 Nov 3;7(11):e014576. doi: 10.1136/bmjopen-2016-014576.


Sociodemographic inequalities in the management of depression in adults aged 55 and over: an analysis of English primary care data.

Walters K, Falcaro M, Freemantle N, King M, Ben-Shlomo Y.

Psychol Med. 2018 Jul;48(9):1504-1513. doi: 10.1017/S0033291717003014. Epub 2017 Oct 11.


Reply to Kalra et al.

Barili F, Freemantle N, Folliguet T, Parolari A.

Eur J Cardiothorac Surg. 2018 Feb 1;53(2):486-487. doi: 10.1093/ejcts/ezx323. No abstract available.


Cost-effectiveness of early intervention services for psychosis and fidelity to national policy implementation guidance.

Radhakrishnan M, McCrone P, Lafortune L, Everard L, Fowler D, Amos T, Freemantle N, Singh SP, Marshall M, Sharma V, Lavis A, Jones PB, Birchwood M.

Early Interv Psychiatry. 2018 Aug;12(4):747-756. doi: 10.1111/eip.12481. Epub 2017 Aug 31.


Ophthalmic statistics note 12: multivariable or multivariate: what's in a name?

Bunce C, Czanner G, Grzeda MT, Doré CJ, Freemantle N.

Br J Ophthalmol. 2017 Oct;101(10):1303-1305. doi: 10.1136/bjophthalmol-2017-310846. Epub 2017 Aug 16. No abstract available.


Beliefs about hypertension among Nigerian immigrants to the United Kingdom: A qualitative study.

Akinlua JT, Meakin R, Freemantle N.

PLoS One. 2017 Jul 27;12(7):e0181909. doi: 10.1371/journal.pone.0181909. eCollection 2017.


The flaws in the detail of an observational study on transcatheter aortic valve implantation versus surgical aortic valve replacement in intermediate-risks patients.

Barili F, Freemantle N, Folliguet T, Muneretto C, De Bonis M, Czerny M, Obadia JF, Al-Attar N, Bonaros N, Kluin J, Lorusso R, Punjabi P, Sadaba R, Suwalski P, Benedetto U, Böning A, Falk V, Sousa-Uva M, Kappetein PA, Menicanti L.

Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1031-1035. doi: 10.1093/ejcts/ezx058.


Ketogenic diet in the treatment of epilepsy in children under the age of 2 years: study protocol for a randomised controlled trial.

Titre-Johnson S, Schoeler N, Eltze C, Williams R, Vezyroglou K, McCullagh H, Freemantle N, Heales S, Kneen R, Marston L, Martland T, Nazareth I, Neal E, Lux A, Parker A, Agrawal S, Fallon P, Cross JH.

Trials. 2017 Apr 26;18(1):195. doi: 10.1186/s13063-017-1918-3.


The Men's Safer Sex project: intervention development and feasibility randomised controlled trial of an interactive digital intervention to increase condom use in men.

Bailey JV, Webster R, Hunter R, Griffin M, Freemantle N, Rait G, Estcourt C, Michie S, Anderson J, Stephenson J, Gerressu M, Ang CS, Murray E.

Health Technol Assess. 2016 Dec;20(91):1-124.


The Men's Safer Sex Trial: A feasibility randomised controlled trial of an interactive digital intervention to increase condom use in men.

Bailey JV, Webster R, Griffin M, Freemantle N, Hunter R, Rait G, Estcourt C, Anderson J, Gerressu M, Stephenson J, Michie S, Murray E.

Digit Health. 2016 Nov 22;2:2055207616679002. doi: 10.1177/2055207616679002. eCollection 2016 Jan-Dec.

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