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Items: 1 to 50 of 82

1.

The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis.

Bellizzi MJ, Hammond JW, Li H, Gantz Marker MA, Marker DF, Freeman RS, Gelbard HA.

eNeuro. 2018 Dec 3;5(6). pii: ENEURO.0245-18.2018. doi: 10.1523/ENEURO.0245-18.2018. eCollection 2018 Nov-Dec.

2.

Dual phosphorylation of Ric-8A enhances its ability to mediate G protein α subunit folding and to stimulate guanine nucleotide exchange.

Papasergi-Scott MM, Stoveken HM, MacConnachie L, Chan PY, Gabay M, Wong D, Freeman RS, Beg AA, Tall GG.

Sci Signal. 2018 May 29;11(532). pii: eaap8113. doi: 10.1126/scisignal.aap8113.

3.

mTORC2/AKT/HSF1/HuR constitute a feed-forward loop regulating Rictor expression and tumor growth in glioblastoma.

Holmes B, Benavides-Serrato A, Freeman RS, Landon KA, Bashir T, Nishimura RN, Gera J.

Oncogene. 2018 Feb 8;37(6):732-743. doi: 10.1038/onc.2017.360. Epub 2017 Oct 23.

4.

JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT.

Neurobiol Dis. 2012 May;46(2):393-401. doi: 10.1016/j.nbd.2012.02.003. Epub 2012 Feb 14.

5.

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.

Guo H, Barrett TM, Zhong Z, Fernández JA, Griffin JH, Freeman RS, Zlokovic BV.

Mol Neurodegener. 2011 Feb 3;6:13. doi: 10.1186/1750-1326-6-13.

6.

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

Zhong Z, Wang Y, Guo H, Sagare A, Fernández JA, Bell RD, Barrett TM, Griffin JH, Freeman RS, Zlokovic BV.

J Neurosci. 2010 Nov 17;30(46):15521-34. doi: 10.1523/JNEUROSCI.4437-10.2010.

7.

Delayed adjustable sutures: a multicentred clinical review.

Robbins SL, Granet DB, Burns C, Freeman RS, Eustis HS, Yafai S, Cruz F, Danylyshyn-Adams K, Langham K.

Br J Ophthalmol. 2010 Sep;94(9):1169-73. doi: 10.1136/bjo.2009.169987. Epub 2010 Jun 24.

PMID:
20576786
8.

Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.

Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS.

Sci Signal. 2009 Jul 7;2(78):ra33. doi: 10.1126/scisignal.2000444.

9.

The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL).

Guo Y, Schoell MC, Freeman RS.

Oncogene. 2009 Apr 23;28(16):1864-74. doi: 10.1038/onc.2009.35. Epub 2009 Mar 23.

11.

Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.

Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I.

Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033.

12.

Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity.

Barone MC, Desouza LA, Freeman RS.

J Neurochem. 2008 Jul;106(2):734-45. doi: 10.1111/j.1471-4159.2008.05427.x. Epub 2008 Apr 14.

13.

Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation.

Lomb DJ, Straub JA, Freeman RS.

J Neurochem. 2007 Dec;103(5):1897-906. Epub 2007 Aug 30.

14.

EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability.

Fu J, Menzies K, Freeman RS, Taubman MB.

J Biol Chem. 2007 Apr 27;282(17):12410-8. Epub 2007 Mar 6.

15.

A shortcut to mitochondrial signaling and pathology: a commentary on "Nonenzymatic formation of succinate in mitochondria under oxidative stress".

Brookes PS, Freeman RS, Barone MC.

Free Radic Biol Med. 2006 Jul 1;41(1):41-5. Epub 2006 Apr 1. No abstract available.

PMID:
16781451
16.

Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB.

Clifton DR, Rydkina E, Huyck H, Pryhuber G, Freeman RS, Silverman DJ, Sahni SK.

Int J Med Microbiol. 2005 Aug;295(4):267-78.

PMID:
16128401
17.

Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer.

Lee S, Nakamura E, Yang H, Wei W, Linggi MS, Sajan MP, Farese RV, Freeman RS, Carter BD, Kaelin WG Jr, Schlisio S.

Cancer Cell. 2005 Aug;8(2):155-67.

18.
19.

Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders.

Freeman RS, Barone MC.

Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):85-92. Review.

PMID:
15723616
21.

Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities.

Farhana L, Dawson MI, Huang Y, Zhang Y, Rishi AK, Reddy KB, Freeman RS, Fontana JA.

Oncogene. 2004 Mar 11;23(10):1874-84.

PMID:
14981538
22.

NGF deprivation-induced gene expression: after ten years, where do we stand?

Freeman RS, Burch RL, Crowder RJ, Lomb DJ, Schoell MC, Straub JA, Xie L.

Prog Brain Res. 2004;146:111-26. Review.

PMID:
14699960
23.

SM-20, EGL-9, and the EGLN family of hypoxia-inducible factor prolyl hydroxylases.

Freeman RS, Hasbani DM, Lipscomb EA, Straub JA, Xie L.

Mol Cells. 2003 Aug 31;16(1):1-12. Review.

24.

Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons.

Besirli CG, Deckwerth TL, Crowder RJ, Freeman RS, Johnson EM Jr.

Cell Death Differ. 2003 Sep;10(9):1045-58.

25.

Flowering phenology and compensation for herbivory in Ipomopsis aggregata.

Freeman RS, Brody AK, Neefus CD.

Oecologia. 2003 Aug;136(3):394-401. Epub 2003 May 29.

PMID:
12783294
26.
27.

Angiotensin II's antiproliferative effects mediated through AT2-receptors depend on down-regulation of SM-20.

Wolf G, Harendza S, Schroeder R, Wenzel U, Zahner G, Butzmann U, Freeman RS, Stahl RA.

Lab Invest. 2002 Oct;82(10):1305-17.

28.
29.

Grand rounds #63: a case of a bilateral gaze limitation with diplopia for reading after two surgical procedures to treat a right medical rectus muscle paresis.

Kushner BJ, Hunter DG, Freeman RS, Cruz OA, Castanera de Molina A, Brodsky MC, Siatkowski RM.

Binocul Vis Strabismus Q. 2001;16(3):192-200. No abstract available.

PMID:
11511286
30.

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons.

Lipscomb EA, Sarmiere PD, Freeman RS.

J Biol Chem. 2001 Feb 16;276(7):5085-92. Epub 2000 Nov 1.

33.

Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons.

Lipscomb EA, Sarmiere PD, Crowder RJ, Freeman RS.

J Neurochem. 1999 Jul;73(1):429-32.

34.

Nerve growth factor-dependent activation of NF-kappaB contributes to survival of sympathetic neurons.

Maggirwar SB, Sarmiere PD, Dewhurst S, Freeman RS.

J Neurosci. 1998 Dec 15;18(24):10356-65.

36.

Cloudy lenses and issues: a pedigree of unoperated congenital cataracts.

Freeman RS, Rovick LP.

J Ophthalmic Nurs Technol. 1995 May-Jun;14(3):118-23.

PMID:
7616584
37.

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

Estus S, Zaks WJ, Freeman RS, Gruda M, Bravo R, Johnson EM Jr.

J Cell Biol. 1994 Dec;127(6 Pt 1):1717-27.

38.

Adult treatment with removal of all four permanent canines.

Freeman RS.

Am J Orthod Dentofacial Orthop. 1994 Nov;106(5):549-54.

PMID:
7977196
39.

Cloudy lenses and issues: a pedigree of unoperated congenital cataracts.

Freeman RS, Rovick LP.

J Pediatr Ophthalmol Strabismus. 1994 Sep-Oct;31(5):318-22.

PMID:
7837020
40.
41.

NGF deprivation and neuronal degeneration trigger altered beta-amyloid precursor protein gene expression in the rat superior cervical ganglia in vivo and in vitro.

Smith CJ, Johnson EM Jr, Osborne P, Freeman RS, Neveu I, Brachet P.

Brain Res Mol Brain Res. 1993 Mar;17(3-4):328-34.

PMID:
8510504
42.

Cell death genes in invertebrates and (maybe) vertebrates.

Freeman RS, Estus S, Horigome K, Johnson EM Jr.

Curr Opin Neurobiol. 1993 Feb;3(1):25-31. Review.

PMID:
8453285
44.

Protein kinases and protooncogenes: biochemical regulators of the eukaryotic cell cycle.

Freeman RS, Donoghue DJ.

Biochemistry. 1991 Mar 5;30(9):2293-302. Review. No abstract available.

PMID:
2001361
45.

Meiotic induction by Xenopus cyclin B is accelerated by coexpression with mosXe.

Freeman RS, Ballantyne SM, Donoghue DJ.

Mol Cell Biol. 1991 Mar;11(3):1713-7.

46.

Effects of the v-mos oncogene on Xenopus development: meiotic induction in oocytes and mitotic arrest in cleaving embryos.

Freeman RS, Kanki JP, Ballantyne SM, Pickham KM, Donoghue DJ.

J Cell Biol. 1990 Aug;111(2):533-41.

47.
48.

Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.

Freeman RS, Pickham KM, Kanki JP, Lee BA, Pena SV, Donoghue DJ.

Proc Natl Acad Sci U S A. 1989 Aug;86(15):5805-9.

49.

The use of part-time occlusion for early onset unilateral exotropia.

Freeman RS, Isenberg SJ.

J Pediatr Ophthalmol Strabismus. 1989 Mar-Apr;26(2):94-6.

PMID:
2709283
50.

Residual incomitant DVD following large bilateral superior rectus recession.

Freeman RS, Rosenbaum AL.

J Pediatr Ophthalmol Strabismus. 1989 Mar-Apr;26(2):76-80.

PMID:
2709280

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