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Items: 23

1.

Reporting practices of pharmacodynamic studies involving invasive research procedures in cancer trials.

Freeman GA, Kimmelman J, Dancey J, Monzon JG.

Br J Cancer. 2013 Aug 20;109(4):897-908. doi: 10.1038/bjc.2013.417. Epub 2013 Jul 25.

2.

Publication and reporting conduct for pharmacodynamic analyses of tumor tissue in early-phase oncology trials.

Freeman GA, Kimmelman J.

Clin Cancer Res. 2012 Dec 1;18(23):6478-84. doi: 10.1158/1078-0432.CCR-12-1384. Epub 2012 Aug 21.

3.

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1.

Tallant MD, Duan M, Freeman GA, Ferris RG, Edelstein MP, Kazmierski WM, Wheelan PJ.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1394-8. doi: 10.1016/j.bmcl.2011.01.030. Epub 2011 Jan 11.

PMID:
21292480
4.

Electrocardiographic analysis during uninterrupted cardiopulmonary resuscitation.

Tan Q, Freeman GA, Geheb F, Bisera J.

Crit Care Med. 2008 Nov;36(11 Suppl):S409-12.

PMID:
20449902
5.

Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.

Romines KR, Freeman GA, Schaller LT, Cowan JR, Gonzales SS, Tidwell JH, Andrews CW 3rd, Stammers DK, Hazen RJ, Ferris RG, Short SA, Chan JH, Boone LR.

J Med Chem. 2006 Jan 26;49(2):727-39.

PMID:
16420058
6.

Anti-human immunodeficiency virus type 1 activity of the nonnucleoside reverse transcriptase inhibitor GW678248 in combination with other antiretrovirals against clinical isolate viruses and in vitro selection for resistance.

Hazen RJ, Harvey RJ, St Clair MH, Ferris RG, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Romines KR, Chan JH, Boone LR.

Antimicrob Agents Chemother. 2005 Nov;49(11):4465-73.

7.

Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

Allen SH, Johns BA, Gudmundsson KS, Freeman GA, Boyd FL Jr, Sexton CH, Selleseth DW, Creech KL, Moniri KR.

Bioorg Med Chem. 2006 Feb 15;14(4):944-54. Epub 2005 Oct 4.

PMID:
16213142
8.

Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.

Ferris RG, Hazen RJ, Roberts GB, St Clair MH, Chan JH, Romines KR, Freeman GA, Tidwell JH, Schaller LT, Cowan JR, Short SA, Weaver KL, Selleseth DW, Moniri KR, Boone LR.

Antimicrob Agents Chemother. 2005 Oct;49(10):4046-51.

9.

Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

Gudmundsson KS, Johns BA, Wang Z, Turner EM, Allen SH, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Moniri KR, Creech KL.

Bioorg Med Chem. 2005 Sep 15;13(18):5346-61.

PMID:
16039862
10.

Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.

Johns BA, Gudmundsson KS, Turner EM, Allen SH, Samano VA, Ray JA, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Creech KL, Moniri KR.

Bioorg Med Chem. 2005 Apr 1;13(7):2397-411.

PMID:
15755642
11.

Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.

Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH.

J Med Chem. 2004 Nov 18;47(24):5923-36.

PMID:
15537347
12.

Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.

Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW 3rd, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR.

J Med Chem. 2004 Feb 26;47(5):1175-82.

PMID:
14971897
13.
14.

Benzimidazole 2'-isonucleosides: design, synthesis, and antiviral activity of 2-substituted-5,6-dichlorobenzimidazole 2'-isonucleosides.

Freeman GA, Selleseth DW, Rideout JL, Harvey RJ.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):155-74.

PMID:
10772707
15.

Design, synthesis, and antiviral evaluation of 2-deoxy-D-ribosides of substituted benzimidazoles as potential agents for human cytomegalovirus infections.

Zou R, Kawashima E, Freeman GA, Koszalka GW, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2000 Jan-Feb;19(1-2):125-53.

PMID:
10772706
16.

Studies designed to increase the stability and antiviral activity (HCMV) of the active benzimidazole nucleoside, TCRB.

Townsend LB, Gudmundsson KS, Daluge SM, Chen JJ, Zhu Z, Koszalka GW, Boyd L, Chamberlain SD, Freeman GA, Biron KK, Drach JC.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):509-19.

PMID:
10432642
17.

DNA polymerase activity of hepatitis B virus particles: differential inhibition by L-enantiomers of nucleotide analogs.

Davis MG, Wilson JE, VanDraanen NA, Miller WH, Freeman GA, Daluge SM, Boyd FL, Aulabaugh AE, Painter GR, Boone LR.

Antiviral Res. 1996 May;30(2-3):133-45.

PMID:
8783805
18.

Synthesis and antiviral activity of 2'-deoxy-4'-thio purine nucleosides.

Van Draanen NA, Freeman GA, Short SA, Harvey R, Jansen R, Szczech G, Koszalka GW.

J Med Chem. 1996 Jan 19;39(2):538-42.

PMID:
8558524
19.

2-amino-9-(3-azido-2,3-dideoxy-beta-D-erythro-pentofuranosyl)-6-substituted-9H-purines: synthesis and anti-HIV activity.

Freeman GA, Shaver SR, Rideout JL, Short SA.

Bioorg Med Chem. 1995 Apr;3(4):447-58.

PMID:
8581428
20.

3'-Azido-3',5'-dideoxythymidine-5'-methylphosphonic acid diphosphate: synthesis and HIV-1 reverse transcriptase inhibition.

Freeman GA, Rideout JL, Miller WH, Reardon JE.

J Med Chem. 1992 Aug 21;35(17):3192-6.

PMID:
1380561
21.

Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U).

Elwell LP, Ferone R, Freeman GA, Fyfe JA, Hill JA, Ray PH, Richards CA, Singer SC, Knick VB, Rideout JL, et al.

Antimicrob Agents Chemother. 1987 Feb;31(2):274-80.

22.

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

Furman PA, Fyfe JA, St Clair MH, Weinhold K, Rideout JL, Freeman GA, Lehrman SN, Bolognesi DP, Broder S, Mitsuya H, et al.

Proc Natl Acad Sci U S A. 1986 Nov;83(21):8333-7.

23.

3'-Amino-2',3'-dideoxyribonucleosides of some pyrimidines: synthesis and biological activities.

Krenitsky TA, Freeman GA, Shaver SR, Beacham LM 3rd, Hurlbert S, Cohn NK, Elwell LP, Selway JW.

J Med Chem. 1983 Jun;26(6):891-5.

PMID:
6854592

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