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Items: 1 to 50 of 300

1.

Nitro-fatty acids: New drug candidates for chronic inflammatory and fibrotic diseases.

Schopfer FJ, Vitturi DA, Jorkasky DK, Freeman BA.

Nitric Oxide. 2018 Jun 23;79:31-37. doi: 10.1016/j.niox.2018.06.006. [Epub ahead of print] Review.

PMID:
29944935
2.

The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling.

Freeman BA, O'Donnell VB, Schopfer FJ.

Nitric Oxide. 2018 Jul 1;77:106-111. doi: 10.1016/j.niox.2018.05.002. Epub 2018 May 6. Review.

PMID:
29742447
3.

Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid.

Li S, Chang Z, Zhu T, Villacorta L, Li Y, Freeman BA, Chen YE, Zhang J.

Physiol Genomics. 2018 Apr 1;50(4):287-295. doi: 10.1152/physiolgenomics.00090.2017. Epub 2018 Feb 23.

PMID:
29473818
4.

In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation.

Villacorta L, Minarrieta L, Salvatore SR, Khoo NK, Rom O, Gao Z, Berman RC, Jobbagy S, Li L, Woodcock SR, Chen YE, Freeman BA, Ferreira AM, Schopfer FJ, Vitturi DA.

Redox Biol. 2018 May;15:522-531. doi: 10.1016/j.redox.2018.01.005. Epub 2018 Jan 12.

5.

Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships.

Khoo NKH, Li L, Salvatore SR, Schopfer FJ, Freeman BA.

Sci Rep. 2018 Feb 2;8(1):2295. doi: 10.1038/s41598-018-20460-8.

6.

Nitro-Oleic Acid (NO2-OA) Release Enhances Regional Angiogenesis in a Rat Abdominal Wall Defect Model.

D'Amore A, Fazzari M, Jiang HB, Luketich SK, Luketich ME, Hoff R, Jacobs DL, Gu X, Badylak SF, Freeman BA, Wagner WR.

Tissue Eng Part A. 2018 Jun;24(11-12):889-904. doi: 10.1089/ten.TEA.2017.0349. Epub 2018 Feb 27.

PMID:
29187125
7.

Nitro-fatty acid inhibition of triple-negative breast cancer cell viability, migration, invasion, and tumor growth.

Woodcock CC, Huang Y, Woodcock SR, Salvatore SR, Singh B, Golin-Bisello F, Davidson NE, Neumann CA, Freeman BA, Wendell SG.

J Biol Chem. 2018 Jan 26;293(4):1120-1137. doi: 10.1074/jbc.M117.814368. Epub 2017 Nov 20.

PMID:
29158255
8.

Topical electrophilic nitro-fatty acids potentiate cutaneous inflammation.

Mathers AR, Carey CD, Killeen ME, Salvatore SR, Ferris LK, Freeman BA, Schopfer FJ, Falo LD Jr.

Free Radic Biol Med. 2018 Feb 1;115:31-42. doi: 10.1016/j.freeradbiomed.2017.11.009. Epub 2017 Nov 10.

PMID:
29132974
9.

Conjugated Linoleic Acid Modulates Clinical Responses to Oral Nitrite and Nitrate.

Hughan KS, Wendell SG, Delmastro-Greenwood M, Helbling N, Corey C, Bellavia L, Potti G, Grimes G, Goodpaster B, Kim-Shapiro DB, Shiva S, Freeman BA, Gladwin MT.

Hypertension. 2017 Jul 24. pii: HYPERTENSIONAHA.117.09016. doi: 10.1161/HYPERTENSIONAHA.117.09016. [Epub ahead of print]

PMID:
28739973
10.

Nitro-oleic acid regulates growth factor-induced differentiation of bone marrow-derived macrophages.

Verescakova H, Ambrozova G, Kubala L, Perecko T, Koudelka A, Vasicek O, Rudolph TK, Klinke A, Woodcock SR, Freeman BA, Pekarova M.

Free Radic Biol Med. 2017 Mar;104:10-19. doi: 10.1016/j.freeradbiomed.2017.01.003. Epub 2017 Jan 4.

11.

Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health.

Koch CD, Gladwin MT, Freeman BA, Lundberg JO, Weitzberg E, Morris A.

Free Radic Biol Med. 2017 Apr;105:48-67. doi: 10.1016/j.freeradbiomed.2016.12.015. Epub 2016 Dec 16. Review.

12.

Nitro-fatty acid pharmacokinetics in the adipose tissue compartment.

Fazzari M, Khoo NK, Woodcock SR, Jorkasky DK, Li L, Schopfer FJ, Freeman BA.

J Lipid Res. 2017 Feb;58(2):375-385. doi: 10.1194/jlr.M072058. Epub 2016 Dec 2.

13.

Nitro-Oleic Acid Prevents Hypoxia- and Asymmetric Dimethylarginine-Induced Pulmonary Endothelial Dysfunction.

Koudelka A, Ambrozova G, Klinke A, Fidlerova T, Martiskova H, Kuchta R, Rudolph TK, Kadlec J, Kuchtova Z, Woodcock SR, Freeman BA, Kubala L, Pekarova M.

Cardiovasc Drugs Ther. 2016 Dec;30(6):579-586.

14.

Electrophilic nitro-fatty acids suppress allergic contact dermatitis in mice.

Mathers AR, Carey CD, Killeen ME, Diaz-Perez JA, Salvatore SR, Schopfer FJ, Freeman BA, Falo LD Jr.

Allergy. 2017 Apr;72(4):656-664. doi: 10.1111/all.13067. Epub 2016 Nov 11.

15.

Nitro-oleic acid inhibits vascular endothelial inflammatory responses and the endothelial-mesenchymal transition.

Ambrozova G, Fidlerova T, Verescakova H, Koudelka A, Rudolph TK, Woodcock SR, Freeman BA, Kubala L, Pekarova M.

Biochim Biophys Acta. 2016 Nov;1860(11 Pt A):2428-2437. doi: 10.1016/j.bbagen.2016.07.010. Epub 2016 Jul 16.

16.

Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling.

Zhou C, Ramaswamy SS, Johnson DE, Vitturi DA, Schopfer FJ, Freeman BA, Hudmon A, Levitan ES.

Sci Rep. 2016 Apr 15;6:23416. doi: 10.1038/srep23416.

17.

Electrophilic nitro-fatty acids prevent astrocyte-mediated toxicity to motor neurons in a cell model of familial amyotrophic lateral sclerosis via nuclear factor erythroid 2-related factor activation.

Diaz-Amarilla P, Miquel E, Trostchansky A, Trias E, Ferreira AM, Freeman BA, Cassina P, Barbeito L, Vargas MR, Rubbo H.

Free Radic Biol Med. 2016 Jun;95:112-20. doi: 10.1016/j.freeradbiomed.2016.03.013. Epub 2016 Mar 22.

18.

Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.

Villacorta L, Gao Z, Schopfer FJ, Freeman BA, Chen YE.

Front Biosci (Landmark Ed). 2016 Jan 1;21:873-89. Review.

19.

Nitro-oleic acid modulates classical and regulatory activation of macrophages and their involvement in pro-fibrotic responses.

Ambrozova G, Martiskova H, Koudelka A, Ravekes T, Rudolph TK, Klinke A, Rudolph V, Freeman BA, Woodcock SR, Kubala L, Pekarova M.

Free Radic Biol Med. 2016 Jan;90:252-260. doi: 10.1016/j.freeradbiomed.2015.11.026. Epub 2015 Nov 24.

20.

Nitrated fatty acids suppress angiotensin II-mediated fibrotic remodelling and atrial fibrillation.

Rudolph TK, Ravekes T, Klinke A, Friedrichs K, Mollenhauer M, Pekarova M, Ambrozova G, Martiskova H, Kaur JJ, Matthes B, Schwoerer A, Woodcock SR, Kubala L, Freeman BA, Baldus S, Rudolph V.

Cardiovasc Res. 2016 Jan 1;109(1):174-84. doi: 10.1093/cvr/cvv254. Epub 2015 Nov 23.

21.

Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes.

Delmastro-Greenwood M, Hughan KS, Vitturi DA, Salvatore SR, Grimes G, Potti G, Shiva S, Schopfer FJ, Gladwin MT, Freeman BA, Gelhaus Wendell S.

Free Radic Biol Med. 2015 Dec;89:333-41. doi: 10.1016/j.freeradbiomed.2015.07.149. Epub 2015 Sep 16.

22.

Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglycerides.

Fazzari M, Khoo N, Woodcock SR, Li L, Freeman BA, Schopfer FJ.

Free Radic Biol Med. 2015 Oct;87:113-24. doi: 10.1016/j.freeradbiomed.2015.05.033. Epub 2015 Jun 9.

23.

Convergence of biological nitration and nitrosation via symmetrical nitrous anhydride.

Vitturi DA, Minarrieta L, Salvatore SR, Postlethwait EM, Fazzari M, Ferrer-Sueta G, Lancaster JR Jr, Freeman BA, Schopfer FJ.

Nat Chem Biol. 2015 Jul;11(7):504-10. doi: 10.1038/nchembio.1814. Epub 2015 May 25.

24.

15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids.

Wendell SG, Golin-Bisello F, Wenzel S, Sobol RW, Holguin F, Freeman BA.

J Biol Chem. 2015 Feb 27;290(9):5868-80. doi: 10.1074/jbc.M114.635151. Epub 2015 Jan 12.

25.

15-Oxoeicosatetraenoic acid is a 15-hydroxyprostaglandin dehydrogenase-derived electrophilic mediator of inflammatory signaling pathways.

Snyder NW, Golin-Bisello F, Gao Y, Blair IA, Freeman BA, Wendell SG.

Chem Biol Interact. 2015 Jun 5;234:144-53. doi: 10.1016/j.cbi.2014.10.029. Epub 2014 Nov 4.

26.

Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons.

Zhang X, Beckel JM, Daugherty SL, Wang T, Woodcock SR, Freeman BA, de Groat WC.

J Physiol. 2014 Oct 1;592(19):4297-312. doi: 10.1113/jphysiol.2014.271783. Epub 2014 Aug 15.

27.

Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase.

Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8167-72. doi: 10.1073/pnas.1402965111. Epub 2014 May 19.

28.

Generation and dietary modulation of anti-inflammatory electrophilic omega-3 fatty acid derivatives.

Cipollina C, Salvatore SR, Muldoon MF, Freeman BA, Schopfer FJ.

PLoS One. 2014 Apr 15;9(4):e94836. doi: 10.1371/journal.pone.0094836. eCollection 2014.

29.

Nitro-oleic acid and epoxyoleic acid are not altered in obesity and type 2 diabetes: reply.

Schopfer FJ, Freeman BA, Khoo NK.

Cardiovasc Res. 2014 Jun 1;102(3):518. doi: 10.1093/cvr/cvu042. Epub 2014 Feb 21. No abstract available.

30.

Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertension.

Klinke A, Möller A, Pekarova M, Ravekes T, Friedrichs K, Berlin M, Scheu KM, Kubala L, Kolarova H, Ambrozova G, Schermuly RT, Woodcock SR, Freeman BA, Rosenkranz S, Baldus S, Rudolph V, Rudolph TK.

Am J Respir Cell Mol Biol. 2014 Jul;51(1):155-62. doi: 10.1165/rcmb.2013-0063OC.

31.

Olives and olive oil are sources of electrophilic fatty acid nitroalkenes.

Fazzari M, Trostchansky A, Schopfer FJ, Salvatore SR, Sánchez-Calvo B, Vitturi D, Valderrama R, Barroso JB, Radi R, Freeman BA, Rubbo H.

PLoS One. 2014 Jan 14;9(1):e84884. doi: 10.1371/journal.pone.0084884. eCollection 2014.

32.

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity.

Kelley EE, Baust J, Bonacci G, Golin-Bisello F, Devlin JE, St Croix CM, Watkins SC, Gor S, Cantu-Medellin N, Weidert ER, Frisbee JC, Gladwin MT, Champion HC, Freeman BA, Khoo NK.

Cardiovasc Res. 2014 Mar 1;101(3):352-63. doi: 10.1093/cvr/cvt341. Epub 2014 Jan 2.

33.

Biomimetic nitration of conjugated linoleic acid: formation and characterization of naturally occurring conjugated nitrodienes.

Woodcock SR, Salvatore SR, Bonacci G, Schopfer FJ, Freeman BA.

J Org Chem. 2014 Jan 3;79(1):25-33. doi: 10.1021/jo4021562. Epub 2013 Dec 19.

34.

HPLC separation of human serum albumin isoforms based on their isoelectric points.

Turell L, Botti H, Bonilla L, Torres MJ, Schopfer F, Freeman BA, Armas L, Ricciardi A, Alvarez B, Radi R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jan 1;944:144-151. doi: 10.1016/j.jchromb.2013.11.019. Epub 2013 Nov 20.

35.

Nitro-oleic acid desensitizes TRPA1 and TRPV1 agonist responses in adult rat DRG neurons.

Zhang X, Koronowski KB, Li L, Freeman BA, Woodcock S, de Groat WC.

Exp Neurol. 2014 Jan;251:12-21. doi: 10.1016/j.expneurol.2013.10.020. Epub 2013 Nov 8.

36.

Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.

Awwad K, Steinbrink SD, Frömel T, Lill N, Isaak J, Häfner AK, Roos J, Hofmann B, Heide H, Geisslinger G, Steinhilber D, Freeman BA, Maier TJ, Fleming I.

Antioxid Redox Signal. 2014 Jun 10;20(17):2667-80. doi: 10.1089/ars.2013.5473. Epub 2014 Feb 3.

37.

Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acids.

Delmastro-Greenwood M, Freeman BA, Wendell SG.

Annu Rev Physiol. 2014;76:79-105. doi: 10.1146/annurev-physiol-021113-170341. Epub 2013 Oct 16. Review.

38.

Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.

Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ.

J Biol Chem. 2013 Aug 30;288(35):25626-37. doi: 10.1074/jbc.M113.486282. Epub 2013 Jul 22.

39.

Inhibition of Mycobacterium tuberculosis PknG by non-catalytic rubredoxin domain specific modification: reaction of an electrophilic nitro-fatty acid with the Fe-S center.

Gil M, Graña M, Schopfer FJ, Wagner T, Denicola A, Freeman BA, Alzari PM, Batthyány C, Durán R.

Free Radic Biol Med. 2013 Dec;65:150-61. doi: 10.1016/j.freeradbiomed.2013.06.021. Epub 2013 Jun 20.

40.

AuD-degree holders in tenure-track positions: survey of program chairpersons and AuD-degree holders.

Johnson CE, Danhauer JL, Page AS, Freeman BA, Borton TE, Borton BC, Northern JL.

J Am Acad Audiol. 2013 May;24(5):425-46. doi: 10.3766/jaaa.24.5.9. Review.

PMID:
23739062
41.

Demand for audiology services: 30-yr projections and impact on academic programs.

Windmill IM, Freeman BA.

J Am Acad Audiol. 2013 May;24(5):407-16. doi: 10.3766/jaaa.24.5.7. Review.

PMID:
23739060
42.

Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T.

J Neurosci. 2013 May 29;33(22):9259-72. doi: 10.1523/JNEUROSCI.0237-13.2013. Erratum in: J Neurosci. 2014 May 21;34(21):7394.

43.

Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.

Salvatore SR, Vitturi DA, Baker PR, Bonacci G, Koenitzer JR, Woodcock SR, Freeman BA, Schopfer FJ.

J Lipid Res. 2013 Jul;54(7):1998-2009. doi: 10.1194/jlr.M037804. Epub 2013 Apr 25.

44.

Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.

Villacorta L, Chang L, Salvatore SR, Ichikawa T, Zhang J, Petrovic-Djergovic D, Jia L, Carlsen H, Schopfer FJ, Freeman BA, Chen YE.

Cardiovasc Res. 2013 Apr 1;98(1):116-24. doi: 10.1093/cvr/cvt002. Epub 2013 Jan 17.

45.

Conjugated linoleic acid is a preferential substrate for fatty acid nitration.

Bonacci G, Baker PR, Salvatore SR, Shores D, Khoo NK, Koenitzer JR, Vitturi DA, Woodcock SR, Golin-Bisello F, Cole MP, Watkins S, St Croix C, Batthyany CI, Freeman BA, Schopfer FJ.

J Biol Chem. 2012 Dec 28;287(53):44071-82. doi: 10.1074/jbc.M112.401356. Epub 2012 Nov 9.

46.

Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.

Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB.

J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11.

47.

A retrospective mathematical analysis of controlled release design and experimentation.

Rothstein SN, Kay JE, Schopfer FJ, Freeman BA, Little SR.

Mol Pharm. 2012 Nov 5;9(11):3003-11. doi: 10.1021/mp300388w. Epub 2012 Oct 10.

PMID:
23009671
48.

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.

Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

Nat Chem Biol. 2012 Aug;8(8):714-24. doi: 10.1038/nchembio.1018. Epub 2012 Jul 1.

49.

Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study.

Khoo NK, Cantu-Medellin N, Devlin JE, St Croix CM, Watkins SC, Fleming AM, Champion HC, Mason RP, Freeman BA, Kelley EE.

Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2312-9. doi: 10.1016/j.freeradbiomed.2012.04.011. Epub 2012 Apr 21.

50.

Small molecule signaling agents: the integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species.

Fukuto JM, Carrington SJ, Tantillo DJ, Harrison JG, Ignarro LJ, Freeman BA, Chen A, Wink DA.

Chem Res Toxicol. 2012 Apr 16;25(4):769-93. doi: 10.1021/tx2005234. Epub 2012 Feb 9. Review.

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